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Q55DK5

- MGP3_DICDI

UniProt

Q55DK5 - MGP3_DICDI

Protein

Mental retardation GTPase activating protein homolog 3

Gene

mgp3

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 52 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Rho GTPase-activating protein involved in the signal transduction pathway.By similarity

    GO - Molecular functioni

    1. GTPase activator activity Source: UniProtKB-KW

    GO - Biological processi

    1. signal transduction Source: InterPro

    Keywords - Molecular functioni

    GTPase activation

    Enzyme and pathway databases

    ReactomeiREACT_204273. Rho GTPase cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mental retardation GTPase activating protein homolog 3
    Alternative name(s):
    GTPase activating factor for raC protein AA
    Rho GTPase-activating protein gacAA
    Gene namesi
    Name:mgp3
    Synonyms:gacAA
    ORF Names:DDB_G0269624
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0269624. mgp3.

    Subcellular locationi

    GO - Cellular componenti

    1. contractile vacuole Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Vacuole

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13371337Mental retardation GTPase activating protein homolog 3PRO_0000380226Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0190412.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55DK5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 8880FCHPROSITE-ProRule annotationAdd
    BLAST
    Domaini422 – 611190Rho-GAPPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili830 – 85930Sequence AnalysisAdd
    BLAST
    Coiled coili1189 – 121931Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi294 – 3007Poly-Pro
    Compositional biasi319 – 3246Poly-Ser
    Compositional biasi621 – 6299Poly-Ser
    Compositional biasi665 – 67511Poly-GlnAdd
    BLAST
    Compositional biasi734 – 74916Poly-AsnAdd
    BLAST
    Compositional biasi1086 – 109611Poly-AsnAdd
    BLAST
    Compositional biasi1120 – 113213Poly-AsnAdd
    BLAST
    Compositional biasi1144 – 115815Poly-ThrAdd
    BLAST
    Compositional biasi1322 – 133615Poly-AsnAdd
    BLAST

    Sequence similaritiesi

    Contains 1 FCH domain.PROSITE-ProRule annotation
    Contains 1 Rho-GAP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG137357.
    InParanoidiQ55DK5.
    OMAiWLREITE.

    Family and domain databases

    Gene3Di1.10.555.10. 1 hit.
    InterProiIPR001060. FCH_dom.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view]
    PfamiPF00611. FCH. 1 hit.
    PF00620. RhoGAP. 1 hit.
    [Graphical view]
    SMARTiSM00324. RhoGAP. 1 hit.
    [Graphical view]
    SUPFAMiSSF48350. SSF48350. 1 hit.
    PROSITEiPS50133. FCH. 1 hit.
    PS50238. RHOGAP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q55DK5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTVDNSQIPN LNQPESFADL WDGYENVSKA TEKGVLLLKD ITKFFKKRIQ     50
    SEDEYSKTLS KLVLKFEPMA PDGYIGPRLK NTWDQIKLET LTHSNHHENI 100
    CNNISTHIIE PIEGLIVDLE QKMKSIHVDA EKSFIHYQES VAKLKKAKQN 150
    YDRLCKDSFE ITGVSKGETQ KVQKRAIKAA QDVIKADKDY RAQINETNTS 200
    QKQFLTELIP KIMNDLQRLE MVRIHMVKSY FHRYFKSMES TPQKFNTETE 250
    NLLNLINSIN NEDEIQDFVR KSKTTHKYPK PFEYEPYLDR FTTPPPPPPP 300
    QISSPQLLSP RGDISIQHSS SSNSLPIFPT QHQLLSNKEK ADNNITNSLS 350
    LSSDSLQTNL NNGNNGGNGN NGSNTPTKEK KPSSWGLKRF STSVSSTSDR 400
    KLLNKQIQSI GLAHNGGNIF NCKIEDIMVA QKKKYPYLEI PFIVVFLKHK 450
    LVALDVFKTQ GIFRVPGNVV DINSLKKRFD EGNYEVAPTE NVYTIASLLK 500
    LWLREITEPL FPLTVYDQCI ENSNKREKIF EIISSLPILN QKTISYIIEL 550
    LQECGKSVNV EHNKMNFPNL AMVFSPCFLR CSHTDPNILL GNIFKEKEFV 600
    QNIIEHFKPL QVNDSLEGPP SSSSSSSTSI NQSSIESPPT SPLRSSTNSN 650
    ANKSSTPIKP SSPSQQQQQQ QQQQQSSTPS TPLSSTTNTN VKHNILSPIV 700
    EQQSPNNGKQ PIALTQTYSH LNIGSVPLII NTVNNNNQNQ NQNQNQNQNQ 750
    DQNQNQSKQP IQSSNQTQQQ VSAPATPHTV AVNPKINQIK AETITTPQKS 800
    IGDGNGLIGQ SPSAHLMSPS EVKRRSNAIY LEDQERCKQR IDELHTQVNE 850
    LYSDITTIET TTYFAMQSSL LITKLTKSLE SFLTIDMWNL TLQDIKEAIE 900
    KNKFVSPPPI NFKIPSKMPK LSPIELVQNE QSSELLRSWL SNVTLTVNRI 950
    NEYLCYLGGV VIRIHSPDTL FAISNLFTDY DLSPQQNPKF VSLTLEQSTI 1000
    FIQKTLALLE PLNPFTSDEL NINVKVQDTI TPASFSPALI SDPDCNSPPT 1050
    ISNTTNRLLN TSGSTDFSTT PLSSSPSTSS TSLSTNNNNN NNGNRNLDIN 1100
    NSPTIVITNS SLNKSALSTN NNNNNNNNNN NNPTTKLSSS TSSTSTTTTT 1150
    NTNTNTTTNE KIAHAIISPS SSTTSFKFDD DEDEDEDLLE INNKLHSQLT 1200
    EELKKKQQQY KQLIFDIIDM IKDKKKLMNS LDLTNSDSQL DIKSIAKLSL 1250
    SLKRALDNFT SESGFDIEDE QDPIINKEND SFVNLKIMTS HFISRIVLIL 1300
    TTILSISNEF NSTLYQLLLP FNENNNNNNE NNNINNQ 1337
    Length:1,337
    Mass (Da):150,248
    Last modified:May 24, 2005 - v1
    Checksum:i73393E0FD5FD8AF4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAL72162.1.
    RefSeqiXP_646126.1. XM_641034.1.

    Genome annotation databases

    EnsemblProtistsiDDB0233874; DDB0233874; DDB_G0269624.
    GeneIDi8617075.
    KEGGiddi:DDB_G0269624.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAL72162.1 .
    RefSeqi XP_646126.1. XM_641034.1.

    3D structure databases

    ProteinModelPortali Q55DK5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0190412.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0233874 ; DDB0233874 ; DDB_G0269624 .
    GeneIDi 8617075.
    KEGGi ddi:DDB_G0269624.

    Organism-specific databases

    dictyBasei DDB_G0269624. mgp3.

    Phylogenomic databases

    eggNOGi NOG137357.
    InParanoidi Q55DK5.
    OMAi WLREITE.

    Enzyme and pathway databases

    Reactomei REACT_204273. Rho GTPase cycle.

    Family and domain databases

    Gene3Di 1.10.555.10. 1 hit.
    InterProi IPR001060. FCH_dom.
    IPR008936. Rho_GTPase_activation_prot.
    IPR000198. RhoGAP_dom.
    [Graphical view ]
    Pfami PF00611. FCH. 1 hit.
    PF00620. RhoGAP. 1 hit.
    [Graphical view ]
    SMARTi SM00324. RhoGAP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48350. SSF48350. 1 hit.
    PROSITEi PS50133. FCH. 1 hit.
    PS50238. RHOGAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "Dictyostelium MEGAPs: F-BAR domain proteins that regulate motility and membrane tubulation in contractile vacuoles."
      Heath R.J., Insall R.H.
      J. Cell Sci. 121:1054-1064(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION.

    Entry informationi

    Entry nameiMGP3_DICDI
    AccessioniPrimary (citable) accession number: Q55DK5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 28, 2009
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 52 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3