Reviewed, UniProtKB/Swiss-Prot Q55DT8 (ARGD_DICDI)

Names and origin

Protein names

Recommended name:
    Probable acetylornithine aminotransferase, mitochondrial
      Short name=ACOAT
    EC=2.6.1.11

Gene names

Name:	argD
Synonyms:	arg8
ORF Names:	DDB_G0269526

Organism

Dictyostelium discoideum (Slime mold) [Complete proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	453 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N(2)-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate.
Cofactor	Pyridoxal phosphate By similarity.
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 4/4.
Subcellular location	Mitochondrion matrix By similarity.
Sequence similarities	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Mitochondrion
Domain	Transit peptide
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	mitochondrial matrix Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Transit peptide	1 – ?		Mitochondrion Potential
	Chain	? – 453		Probable acetylornithine aminotransferase, mitochondrial		PRO_0000327776
Amino acid modifications
	Modified residue	302	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55DT8-1 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 4328E466B96BCDFD	FASTA	453	50,122
	10 20 30 40 50 60 MFNKLNKINK IKNCFNKSIY QINYSSKPIF KEGITNVKLD RDNKDGTSDY IKLHDNVIMN 70 80 90 100 110 120 TYGRVSDIVF THGKDSWLYD MKGDKYLDFG AGIAVNALGH SNDGWSEVVA NQSKKLTHLS 130 140 150 160 170 180 NLYYNQPAIE LAQSMIASTP IFDKVFFANS GTEANEAALK FAKKIGIAKG GVDKHEIIAF 190 200 210 220 230 240 SHGFSGRSMG SLSCTHKSKY REIYGPLVPG VHFAEYNDIE SVKKLMSKSK TCAVIIEPVQ 250 260 270 280 290 300 GEGGLEAATV EFMQQLYKLC KENDCLLIVD EVQCGIGRTG QLWAHTRFDT EKCKPDIMTL 310 320 330 340 350 360 AKPLAGGLPI GAVLVSDKVA SEIKPGDHGT TFGGGPLVCE VGKYVFERIS QPSFLKEVQE 370 380 390 400 410 420 KGKYLTDGLK KLKDQFPNSI LEIRTVGGLF VGIQLDHNVS DLVSYAKSQK ILIINAGDDV 430 440 450 IRFCPPLTIT KQEIDQLLLV LKNYLIKVNS NKK

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000005 Genomic DNA. Translation: EAL72113.1.
RefSeq	XP_646043.1.
3D structure databases
HSSP	HSSP built from PDB template 1S08 based on UniProtKB P12995.
SMR	Q55DT8. Positions 57-446.
ModBase	Search...
Protein-protein interaction databases
STRING	Q55DT8.
Genome annotation databases
GeneID	8616990.
KEGG	ddi:DDB_0231481.
Organism-specific databases
dictyBase	DDB_G0269526. argD.
Phylogenomic databases
eggNOG	KOG1401.
HOGENOM	HBG725944.
PhylomeDB	Q55DT8.
Enzyme and pathway databases
BRENDA	2.6.1.11. 424.
Family and domain databases
InterPro	IPR004636. AcOrn/succinylOrn_aminoTrfase. IPR005814. Aminotrans_3. IPR015424. PyrdxlP-dep_Trfase_major_dom. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11986. Aminotrans_3. 1 hit. PTHR11986:SF19. ArgD_aminotrans. 1 hit.
Pfam	PF00202. Aminotran_3. 1 hit. [Graphical view]
TIGRFAMs	TIGR00707. argD. 1 hit.
PROSITE	PS00600. AA_TRANSFER_CLASS_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGD_DICDI

Accession

Primary (citable) accession number: Q55DT8

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	February 9, 2010
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)