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Q55D87

- Q55D87_DICDI

UniProt

Q55D87 - Q55D87_DICDI

Protein

Inositol-tetrakisphosphate 1-kinase

Gene

ITPK1

Organism
Dictyostelium discoideum (Slime mold)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.UniRule annotation

    Catalytic activityi

    ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.UniRule annotation

    Cofactori

    Binds 2 magnesium ions per subunit.UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. inositol-1,3,4-trisphosphate 5-kinase activity Source: InterPro
    3. inositol-1,3,4-trisphosphate 6-kinase activity Source: InterPro
    4. inositol tetrakisphosphate 1-kinase activity Source: UniProtKB-EC
    5. magnesium ion binding Source: InterPro

    GO - Biological processi

    1. inositol phosphate-mediated signaling Source: dictyBase
    2. inositol trisphosphate metabolic process Source: InterPro

    Keywords - Molecular functioni

    KinaseUniRule annotationImported, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Inositol-tetrakisphosphate 1-kinaseUniRule annotation (EC:2.7.1.134UniRule annotation)
    Gene namesi
    Name:ITPK1Imported
    ORF Names:DDB_G0269746Imported
    OrganismiDictyostelium discoideum (Slime mold)Imported
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0269746. itpk1.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: dictyBase

    Interactioni

    Subunit structurei

    Monomer.UniRule annotation

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0190521.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ITPK1 family.UniRule annotation

    Phylogenomic databases

    eggNOGiNOG85132.
    KOiK00913.
    OMAiVVDINYF.
    PhylomeDBiQ55D87.

    Family and domain databases

    InterProiIPR008656. Inositol_tetrakis-P_1-kinase.
    IPR017427. Inositol_tetrakis-P_kinase_pln.
    [Graphical view]
    PfamiPF05770. Ins134_P3_kin. 1 hit.
    [Graphical view]
    PIRSFiPIRSF038186. ITPK. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q55D87-1 [UniParc]FASTAAdd to Basket

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    MGRNNTLPND FTVGYYLSDS KINKLKWNLF VDMCKEKYNI NVVPIDMNKD    50
    INSINTRPYH VIIDKLTDEL GDLDNPSNKQ KVDYIQSLID KFPSIVEVDP 100
    LESQKPVLSR DTLTKLLDKL NDVSPELNIK NPKFVLVPED YNNNDYNQLL 150
    KDANIKFPVV CKTIKACGSK ESHYMGIVFN EKDIHQFKQP MLIQEFINHN 200
    AIIYKVFAIG DFIQVVHRKS IRNMNENENE LIKFDSQKPF PTSLLPTDGQ 250
    ELKIEMPSKS TLSVISKDIQ KNLDISLFGF DVIVDCETKK LAVVDINYFP 300
    TFSGVDDFYT LLIEHVINVY KRKSSV 326
    Length:326
    Mass (Da):37,565
    Last modified:May 24, 2005 - v1
    Checksum:i83D7D34AC2301E03
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAL72223.1.
    RefSeqiXP_646244.1. XM_641152.1.

    Genome annotation databases

    EnsemblProtistsiDDB0238430; DDB0238430; DDB_G0269746.
    GeneIDi8617200.
    KEGGiddi:DDB_G0269746.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAL72223.1 .
    RefSeqi XP_646244.1. XM_641152.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0190521.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0238430 ; DDB0238430 ; DDB_G0269746 .
    GeneIDi 8617200.
    KEGGi ddi:DDB_G0269746.

    Organism-specific databases

    dictyBasei DDB_G0269746. itpk1.

    Phylogenomic databases

    eggNOGi NOG85132.
    KOi K00913.
    OMAi VVDINYF.
    PhylomeDBi Q55D87.

    Family and domain databases

    InterProi IPR008656. Inositol_tetrakis-P_1-kinase.
    IPR017427. Inositol_tetrakis-P_kinase_pln.
    [Graphical view ]
    Pfami PF05770. Ins134_P3_kin. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF038186. ITPK. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      The Dictyostelium discoideum Sequencing Consortium
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4Imported.

    Entry informationi

    Entry nameiQ55D87_DICDI
    AccessioniPrimary (citable) accession number: Q55D87
    Entry historyi
    Integrated into UniProtKB/TrEMBL: May 24, 2005
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3