Q55D90 (CDSA_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable phosphatidate cytidylyltransferase
EC=2.7.7.41

Alternative name(s):
CDP-DAG synthase
CDP-DG synthase
CDP-diacylglycerol synthase
Short name=CDS
CDP-diglyceride pyrophosphorylase
CDP-diglyceride synthase
CTP:phosphatidate cytidylyltransferase

Gene names

Name:	cdsA
ORF Names:	DDB_G0269742

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	479 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	CTP + phosphatidate = diphosphate + CDP-diacylglycerol.
Pathway	Phospholipid metabolism; CDP-diacylglycerol biosynthesis; CDP-diacylglycerol from sn-glycerol 3-phosphate: step 3/3.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the CDS family.

Ontologies

Keywords
Biological process	Phospholipid biosynthesis
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	phospholipid biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate cytidylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 479	479	Probable phosphatidate cytidylyltransferase		PRO_0000327387
Regions
	Topological domain	1 – 108	108	Cytoplasmic Potential
	Transmembrane	109 – 129	21	Helical; Potential
	Topological domain	130 – 159	30	Extracellular Potential
	Transmembrane	160 – 180	21	Helical; Potential
	Topological domain	181 – 192	12	Cytoplasmic Potential
	Transmembrane	193 – 213	21	Helical; Potential
	Topological domain	214 – 240	27	Extracellular Potential
	Transmembrane	241 – 261	21	Helical; Potential
	Topological domain	262 – 293	32	Cytoplasmic Potential
	Transmembrane	294 – 314	21	Helical; Potential
	Topological domain	315 – 375	61	Extracellular Potential
	Transmembrane	376 – 396	21	Helical; Potential
	Topological domain	397 – 479	83	Cytoplasmic Potential
	Compositional bias	50 – 85	36	Asn-rich

Sequences

	Sequence		Length	Mass (Da)
	Q55D90 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 6EC7D88810AA3A1A	FASTA	479	55,732
	10 20 30 40 50 60 MRTDNIRNRK EQLKKQEKKD FDSSKDEETS TSDEEESSGG NRSKIAGKEN HQNKNIINQK 70 80 90 100 110 120 TNNNNNNNNI KEKDIIDSSV NNADNLKATD PPSAKYKKLA IRSVMGAFMI GFFTIVLSTD 130 140 150 160 170 180 HFIVALFVIA LQLLVFKEMI ALRYIEAKEK KIPHFRTLNW FFLFTSFFFF YAKPILITLA 190 200 210 220 230 240 NYYPDIFQHF VRYHLWHSFS LYCIGFVLFI LTLRKGVYRY QFSQLTWTLM ILMMVVVQSN 250 260 270 280 290 300 FLISNIYQGL IWFILPVSII VCNDIFAYFN GFFLGKKFIN RPLMKISPNK TWEGFIGATG 310 320 330 340 350 360 WTLLFAYYFC GFLLKYDWIV CPKGNTGFME SLHCTRDPVF LEKEFIFPPE ITTIAFKYLG 370 380 390 400 410 420 ITLLPFTYIP IQFHALVLAL FGSLIAPFGG FFASGIKRAY KVKDFDTIFP GHGGVTDRTD 430 440 450 460 470 CQFIMGLFIH VYYNTFIKTL EIDPTFIWQN IMMLSMEEKM VIYEKLKQSI EFTTGTITA

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000005 Genomic DNA. Translation: EAL72221.1.
RefSeq	XP_646241.1. XM_641149.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q55D90.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0233125; DDB0233125; DDB_G0269742.
GeneID	8617197.
GenomeReviews	Gene locus cdsA in contig CM000150_GR.
KEGG	ddi:DDB_G0269742.
Organism-specific databases
dictyBase	DDB_G0269742. cdsA.
Phylogenomic databases
eggNOG	KOG1440.
GeneTree	EPrGT00050000001380.
HOGENOM	HBG629124.
OMA	VVYMGHL.
PhylomeDB	Q55D90.
Family and domain databases
InterPro	IPR000374. PC_trans. IPR016720. PC_Trfase_euk. [Graphical view]
KO	K00981.
Pfam	PF01148. CTP_transf_1. 1 hit. [Graphical view]
PIRSF	PIRSF018269. PC_trans_euk. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CDSA_DICDI

Accession

Primary (citable) accession number: Q55D90

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)