Q55DU1 (ACTOB_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actobindin-B/C

Gene names

Name:	abnB
ORF Names:	DDB_G0269518
AND
Name:	abnC
ORF Names:	DDB_G0269520

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	90 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Is able to bind two actin monomers at high concentrations of G-actin. Inhibits actin polymerization by sequestering G-actin and stabilizing actin dimers By similarity.
Subunit structure	Monomer By similarity.
Sequence similarities	Contains 2 WH2 domains.

Ontologies

Keywords
Domain	Repeat
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	actin binding Inferred from sequence or structural similarity. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 90	90	Actobindin-B/C		PRO_0000383095
Regions
	Domain	4 – 21	18	WH2 1
	Domain	40 – 57	18	WH2 2

Sequences

	Sequence		Length	Mass (Da)
	Q55DU1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 3C54B8C20A34C24E	FASTA	90	9,640
	10 20 30 40 50 60 MSTTANPLLA EINKGTDLKH AETQDKSAPI IENVPIKKND HSSLLGEVEK GAQLKHVETQ 70 80 90 DRSAPVTEGA TVKSNNHSAL LGEIKSKAQE

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000005 Genomic DNA. Translation: EAL72109.1. AAFI02000005 Genomic DNA. Translation: EAL72110.1.
RefSeq	XP_646039.1. XM_640947.1. XP_646040.1. XM_640948.1.
3D structure databases
ProteinModelPortal	Q55DU1.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0231662; DDB0231662; DDB_G0269518. DDB0231663; DDB0231663; DDB_G0269520.
GeneID	8616986. 8616987.
GenomeReviews	Gene locus abnC in contig CM000150_GR.
KEGG	ddi:DDB_G0269518. ddi:DDB_G0269520.
Organism-specific databases
dictyBase	DDB_G0269518. abnB. DDB_G0269520. abnC.
Phylogenomic databases
GeneTree	EPrGT00050000005118.
HOGENOM	HBG075085.
InParanoid	Q55DU1.
ProtClustDB	CLSZ2431377.
Family and domain databases
InterPro	IPR016365. Actobindin. IPR003124. WH2_actin-bd. [Graphical view]
Pfam	PF02205. WH2. 2 hits. [Graphical view]
PIRSF	PIRSF002724. Actobindin. 1 hit.
SMART	SM00246. WH2. 2 hits. [Graphical view]
PROSITE	PS51082. WH2. 2 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACTOB_DICDI

Accession

Primary (citable) accession number: Q55DU1

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 1, 2009
Last sequence update:	May 24, 2005
Last modified:	January 25, 2012
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)