Q55DA3 (PGTB1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Geranylgeranyl transferase type-1 subunit beta
EC=2.5.1.59

Alternative name(s):
Geranylgeranyl transferase type I subunit beta
Short name=GGTase-I-beta
Type I protein geranyl-geranyltransferase subunit beta

Gene names

Name:	pggt1b
ORF Names:	DDB_G0269726

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X By similarity.
Catalytic activity	Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Heterodimer of an alpha and a beta subunit By similarity.
Sequence similarities	Belongs to the protein prenyltransferase subunit beta family. Contains 4 PFTB repeats.

Ontologies

Keywords
Domain	Repeat
Ligand	Metal-binding Zinc
Molecular function	Prenyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Molecular function	CAAX-protein geranylgeranyltransferase activity Inferred from electronic annotation. Source: EC metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	Geranylgeranyl transferase type-1 subunit beta		PRO_0000330936
Regions
	Repeat	135 – 180	46	PFTB 1
	Repeat	187 – 228	42	PFTB 2
	Repeat	236 – 276	41	PFTB 3
	Repeat	283 – 325	43	PFTB 4
Sites
	Metal binding	261	1	Zinc By similarity
	Metal binding	263	1	Zinc By similarity
	Metal binding	313	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55DA3 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 3E8A27894C60C97A	FASTA	352	39,168
	10 20 30 40 50 60 MGSCINEEKL AKFFQRSLNA LPAPYTSGLP NHLSLIFFVV SGLDLLNKTD ILEKEKQDII 70 80 90 100 110 120 NWVYSRQILP SKDNPEINLE NCGFRGYNFL GQEFCCDKSV HTSENGPLEY DLPSTPNTYC 130 140 150 160 170 180 ALLILRILGD DFSGVNKKAI IDSLRKRQRE SDGAISGSPN VGDYDLRHLF SACAISFILD 190 200 210 220 230 240 DWSAINKESA IDYIKSCLSY EFAFGQTPQQ EAHGGPTYCA IASLSLLGRL DVLEPFKEQL 250 260 270 280 290 300 TFWLVKKQIT GFCGRTNKDP DTCYAFWIGA SLMMIDRYDL IDFASINAFI GSAQHEAIGG 310 320 330 340 350 VAKEPGQLPD VMHSYLSLVG LSFGNIPSIQ QVIPCLNLSK RAAGKDWFEK LI

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000005 Genomic DNA. Translation: EAL72213.1.
RefSeq	XP_646228.1. XM_641136.1.
3D structure databases
HSSP	HSSP built from PDB template 1N4Q based on UniProtKB P53610.
ProteinModelPortal	Q55DA3.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8617182.
GenomeReviews	Gene locus pggt1b in contig CM000150_GR.
KEGG	ddi:DDB_G0269726.
Organism-specific databases
dictyBase	DDB_G0269726. pggt1b.
Phylogenomic databases
eggNOG	KOG0367.
HOGENOM	HBG398025.
OMA	HGGTTFC.
PhylomeDB	Q55DA3.
ProtClustDB	CLSZ2431398.
Family and domain databases
InterPro	IPR001330. Prenyltrans. IPR008930. Terpenoid_cyclase/PrenylTrfase. [Graphical view]
KO	K11713.
Pfam	PF00432. Prenyltrans. 1 hit. [Graphical view]
SUPFAM	SSF48239. Terp_cyc_toroid. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PGTB1_DICDI

Accession

Primary (citable) accession number: Q55DA3

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)