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Q55CT0

- TPP1_DICDI

UniProt

Q55CT0 - TPP1_DICDI

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Protein

Tripeptidyl-peptidase 1

Gene
tpp1, DDB_G0269914
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Serine protease with tripeptidyl-peptidase I activity By similarity.

Catalytic activityi

Release of an N-terminal tripeptide from a polypeptide, but also has endopeptidase activity.

Cofactori

Binds 1 calcium ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei318 – 3181Charge relay system By similarity
Active sitei322 – 3221Charge relay system By similarity
Active sitei514 – 5141Charge relay system By similarity
Metal bindingi559 – 5591Calcium By similarity
Metal bindingi560 – 5601Calcium; via carbonyl oxygen By similarity
Metal bindingi579 – 5791Calcium; via carbonyl oxygen By similarity
Metal bindingi581 – 5811Calcium By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. serine-type endopeptidase activity Source: InterPro
  3. tripeptidyl-peptidase activity Source: dictyBase

GO - Biological processi

  1. proteolysis Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_218739. XBP1(S) activates chaperone genes.

Protein family/group databases

MEROPSiS53.A02.

Names & Taxonomyi

Protein namesi
Recommended name:
Tripeptidyl-peptidase 1 (EC:3.4.14.9)
Short name:
TPP-1
Alternative name(s):
Tripeptidyl aminopeptidase
Tripeptidyl-peptidase I
Short name:
TPP-I
Gene namesi
Name:tpp1
ORF Names:DDB_G0269914
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0269914. tpp1.

Subcellular locationi

Secreted Reviewed prediction

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2222 Reviewed predictionAdd
BLAST
Propeptidei23 – 220198Removed in mature form By similarityPRO_0000327570Add
BLAST
Chaini221 – 600380Tripeptidyl-peptidase 1PRO_0000327571Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi91 – 911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi259 – 2591N-linked (GlcNAc...) Reviewed prediction
Glycosylationi266 – 2661N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi411 ↔ 570 By similarity
Glycosylationi475 – 4751N-linked (GlcNAc...) Reviewed prediction
Glycosylationi483 – 4831N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

Activated by autocatalytic proteolytical processing upon acidification. N-glycosylation is required for processing and activity By similarity.

Keywords - PTMi

Autocatalytic cleavage, Disulfide bond, Glycoprotein, Zymogen

Interactioni

Subunit structurei

Monomer By similarity.

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0190668.

Structurei

3D structure databases

ProteinModelPortaliQ55CT0.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini248 – 600353Peptidase S53Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4934.
KOiK01279.
OMAiQVHETRE.
PhylomeDBiQ55CT0.

Family and domain databases

Gene3Di3.40.50.200. 1 hit.
InterProiIPR015366. Peptidase_S53_propep.
IPR000209. Peptidase_S8/S53_dom.
IPR023828. Peptidase_S8_Ser-AS.
IPR009020. Prot_inh_propept.
[Graphical view]
PfamiPF00082. Peptidase_S8. 1 hit.
PF09286. Pro-kuma_activ. 1 hit.
[Graphical view]
SMARTiSM00944. Pro-kuma_activ. 1 hit.
[Graphical view]
SUPFAMiSSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEiPS51695. SEDOLISIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q55CT0-1 [UniParc]FASTAAdd to Basket

« Hide

MNIKFNLIII ILFILFISNV NCKKIKNKKH LTPQRLRRFV EHSKPISLNK    50
KVWKITEIEN IFSAQIELTF GIRQRNIVEL EDFVWRVSDP NDSLYGSYKT 100
FEEIKEWVKP LDESIDAVKN WLIENDINEF TVTKSGDFIR TIVSIDKAEE 150
LLSVRYNKMV HKLSKQSFFR SLDPYTIPRE LYDHIDFIGG VNHLPLLSPR 200
PKESSGSAGG GGGGKVNGIG YELESLRNNK QIKSFNDKKV AARNGDPYLS 250
PDLIRKEMNV SQTSTNSTHL GNSQAIAQFL KEYFSPSDLK IFQYRFGLEP 300
SQVDNIIGPN QNLNPGIETA LDIQYIMAMA PDVPTWIVST GGLHEGQEPF 350
LDWLVDLSSN PKLPLVHSIS YGDDESSIGL AYTDRVDTEF KKYAAMGRTI 400
VFSSGDFGVG CNDDCDSFSP GWPASSRFVL AVGGVIKKKD GSIIGDEISG 450
GGFSNYFSRP WYQVDECSSY IEWLNGSLSS FYNQSGRGFP DISSFSENVV 500
ILYKDKLMPI GGTSASAPII AGLLSLINDQ RLQKNQSPIG LFNPLLYKIA 550
RDHPNSFLDI DFGENNYKCC TNGFKSKSGW DPVTGLGLPN FDELVKYCLE 600
Length:600
Mass (Da):67,296
Last modified:May 24, 2005 - v1
Checksum:iD9E97C1279BC9C18
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72307.1.
RefSeqiXP_646401.1. XM_641309.1.

Genome annotation databases

EnsemblProtistsiDDB0234303; DDB0234303; DDB_G0269914.
GeneIDi8617356.
KEGGiddi:DDB_G0269914.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72307.1 .
RefSeqi XP_646401.1. XM_641309.1.

3D structure databases

ProteinModelPortali Q55CT0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0190668.

Protein family/group databases

MEROPSi S53.A02.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0234303 ; DDB0234303 ; DDB_G0269914 .
GeneIDi 8617356.
KEGGi ddi:DDB_G0269914.

Organism-specific databases

dictyBasei DDB_G0269914. tpp1.

Phylogenomic databases

eggNOGi COG4934.
KOi K01279.
OMAi QVHETRE.
PhylomeDBi Q55CT0.

Enzyme and pathway databases

Reactomei REACT_218739. XBP1(S) activates chaperone genes.

Miscellaneous databases

PROi Q55CT0.

Family and domain databases

Gene3Di 3.40.50.200. 1 hit.
InterProi IPR015366. Peptidase_S53_propep.
IPR000209. Peptidase_S8/S53_dom.
IPR023828. Peptidase_S8_Ser-AS.
IPR009020. Prot_inh_propept.
[Graphical view ]
Pfami PF00082. Peptidase_S8. 1 hit.
PF09286. Pro-kuma_activ. 1 hit.
[Graphical view ]
SMARTi SM00944. Pro-kuma_activ. 1 hit.
[Graphical view ]
SUPFAMi SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
PROSITEi PS51695. SEDOLISIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiTPP1_DICDI
AccessioniPrimary (citable) accession number: Q55CT0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3