ID PGTA_DICDI Reviewed; 311 AA. AC Q55DQ4; DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot. DT 18-MAR-2008, sequence version 2. DT 24-JAN-2024, entry version 103. DE RecName: Full=Geranylgeranyl transferase type-2 subunit alpha; DE EC=2.5.1.60; DE AltName: Full=GGTase-II-alpha; DE AltName: Full=Geranylgeranyl transferase type II subunit alpha; DE AltName: Full=PGGT; DE AltName: Full=Type II protein geranyl-geranyltransferase subunit alpha; GN Name=rabggta; ORFNames=DDB_G0269570; OS Dictyostelium discoideum (Social amoeba). OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales; OC Dictyosteliaceae; Dictyostelium. OX NCBI_TaxID=44689; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=AX4; RX PubMed=15875012; DOI=10.1038/nature03481; RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G., RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.; RT "The genome of the social amoeba Dictyostelium discoideum."; RL Nature 435:43-57(2005). CC -!- FUNCTION: Catalyzes the transfer of a geranylgeranyl moiety from CC geranylgeranyl diphosphate to proteins with a C-terminal sequence motif CC -XCC or -XCXC, where both cysteines may become modified. {ECO:0000250}. CC -!- CATALYTIC ACTIVITY: CC Reaction=geranylgeranyl diphosphate + L-cysteinyl-[protein] = CC diphosphate + S-geranylgeranyl-L-cysteinyl-[protein]; CC Xref=Rhea:RHEA:21240, Rhea:RHEA-COMP:10131, Rhea:RHEA-COMP:11537, CC ChEBI:CHEBI:29950, ChEBI:CHEBI:33019, ChEBI:CHEBI:57533, CC ChEBI:CHEBI:86021; EC=2.5.1.60; CC -!- SUBUNIT: Heterodimer of an alpha and a beta subunit. {ECO:0000250}. CC -!- SIMILARITY: Belongs to the protein prenyltransferase subunit alpha CC family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AAFI02000005; EAL72135.2; -; Genomic_DNA. DR RefSeq; XP_646077.2; XM_640985.2. DR AlphaFoldDB; Q55DQ4; -. DR SMR; Q55DQ4; -. DR STRING; 44689.Q55DQ4; -. DR PaxDb; 44689-DDB0233950; -. DR EnsemblProtists; EAL72135; EAL72135; DDB_G0269570. DR GeneID; 8617027; -. DR KEGG; ddi:DDB_G0269570; -. DR dictyBase; DDB_G0269570; rabggta. DR eggNOG; KOG0529; Eukaryota. DR HOGENOM; CLU_031996_0_0_1; -. DR InParanoid; Q55DQ4; -. DR OMA; RKFPKCY; -. DR PhylomeDB; Q55DQ4; -. DR Reactome; R-DDI-6803205; TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain. DR Reactome; R-DDI-8873719; RAB geranylgeranylation. DR PRO; PR:Q55DQ4; -. DR Proteomes; UP000002195; Chromosome 1. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005968; C:Rab-protein geranylgeranyltransferase complex; ISS:UniProtKB. DR GO; GO:0004663; F:Rab geranylgeranyltransferase activity; ISS:UniProtKB. DR GO; GO:0031267; F:small GTPase binding; ISS:UniProtKB. DR GO; GO:0018344; P:protein geranylgeranylation; ISS:UniProtKB. DR Gene3D; 1.25.40.120; Protein prenylyltransferase; 1. DR InterPro; IPR002088; Prenyl_trans_a. DR PANTHER; PTHR11129:SF2; GERANYLGERANYL TRANSFERASE TYPE-2 SUBUNIT ALPHA; 1. DR PANTHER; PTHR11129; PROTEIN FARNESYLTRANSFERASE ALPHA SUBUNIT/RAB GERANYLGERANYL TRANSFERASE ALPHA SUBUNIT; 1. DR Pfam; PF01239; PPTA; 5. DR SUPFAM; SSF48439; Protein prenylyltransferase; 1. DR PROSITE; PS51147; PFTA; 5. PE 3: Inferred from homology; KW Coiled coil; Prenyltransferase; Reference proteome; Repeat; Transferase. FT CHAIN 1..311 FT /note="Geranylgeranyl transferase type-2 subunit alpha" FT /id="PRO_0000331287" FT REPEAT 49..82 FT /note="PFTA 1" FT REPEAT 93..126 FT /note="PFTA 2" FT REPEAT 129..162 FT /note="PFTA 3" FT REPEAT 164..197 FT /note="PFTA 4" FT REPEAT 206..239 FT /note="PFTA 5" FT COILED 12..43 FT /evidence="ECO:0000255" SQ SEQUENCE 311 AA; 37779 MW; F6640179FFC4DC41 CRC64; MHGVLKVRTS EEKAKAQRLK ELEKIESYNK LVKSFEELRE KQNGRYDEIS LSVSKLVLIE NPEFYTIWNY RRLAILQFTE TKENSELQVI YQNEMKFLEE CIQRFTKSYW IWFHRQWIAL RMDNCDWERE MKLCTKLLNF DLRNFHCWGH RRFILKHSNI KLEDELKYTT EKVEQNFSNY SAWHQRSSIL PKIYKEPEQL LEKILEEFEL VRNAVYTEPK DSSSWIYHKW LVATIKSIPN SNYIEVLKNE LTQIYDLIEL EPDCKWPIYT TLLLKIEIGG FEKQELLDII SQLIKLDPDH KNYYKSLETK I //