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Q55CT0 (TPP1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 58. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Tripeptidyl-peptidase 1

Short name=TPP-1
EC=3.4.14.9
Alternative name(s):
Tripeptidyl aminopeptidase
Tripeptidyl-peptidase I
Short name=TPP-I
Gene names
Name:tpp1
ORF Names:DDB_G0269914
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length600 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Serine protease with tripeptidyl-peptidase I activity By similarity.

Catalytic activity

Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity.

Cofactor

Binds 1 calcium ion per subunit By similarity.

Subunit structure

Monomer By similarity.

Subcellular location

Secreted Potential.

Post-translational modification

Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity By similarity.

Sequence similarities

Contains 1 peptidase S53 domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2222 Potential
Propeptide23 – 220198Removed in mature form By similarity
PRO_0000327570
Chain221 – 600380Tripeptidyl-peptidase 1
PRO_0000327571

Regions

Domain248 – 600353Peptidase S53

Sites

Active site3181Charge relay system By similarity
Active site3221Charge relay system By similarity
Active site5141Charge relay system By similarity
Metal binding5591Calcium By similarity
Metal binding5601Calcium; via carbonyl oxygen By similarity
Metal binding5791Calcium; via carbonyl oxygen By similarity
Metal binding5811Calcium By similarity

Amino acid modifications

Glycosylation911N-linked (GlcNAc...) Potential
Glycosylation2591N-linked (GlcNAc...) Potential
Glycosylation2661N-linked (GlcNAc...) Potential
Glycosylation4751N-linked (GlcNAc...) Potential
Glycosylation4831N-linked (GlcNAc...) Potential
Disulfide bond411 ↔ 570 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q55CT0 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: D9E97C1279BC9C18

FASTA60067,296
        10         20         30         40         50         60 
MNIKFNLIII ILFILFISNV NCKKIKNKKH LTPQRLRRFV EHSKPISLNK KVWKITEIEN 

        70         80         90        100        110        120 
IFSAQIELTF GIRQRNIVEL EDFVWRVSDP NDSLYGSYKT FEEIKEWVKP LDESIDAVKN 

       130        140        150        160        170        180 
WLIENDINEF TVTKSGDFIR TIVSIDKAEE LLSVRYNKMV HKLSKQSFFR SLDPYTIPRE 

       190        200        210        220        230        240 
LYDHIDFIGG VNHLPLLSPR PKESSGSAGG GGGGKVNGIG YELESLRNNK QIKSFNDKKV 

       250        260        270        280        290        300 
AARNGDPYLS PDLIRKEMNV SQTSTNSTHL GNSQAIAQFL KEYFSPSDLK IFQYRFGLEP 

       310        320        330        340        350        360 
SQVDNIIGPN QNLNPGIETA LDIQYIMAMA PDVPTWIVST GGLHEGQEPF LDWLVDLSSN 

       370        380        390        400        410        420 
PKLPLVHSIS YGDDESSIGL AYTDRVDTEF KKYAAMGRTI VFSSGDFGVG CNDDCDSFSP 

       430        440        450        460        470        480 
GWPASSRFVL AVGGVIKKKD GSIIGDEISG GGFSNYFSRP WYQVDECSSY IEWLNGSLSS 

       490        500        510        520        530        540 
FYNQSGRGFP DISSFSENVV ILYKDKLMPI GGTSASAPII AGLLSLINDQ RLQKNQSPIG 

       550        560        570        580        590        600 
LFNPLLYKIA RDHPNSFLDI DFGENNYKCC TNGFKSKSGW DPVTGLGLPN FDELVKYCLE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000005 Genomic DNA. Translation: EAL72307.1.

3D structure databases

ProteinModelPortalQ55CT0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0190668.

Protein family/group databases

MEROPSS53.A02.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0234303; DDB0234303; DDB_G0269914.
KEGGddi:DDB_G0269914.

Organism-specific databases

dictyBaseDDB_G0269914. tpp1.

Phylogenomic databases

eggNOGCOG4934.
KOK01279.
OMAYIMAMAP.
PhylomeDBQ55CT0.
ProtClustDBCLSZ2429688.

Family and domain databases

Gene3D3.40.50.200. 1 hit.
InterProIPR015366. Peptidase_S53_propep.
IPR000209. Peptidase_S8/S53_dom.
IPR023828. Peptidase_S8_Ser-AS.
IPR009020. Prot_inh_propept.
[Graphical view]
PfamPF00082. Peptidase_S8. 1 hit.
PF09286. Pro-kuma_activ. 1 hit.
[Graphical view]
SMARTSM00944. Pro-kuma_activ. 1 hit.
[Graphical view]
SUPFAMSSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEPS51695. SEDOLISIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ55CT0.

Entry information

Entry nameTPP1_DICDI
AccessionPrimary (citable) accession number: Q55CT0
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase