Q55DU3 (ACTOA_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actobindin-A

Gene names

Name:	abnA
ORF Names:	DDB_G0270884

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	92 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Is able to bind two actin monomers at high concentrations of G-actin. Inhibits actin polymerization by sequestering G-actin and stabilizing actin dimers By similarity.
Subunit structure	Monomer By similarity.
Induction	Down-regulated by phagocytic stimuli. Ref.2
Sequence similarities	Contains 2 WH2 domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	actin binding Inferred from sequence or structural similarity. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 92	92	Actobindin-A		PRO_0000383094
Regions
	Domain	3 – 20	18	WH2 1
	Domain	40 – 57	18	WH2 2

Sequences

	Sequence		Length	Mass (Da)
	Q55DU3 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 8D7D086A1BB1B6B6	FASTA	92	9,817
	10 20 30 40 50 60 MSAPNPLLAE INKGADLKHT ETQDKSAPKI GSDVHIKKND HASLLSEVEQ GAKLKHAETD 70 80 90 DKSAPKINEN TTIKPNNHSA LLGEIKAKAA DS

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

[2]

"Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium." Sillo A., Bloomfield G., Balest A., Balbo A., Pergolizzi B., Peracino B., Skelton J., Ivens A., Bozzaro S. BMC Genomics 9:291-291(2008) [PubMed: 18559084] [Abstract] Cited for: INDUCTION [LARGE SCALE ANALYSIS].

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000005 Genomic DNA. Translation: EAL72792.1.
RefSeq	XP_646038.1. XM_640946.1.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0231649; DDB0231649; DDB_G0270884.
GeneID	8616985.
GenomeReviews	Gene locus abnA in contig CM000150_GR.
KEGG	ddi:DDB_G0270884.
Organism-specific databases
dictyBase	DDB_G0270884. abnA.
Phylogenomic databases
GeneTree	EPrGT00050000005118.
HOGENOM	HBG075085.
InParanoid	Q55DU3.
OMA	TDDKSAP.
ProtClustDB	CLSZ2431377.
Family and domain databases
InterPro	IPR016365. Actobindin. IPR003124. WH2_actin-bd. [Graphical view]
Pfam	PF02205. WH2. 1 hit. [Graphical view]
PIRSF	PIRSF002724. Actobindin. 1 hit.
SMART	SM00246. WH2. 2 hits. [Graphical view]
PROSITE	PS51082. WH2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACTOA_DICDI

Accession

Primary (citable) accession number: Q55DU3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	May 24, 2005
Last modified:	September 21, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)