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Protein

Probable phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

Pathway:iCDP-diacylglycerol biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate.
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Probable phosphatidate cytidylyltransferase (cdsA), Phosphatidate cytidylyltransferase, mitochondrial (DDB_G0277049)
This subpathway is part of the pathway CDP-diacylglycerol biosynthesis, which is itself part of Phospholipid metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CDP-diacylglycerol from sn-glycerol 3-phosphate, the pathway CDP-diacylglycerol biosynthesis and in Phospholipid metabolism.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

Enzyme and pathway databases

ReactomeiREACT_292526. Synthesis of PI.
REACT_344864. Synthesis of PG.
UniPathwayiUPA00557; UER00614.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable phosphatidate cytidylyltransferase (EC:2.7.7.41)
Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name:
CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase
Gene namesi
Name:cdsA
ORF Names:DDB_G0269742
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0269742. cdsA.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 108108CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei109 – 12921HelicalSequence AnalysisAdd
BLAST
Topological domaini130 – 15930ExtracellularSequence AnalysisAdd
BLAST
Transmembranei160 – 18021HelicalSequence AnalysisAdd
BLAST
Topological domaini181 – 19212CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei193 – 21321HelicalSequence AnalysisAdd
BLAST
Topological domaini214 – 24027ExtracellularSequence AnalysisAdd
BLAST
Transmembranei241 – 26121HelicalSequence AnalysisAdd
BLAST
Topological domaini262 – 29332CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei294 – 31421HelicalSequence AnalysisAdd
BLAST
Topological domaini315 – 37561ExtracellularSequence AnalysisAdd
BLAST
Transmembranei376 – 39621HelicalSequence AnalysisAdd
BLAST
Topological domaini397 – 47983CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 479479Probable phosphatidate cytidylyltransferasePRO_0000327387Add
BLAST

Proteomic databases

PRIDEiQ55D90.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0233125.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi50 – 8536Asn-richAdd
BLAST

Sequence similaritiesi

Belongs to the CDS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0575.
InParanoidiQ55D90.
KOiK00981.
OMAiLITLANY.
PhylomeDBiQ55D90.

Family and domain databases

InterProiIPR016720. PC_Trfase_euk.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55D90-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTDNIRNRK EQLKKQEKKD FDSSKDEETS TSDEEESSGG NRSKIAGKEN
60 70 80 90 100
HQNKNIINQK TNNNNNNNNI KEKDIIDSSV NNADNLKATD PPSAKYKKLA
110 120 130 140 150
IRSVMGAFMI GFFTIVLSTD HFIVALFVIA LQLLVFKEMI ALRYIEAKEK
160 170 180 190 200
KIPHFRTLNW FFLFTSFFFF YAKPILITLA NYYPDIFQHF VRYHLWHSFS
210 220 230 240 250
LYCIGFVLFI LTLRKGVYRY QFSQLTWTLM ILMMVVVQSN FLISNIYQGL
260 270 280 290 300
IWFILPVSII VCNDIFAYFN GFFLGKKFIN RPLMKISPNK TWEGFIGATG
310 320 330 340 350
WTLLFAYYFC GFLLKYDWIV CPKGNTGFME SLHCTRDPVF LEKEFIFPPE
360 370 380 390 400
ITTIAFKYLG ITLLPFTYIP IQFHALVLAL FGSLIAPFGG FFASGIKRAY
410 420 430 440 450
KVKDFDTIFP GHGGVTDRTD CQFIMGLFIH VYYNTFIKTL EIDPTFIWQN
460 470
IMMLSMEEKM VIYEKLKQSI EFTTGTITA
Length:479
Mass (Da):55,732
Last modified:May 24, 2005 - v1
Checksum:i6EC7D88810AA3A1A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72221.1.
RefSeqiXP_646241.1. XM_641149.1.

Genome annotation databases

EnsemblProtistsiDDB0233125; DDB0233125; DDB_G0269742.
GeneIDi8617197.
KEGGiddi:DDB_G0269742.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72221.1.
RefSeqiXP_646241.1. XM_641149.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0233125.

Proteomic databases

PRIDEiQ55D90.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0233125; DDB0233125; DDB_G0269742.
GeneIDi8617197.
KEGGiddi:DDB_G0269742.

Organism-specific databases

dictyBaseiDDB_G0269742. cdsA.

Phylogenomic databases

eggNOGiCOG0575.
InParanoidiQ55D90.
KOiK00981.
OMAiLITLANY.
PhylomeDBiQ55D90.

Enzyme and pathway databases

UniPathwayiUPA00557; UER00614.
ReactomeiREACT_292526. Synthesis of PI.
REACT_344864. Synthesis of PG.

Miscellaneous databases

PROiQ55D90.

Family and domain databases

InterProiIPR016720. PC_Trfase_euk.
[Graphical view]
PIRSFiPIRSF018269. PC_trans_euk. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiCDSA_DICDI
AccessioniPrimary (citable) accession number: Q55D90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: July 22, 2015
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.