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Q55DP8 (ACY1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aminoacylase-1

Short name=ACY-1
EC=3.5.1.14
Alternative name(s):
N-acyl-L-amino-acid amidohydrolase
Gene names
Name:acy1
ORF Names:DDB_G0270562
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length408 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate) By similarity.

Catalytic activity

An N-acyl-aliphatic-L-amino acid + H2O = an aliphatic L-amino acid + a carboxylate.

An N-acetyl-L-cysteine-S-conjugate + H2O = an L-cysteine-S-conjugate + acetate.

Cofactor

Binds 2 zinc ions per subunit By similarity.

Subunit structure

Homodimer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the peptidase M20A family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
Zinc
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcellular amino acid metabolic process

Inferred from electronic annotation. Source: InterPro

proteolysis

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionaminoacylase activity

Inferred from electronic annotation. Source: UniProtKB-EC

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

metallopeptidase activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 408408Aminoacylase-1
PRO_0000331214

Sites

Active site781 By similarity
Active site1431Proton acceptor By similarity
Metal binding761Zinc 1 By similarity
Metal binding1091Zinc 1 By similarity
Metal binding1091Zinc 2 By similarity
Metal binding1441Zinc 2 By similarity
Metal binding1721Zinc 1 By similarity
Metal binding3791Zinc 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q55DP8 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 8AD17E450D2FF224

FASTA40846,568
        10         20         30         40         50         60 
MNSIQENEHV TVFREFLKIR TDHPTPDYES STKFLVEKAK EYNIPYEVYR ETGTPIVLMK 

        70         80         90        100        110        120 
IEGLEPNLKT VLLNSHVDVV PAVHDSWKVD PFSAWKDESG NIFGRGTQDM KCVCMQFLEV 

       130        140        150        160        170        180 
ARRIVQSGQK LKRTLHLSFV PDEEIGGSGK GMEKFVYTEK FRQLNIGLCL DEGLASPTND 

       190        200        210        220        230        240 
FTVFYGERAP WWVHITAVGN AGHGSRFIEG TAIEKLMRTI NKMLAFRQEQ FESLHHGQHE 

       250        260        270        280        290        300 
CGKKLGDVTS LNLTVLKAGI PIDHSNNFSY NVIPTQAEAG FDIRIPPTVN LDQFLDQIKE 

       310        320        330        340        350        360 
WTAEEGLSFK FASYIPKNEM TKLDSDNKWW ENFKESCKKM DINLVTEIFP AATDSRFIRN 

       370        380        390        400 
LGIPAFGFSP INNTPILLHD HNEFLNEKVY LRGIDIFMGI IPNLVNME 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000005 Genomic DNA. Translation: EAL72631.1.

3D structure databases

ProteinModelPortalQ55DP8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0201767.

Proteomic databases

PRIDEQ55DP8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0266648; DDB0266648; DDB_G0270562.
KEGGddi:DDB_G0270562.

Organism-specific databases

dictyBaseDDB_G0270562. acy1.

Phylogenomic databases

eggNOGCOG0624.
KOK14677.
OMAKSEWENN.
PhylomeDBQ55DP8.
ProtClustDBCLSZ2431382.

Family and domain databases

Gene3D3.30.70.360. 1 hit.
InterProIPR001261. ArgE/DapE_CS.
IPR010159. N-acyl_aa_amidohydrolase.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
PIRSFPIRSF036696. ACY-1. 1 hit.
SUPFAMSSF55031. SSF55031. 1 hit.
TIGRFAMsTIGR01880. Ac-peptdase-euk. 1 hit.
PROSITEPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameACY1_DICDI
AccessionPrimary (citable) accession number: Q55DP8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase