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Q55DK5

- MGP3_DICDI

UniProt

Q55DK5 - MGP3_DICDI

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Protein
Mental retardation GTPase activating protein homolog 3
Gene
mgp3, gacAA, DDB_G0269624
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Rho GTPase-activating protein involved in the signal transduction pathway By similarity.

GO - Molecular functioni

  1. GTPase activator activity Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. signal transduction Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GTPase activation

Enzyme and pathway databases

ReactomeiREACT_204273. Rho GTPase cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Mental retardation GTPase activating protein homolog 3
Alternative name(s):
GTPase activating factor for raC protein AA
Rho GTPase-activating protein gacAA
Gene namesi
Name:mgp3
Synonyms:gacAA
ORF Names:DDB_G0269624
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0269624. mgp3.

Subcellular locationi

GO - Cellular componenti

  1. contractile vacuole Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13371337Mental retardation GTPase activating protein homolog 3
PRO_0000380226Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0190412.

Structurei

3D structure databases

ProteinModelPortaliQ55DK5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 8880FCH
Add
BLAST
Domaini422 – 611190Rho-GAP
Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili830 – 85930 Reviewed prediction
Add
BLAST
Coiled coili1189 – 121931 Reviewed prediction
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi294 – 3007Poly-Pro
Compositional biasi319 – 3246Poly-Ser
Compositional biasi621 – 6299Poly-Ser
Compositional biasi665 – 67511Poly-Gln
Add
BLAST
Compositional biasi734 – 74916Poly-Asn
Add
BLAST
Compositional biasi1086 – 109611Poly-Asn
Add
BLAST
Compositional biasi1120 – 113213Poly-Asn
Add
BLAST
Compositional biasi1144 – 115815Poly-Thr
Add
BLAST
Compositional biasi1322 – 133615Poly-Asn
Add
BLAST

Sequence similaritiesi

Contains 1 FCH domain.
Contains 1 Rho-GAP domain.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG137357.
InParanoidiQ55DK5.
OMAiWLREITE.

Family and domain databases

Gene3Di1.10.555.10. 1 hit.
InterProiIPR001060. FCH_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view]
PfamiPF00611. FCH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view]
SMARTiSM00324. RhoGAP. 1 hit.
[Graphical view]
SUPFAMiSSF48350. SSF48350. 1 hit.
PROSITEiPS50133. FCH. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55DK5-1 [UniParc]FASTAAdd to Basket

