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Protein

Tripeptidyl-peptidase 1

Gene

tpp1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Serine protease with tripeptidyl-peptidase I activity.By similarity

Catalytic activityi

Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity.

Cofactori

Ca2+By similarityNote: Binds 1 Ca2+ ion per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei318Charge relay systemBy similarity1
Active sitei322Charge relay systemBy similarity1
Active sitei514Charge relay systemBy similarity1
Metal bindingi559CalciumBy similarity1
Metal bindingi560Calcium; via carbonyl oxygenBy similarity1
Metal bindingi579Calcium; via carbonyl oxygenBy similarity1
Metal bindingi581CalciumBy similarity1

GO - Molecular functioni

  • endopeptidase activity Source: GO_Central
  • metal ion binding Source: UniProtKB-KW
  • serine-type endopeptidase activity Source: InterPro
  • tripeptidyl-peptidase activity Source: dictyBase

GO - Biological processi

  • proteolysis Source: dictyBase
  • response to chloroquine Source: dictyBase
  • sorocarp development Source: dictyBase

Keywordsi

Molecular functionHydrolase, Protease, Serine protease
LigandCalcium, Metal-binding

Protein family/group databases

MEROPSiS53.003

Names & Taxonomyi

Protein namesi
Recommended name:
Tripeptidyl-peptidase 1 (EC:3.4.14.9)
Short name:
TPP-1
Alternative name(s):
Tripeptidyl aminopeptidase
Tripeptidyl-peptidase I
Short name:
TPP-I
Gene namesi
Name:tpp1
ORF Names:DDB_G0269914
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0269914 tpp1

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB-SubCell
  • lysosome Source: dictyBase

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
PropeptideiPRO_000032757023 – 220Removed in mature formBy similarityAdd BLAST198
ChainiPRO_0000327571221 – 600Tripeptidyl-peptidase 1Add BLAST380

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi91N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi259N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi266N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi411 ↔ 570By similarity
Glycosylationi475N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi483N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity (By similarity).By similarity

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ55CT0
PRIDEiQ55CT0

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0234303

Structurei

3D structure databases

ProteinModelPortaliQ55CT0
SMRiQ55CT0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini248 – 600Peptidase S53Add BLAST353

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IICY Eukaryota
COG4934 LUCA
InParanoidiQ55CT0
KOiK01279
OMAiHIDFIGG
PhylomeDBiQ55CT0

Family and domain databases

CDDicd04056 Peptidases_S53, 1 hit
cd11377 Pro-peptidase_S53, 1 hit
Gene3Di3.40.50.200, 1 hit
InterProiView protein in InterPro
IPR036852 Peptidase_S8/S53_dom_sf
IPR023828 Peptidase_S8_Ser-AS
IPR015366 S53_propep
IPR030400 Sedolisin_dom
PfamiView protein in Pfam
PF09286 Pro-kuma_activ, 1 hit
SMARTiView protein in SMART
SM00944 Pro-kuma_activ, 1 hit
SUPFAMiSSF52743 SSF52743, 1 hit
PROSITEiView protein in PROSITE
PS51695 SEDOLISIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q55CT0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIKFNLIII ILFILFISNV NCKKIKNKKH LTPQRLRRFV EHSKPISLNK
60 70 80 90 100
KVWKITEIEN IFSAQIELTF GIRQRNIVEL EDFVWRVSDP NDSLYGSYKT
110 120 130 140 150
FEEIKEWVKP LDESIDAVKN WLIENDINEF TVTKSGDFIR TIVSIDKAEE
160 170 180 190 200
LLSVRYNKMV HKLSKQSFFR SLDPYTIPRE LYDHIDFIGG VNHLPLLSPR
210 220 230 240 250
PKESSGSAGG GGGGKVNGIG YELESLRNNK QIKSFNDKKV AARNGDPYLS
260 270 280 290 300
PDLIRKEMNV SQTSTNSTHL GNSQAIAQFL KEYFSPSDLK IFQYRFGLEP
310 320 330 340 350
SQVDNIIGPN QNLNPGIETA LDIQYIMAMA PDVPTWIVST GGLHEGQEPF
360 370 380 390 400
LDWLVDLSSN PKLPLVHSIS YGDDESSIGL AYTDRVDTEF KKYAAMGRTI
410 420 430 440 450
VFSSGDFGVG CNDDCDSFSP GWPASSRFVL AVGGVIKKKD GSIIGDEISG
460 470 480 490 500
GGFSNYFSRP WYQVDECSSY IEWLNGSLSS FYNQSGRGFP DISSFSENVV
510 520 530 540 550
ILYKDKLMPI GGTSASAPII AGLLSLINDQ RLQKNQSPIG LFNPLLYKIA
560 570 580 590 600
RDHPNSFLDI DFGENNYKCC TNGFKSKSGW DPVTGLGLPN FDELVKYCLE
Length:600
Mass (Da):67,296
Last modified:May 24, 2005 - v1
Checksum:iD9E97C1279BC9C18
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAL72307.1
RefSeqiXP_646401.1, XM_641309.1

Genome annotation databases

EnsemblProtistsiEAL72307; EAL72307; DDB_G0269914
GeneIDi8617356
KEGGiddi:DDB_G0269914

Similar proteinsi

Entry informationi

Entry nameiTPP1_DICDI
AccessioniPrimary (citable) accession number: Q55CT0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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