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Q55D90

- CDSA_DICDI

UniProt

Q55D90 - CDSA_DICDI

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Protein

Probable phosphatidate cytidylyltransferase

Gene
cdsA, DDB_G0269742
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathwayi

GO - Molecular functioni

  1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

GO - Biological processi

  1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiREACT_204734. Synthesis of PI.
REACT_221051. Synthesis of PG.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
ORF Names:DDB_G0269742
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0269742. cdsA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 108108Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei109 – 12921Helical; Reviewed predictionAdd
BLAST
Topological domaini130 – 15930Extracellular Reviewed predictionAdd
BLAST
Transmembranei160 – 18021Helical; Reviewed predictionAdd
BLAST
Topological domaini181 – 19212Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei193 – 21321Helical; Reviewed predictionAdd
BLAST
Topological domaini214 – 24027Extracellular Reviewed predictionAdd
BLAST
Transmembranei241 – 26121Helical; Reviewed predictionAdd
BLAST
Topological domaini262 – 29332Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei294 – 31421Helical; Reviewed predictionAdd
BLAST
Topological domaini315 – 37561Extracellular Reviewed predictionAdd
BLAST
Transmembranei376 – 39621Helical; Reviewed predictionAdd
BLAST
Topological domaini397 – 47983Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Probable phosphatidate cytidylyltransferasePRO_0000327387Add
BLAST

Proteomic databases

PRIDEiQ55D90.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0233125.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi50 – 8536Asn-richAdd
BLAST

Sequence similaritiesi

Belongs to the CDS family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
KOiK00981.
OMAiYIYYQSF.
PhylomeDBiQ55D90.

Family and domain databases

InterProiIPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view]
PfamiPF01148. CTP_transf_1. 1 hit.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55D90-1 [UniParc]FASTAAdd to Basket

« Hide

MRTDNIRNRK EQLKKQEKKD FDSSKDEETS TSDEEESSGG NRSKIAGKEN    50
HQNKNIINQK TNNNNNNNNI KEKDIIDSSV NNADNLKATD PPSAKYKKLA 100
IRSVMGAFMI GFFTIVLSTD HFIVALFVIA LQLLVFKEMI ALRYIEAKEK 150
KIPHFRTLNW FFLFTSFFFF YAKPILITLA NYYPDIFQHF VRYHLWHSFS 200
LYCIGFVLFI LTLRKGVYRY QFSQLTWTLM ILMMVVVQSN FLISNIYQGL 250
IWFILPVSII VCNDIFAYFN GFFLGKKFIN RPLMKISPNK TWEGFIGATG 300
WTLLFAYYFC GFLLKYDWIV CPKGNTGFME SLHCTRDPVF LEKEFIFPPE 350
ITTIAFKYLG ITLLPFTYIP IQFHALVLAL FGSLIAPFGG FFASGIKRAY 400
KVKDFDTIFP GHGGVTDRTD CQFIMGLFIH VYYNTFIKTL EIDPTFIWQN 450
IMMLSMEEKM VIYEKLKQSI EFTTGTITA 479
Length:479
Mass (Da):55,732
Last modified:May 24, 2005 - v1
Checksum:i6EC7D88810AA3A1A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72221.1.
RefSeqiXP_646241.1. XM_641149.1.

Genome annotation databases

EnsemblProtistsiDDB0233125; DDB0233125; DDB_G0269742.
GeneIDi8617197.
KEGGiddi:DDB_G0269742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72221.1 .
RefSeqi XP_646241.1. XM_641149.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0233125.

Proteomic databases

PRIDEi Q55D90.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0233125 ; DDB0233125 ; DDB_G0269742 .
GeneIDi 8617197.
KEGGi ddi:DDB_G0269742.

Organism-specific databases

dictyBasei DDB_G0269742. cdsA.

Phylogenomic databases

eggNOGi COG0575.
KOi K00981.
OMAi YIYYQSF.
PhylomeDBi Q55D90.

Enzyme and pathway databases

UniPathwayi UPA00557 ; UER00614 .
Reactomei REACT_204734. Synthesis of PI.
REACT_221051. Synthesis of PG.

Family and domain databases

InterProi IPR000374. PC_trans.
IPR016720. PC_Trfase_euk.
[Graphical view ]
Pfami PF01148. CTP_transf_1. 1 hit.
[Graphical view ]
PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiCDSA_DICDI
AccessioniPrimary (citable) accession number: Q55D90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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