Q55DQ4 (PGTA_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Geranylgeranyl transferase type-2 subunit alpha
EC=2.5.1.60

Alternative name(s):
GGTase-II-alpha
Geranylgeranyl transferase type II subunit alpha
PGGT
Type II protein geranyl-geranyltransferase subunit alpha

Gene names

Name:	rabggta
ORF Names:	DDB_G0269570

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	311 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to proteins having the C-terminal-XCC or -XCXC, where both cysteines may become modified By similarity.
Catalytic activity	Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Subunit structure	Heterodimer of an alpha and a beta subunit By similarity.
Sequence similarities	Belongs to the protein prenyltransferase subunit alpha family. Contains 5 PFTA repeats.

Ontologies

Keywords
Domain	Coiled coil Repeat
Ligand	Metal-binding Zinc
Molecular function	Prenyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein geranylgeranylation Inferred from sequence or structural similarity. Source: dictyBase
Cellular component	Rab-protein geranylgeranyltransferase complex Inferred from sequence or structural similarity. Source: dictyBase
Molecular function	Rab geranylgeranyltransferase activity Inferred from sequence or structural similarity. Source: dictyBase metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 311	311	Geranylgeranyl transferase type-2 subunit alpha		PRO_0000331287
Regions
	Repeat	49 – 82	34	PFTA 1
	Repeat	93 – 126	34	PFTA 2
	Repeat	129 – 162	34	PFTA 3
	Repeat	164 – 197	34	PFTA 4
	Repeat	206 – 239	34	PFTA 5
	Coiled coil	12 – 43	32	Potential
Sites
	Metal binding	2	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55DQ4 [UniParc]. Last modified March 18, 2008. Version 2. Checksum: F6640179FFC4DC41	FASTA	311	37,779
	10 20 30 40 50 60 MHGVLKVRTS EEKAKAQRLK ELEKIESYNK LVKSFEELRE KQNGRYDEIS LSVSKLVLIE 70 80 90 100 110 120 NPEFYTIWNY RRLAILQFTE TKENSELQVI YQNEMKFLEE CIQRFTKSYW IWFHRQWIAL 130 140 150 160 170 180 RMDNCDWERE MKLCTKLLNF DLRNFHCWGH RRFILKHSNI KLEDELKYTT EKVEQNFSNY 190 200 210 220 230 240 SAWHQRSSIL PKIYKEPEQL LEKILEEFEL VRNAVYTEPK DSSSWIYHKW LVATIKSIPN 250 260 270 280 290 300 SNYIEVLKNE LTQIYDLIEL EPDCKWPIYT TLLLKIEIGG FEKQELLDII SQLIKLDPDH 310 KNYYKSLETK I

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000005 Genomic DNA. Translation: EAL72135.2.
RefSeq	XP_646077.2. XM_640985.2.
3D structure databases
HSSP	HSSP built from PDB template 1LTX based on UniProtKB Q08602.
ProteinModelPortal	Q55DQ4.
ModBase	Search...
Protein-protein interaction databases
STRING	Q55DQ4.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0233950; DDB0233950; DDB_G0269570.
GeneID	8617027.
GenomeReviews	Gene locus rabggta in contig CM000150_GR.
KEGG	ddi:DDB_G0269570.
Organism-specific databases
dictyBase	DDB_G0269570. rabggta.
Phylogenomic databases
eggNOG	KOG0529.
GeneTree	EPrGT00050000003908.
HOGENOM	HBG464445.
OMA	SAWHYRT.
ProtClustDB	CLSZ2501688.
Family and domain databases
InterPro	IPR002088. Prenyl_trans_a. IPR008940. Prenyltransferase. [Graphical view]
Gene3D	G3DSA:1.25.40.120. Prenyl_trans. 1 hit.
KO	K14050.
Pfam	PF01239. PPTA. 4 hits. [Graphical view]
PROSITE	PS51147. PFTA. 5 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PGTA_DICDI

Accession

Primary (citable) accession number: Q55DQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	March 18, 2008
Last modified:	November 16, 2011
This is version 50 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)