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Protein

Fatty acyl-CoA synthetase A

Gene

fcsA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process. May mediate fatty acid retrieval from the lumen of endosomes into the cytoplasm.1 Publication

Catalytic activityi

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • decanoate-CoA ligase activity Source: UniProtKB-EC
  • long-chain fatty acid-CoA ligase activity Source: dictyBase

GO - Biological processi

  • fatty acid metabolic process Source: dictyBase

Keywordsi

Molecular functionLigase
Biological processFatty acid metabolism, Lipid metabolism
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DDI-2046105 Linoleic acid (LA) metabolism
R-DDI-2046106 alpha-linolenic acid (ALA) metabolism
R-DDI-75876 Synthesis of very long-chain fatty acyl-CoAs

Names & Taxonomyi

Protein namesi
Recommended name:
Fatty acyl-CoA synthetase A (EC:6.2.1.3)
Alternative name(s):
Long chain fatty acyl coenzyme A-synthetase 1
Short name:
LC-FACS 1
Long-chain-fatty-acid--CoA synthetase 1
Gene namesi
Name:fcsA
ORF Names:DDB_G0269242
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0269242 fcsA

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: dictyBase
  • cytoplasmic side of endosome membrane Source: dictyBase
  • phagocytic vesicle Source: dictyBase

Keywords - Cellular componenti

Endosome, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003285581 – 667Fatty acyl-CoA synthetase AAdd BLAST667

Proteomic databases

PaxDbiQ55DR6

Expressioni

Developmental stagei

Expressed at all stages of development.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0191105

Structurei

3D structure databases

ProteinModelPortaliQ55DR6
SMRiQ55DR6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1256 Eukaryota
COG1022 LUCA
InParanoidiQ55DR6
KOiK01897
OMAiLGCQIFE
PhylomeDBiQ55DR6

Family and domain databases

InterProiView protein in InterPro
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
PfamiView protein in Pfam
PF00501 AMP-binding, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit

Sequencei

Sequence statusi: Complete.

Q55DR6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLSTKTDL LGDPDFIRLQ SVEVDGSEVI PGETRPRRNT KFPKLTNSPD
60 70 80 90 100
GKTFTLYDVY RINKDSDSNF LGIRELLADG KRGDYKWISY KQACIRANNI
110 120 130 140 150
GSALVQLGLN KGDRIGIFSI NRPEWVLSDM AAMNHSLVPV ALYATLGANA
160 170 180 190 200
IEYVVNHSEI SVLLCEGKNV EKILSMPGTT IKTIVSYDPL PQATLDKFKD
210 220 230 240 250
NENVKLYLLS DFEKLGEQNP AQHEVPSPED LCTLLYTSGS TGNPKGVMLT
260 270 280 290 300
HTNMVSEVAG ANFSPAGVIP EDVHMSYLPL AHSFERAVVS LMCYVGGQIG
310 320 330 340 350
FFSGLIPELF NDIQVLRPTF LCGAPRVWQR LHDKLWFTVN NDSWLKKFLF
360 370 380 390 400
NWGLNSKQSA LRLGSTTPIW DKLVFSKTKD RLGGRVKFIL SGSAPLDPKL
410 420 430 440 450
AEFLRACFCC PVVSGYGLSE NVGGASVAYP EDNNVGHVGP PLSACEMKLI
460 470 480 490 500
DVPEMNYFST DKPCPRGEVC IRGFNVFKGY FKDPEKTKED LKEDGWFHTG
510 520 530 540 550
DIGRWNENGT LSIIDRKKNI FKLSQGEYVA AEYLESVFVR SPFASQVFVY
560 570 580 590 600
GDSLNSFLVG VVVPDFEVVQ KLFASKYPEL DVSNHATLAK SKELYKEILS
610 620 630 640 650
SFDACAAEAK LHGFEKLKHI YVEHEPFTEE NNLLTPSFKP KRPQLKERYQ
660
TIIDTLYAEY KRDHPDV
Length:667
Mass (Da):74,609
Last modified:May 24, 2005 - v1
Checksum:i3F7A9C4B4AFBB2B4
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti199K → T in AAO43007 (PubMed:14629118).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY196478 mRNA Translation: AAO43007.1
AAFI02000005 Genomic DNA Translation: EAL71971.1
RefSeqiXP_646065.1, XM_640973.1

Genome annotation databases

EnsemblProtistsiEAL71971; EAL71971; DDB_G0269242
GeneIDi8617013
KEGGiddi:DDB_G0269242

Similar proteinsi

Entry informationi

Entry nameiFCSA_DICDI
AccessioniPrimary (citable) accession number: Q55DR6
Secondary accession number(s): Q86PL9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 25, 2018
This is version 83 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health