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Q55DK5

- MGP3_DICDI

UniProt

Q55DK5 - MGP3_DICDI

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Protein

Mental retardation GTPase activating protein homolog 3

Gene

mgp3

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Rho GTPase-activating protein involved in the signal transduction pathway.By similarity

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW

GO - Biological processi

  1. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
Mental retardation GTPase activating protein homolog 3
Alternative name(s):
GTPase activating factor for raC protein AA
Rho GTPase-activating protein gacAA
Gene namesi
Name:mgp3
Synonyms:gacAA
ORF Names:DDB_G0269624
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0269624. mgp3.

Subcellular locationi

GO - Cellular componenti

  1. vacuole Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13371337Mental retardation GTPase activating protein homolog 3PRO_0000380226Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0190412.

Structurei

3D structure databases

ProteinModelPortaliQ55DK5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 8880FCHPROSITE-ProRule annotationAdd
BLAST
Domaini422 – 611190Rho-GAPPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili830 – 85930Sequence AnalysisAdd
BLAST
Coiled coili1189 – 121931Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi294 – 3007Poly-Pro
Compositional biasi319 – 3246Poly-Ser
Compositional biasi621 – 6299Poly-Ser
Compositional biasi665 – 67511Poly-GlnAdd
BLAST
Compositional biasi734 – 74916Poly-AsnAdd
BLAST
Compositional biasi1086 – 109611Poly-AsnAdd
BLAST
Compositional biasi1120 – 113213Poly-AsnAdd
BLAST
Compositional biasi1144 – 115815Poly-ThrAdd
BLAST
Compositional biasi1322 – 133615Poly-AsnAdd
BLAST

Sequence similaritiesi

Contains 1 FCH domain.PROSITE-ProRule annotation
Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG137357.
InParanoidiQ55DK5.
OMAiWLREITE.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR001060. FCH_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50133. FCH. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55DK5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTVDNSQIPN LNQPESFADL WDGYENVSKA TEKGVLLLKD ITKFFKKRIQ
60 70 80 90 100
SEDEYSKTLS KLVLKFEPMA PDGYIGPRLK NTWDQIKLET LTHSNHHENI
110 120 130 140 150
CNNISTHIIE PIEGLIVDLE QKMKSIHVDA EKSFIHYQES VAKLKKAKQN
160 170 180 190 200
YDRLCKDSFE ITGVSKGETQ KVQKRAIKAA QDVIKADKDY RAQINETNTS
210 220 230 240 250
QKQFLTELIP KIMNDLQRLE MVRIHMVKSY FHRYFKSMES TPQKFNTETE
260 270 280 290 300
NLLNLINSIN NEDEIQDFVR KSKTTHKYPK PFEYEPYLDR FTTPPPPPPP
310 320 330 340 350
QISSPQLLSP RGDISIQHSS SSNSLPIFPT QHQLLSNKEK ADNNITNSLS
360 370 380 390 400
LSSDSLQTNL NNGNNGGNGN NGSNTPTKEK KPSSWGLKRF STSVSSTSDR
410 420 430 440 450
KLLNKQIQSI GLAHNGGNIF NCKIEDIMVA QKKKYPYLEI PFIVVFLKHK
460 470 480 490 500
LVALDVFKTQ GIFRVPGNVV DINSLKKRFD EGNYEVAPTE NVYTIASLLK
510 520 530 540 550
LWLREITEPL FPLTVYDQCI ENSNKREKIF EIISSLPILN QKTISYIIEL
560 570 580 590 600
LQECGKSVNV EHNKMNFPNL AMVFSPCFLR CSHTDPNILL GNIFKEKEFV
610 620 630 640 650
QNIIEHFKPL QVNDSLEGPP SSSSSSSTSI NQSSIESPPT SPLRSSTNSN
660 670 680 690 700
ANKSSTPIKP SSPSQQQQQQ QQQQQSSTPS TPLSSTTNTN VKHNILSPIV
710 720 730 740 750
EQQSPNNGKQ PIALTQTYSH LNIGSVPLII NTVNNNNQNQ NQNQNQNQNQ
760 770 780 790 800
DQNQNQSKQP IQSSNQTQQQ VSAPATPHTV AVNPKINQIK AETITTPQKS
810 820 830 840 850
IGDGNGLIGQ SPSAHLMSPS EVKRRSNAIY LEDQERCKQR IDELHTQVNE
860 870 880 890 900
LYSDITTIET TTYFAMQSSL LITKLTKSLE SFLTIDMWNL TLQDIKEAIE
910 920 930 940 950
KNKFVSPPPI NFKIPSKMPK LSPIELVQNE QSSELLRSWL SNVTLTVNRI
960 970 980 990 1000
NEYLCYLGGV VIRIHSPDTL FAISNLFTDY DLSPQQNPKF VSLTLEQSTI
1010 1020 1030 1040 1050
FIQKTLALLE PLNPFTSDEL NINVKVQDTI TPASFSPALI SDPDCNSPPT
1060 1070 1080 1090 1100
ISNTTNRLLN TSGSTDFSTT PLSSSPSTSS TSLSTNNNNN NNGNRNLDIN
1110 1120 1130 1140 1150
NSPTIVITNS SLNKSALSTN NNNNNNNNNN NNPTTKLSSS TSSTSTTTTT
1160 1170 1180 1190 1200
NTNTNTTTNE KIAHAIISPS SSTTSFKFDD DEDEDEDLLE INNKLHSQLT
1210 1220 1230 1240 1250
EELKKKQQQY KQLIFDIIDM IKDKKKLMNS LDLTNSDSQL DIKSIAKLSL
1260 1270 1280 1290 1300
SLKRALDNFT SESGFDIEDE QDPIINKEND SFVNLKIMTS HFISRIVLIL
1310 1320 1330
TTILSISNEF NSTLYQLLLP FNENNNNNNE NNNINNQ
Length:1,337
Mass (Da):150,248
Last modified:May 24, 2005 - v1
Checksum:i73393E0FD5FD8AF4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72162.1.
RefSeqiXP_646126.1. XM_641034.1.

Genome annotation databases

EnsemblProtistsiDDB0233874; DDB0233874; DDB_G0269624.
GeneIDi8617075.
KEGGiddi:DDB_G0269624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72162.1 .
RefSeqi XP_646126.1. XM_641034.1.

3D structure databases

ProteinModelPortali Q55DK5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0190412.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0233874 ; DDB0233874 ; DDB_G0269624 .
GeneIDi 8617075.
KEGGi ddi:DDB_G0269624.

Organism-specific databases

dictyBasei DDB_G0269624. mgp3.

Phylogenomic databases

eggNOGi NOG137357.
InParanoidi Q55DK5.
OMAi WLREITE.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
InterProi IPR001060. FCH_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view ]
Pfami PF00611. FCH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view ]
SMARTi SM00324. RhoGAP. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
PROSITEi PS50133. FCH. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Dictyostelium MEGAPs: F-BAR domain proteins that regulate motility and membrane tubulation in contractile vacuoles."
    Heath R.J., Insall R.H.
    J. Cell Sci. 121:1054-1064(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiMGP3_DICDI
AccessioniPrimary (citable) accession number: Q55DK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 24, 2005
Last modified: November 26, 2014
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3