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Q55CS8

- MPL2_DICDI

UniProt

Q55CS8 - MPL2_DICDI

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Protein
MAP kinase phosphatase with leucine-rich repeats protein 2
Gene
mpl2, DDB_G0270688
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins By similarity.

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei639 – 6391Phosphocysteine intermediate By similarity

GO - Molecular functioni

  1. protein tyrosine phosphatase activity Source: UniProtKB-EC
  2. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome

GO - Biological processi

  1. protein dephosphorylation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
MAP kinase phosphatase with leucine-rich repeats protein 2 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:mpl2
ORF Names:DDB_G0270688
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270688. mpl2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695MAP kinase phosphatase with leucine-rich repeats protein 2
PRO_0000332955Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0201902.

Structurei

3D structure databases

ProteinModelPortaliQ55CS8.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati101 – 12222LRR 1
Add
BLAST
Repeati124 – 14522LRR 2
Add
BLAST
Repeati147 – 16721LRR 3
Add
BLAST
Repeati170 – 19122LRR 4
Add
BLAST
Repeati193 – 21422LRR 5
Add
BLAST
Repeati215 – 23521LRR 6
Add
BLAST
Repeati239 – 26022LRR 7
Add
BLAST
Repeati262 – 28322LRR 8
Add
BLAST
Repeati286 – 30722LRR 9
Add
BLAST
Repeati309 – 33022LRR 10
Add
BLAST
Domaini556 – 694139Tyrosine-protein phosphatase
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi364 – 42259Asn-rich
Add
BLAST
Compositional biasi368 – 3736Poly-Asn
Compositional biasi459 – 52668Gln-rich
Add
BLAST
Compositional biasi511 – 52212Poly-Gln
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiCOG4886.
OMAiNTEYENT.
PhylomeDBiQ55CS8.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR001611. Leu-rich_rpt.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55CS8-1 [UniParc]FASTAAdd to Basket

« Hide

MFLKKLLKGS SNSTRPRGAT FNGIYTGGDN LSGSSEQNYN NSLTTSTKQT    50
NRQTLLLKSM EYINGSSTYY GNYMDYFDIP VQLFVGGEQS EIYPMLSYNQ 100
SLKSLILDFN KITEIPDCIT LLPNLNHLSL AANQLTHVPE FLSQLKSLET 150
FEIGINQFTC FPLNVCKIKS LTSLHLETNN IKSLPEEFLN LVNLKDLSLF 200
DNQLKEIPDS LPNNIEKLNL GCNDISSSKS DSLIRISHSL TTLNLSENKI 250
EELDESLSCL VNVKTLMLDC NMIKVIPGSV LGSWKSLVTL NLPHNLISDL 300
PPEVILLSNL RIIDLRGNNF ENCKKLIPTE SSTPISFKIE DFIQNKERIN 350
SLKFDNIEIL PTTNSIINSN NNNYEVITTT ATTKNIIENK EDNDEKLLNN 400
STISIVLDSN NKSENNEINE NNQLLTTDDD YNTDKNDSFT ESEDIIKKIQ 450
IELDSIEIQQ KQLLLKQIKL KEKMKKEKNK LFKFQQQEII HQEQLPQSKP 500
ENEKLTNIPE QQQKQQQQQQ QQEVQQPIIT LTKSTSSKVE VEMIVPNQLI 550
FWQSIVPDLI IDKLYLGCRE CAMNKSWLKD NNVTHILTVA NFKPLYPDLF 600
KYLIINIEDV DEANIYQHFK EMNAFIDEGR EKGGVLIHCR AGVSRSASAT 650
MAFIMMKNSL KFQEAFDITI KGRPRIYPNI GFINQLKKFE KDLFK 695
Length:695
Mass (Da):79,425
Last modified:May 2, 2006 - v2
Checksum:i8E8B6432645BDC30
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72694.2.
RefSeqiXP_646403.2. XM_641311.2.

Genome annotation databases

EnsemblProtistsiDDB0238870; DDB0238870; DDB_G0270688.
GeneIDi8617359.
KEGGiddi:DDB_G0270688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72694.2 .
RefSeqi XP_646403.2. XM_641311.2.

3D structure databases

ProteinModelPortali Q55CS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0201902.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0238870 ; DDB0238870 ; DDB_G0270688 .
GeneIDi 8617359.
KEGGi ddi:DDB_G0270688.

Organism-specific databases

dictyBasei DDB_G0270688. mpl2.

Phylogenomic databases

eggNOGi COG4886.
OMAi NTEYENT.
PhylomeDBi Q55CS8.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR001611. Leu-rich_rpt.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
PF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view ]
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS51450. LRR. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiMPL2_DICDI
AccessioniPrimary (citable) accession number: Q55CS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 2, 2006
Last modified: June 11, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi