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Q55DK5 (MGP3_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 50. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mental retardation GTPase activating protein homolog 3
Alternative name(s):
GTPase activating factor for raC protein AA
Rho GTPase-activating protein gacAA
Gene names
Name:mgp3
Synonyms:gacAA
ORF Names:DDB_G0269624
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length1337 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Rho GTPase-activating protein involved in the signal transduction pathway By similarity.

Subcellular location

Cytoplasm. Contractile vacuole By similarity.

Sequence similarities

Contains 1 FCH domain.

Contains 1 Rho-GAP domain.

Ontologies

Keywords
   Cellular componentCytoplasm
Vacuole
   DomainCoiled coil
   Molecular functionGTPase activation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsignal transduction

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcontractile vacuole

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionGTPase activator activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13371337Mental retardation GTPase activating protein homolog 3
PRO_0000380226

Regions

Domain9 – 8880FCH
Domain422 – 611190Rho-GAP
Coiled coil830 – 85930 Potential
Coiled coil1189 – 121931 Potential
Compositional bias294 – 3007Poly-Pro
Compositional bias319 – 3246Poly-Ser
Compositional bias621 – 6299Poly-Ser
Compositional bias665 – 67511Poly-Gln
Compositional bias734 – 74916Poly-Asn
Compositional bias1086 – 109611Poly-Asn
Compositional bias1120 – 113213Poly-Asn
Compositional bias1144 – 115815Poly-Thr
Compositional bias1322 – 133615Poly-Asn

Sequences

Sequence LengthMass (Da)Tools
Q55DK5 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 73393E0FD5FD8AF4

FASTA1,337150,248
        10         20         30         40         50         60 
MTVDNSQIPN LNQPESFADL WDGYENVSKA TEKGVLLLKD ITKFFKKRIQ SEDEYSKTLS 

        70         80         90        100        110        120 
KLVLKFEPMA PDGYIGPRLK NTWDQIKLET LTHSNHHENI CNNISTHIIE PIEGLIVDLE 

       130        140        150        160        170        180 
QKMKSIHVDA EKSFIHYQES VAKLKKAKQN YDRLCKDSFE ITGVSKGETQ KVQKRAIKAA 

       190        200        210        220        230        240 
QDVIKADKDY RAQINETNTS QKQFLTELIP KIMNDLQRLE MVRIHMVKSY FHRYFKSMES 

       250        260        270        280        290        300 
TPQKFNTETE NLLNLINSIN NEDEIQDFVR KSKTTHKYPK PFEYEPYLDR FTTPPPPPPP 

       310        320        330        340        350        360 
QISSPQLLSP RGDISIQHSS SSNSLPIFPT QHQLLSNKEK ADNNITNSLS LSSDSLQTNL 

       370        380        390        400        410        420 
NNGNNGGNGN NGSNTPTKEK KPSSWGLKRF STSVSSTSDR KLLNKQIQSI GLAHNGGNIF 

       430        440        450        460        470        480 
NCKIEDIMVA QKKKYPYLEI PFIVVFLKHK LVALDVFKTQ GIFRVPGNVV DINSLKKRFD 

       490        500        510        520        530        540 
EGNYEVAPTE NVYTIASLLK LWLREITEPL FPLTVYDQCI ENSNKREKIF EIISSLPILN 

       550        560        570        580        590        600 
QKTISYIIEL LQECGKSVNV EHNKMNFPNL AMVFSPCFLR CSHTDPNILL GNIFKEKEFV 

       610        620        630        640        650        660 
QNIIEHFKPL QVNDSLEGPP SSSSSSSTSI NQSSIESPPT SPLRSSTNSN ANKSSTPIKP 

       670        680        690        700        710        720 
SSPSQQQQQQ QQQQQSSTPS TPLSSTTNTN VKHNILSPIV EQQSPNNGKQ PIALTQTYSH 

       730        740        750        760        770        780 
LNIGSVPLII NTVNNNNQNQ NQNQNQNQNQ DQNQNQSKQP IQSSNQTQQQ VSAPATPHTV 

       790        800        810        820        830        840 
AVNPKINQIK AETITTPQKS IGDGNGLIGQ SPSAHLMSPS EVKRRSNAIY LEDQERCKQR 

       850        860        870        880        890        900 
IDELHTQVNE LYSDITTIET TTYFAMQSSL LITKLTKSLE SFLTIDMWNL TLQDIKEAIE 

       910        920        930        940        950        960 
KNKFVSPPPI NFKIPSKMPK LSPIELVQNE QSSELLRSWL SNVTLTVNRI NEYLCYLGGV 

       970        980        990       1000       1010       1020 
VIRIHSPDTL FAISNLFTDY DLSPQQNPKF VSLTLEQSTI FIQKTLALLE PLNPFTSDEL 

      1030       1040       1050       1060       1070       1080 
NINVKVQDTI TPASFSPALI SDPDCNSPPT ISNTTNRLLN TSGSTDFSTT PLSSSPSTSS 

      1090       1100       1110       1120       1130       1140 
TSLSTNNNNN NNGNRNLDIN NSPTIVITNS SLNKSALSTN NNNNNNNNNN NNPTTKLSSS 

      1150       1160       1170       1180       1190       1200 
TSSTSTTTTT NTNTNTTTNE KIAHAIISPS SSTTSFKFDD DEDEDEDLLE INNKLHSQLT 

      1210       1220       1230       1240       1250       1260 
EELKKKQQQY KQLIFDIIDM IKDKKKLMNS LDLTNSDSQL DIKSIAKLSL SLKRALDNFT 

      1270       1280       1290       1300       1310       1320 
SESGFDIEDE QDPIINKEND SFVNLKIMTS HFISRIVLIL TTILSISNEF NSTLYQLLLP 

      1330 
FNENNNNNNE NNNINNQ 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"Dictyostelium MEGAPs: F-BAR domain proteins that regulate motility and membrane tubulation in contractile vacuoles."
Heath R.J., Insall R.H.
J. Cell Sci. 121:1054-1064(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000005 Genomic DNA. Translation: EAL72162.1.
RefSeqXP_646126.1. XM_641034.1.

3D structure databases

ProteinModelPortalQ55DK5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0190412.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0233874; DDB0233874; DDB_G0269624.
GeneID8617075.
KEGGddi:DDB_G0269624.

Organism-specific databases

dictyBaseDDB_G0269624. mgp3.

Phylogenomic databases

eggNOGNOG137357.
InParanoidQ55DK5.
OMAWLREITE.

Family and domain databases

Gene3D1.10.555.10. 1 hit.
InterProIPR001060. FCH_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamPF00611. FCH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMSSF48350. SSF48350. 1 hit.
PROSITEPS50133. FCH. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMGP3_DICDI
AccessionPrimary (citable) accession number: Q55DK5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 24, 2005
Last modified: May 14, 2014
This is version 50 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase