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Q55CT5

- SEC31_DICDI

UniProt

Q55CT5 - SEC31_DICDI

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Protein
Protein transport protein SEC31
Gene
sec31, DDB_G0270992
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules By similarity.

GO - Biological processi

  1. ER to Golgi vesicle-mediated transport Source: dictyBase
  2. RNA splicing Source: InterPro
  3. intracellular protein transport Source: dictyBase
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Enzyme and pathway databases

ReactomeiREACT_210982. COPII (Coat Protein 2) Mediated Vesicle Transport.
REACT_218739. XBP1(S) activates chaperone genes.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein SEC31
Gene namesi
Name:sec31
ORF Names:DDB_G0270992
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270992. sec31.

Subcellular locationi

GO - Cellular componenti

  1. COPII vesicle coat Source: dictyBase
  2. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  3. spliceosomal complex Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle, Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13551355Protein transport protein SEC31
PRO_0000328076Add
BLAST

Proteomic databases

PRIDEiQ55CT5.

Interactioni

Subunit structurei

The COPII coat is composed of at least 5 proteins: the sec23/24 complex, the sec13/31 complex, and the protein sar1A or sar1B. sec13 and sec31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with sec13 By similarity.

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0216723.

Structurei

3D structure databases

ProteinModelPortaliQ55CT5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati5 – 4844WD 1
Add
BLAST
Repeati65 – 10945WD 2
Add
BLAST
Repeati127 – 16741WD 3
Add
BLAST
Repeati175 – 21541WD 4
Add
BLAST
Repeati220 – 26344WD 5
Add
BLAST
Repeati267 – 30741WD 6
Add
BLAST
Repeati334 – 37441WD 7
Add
BLAST
Repeati412 – 46352WD 8; interaction with sec13 By similarity
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi437 – 4437Poly-Ser
Compositional biasi449 – 4579Poly-Gln
Compositional biasi570 – 5745Poly-Thr
Compositional biasi612 – 6176Poly-Ser
Compositional biasi622 – 6265Poly-Thr
Compositional biasi774 – 7829Poly-Gln
Compositional biasi902 – 9098Poly-Gln
Compositional biasi943 – 95311Poly-Gln
Add
BLAST
Compositional biasi969 – 98012Poly-Gln
Add
BLAST
Compositional biasi984 – 1188205Met/Pro-rich
Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat SEC31 family.
Contains 8 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG248389.
KOiK14005.
OMAiMMNQGPP.
PhylomeDBiQ55CT5.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR004098. Prp18.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF02840. Prp18. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view]
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55CT5-1 [UniParc]FASTAAdd to Basket

« Hide

MSKLKEISRQ STTSWSPIAQ YPDYMAVGTV TGTIGADFDT SSKLEIYSLD     50
ITNESKQMTL KGSTSSSTRF NKVVWGQASS NFQNGIIAGA MDNGTINLWD 100
PTKILASDAT DGGGSDDQSS LIGVGQRHSG PVQSIDFNVQ NPNLLASGGS 150
DSEVFIWDLS DPTQPSALNP GSKSQQSSDI TCVAWNKKVA HILGSASYNG 200
YIVIWDLKSK KTLMTINDRN RKCKYRSIVW HPSEATQIVA ASEDDDHPVI 250
QAWDLRNTTS PVKSMEGHKK GVWGLSWCPS DNALLLSTGK DNKTFCWNFD 300
RQEILCEIND NNSRNNINNN SNNSNSDNNN GNTDPNAWNF EVQWSPRVPA 350
LLSTSSYVGK VNVYSLQDVN EKSTSGSSAG QLNALGIQEQ TSQITPTIKH 400
TPNWLLRPCG AAFGFGGKIA VFGRNKKVTA AANGATSPSS SSSPASSVQQ 450
SQLQQQQRVI HISHVTTEVD IVKSSEQLEN VIHTGQYEQY CQEKIDQSTS 500
DEEKSIWGFL KVKFAKDDRL KILDYLGYDI ETIKKELKQF LGTLPELPIE 550
SGFNELPIEN VDDQSKPEPT TTTTNETVHL EPVVDENNNV VDADSFFDTA 600
ASDANKEQQD DSSSSPSTKS PTTTTTPIEF PGDEKEQMIT KALLVGDHNS 650
AVECCLRLGR YSDALILAHA AGQELWKKTQ EAYFEIVRSP FGRVVSCIVK 700
RDFQLLVKSA DLKDWKASLA ILCTYAPPTD FKILSGILGD RLDKEASDLK 750
SAILCYICAG DIDKTVDIWS RVSQQHQQQQ RQSLTSSGNS ITVLEQESNK 800
DLQNLIEKVS IFRSACNGNS NNNTLNQVLS MKYAKYAEIL ASQGNLSASL 850
RYLAPITNSQ CKQEYGVLFD RVYRATSNHQ GIPQPPFPFQ LVDVYSSNQP 900
IQQQQQQQQN KAQQVGHQHQ HQHQHQNQHQ HQHQHQHQHQ PPQQQQQQQQ 950
QQQMGRQNTF NQPPQPMGQH QHQQQQQQQQ PPIMMNQSPM QNNNNNRIPM 1000
MNQPPMMNQP PMMNQPPMMN QPPQMMNQPP QMMNQPPPQM MNQPPPQMMN 1050
NNQPPIMMRP MQPSGPSPMN PPPTMNNTQP PPMMNTMGGP SSVNNSQPPI 1100
IPMNGNPLPM NPMSPMMSDK SNQPPMNPMM NPMNPMNPMM NPIQPTAPPP 1150
MNPMIPQGGS PMINHPPPPM NPMINNGPVS TPPMNPMMNQ VVPQNISPPQ 1200
MPTRSPVLEN KSSSPSSESF TSPAPKPNVH NKTPSIITGQ LGVTTPSEGP 1250
SNEDTERFVE KLQRSIQELN GRTDSKVWED ANKRCQGLIN KVSKKDISAE 1300
AFKALDAILA SIVEKDFKKA SDTYIQITST PLWGEVGSQS MVGLKRLIDL 1350
GLKSH 1355
Length:1,355
Mass (Da):150,127
Last modified:May 24, 2005 - v1
Checksum:i885303FDEEB8959F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72846.1.
RefSeqiXP_646396.1. XM_641304.1.

Genome annotation databases

EnsemblProtistsiDDB0235185; DDB0235185; DDB_G0270992.
GeneIDi8617351.
KEGGiddi:DDB_G0270992.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72846.1 .
RefSeqi XP_646396.1. XM_641304.1.

3D structure databases

ProteinModelPortali Q55CT5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0216723.

Proteomic databases

PRIDEi Q55CT5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0235185 ; DDB0235185 ; DDB_G0270992 .
GeneIDi 8617351.
KEGGi ddi:DDB_G0270992.

Organism-specific databases

dictyBasei DDB_G0270992. sec31.

Phylogenomic databases

eggNOGi NOG248389.
KOi K14005.
OMAi MMNQGPP.
PhylomeDBi Q55CT5.

Enzyme and pathway databases

Reactomei REACT_210982. COPII (Coat Protein 2) Mediated Vesicle Transport.
REACT_218739. XBP1(S) activates chaperone genes.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR004098. Prp18.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF02840. Prp18. 1 hit.
PF00400. WD40. 3 hits.
[Graphical view ]
SMARTi SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 1 hit.
PROSITEi PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiSEC31_DICDI
AccessioniPrimary (citable) accession number: Q55CT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3