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Protein

Inositol-tetrakisphosphate 1-kinase

Gene

DDB0190521

Organism
Dictyostelium discoideum (Slime mold)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.UniRule annotation

Catalytic activityi

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 2 magnesium ions per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi281 – 2811magnesium 1UniRule annotation
Metal bindingi295 – 2951magnesium 1UniRule annotation
Metal bindingi295 – 2951magnesium 2UniRule annotation
Metal bindingi297 – 2971magnesium 2UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiREACT_277218. Factors involved in megakaryocyte development and platelet production.
REACT_290276. Synthesis of IP3 and IP4 in the cytosol.
REACT_325779. Synthesis of pyrophosphates in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-tetrakisphosphate 1-kinaseUniRule annotation (EC:2.7.1.134UniRule annotation)
Gene namesi
ORF Names:DDB0190521Imported
OrganismiDictyostelium discoideum (Slime mold)Imported
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componenti: Chromosome 1

Organism-specific databases

dictyBaseiDDB_G0269746. itpk1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi44689.DDB0238430.

Family & Domainsi

Sequence similaritiesi

Belongs to the ITPK1 family.UniRule annotation

Phylogenomic databases

eggNOGiNOG85132.
InParanoidiQ55D87.
KOiK00913.
OMAiSNIERNI.
PhylomeDBiQ55D87.

Family and domain databases

InterProiIPR008656. Inositol_tetrakis-P_1-kinase.
[Graphical view]
PfamiPF05770. Ins134_P3_kin. 1 hit.
[Graphical view]
PIRSFiPIRSF038186. ITPK. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55D87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRNNTLPND FTVGYYLSDS KINKLKWNLF VDMCKEKYNI NVVPIDMNKD
60 70 80 90 100
INSINTRPYH VIIDKLTDEL GDLDNPSNKQ KVDYIQSLID KFPSIVEVDP
110 120 130 140 150
LESQKPVLSR DTLTKLLDKL NDVSPELNIK NPKFVLVPED YNNNDYNQLL
160 170 180 190 200
KDANIKFPVV CKTIKACGSK ESHYMGIVFN EKDIHQFKQP MLIQEFINHN
210 220 230 240 250
AIIYKVFAIG DFIQVVHRKS IRNMNENENE LIKFDSQKPF PTSLLPTDGQ
260 270 280 290 300
ELKIEMPSKS TLSVISKDIQ KNLDISLFGF DVIVDCETKK LAVVDINYFP
310 320
TFSGVDDFYT LLIEHVINVY KRKSSV
Length:326
Mass (Da):37,565
Last modified:May 24, 2005 - v1
Checksum:i83D7D34AC2301E03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI01000011 Genomic DNA. Translation: EAL72223.1.
RefSeqiXP_646244.1. XM_641152.1.

Genome annotation databases

EnsemblProtistsiDDB0238430; DDB0238430; DDB_G0269746.
GeneIDi8617200.
KEGGiddi:DDB_G0269746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI01000011 Genomic DNA. Translation: EAL72223.1.
RefSeqiXP_646244.1. XM_641152.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0238430.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0238430; DDB0238430; DDB_G0269746.
GeneIDi8617200.
KEGGiddi:DDB_G0269746.

Organism-specific databases

dictyBaseiDDB_G0269746. itpk1.

Phylogenomic databases

eggNOGiNOG85132.
InParanoidiQ55D87.
KOiK00913.
OMAiSNIERNI.
PhylomeDBiQ55D87.

Enzyme and pathway databases

ReactomeiREACT_277218. Factors involved in megakaryocyte development and platelet production.
REACT_290276. Synthesis of IP3 and IP4 in the cytosol.
REACT_325779. Synthesis of pyrophosphates in the cytosol.

Family and domain databases

InterProiIPR008656. Inositol_tetrakis-P_1-kinase.
[Graphical view]
PfamiPF05770. Ins134_P3_kin. 1 hit.
[Graphical view]
PIRSFiPIRSF038186. ITPK. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    The Dictyostelium discoideum Sequencing Consortium
    Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H., Noegel A.A., Barrell B., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4Imported.

Entry informationi

Entry nameiQ55D87_DICDI
AccessioniPrimary (citable) accession number: Q55D87
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: July 22, 2015
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.