« Hide

MTVDNSQIPN LNQPESFADL WDGYENVSKA TEKGVLLLKD ITKFFKKRIQ     50
SEDEYSKTLS KLVLKFEPMA PDGYIGPRLK NTWDQIKLET LTHSNHHENI 100
CNNISTHIIE PIEGLIVDLE QKMKSIHVDA EKSFIHYQES VAKLKKAKQN 150
YDRLCKDSFE ITGVSKGETQ KVQKRAIKAA QDVIKADKDY RAQINETNTS 200
QKQFLTELIP KIMNDLQRLE MVRIHMVKSY FHRYFKSMES TPQKFNTETE 250
NLLNLINSIN NEDEIQDFVR KSKTTHKYPK PFEYEPYLDR FTTPPPPPPP 300
QISSPQLLSP RGDISIQHSS SSNSLPIFPT QHQLLSNKEK ADNNITNSLS 350
LSSDSLQTNL NNGNNGGNGN NGSNTPTKEK KPSSWGLKRF STSVSSTSDR 400
KLLNKQIQSI GLAHNGGNIF NCKIEDIMVA QKKKYPYLEI PFIVVFLKHK 450
LVALDVFKTQ GIFRVPGNVV DINSLKKRFD EGNYEVAPTE NVYTIASLLK 500
LWLREITEPL FPLTVYDQCI ENSNKREKIF EIISSLPILN QKTISYIIEL 550
LQECGKSVNV EHNKMNFPNL AMVFSPCFLR CSHTDPNILL GNIFKEKEFV 600
QNIIEHFKPL QVNDSLEGPP SSSSSSSTSI NQSSIESPPT SPLRSSTNSN 650
ANKSSTPIKP SSPSQQQQQQ QQQQQSSTPS TPLSSTTNTN VKHNILSPIV 700
EQQSPNNGKQ PIALTQTYSH LNIGSVPLII NTVNNNNQNQ NQNQNQNQNQ 750
DQNQNQSKQP IQSSNQTQQQ VSAPATPHTV AVNPKINQIK AETITTPQKS 800
IGDGNGLIGQ SPSAHLMSPS EVKRRSNAIY LEDQERCKQR IDELHTQVNE 850
LYSDITTIET TTYFAMQSSL LITKLTKSLE SFLTIDMWNL TLQDIKEAIE 900
KNKFVSPPPI NFKIPSKMPK LSPIELVQNE QSSELLRSWL SNVTLTVNRI 950
NEYLCYLGGV VIRIHSPDTL FAISNLFTDY DLSPQQNPKF VSLTLEQSTI 1000
FIQKTLALLE PLNPFTSDEL NINVKVQDTI TPASFSPALI SDPDCNSPPT 1050
ISNTTNRLLN TSGSTDFSTT PLSSSPSTSS TSLSTNNNNN NNGNRNLDIN 1100
NSPTIVITNS SLNKSALSTN NNNNNNNNNN NNPTTKLSSS TSSTSTTTTT 1150
NTNTNTTTNE KIAHAIISPS SSTTSFKFDD DEDEDEDLLE INNKLHSQLT 1200
EELKKKQQQY KQLIFDIIDM IKDKKKLMNS LDLTNSDSQL DIKSIAKLSL 1250
SLKRALDNFT SESGFDIEDE QDPIINKEND SFVNLKIMTS HFISRIVLIL 1300
TTILSISNEF NSTLYQLLLP FNENNNNNNE NNNINNQ 1337
Length:1,337
Mass (Da):150,248
Last modified:May 24, 2005 - v1
Checksum:i73393E0FD5FD8AF4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72162.1.
RefSeqiXP_646126.1. XM_641034.1.

Genome annotation databases

EnsemblProtistsiDDB0233874; DDB0233874; DDB_G0269624.
GeneIDi8617075.
KEGGiddi:DDB_G0269624.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72162.1 .
RefSeqi XP_646126.1. XM_641034.1.

3D structure databases

ProteinModelPortali Q55DK5.
ModBasei Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0190412.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0233874 ; DDB0233874 ; DDB_G0269624 .
GeneIDi 8617075.
KEGGi ddi:DDB_G0269624.

Organism-specific databases

dictyBasei DDB_G0269624. mgp3.

Phylogenomic databases

eggNOGi NOG137357.
InParanoidi Q55DK5.
OMAi WLREITE.

Enzyme and pathway databases

Reactomei REACT_204273. Rho GTPase cycle.

Family and domain databases

Gene3Di 1.10.555.10. 1 hit.
InterProi IPR001060. FCH_dom.
IPR008936. Rho_GTPase_activation_prot.
IPR000198. RhoGAP_dom.
[Graphical view ]
Pfami PF00611. FCH. 1 hit.
PF00620. RhoGAP. 1 hit.
[Graphical view ]
SMARTi SM00324. RhoGAP. 1 hit.
[Graphical view ]
SUPFAMi SSF48350. SSF48350. 1 hit.
PROSITEi PS50133. FCH. 1 hit.
PS50238. RHOGAP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "Dictyostelium MEGAPs: F-BAR domain proteins that regulate motility and membrane tubulation in contractile vacuoles."
    Heath R.J., Insall R.H.
    J. Cell Sci. 121:1054-1064(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION.

Entry informationi

Entry nameiMGP3_DICDI
AccessioniPrimary (citable) accession number: Q55DK5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi