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Q55DR6 (FCSA_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Fatty acyl-CoA synthetase A

EC=6.2.1.3
Alternative name(s):
Long chain fatty acyl coenzyme A-synthetase 1
Short name=LC-FACS 1
Long-chain-fatty-acid--CoA synthetase 1
Gene names
Name:fcsA
ORF Names:DDB_G0269242
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length667 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Long chain fatty acid acyl-CoA synthetases catalyze the formation of a thiester bond between a free fatty acid and coenzyme A during fatty acid metabolic process. May mediate fatty acid retrieval from the lumen of endosomes into the cytoplasm. Ref.1

Catalytic activity

ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.

Subcellular location

Endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note: Associates with endosomes a few minutes after their formation, remains bound through the acidic phase of endocytic maturation and dissociates early in the phase where the endosomal content is neutralized prior to exocytosis. Ref.1

Developmental stage

Expressed at all stages of development. Ref.1

Sequence similarities

Belongs to the ATP-dependent AMP-binding enzyme family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 667667Fatty acyl-CoA synthetase A
PRO_0000328558

Experimental info

Sequence conflict1991K → T in AAO43007. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q55DR6 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 3F7A9C4B4AFBB2B4

FASTA66774,609
        10         20         30         40         50         60 
MSSLSTKTDL LGDPDFIRLQ SVEVDGSEVI PGETRPRRNT KFPKLTNSPD GKTFTLYDVY 

        70         80         90        100        110        120 
RINKDSDSNF LGIRELLADG KRGDYKWISY KQACIRANNI GSALVQLGLN KGDRIGIFSI 

       130        140        150        160        170        180 
NRPEWVLSDM AAMNHSLVPV ALYATLGANA IEYVVNHSEI SVLLCEGKNV EKILSMPGTT 

       190        200        210        220        230        240 
IKTIVSYDPL PQATLDKFKD NENVKLYLLS DFEKLGEQNP AQHEVPSPED LCTLLYTSGS 

       250        260        270        280        290        300 
TGNPKGVMLT HTNMVSEVAG ANFSPAGVIP EDVHMSYLPL AHSFERAVVS LMCYVGGQIG 

       310        320        330        340        350        360 
FFSGLIPELF NDIQVLRPTF LCGAPRVWQR LHDKLWFTVN NDSWLKKFLF NWGLNSKQSA 

       370        380        390        400        410        420 
LRLGSTTPIW DKLVFSKTKD RLGGRVKFIL SGSAPLDPKL AEFLRACFCC PVVSGYGLSE 

       430        440        450        460        470        480 
NVGGASVAYP EDNNVGHVGP PLSACEMKLI DVPEMNYFST DKPCPRGEVC IRGFNVFKGY 

       490        500        510        520        530        540 
FKDPEKTKED LKEDGWFHTG DIGRWNENGT LSIIDRKKNI FKLSQGEYVA AEYLESVFVR 

       550        560        570        580        590        600 
SPFASQVFVY GDSLNSFLVG VVVPDFEVVQ KLFASKYPEL DVSNHATLAK SKELYKEILS 

       610        620        630        640        650        660 
SFDACAAEAK LHGFEKLKHI YVEHEPFTEE NNLLTPSFKP KRPQLKERYQ TIIDTLYAEY 


KRDHPDV 

« Hide

References

« Hide 'large scale' references
[1]"A Dictyostelium long chain fatty acyl coenzyme A-synthetase mediates fatty acid retrieval from endosomes."
von Loehneysen K., Pawolleck N., Ruehling H., Maniak M.
Eur. J. Cell Biol. 82:505-514(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[3]"Proteomics fingerprinting of phagosome maturation and evidence for the role of a Galpha during uptake."
Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M., Soldati T.
Mol. Cell. Proteomics 5:2228-2243(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Strain: AX2.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY196478 mRNA. Translation: AAO43007.1.
AAFI02000005 Genomic DNA. Translation: EAL71971.1.

3D structure databases

ProteinModelPortalQ55DR6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0191105.

Proteomic databases

PRIDEQ55DR6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0191105; DDB0191105; DDB_G0269242.
KEGGddi:DDB_G0269242.

Organism-specific databases

dictyBaseDDB_G0269242. fcsA.

Phylogenomic databases

eggNOGCOG1022.
KOK01897.
OMAPRRNTKF.
PhylomeDBQ55DR6.
ProtClustDBCLSZ2431379.

Family and domain databases

InterProIPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamPF00501. AMP-binding. 1 hit.
[Graphical view]
PROSITEPS00455. AMP_BINDING. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ55DR6.

Entry information

Entry nameFCSA_DICDI
AccessionPrimary (citable) accession number: Q55DR6
Secondary accession number(s): Q86PL9
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase