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Q55DQ4

- PGTA_DICDI

UniProt

Q55DQ4 - PGTA_DICDI

Protein

Geranylgeranyl transferase type-2 subunit alpha

Gene

rabggta

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 66 (01 Oct 2014)
      Sequence version 2 (18 Mar 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to proteins with a C-terminal sequence motif -XCC or -XCXC, where both cysteines may become modified.By similarity

    Catalytic activityi

    Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

    GO - Molecular functioni

    1. Rab geranylgeranyltransferase activity Source: UniProtKB
    2. Rab GTPase binding Source: UniProtKB

    GO - Biological processi

    1. protein geranylgeranylation Source: UniProtKB

    Keywords - Molecular functioni

    Prenyltransferase, Transferase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60)
    Alternative name(s):
    GGTase-II-alpha
    Geranylgeranyl transferase type II subunit alpha
    PGGT
    Type II protein geranyl-geranyltransferase subunit alpha
    Gene namesi
    Name:rabggta
    ORF Names:DDB_G0269570
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0269570. rabggta.

    Subcellular locationi

    GO - Cellular componenti

    1. Rab-protein geranylgeranyltransferase complex Source: UniProtKB

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 311311Geranylgeranyl transferase type-2 subunit alphaPRO_0000331287Add
    BLAST

    Interactioni

    Subunit structurei

    Heterodimer of an alpha and a beta subunit.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0190367.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55DQ4.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati49 – 8234PFTA 1Add
    BLAST
    Repeati93 – 12634PFTA 2Add
    BLAST
    Repeati129 – 16234PFTA 3Add
    BLAST
    Repeati164 – 19734PFTA 4Add
    BLAST
    Repeati206 – 23934PFTA 5Add
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili12 – 4332Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 5 PFTA repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiCOG5536.
    KOiK14050.
    OMAiAWNYRRY.
    PhylomeDBiQ55DQ4.

    Family and domain databases

    InterProiIPR002088. Prenyl_trans_a.
    [Graphical view]
    PfamiPF01239. PPTA. 4 hits.
    [Graphical view]
    PROSITEiPS51147. PFTA. 5 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q55DQ4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHGVLKVRTS EEKAKAQRLK ELEKIESYNK LVKSFEELRE KQNGRYDEIS    50
    LSVSKLVLIE NPEFYTIWNY RRLAILQFTE TKENSELQVI YQNEMKFLEE 100
    CIQRFTKSYW IWFHRQWIAL RMDNCDWERE MKLCTKLLNF DLRNFHCWGH 150
    RRFILKHSNI KLEDELKYTT EKVEQNFSNY SAWHQRSSIL PKIYKEPEQL 200
    LEKILEEFEL VRNAVYTEPK DSSSWIYHKW LVATIKSIPN SNYIEVLKNE 250
    LTQIYDLIEL EPDCKWPIYT TLLLKIEIGG FEKQELLDII SQLIKLDPDH 300
    KNYYKSLETK I 311
    Length:311
    Mass (Da):37,779
    Last modified:March 18, 2008 - v2
    Checksum:iF6640179FFC4DC41
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAL72135.2.
    RefSeqiXP_646077.2. XM_640985.2.

    Genome annotation databases

    EnsemblProtistsiDDB0233950; DDB0233950; DDB_G0269570.
    GeneIDi8617027.
    KEGGiddi:DDB_G0269570.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAL72135.2 .
    RefSeqi XP_646077.2. XM_640985.2.

    3D structure databases

    ProteinModelPortali Q55DQ4.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0190367.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0233950 ; DDB0233950 ; DDB_G0269570 .
    GeneIDi 8617027.
    KEGGi ddi:DDB_G0269570.

    Organism-specific databases

    dictyBasei DDB_G0269570. rabggta.

    Phylogenomic databases

    eggNOGi COG5536.
    KOi K14050.
    OMAi AWNYRRY.
    PhylomeDBi Q55DQ4.

    Miscellaneous databases

    PROi Q55DQ4.

    Family and domain databases

    InterProi IPR002088. Prenyl_trans_a.
    [Graphical view ]
    Pfami PF01239. PPTA. 4 hits.
    [Graphical view ]
    PROSITEi PS51147. PFTA. 5 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiPGTA_DICDI
    AccessioniPrimary (citable) accession number: Q55DQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: March 18, 2008
    Last modified: October 1, 2014
    This is version 66 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3