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Protein

Aminoacylase-1

Gene

acy1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).By similarity

Catalytic activityi

An N-acyl-aliphatic-L-amino acid + H2O = an aliphatic L-amino acid + a carboxylate.
An N-acetyl-L-cysteine-S-conjugate + H2O = an L-cysteine-S-conjugate + acetate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi76Zinc 1By similarity1
Active sitei78By similarity1
Metal bindingi109Zinc 1By similarity1
Metal bindingi109Zinc 2By similarity1
Active sitei143Proton acceptorBy similarity1
Metal bindingi144Zinc 2By similarity1
Metal bindingi172Zinc 1By similarity1
Metal bindingi379Zinc 2By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-DDI-5423646 Aflatoxin activation and detoxification

Names & Taxonomyi

Protein namesi
Recommended name:
Aminoacylase-1 (EC:3.5.1.14)
Short name:
ACY-1
Alternative name(s):
N-acyl-L-amino-acid amidohydrolase
Gene namesi
Name:acy1
ORF Names:DDB_G0270562
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270562 acy1

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003312141 – 408Aminoacylase-1Add BLAST408

Proteomic databases

PaxDbiQ55DP8
PRIDEiQ55DP8

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0266648

Structurei

3D structure databases

ProteinModelPortaliQ55DP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family.Curated

Phylogenomic databases

eggNOGiKOG2275 Eukaryota
COG0624 LUCA
InParanoidiQ55DP8
KOiK14677
OMAiMDCVETI
PhylomeDBiQ55DP8

Family and domain databases

CDDicd05646 M20_AcylaseI_like, 1 hit
InterProiView protein in InterPro
IPR001261 ArgE/DapE_CS
IPR036264 Bact_exopeptidase_dim_dom
IPR010159 N-acyl_aa_amidohydrolase
IPR002933 Peptidase_M20
IPR011650 Peptidase_M20_dimer
PfamiView protein in Pfam
PF07687 M20_dimer, 1 hit
PF01546 Peptidase_M20, 1 hit
SUPFAMiSSF55031 SSF55031, 1 hit
TIGRFAMsiTIGR01880 Ac-peptdase-euk, 1 hit
PROSITEiView protein in PROSITE
PS00758 ARGE_DAPE_CPG2_1, 1 hit
PS00759 ARGE_DAPE_CPG2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q55DP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSIQENEHV TVFREFLKIR TDHPTPDYES STKFLVEKAK EYNIPYEVYR
60 70 80 90 100
ETGTPIVLMK IEGLEPNLKT VLLNSHVDVV PAVHDSWKVD PFSAWKDESG
110 120 130 140 150
NIFGRGTQDM KCVCMQFLEV ARRIVQSGQK LKRTLHLSFV PDEEIGGSGK
160 170 180 190 200
GMEKFVYTEK FRQLNIGLCL DEGLASPTND FTVFYGERAP WWVHITAVGN
210 220 230 240 250
AGHGSRFIEG TAIEKLMRTI NKMLAFRQEQ FESLHHGQHE CGKKLGDVTS
260 270 280 290 300
LNLTVLKAGI PIDHSNNFSY NVIPTQAEAG FDIRIPPTVN LDQFLDQIKE
310 320 330 340 350
WTAEEGLSFK FASYIPKNEM TKLDSDNKWW ENFKESCKKM DINLVTEIFP
360 370 380 390 400
AATDSRFIRN LGIPAFGFSP INNTPILLHD HNEFLNEKVY LRGIDIFMGI

IPNLVNME
Length:408
Mass (Da):46,568
Last modified:May 24, 2005 - v1
Checksum:i8AD17E450D2FF224
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAL72631.1
RefSeqiXP_646083.1, XM_640991.1

Genome annotation databases

EnsemblProtistsiEAL72631; EAL72631; DDB_G0270562
GeneIDi8617033
KEGGiddi:DDB_G0270562

Similar proteinsi

Entry informationi

Entry nameiACY1_DICDI
AccessioniPrimary (citable) accession number: Q55DP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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