Q55DR6 (FCSA_DICDI) Reviewed, UniProtKB/Swiss-Prot
Last modified
November 16, 2011.
Version 48.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Fatty acyl-CoA synthetase A EC=6.2.1.3 Alternative name(s): Long chain fatty acyl coenzyme A-synthetase 1 Short name=LC-FACS 1 Long-chain-fatty-acid--CoA synthetase 1 | ||||
| Gene names |
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| Organism | Dictyostelium discoideum (Slime mold) | ||||
| Taxonomic identifier | 44689 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium |
Protein attributes
| Sequence length | 667 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process. May mediate fatty acid retrieval from the lumen of endosomes into the cytoplasm. Ref.1 |
| Catalytic activity | ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA. |
| Subcellular location | Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note: Associates with endosomes a few minutes after their formation, remains bound through the acidic phase of endocytic maturation and dissociates early in the phase where the endosomal content is neutralized prior to exocytosis. Ref.1 |
| Developmental stage | Expressed at all stages of development. Ref.1 |
| Sequence similarities | Belongs to the ATP-dependent AMP-binding enzyme family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Fatty acid metabolism Lipid metabolism |
| Cellular component | Endosome Membrane |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Ligase |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological process | fatty acid metabolic process Inferred from mutant phenotype Ref.1. Source: dictyBase |
| Cellular component | external side of endosome membrane Inferred from direct assay Ref.1. Source: dictyBase phagocytic vesicleInferred from direct assay Ref.3. Source: dictyBase |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW long-chain fatty acid-CoA ligase activityTraceable author statement Ref.1. Source: dictyBase |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A Dictyostelium long chain fatty acyl coenzyme A-synthetase mediates fatty acid retrieval from endosomes." von Loehneysen K., Pawolleck N., Ruehling H., Maniak M. Eur. J. Cell Biol. 82:505-514(2003) [PubMed: 14629118] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE. |
| [2] | "The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. Kuspa A.Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4. |
| [3] | "Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake." Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T. Mol. Cell. Proteomics 5:2228-2243(2006) [PubMed: 16926386] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Strain: AX2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AY196478 mRNA. Translation: AAO43007.1. AAFI02000005 Genomic DNA. Translation: EAL71971.1. |
| RefSeq | XP_646065.1. XM_640973.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1BA3 based on UniProtKB P08659. |
| ProteinModelPortal | Q55DR6. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q55DR6. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| EnsemblProtists | DDB0191105; DDB0191105; DDB_G0269242. |
| GeneID | 8617013. |
| GenomeReviews | Gene locus fcsA in contig CM000150_GR. |
| KEGG | ddi:DDB_G0269242. |
Organism-specific databases | |
| dictyBase | DDB_G0269242. fcsA. |
Phylogenomic databases | |
| eggNOG | KOG1256. |
| GeneTree | EPrGT00050000001370. |
| HOGENOM | HBG721674. |
| OMA | ICTEANT. |
| PhylomeDB | Q55DR6. |
| ProtClustDB | CLSZ2431379. |
Family and domain databases | |
| InterPro | IPR020845. AMP-binding_CS. IPR000873. AMP-dep_Synth/Lig. [Graphical view] |
| KO | K01897. |
| Pfam | PF00501. AMP-binding. 1 hit. [Graphical view] |
| PROSITE | PS00455. AMP_BINDING. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | FCSA_DICDI | ||||||||
| Accession | Primary (citable) accession number: Q55DR6 Secondary accession number(s): Q86PL9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
Relevant documents
| Dictyostelium discoideum Dictyostelium discoideum: entries, gene names and cross-references to dictyBase |
| SIMILARITY comments Index of protein domains and families |

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