Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q55CS8

- MPL2_DICDI

UniProt

Q55CS8 - MPL2_DICDI

Protein

MAP kinase phosphatase with leucine-rich repeats protein 2

Gene

mpl2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 2 (02 May 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei639 – 6391Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    2. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein dephosphorylation Source: RefGenome

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MAP kinase phosphatase with leucine-rich repeats protein 2 (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    Name:mpl2
    ORF Names:DDB_G0270688
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0270688. mpl2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 695695MAP kinase phosphatase with leucine-rich repeats protein 2PRO_0000332955Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDBDRAFT_0201902.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55CS8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati101 – 12222LRR 1Add
    BLAST
    Repeati124 – 14522LRR 2Add
    BLAST
    Repeati147 – 16721LRR 3Add
    BLAST
    Repeati170 – 19122LRR 4Add
    BLAST
    Repeati193 – 21422LRR 5Add
    BLAST
    Repeati215 – 23521LRR 6Add
    BLAST
    Repeati239 – 26022LRR 7Add
    BLAST
    Repeati262 – 28322LRR 8Add
    BLAST
    Repeati286 – 30722LRR 9Add
    BLAST
    Repeati309 – 33022LRR 10Add
    BLAST
    Domaini556 – 694139Tyrosine-protein phosphataseAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi364 – 42259Asn-richAdd
    BLAST
    Compositional biasi368 – 3736Poly-Asn
    Compositional biasi459 – 52668Gln-richAdd
    BLAST
    Compositional biasi511 – 52212Poly-GlnAdd
    BLAST

    Sequence similaritiesi

    Contains 10 LRR (leucine-rich) repeats.Curated

    Keywords - Domaini

    Leucine-rich repeat, Repeat

    Phylogenomic databases

    eggNOGiCOG4886.
    OMAiNTEYENT.
    PhylomeDBiQ55CS8.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR001611. Leu-rich_rpt.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    PF00560. LRR_1. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 2 hits.
    [Graphical view]
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS51450. LRR. 9 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q55CS8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFLKKLLKGS SNSTRPRGAT FNGIYTGGDN LSGSSEQNYN NSLTTSTKQT    50
    NRQTLLLKSM EYINGSSTYY GNYMDYFDIP VQLFVGGEQS EIYPMLSYNQ 100
    SLKSLILDFN KITEIPDCIT LLPNLNHLSL AANQLTHVPE FLSQLKSLET 150
    FEIGINQFTC FPLNVCKIKS LTSLHLETNN IKSLPEEFLN LVNLKDLSLF 200
    DNQLKEIPDS LPNNIEKLNL GCNDISSSKS DSLIRISHSL TTLNLSENKI 250
    EELDESLSCL VNVKTLMLDC NMIKVIPGSV LGSWKSLVTL NLPHNLISDL 300
    PPEVILLSNL RIIDLRGNNF ENCKKLIPTE SSTPISFKIE DFIQNKERIN 350
    SLKFDNIEIL PTTNSIINSN NNNYEVITTT ATTKNIIENK EDNDEKLLNN 400
    STISIVLDSN NKSENNEINE NNQLLTTDDD YNTDKNDSFT ESEDIIKKIQ 450
    IELDSIEIQQ KQLLLKQIKL KEKMKKEKNK LFKFQQQEII HQEQLPQSKP 500
    ENEKLTNIPE QQQKQQQQQQ QQEVQQPIIT LTKSTSSKVE VEMIVPNQLI 550
    FWQSIVPDLI IDKLYLGCRE CAMNKSWLKD NNVTHILTVA NFKPLYPDLF 600
    KYLIINIEDV DEANIYQHFK EMNAFIDEGR EKGGVLIHCR AGVSRSASAT 650
    MAFIMMKNSL KFQEAFDITI KGRPRIYPNI GFINQLKKFE KDLFK 695
    Length:695
    Mass (Da):79,425
    Last modified:May 2, 2006 - v2
    Checksum:i8E8B6432645BDC30
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAL72694.2.
    RefSeqiXP_646403.2. XM_641311.2.

    Genome annotation databases

    EnsemblProtistsiDDB0238870; DDB0238870; DDB_G0270688.
    GeneIDi8617359.
    KEGGiddi:DDB_G0270688.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAL72694.2 .
    RefSeqi XP_646403.2. XM_641311.2.

    3D structure databases

    ProteinModelPortali Q55CS8.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDBDRAFT_0201902.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0238870 ; DDB0238870 ; DDB_G0270688 .
    GeneIDi 8617359.
    KEGGi ddi:DDB_G0270688.

    Organism-specific databases

    dictyBasei DDB_G0270688. mpl2.

    Phylogenomic databases

    eggNOGi COG4886.
    OMAi NTEYENT.
    PhylomeDBi Q55CS8.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR001611. Leu-rich_rpt.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    PF00560. LRR_1. 1 hit.
    PF13504. LRR_7. 1 hit.
    PF13855. LRR_8. 2 hits.
    [Graphical view ]
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS51450. LRR. 9 hits.
    PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiMPL2_DICDI
    AccessioniPrimary (citable) accession number: Q55CS8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 64 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3