Q55D51 (FNTB_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein farnesyltransferase subunit beta
Short name=FTase-beta
EC=2.5.1.58

Alternative name(s):
CAAX farnesyltransferase subunit beta
Ras proteins prenyltransferase subunit beta

Gene names

Name:	fntB
ORF Names:	DDB_G0270948

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the transfer of a farnesyl moiety from farnesyl pyrophosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding By similarity.
Catalytic activity	Farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate.
Cofactor	Binds 1 zinc ion per subunit By similarity.
Subunit structure	Heterodimer of an alpha and a beta subunit By similarity.
Sequence similarities	Belongs to the protein prenyltransferase subunit beta family. Contains 5 PFTB repeats.

Ontologies

Keywords
Domain	Repeat
Ligand	Metal-binding Zinc
Molecular function	Prenyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	protein farnesylation Inferred from sequence or structural similarity. Source: dictyBase
Cellular component	protein farnesyltransferase complex Inferred from sequence or structural similarity. Source: dictyBase
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW protein farnesyltransferase activity Inferred from sequence or structural similarity. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Protein farnesyltransferase subunit beta		PRO_0000328342
Regions
	Repeat	121 – 162	42	PFTB 1
	Repeat	172 – 213	42	PFTB 2
	Repeat	220 – 261	42	PFTB 3
	Repeat	268 – 309	42	PFTB 4
	Repeat	343 – 384	42	PFTB 5
	Compositional bias	122 – 128	7	Poly-Asn
	Compositional bias	421 – 432	12	Poly-Asn
	Compositional bias	436 – 446	11	Poly-Asn
Sites
	Metal binding	294	1	Zinc By similarity
	Metal binding	296	1	Zinc By similarity
	Metal binding	372	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55D51 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 886213CE6714B50C	FASTA	500	56,488
	10 20 30 40 50 60 MSSIEEIDTD ETFTSDYVSA RKDEVDDIIT ATTIAQKKME NSILEKLNST ENGNIIEKKK 70 80 90 100 110 120 ILNFLMNGIE KIPMSHQGLD SSKVWISFWI LNGMDMLDSL DSYPNISSRA SKYLSILQND 130 140 150 160 170 180 DNNGNNNNRE NNQNGGGFGG GNSHTSHVVS TFAAVSALYV IGTEESYKTI DREAMYKFLM 190 200 210 220 230 240 RMKTKEGAFT SEDGGEYDSR TTYCAIAVAS MLNILTAELE RGVVDFLLSC QTYEGGFGAY 250 260 270 280 290 300 PFNEAHGGYT FCSVAALSIL NSLHKIDMNS LHRWITYRQS NDGGFEGRTN KLVDTCYSYW 310 320 330 340 350 360 QGAVYIIIQS YFNYYKKQQQ DDGDGKEGDQ QEEGLLFNQA KLQEYVIRFC QQSDKKYSGF 370 380 390 400 410 420 SDHPHRGKDY YHTCYGLSGI SLSQYNEIGK AIQSLNTFTN TFEQPSPPIN KKSTNVFTIS 430 440 450 460 470 480 NNNNNNNNKN NNSDDNNNNS NNNNNNSENQ LVEPVHPIYN IKLSKCEKGF EIDLFLFQKE 490 500 FKDASVSLGT LFFYAKFILK

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000005 Genomic DNA. Translation: EAL72824.1.
RefSeq	XP_646280.1. XM_641188.1.
3D structure databases
HSSP	HSSP built from PDB template 1LD8 based on UniProtKB P49356.
ProteinModelPortal	Q55D51.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0237553; DDB0237553; DDB_G0270948.
GeneID	8617235.
GenomeReviews	Gene locus fntB in contig CM000150_GR.
KEGG	ddi:DDB_G0270948.
Organism-specific databases
dictyBase	DDB_G0270948. fntB.
Phylogenomic databases
eggNOG	KOG0365.
GeneTree	EPrGT00050000001341.
HOGENOM	HBG736019.
OMA	AGQHPAG.
PhylomeDB	Q55D51.
Family and domain databases
InterPro	IPR001330. Prenyltrans. IPR008930. Terpenoid_cyclase/PrenylTrfase. [Graphical view]
KO	K05954.
Pfam	PF00432. Prenyltrans. 3 hits. [Graphical view]
SUPFAM	SSF48239. Terp_cyc_toroid. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FNTB_DICDI

Accession

Primary (citable) accession number: Q55D51

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	May 24, 2005
Last modified:	November 16, 2011
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)