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Q55D90

- CDSA_DICDI

UniProt

Q55D90 - CDSA_DICDI

Protein

Probable phosphatidate cytidylyltransferase

Gene

cdsA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    CTP + phosphatidate = diphosphate + CDP-diacylglycerol.

    Pathwayi

    GO - Molecular functioni

    1. phosphatidate cytidylyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. CDP-diacylglycerol biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Nucleotidyltransferase, Transferase

    Keywords - Biological processi

    Lipid biosynthesis, Lipid metabolism, Phospholipid biosynthesis, Phospholipid metabolism

    Enzyme and pathway databases

    ReactomeiREACT_204734. Synthesis of PI.
    REACT_221051. Synthesis of PG.
    UniPathwayiUPA00557; UER00614.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable phosphatidate cytidylyltransferase (EC:2.7.7.41)
    Alternative name(s):
    CDP-DAG synthase
    CDP-DG synthase
    CDP-diacylglycerol synthase
    Short name:
    CDS
    CDP-diglyceride pyrophosphorylase
    CDP-diglyceride synthase
    CTP:phosphatidate cytidylyltransferase
    Gene namesi
    Name:cdsA
    ORF Names:DDB_G0269742
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0269742. cdsA.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 479479Probable phosphatidate cytidylyltransferasePRO_0000327387Add
    BLAST

    Proteomic databases

    PRIDEiQ55D90.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0233125.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 108108CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini130 – 15930ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini181 – 19212CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini214 – 24027ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini262 – 29332CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini315 – 37561ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini397 – 47983CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei109 – 12921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei160 – 18021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei193 – 21321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei294 – 31421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei376 – 39621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi50 – 8536Asn-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CDS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0575.
    KOiK00981.
    OMAiYIYYQSF.
    PhylomeDBiQ55D90.

    Family and domain databases

    InterProiIPR000374. PC_trans.
    IPR016720. PC_Trfase_euk.
    [Graphical view]
    PfamiPF01148. CTP_transf_1. 1 hit.
    [Graphical view]
    PIRSFiPIRSF018269. PC_trans_euk. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q55D90-1 [UniParc]FASTAAdd to Basket

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    MRTDNIRNRK EQLKKQEKKD FDSSKDEETS TSDEEESSGG NRSKIAGKEN    50
    HQNKNIINQK TNNNNNNNNI KEKDIIDSSV NNADNLKATD PPSAKYKKLA 100
    IRSVMGAFMI GFFTIVLSTD HFIVALFVIA LQLLVFKEMI ALRYIEAKEK 150
    KIPHFRTLNW FFLFTSFFFF YAKPILITLA NYYPDIFQHF VRYHLWHSFS 200
    LYCIGFVLFI LTLRKGVYRY QFSQLTWTLM ILMMVVVQSN FLISNIYQGL 250
    IWFILPVSII VCNDIFAYFN GFFLGKKFIN RPLMKISPNK TWEGFIGATG 300
    WTLLFAYYFC GFLLKYDWIV CPKGNTGFME SLHCTRDPVF LEKEFIFPPE 350
    ITTIAFKYLG ITLLPFTYIP IQFHALVLAL FGSLIAPFGG FFASGIKRAY 400
    KVKDFDTIFP GHGGVTDRTD CQFIMGLFIH VYYNTFIKTL EIDPTFIWQN 450
    IMMLSMEEKM VIYEKLKQSI EFTTGTITA 479
    Length:479
    Mass (Da):55,732
    Last modified:May 24, 2005 - v1
    Checksum:i6EC7D88810AA3A1A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAL72221.1.
    RefSeqiXP_646241.1. XM_641149.1.

    Genome annotation databases

    EnsemblProtistsiDDB0233125; DDB0233125; DDB_G0269742.
    GeneIDi8617197.
    KEGGiddi:DDB_G0269742.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAL72221.1 .
    RefSeqi XP_646241.1. XM_641149.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0233125.

    Proteomic databases

    PRIDEi Q55D90.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0233125 ; DDB0233125 ; DDB_G0269742 .
    GeneIDi 8617197.
    KEGGi ddi:DDB_G0269742.

    Organism-specific databases

    dictyBasei DDB_G0269742. cdsA.

    Phylogenomic databases

    eggNOGi COG0575.
    KOi K00981.
    OMAi YIYYQSF.
    PhylomeDBi Q55D90.

    Enzyme and pathway databases

    UniPathwayi UPA00557 ; UER00614 .
    Reactomei REACT_204734. Synthesis of PI.
    REACT_221051. Synthesis of PG.

    Family and domain databases

    InterProi IPR000374. PC_trans.
    IPR016720. PC_Trfase_euk.
    [Graphical view ]
    Pfami PF01148. CTP_transf_1. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF018269. PC_trans_euk. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiCDSA_DICDI
    AccessioniPrimary (citable) accession number: Q55D90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 8, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3