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Protein

Geranylgeranyl transferase type-2 subunit alpha

Gene

rabggta

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to proteins with a C-terminal sequence motif -XCC or -XCXC, where both cysteines may become modified.By similarity

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Enzyme and pathway databases

ReactomeiR-DDI-6803205. TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60)
Alternative name(s):
GGTase-II-alpha
Geranylgeranyl transferase type II subunit alpha
PGGT
Type II protein geranyl-geranyltransferase subunit alpha
Gene namesi
Name:rabggta
ORF Names:DDB_G0269570
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0269570. rabggta.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003312871 – 311Geranylgeranyl transferase type-2 subunit alphaAdd BLAST311

Proteomic databases

PaxDbiQ55DQ4.

Interactioni

Subunit structurei

Heterodimer of an alpha and a beta subunit.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi44689.DDB0233950.

Structurei

3D structure databases

ProteinModelPortaliQ55DQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati49 – 82PFTA 1Add BLAST34
Repeati93 – 126PFTA 2Add BLAST34
Repeati129 – 162PFTA 3Add BLAST34
Repeati164 – 197PFTA 4Add BLAST34
Repeati206 – 239PFTA 5Add BLAST34

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili12 – 43Sequence analysisAdd BLAST32

Sequence similaritiesi

Contains 5 PFTA repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0529. Eukaryota.
COG5536. LUCA.
InParanoidiQ55DQ4.
KOiK14050.
OMAiAWNYRRY.
PhylomeDBiQ55DQ4.

Family and domain databases

InterProiIPR002088. Prenyl_trans_a.
IPR032955. RabGGTase_alpha.
[Graphical view]
PANTHERiPTHR11129:SF2. PTHR11129:SF2. 1 hit.
PfamiPF01239. PPTA. 3 hits.
[Graphical view]
PROSITEiPS51147. PFTA. 5 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55DQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGVLKVRTS EEKAKAQRLK ELEKIESYNK LVKSFEELRE KQNGRYDEIS
60 70 80 90 100
LSVSKLVLIE NPEFYTIWNY RRLAILQFTE TKENSELQVI YQNEMKFLEE
110 120 130 140 150
CIQRFTKSYW IWFHRQWIAL RMDNCDWERE MKLCTKLLNF DLRNFHCWGH
160 170 180 190 200
RRFILKHSNI KLEDELKYTT EKVEQNFSNY SAWHQRSSIL PKIYKEPEQL
210 220 230 240 250
LEKILEEFEL VRNAVYTEPK DSSSWIYHKW LVATIKSIPN SNYIEVLKNE
260 270 280 290 300
LTQIYDLIEL EPDCKWPIYT TLLLKIEIGG FEKQELLDII SQLIKLDPDH
310
KNYYKSLETK I
Length:311
Mass (Da):37,779
Last modified:March 18, 2008 - v2
Checksum:iF6640179FFC4DC41
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72135.2.
RefSeqiXP_646077.2. XM_640985.2.

Genome annotation databases

EnsemblProtistsiEAL72135; EAL72135; DDB_G0269570.
GeneIDi8617027.
KEGGiddi:DDB_G0269570.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72135.2.
RefSeqiXP_646077.2. XM_640985.2.

3D structure databases

ProteinModelPortaliQ55DQ4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0233950.

Proteomic databases

PaxDbiQ55DQ4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL72135; EAL72135; DDB_G0269570.
GeneIDi8617027.
KEGGiddi:DDB_G0269570.

Organism-specific databases

dictyBaseiDDB_G0269570. rabggta.

Phylogenomic databases

eggNOGiKOG0529. Eukaryota.
COG5536. LUCA.
InParanoidiQ55DQ4.
KOiK14050.
OMAiAWNYRRY.
PhylomeDBiQ55DQ4.

Enzyme and pathway databases

ReactomeiR-DDI-6803205. TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.

Miscellaneous databases

PROiQ55DQ4.

Family and domain databases

InterProiIPR002088. Prenyl_trans_a.
IPR032955. RabGGTase_alpha.
[Graphical view]
PANTHERiPTHR11129:SF2. PTHR11129:SF2. 1 hit.
PfamiPF01239. PPTA. 3 hits.
[Graphical view]
PROSITEiPS51147. PFTA. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGTA_DICDI
AccessioniPrimary (citable) accession number: Q55DQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: March 18, 2008
Last modified: November 2, 2016
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.