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Q55DR6

- FCSA_DICDI

UniProt

Q55DR6 - FCSA_DICDI

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Protein

Fatty acyl-CoA synthetase A

Gene

fcsA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process. May mediate fatty acid retrieval from the lumen of endosomes into the cytoplasm.1 Publication

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. long-chain fatty acid-CoA ligase activity Source: dictyBase

GO - Biological processi

  1. fatty acid metabolic process Source: dictyBase
  2. long-chain fatty acid metabolic process Source: GOC
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Fatty acid metabolism, Lipid metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acyl-CoA synthetase A (EC:6.2.1.3)
Alternative name(s):
Long chain fatty acyl coenzyme A-synthetase 1
Short name:
LC-FACS 1
Long-chain-fatty-acid--CoA synthetase 1
Gene namesi
Name:fcsA
ORF Names:DDB_G0269242
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0269242. fcsA.

Subcellular locationi

Endosome membrane 1 Publication; Peripheral membrane protein 1 Publication; Cytoplasmic side 1 Publication
Note: Associates with endosomes a few minutes after their formation, remains bound through the acidic phase of endocytic maturation and dissociates early in the phase where the endosomal content is neutralized prior to exocytosis.

GO - Cellular componenti

  1. cytoplasm Source: dictyBase
  2. cytoplasmic side of endosome membrane Source: dictyBase
  3. phagocytic vesicle Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 667667Fatty acyl-CoA synthetase APRO_0000328558Add
BLAST

Proteomic databases

PRIDEiQ55DR6.

Expressioni

Developmental stagei

Expressed at all stages of development.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0191105.

Structurei

3D structure databases

ProteinModelPortaliQ55DR6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1022.
InParanoidiQ55DR6.
KOiK01897.
OMAiPRRNTKF.
PhylomeDBiQ55DR6.

Family and domain databases

InterProiIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55DR6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSLSTKTDL LGDPDFIRLQ SVEVDGSEVI PGETRPRRNT KFPKLTNSPD
60 70 80 90 100
GKTFTLYDVY RINKDSDSNF LGIRELLADG KRGDYKWISY KQACIRANNI
110 120 130 140 150
GSALVQLGLN KGDRIGIFSI NRPEWVLSDM AAMNHSLVPV ALYATLGANA
160 170 180 190 200
IEYVVNHSEI SVLLCEGKNV EKILSMPGTT IKTIVSYDPL PQATLDKFKD
210 220 230 240 250
NENVKLYLLS DFEKLGEQNP AQHEVPSPED LCTLLYTSGS TGNPKGVMLT
260 270 280 290 300
HTNMVSEVAG ANFSPAGVIP EDVHMSYLPL AHSFERAVVS LMCYVGGQIG
310 320 330 340 350
FFSGLIPELF NDIQVLRPTF LCGAPRVWQR LHDKLWFTVN NDSWLKKFLF
360 370 380 390 400
NWGLNSKQSA LRLGSTTPIW DKLVFSKTKD RLGGRVKFIL SGSAPLDPKL
410 420 430 440 450
AEFLRACFCC PVVSGYGLSE NVGGASVAYP EDNNVGHVGP PLSACEMKLI
460 470 480 490 500
DVPEMNYFST DKPCPRGEVC IRGFNVFKGY FKDPEKTKED LKEDGWFHTG
510 520 530 540 550
DIGRWNENGT LSIIDRKKNI FKLSQGEYVA AEYLESVFVR SPFASQVFVY
560 570 580 590 600
GDSLNSFLVG VVVPDFEVVQ KLFASKYPEL DVSNHATLAK SKELYKEILS
610 620 630 640 650
SFDACAAEAK LHGFEKLKHI YVEHEPFTEE NNLLTPSFKP KRPQLKERYQ
660
TIIDTLYAEY KRDHPDV
Length:667
Mass (Da):74,609
Last modified:May 24, 2005 - v1
Checksum:i3F7A9C4B4AFBB2B4
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti199 – 1991K → T in AAO43007. (PubMed:14629118)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY196478 mRNA. Translation: AAO43007.1.
AAFI02000005 Genomic DNA. Translation: EAL71971.1.
RefSeqiXP_646065.1. XM_640973.1.

Genome annotation databases

EnsemblProtistsiDDB0191105; DDB0191105; DDB_G0269242.
GeneIDi8617013.
KEGGiddi:DDB_G0269242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY196478 mRNA. Translation: AAO43007.1 .
AAFI02000005 Genomic DNA. Translation: EAL71971.1 .
RefSeqi XP_646065.1. XM_640973.1.

3D structure databases

ProteinModelPortali Q55DR6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0191105.

Proteomic databases

PRIDEi Q55DR6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0191105 ; DDB0191105 ; DDB_G0269242 .
GeneIDi 8617013.
KEGGi ddi:DDB_G0269242.

Organism-specific databases

dictyBasei DDB_G0269242. fcsA.

Phylogenomic databases

eggNOGi COG1022.
InParanoidi Q55DR6.
KOi K01897.
OMAi PRRNTKF.
PhylomeDBi Q55DR6.

Miscellaneous databases

PROi Q55DR6.

Family and domain databases

InterProi IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
[Graphical view ]
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A Dictyostelium long chain fatty acyl coenzyme A-synthetase mediates fatty acid retrieval from endosomes."
    von Loehneysen K., Pawolleck N., Ruehling H., Maniak M.
    Eur. J. Cell Biol. 82:505-514(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake."
    Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T.
    Mol. Cell. Proteomics 5:2228-2243(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Strain: AX2.

Entry informationi

Entry nameiFCSA_DICDI
AccessioniPrimary (citable) accession number: Q55DR6
Secondary accession number(s): Q86PL9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3