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Protein

Cystathionine gamma-lyase

Gene

cysA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate.

Cofactori

Pathwayi: L-cysteine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-cysteine from L-homocysteine and L-serine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Cystathionine beta-synthase (cysB)
  2. Cystathionine gamma-lyase (cysA)
This subpathway is part of the pathway L-cysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-cysteine from L-homocysteine and L-serine, the pathway L-cysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei53SubstrateBy similarity1
Binding sitei105SubstrateBy similarity1
Binding sitei110SubstrateBy similarity1
Binding sitei329SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
Biological processAmino-acid biosynthesis, Cysteine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

ReactomeiR-DDI-1614558 Degradation of cysteine and homocysteine
R-DDI-1614603 Cysteine formation from homocysteine
UniPathwayiUPA00136; UER00202

Names & Taxonomyi

Protein namesi
Recommended name:
Cystathionine gamma-lyase (EC:4.4.1.1)
Alternative name(s):
Gamma-cystathionase
Gene namesi
Name:cysA
ORF Names:DDB_G0269122
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0269122 cysA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003278891 – 387Cystathionine gamma-lyaseAdd BLAST387

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei202N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ55DV9
PRIDEiQ55DV9

Expressioni

Developmental stagei

Up-regulated in aspidocytes, a resistant cell type induced by a range of toxins including heavy metals and antibiotics.1 Publication

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0191318

Structurei

3D structure databases

ProteinModelPortaliQ55DV9
SMRiQ55DV9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the trans-sulfuration enzymes family.Curated

Phylogenomic databases

eggNOGiKOG0053 Eukaryota
COG0626 LUCA
InParanoidiQ55DV9
KOiK01758
OMAiHPGRMTH
PhylomeDBiQ55DV9

Family and domain databases

CDDicd00614 CGS_like, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 1 hit
InterProiView protein in InterPro
IPR000277 Cys/Met-Metab_PyrdxlP-dep_enz
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11808 PTHR11808, 1 hit
PfamiView protein in Pfam
PF01053 Cys_Met_Meta_PP, 1 hit
PIRSFiPIRSF001434 CGS, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q55DV9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTQPNNYKIG TNVIHAGQSA DKNTGAVIVP ISLSTTFLQP SPGVLHSEYD
60 70 80 90 100
YSRSGNPTRK AFEECIAACE NAKYALSFAS GLATLTTITH LLKSGDEVIS
110 120 130 140 150
IDDVYGGTRR YFTRVAANFD LKFSFVDLST LDDLKNAFTD KTRLVWIETP
160 170 180 190 200
TNPLLKVADI KAVADYVHSR GATLVVDNTF MSPYFQNPLD LGADIVMHSV
210 220 230 240 250
TKYINGHSDC VMGVLATNND ELYAKLKFLQ NSIGAVPSPF DCFLALRGLK
260 270 280 290 300
TLHVRMEAHQ KNAFAICNFL EKHPKVERVI YPGLPSHPQH EICKRQMKGY
310 320 330 340 350
GGMVVFFVKG SIDQSRSFLE NIKLFALAES LGGVESLIEL PSVMTHASVP
360 370 380
AEERAKLGIS DTLIRLSVGI EDINDLLADI SQALDKC
Length:387
Mass (Da):42,497
Last modified:May 24, 2005 - v1
Checksum:i1A0D7EF1FE502434
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAL71911.1
RefSeqiXP_646022.1, XM_640930.1

Genome annotation databases

EnsemblProtistsiEAL71911; EAL71911; DDB_G0269122
GeneIDi8616970
KEGGiddi:DDB_G0269122

Similar proteinsi

Entry informationi

Entry nameiCGL_DICDI
AccessioniPrimary (citable) accession number: Q55DV9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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