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Q55D87

- Q55D87_DICDI

UniProt

Q55D87 - Q55D87_DICDI

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Protein

Inositol-tetrakisphosphate 1-kinase

Gene

DDB0190521

Organism
Dictyostelium discoideum (Slime mold)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3.UniRule annotation

Catalytic activityi

ATP + 1D-myo-inositol 3,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate.UniRule annotation

Cofactori

Note: Binds 2 magnesium ions per subunit.UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. inositol-1,3,4-trisphosphate 5-kinase activity Source: InterPro
  3. inositol-1,3,4-trisphosphate 6-kinase activity Source: InterPro
  4. inositol tetrakisphosphate 1-kinase activity Source: UniProtKB-EC
  5. magnesium ion binding Source: InterPro

GO - Biological processi

  1. inositol phosphate-mediated signaling Source: dictyBase
  2. inositol trisphosphate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Inositol-tetrakisphosphate 1-kinaseUniRule annotation (EC:2.7.1.134UniRule annotation)
Gene namesi
ORF Names:DDB0190521Imported
OrganismiDictyostelium discoideum (Slime mold)Imported
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0269746. itpk1.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: dictyBase
Complete GO annotation...

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0190521.

Family & Domainsi

Sequence similaritiesi

Belongs to the ITPK1 family.UniRule annotation

Phylogenomic databases

eggNOGiNOG85132.
InParanoidiQ55D87.
KOiK00913.
OMAiVVDINYF.
PhylomeDBiQ55D87.

Family and domain databases

InterProiIPR008656. Inositol_tetrakis-P_1-kinase.
IPR017427. Inositol_tetrakis-P_kinase_pln.
[Graphical view]
PfamiPF05770. Ins134_P3_kin. 1 hit.
[Graphical view]
PIRSFiPIRSF038186. ITPK. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55D87-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGRNNTLPND FTVGYYLSDS KINKLKWNLF VDMCKEKYNI NVVPIDMNKD
60 70 80 90 100
INSINTRPYH VIIDKLTDEL GDLDNPSNKQ KVDYIQSLID KFPSIVEVDP
110 120 130 140 150
LESQKPVLSR DTLTKLLDKL NDVSPELNIK NPKFVLVPED YNNNDYNQLL
160 170 180 190 200
KDANIKFPVV CKTIKACGSK ESHYMGIVFN EKDIHQFKQP MLIQEFINHN
210 220 230 240 250
AIIYKVFAIG DFIQVVHRKS IRNMNENENE LIKFDSQKPF PTSLLPTDGQ
260 270 280 290 300
ELKIEMPSKS TLSVISKDIQ KNLDISLFGF DVIVDCETKK LAVVDINYFP
310 320
TFSGVDDFYT LLIEHVINVY KRKSSV
Length:326
Mass (Da):37,565
Last modified:May 24, 2005 - v1
Checksum:i83D7D34AC2301E03
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI01000011 Genomic DNA. Translation: EAL72223.1.
RefSeqiXP_646244.1. XM_641152.1.

Genome annotation databases

EnsemblProtistsiDDB0238430; DDB0238430; DDB_G0269746.
GeneIDi8617200.
KEGGiddi:DDB_G0269746.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI01000011 Genomic DNA. Translation: EAL72223.1 .
RefSeqi XP_646244.1. XM_641152.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0190521.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0238430 ; DDB0238430 ; DDB_G0269746 .
GeneIDi 8617200.
KEGGi ddi:DDB_G0269746.

Organism-specific databases

dictyBasei DDB_G0269746. itpk1.

Phylogenomic databases

eggNOGi NOG85132.
InParanoidi Q55D87.
KOi K00913.
OMAi VVDINYF.
PhylomeDBi Q55D87.

Family and domain databases

InterProi IPR008656. Inositol_tetrakis-P_1-kinase.
IPR017427. Inositol_tetrakis-P_kinase_pln.
[Graphical view ]
Pfami PF05770. Ins134_P3_kin. 1 hit.
[Graphical view ]
PIRSFi PIRSF038186. ITPK. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    The Dictyostelium discoideum Sequencing Consortium
    Eichinger L., Pachebat J.A., Glockner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R., Loomis W.F., Platzer M., Kay R.R., Williams J., Dear P.H., Noegel A.A., Barrell B., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4Imported.

Entry informationi

Entry nameiQ55D87_DICDI
AccessioniPrimary (citable) accession number: Q55D87
Entry historyi
Integrated into UniProtKB/TrEMBL: May 24, 2005
Last sequence update: May 24, 2005
Last modified: November 26, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3