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Q55CS8

- MPL2_DICDI

UniProt

Q55CS8 - MPL2_DICDI

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Protein

MAP kinase phosphatase with leucine-rich repeats protein 2

Gene

mpl2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei639 – 6391Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
  2. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein dephosphorylation Source: RefGenome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
MAP kinase phosphatase with leucine-rich repeats protein 2 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:mpl2
ORF Names:DDB_G0270688
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270688. mpl2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 695695MAP kinase phosphatase with leucine-rich repeats protein 2PRO_0000332955Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0201902.

Structurei

3D structure databases

ProteinModelPortaliQ55CS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati101 – 12222LRR 1Add
BLAST
Repeati124 – 14522LRR 2Add
BLAST
Repeati147 – 16721LRR 3Add
BLAST
Repeati170 – 19122LRR 4Add
BLAST
Repeati193 – 21422LRR 5Add
BLAST
Repeati215 – 23521LRR 6Add
BLAST
Repeati239 – 26022LRR 7Add
BLAST
Repeati262 – 28322LRR 8Add
BLAST
Repeati286 – 30722LRR 9Add
BLAST
Repeati309 – 33022LRR 10Add
BLAST
Domaini556 – 694139Tyrosine-protein phosphataseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi364 – 42259Asn-richAdd
BLAST
Compositional biasi368 – 3736Poly-Asn
Compositional biasi459 – 52668Gln-richAdd
BLAST
Compositional biasi511 – 52212Poly-GlnAdd
BLAST

Sequence similaritiesi

Contains 10 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiCOG4886.
InParanoidiQ55CS8.
OMAiNTEYENT.
PhylomeDBiQ55CS8.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR001611. Leu-rich_rpt.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55CS8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFLKKLLKGS SNSTRPRGAT FNGIYTGGDN LSGSSEQNYN NSLTTSTKQT
60 70 80 90 100
NRQTLLLKSM EYINGSSTYY GNYMDYFDIP VQLFVGGEQS EIYPMLSYNQ
110 120 130 140 150
SLKSLILDFN KITEIPDCIT LLPNLNHLSL AANQLTHVPE FLSQLKSLET
160 170 180 190 200
FEIGINQFTC FPLNVCKIKS LTSLHLETNN IKSLPEEFLN LVNLKDLSLF
210 220 230 240 250
DNQLKEIPDS LPNNIEKLNL GCNDISSSKS DSLIRISHSL TTLNLSENKI
260 270 280 290 300
EELDESLSCL VNVKTLMLDC NMIKVIPGSV LGSWKSLVTL NLPHNLISDL
310 320 330 340 350
PPEVILLSNL RIIDLRGNNF ENCKKLIPTE SSTPISFKIE DFIQNKERIN
360 370 380 390 400
SLKFDNIEIL PTTNSIINSN NNNYEVITTT ATTKNIIENK EDNDEKLLNN
410 420 430 440 450
STISIVLDSN NKSENNEINE NNQLLTTDDD YNTDKNDSFT ESEDIIKKIQ
460 470 480 490 500
IELDSIEIQQ KQLLLKQIKL KEKMKKEKNK LFKFQQQEII HQEQLPQSKP
510 520 530 540 550
ENEKLTNIPE QQQKQQQQQQ QQEVQQPIIT LTKSTSSKVE VEMIVPNQLI
560 570 580 590 600
FWQSIVPDLI IDKLYLGCRE CAMNKSWLKD NNVTHILTVA NFKPLYPDLF
610 620 630 640 650
KYLIINIEDV DEANIYQHFK EMNAFIDEGR EKGGVLIHCR AGVSRSASAT
660 670 680 690
MAFIMMKNSL KFQEAFDITI KGRPRIYPNI GFINQLKKFE KDLFK
Length:695
Mass (Da):79,425
Last modified:May 2, 2006 - v2
Checksum:i8E8B6432645BDC30
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72694.2.
RefSeqiXP_646403.2. XM_641311.2.

Genome annotation databases

EnsemblProtistsiDDB0238870; DDB0238870; DDB_G0270688.
GeneIDi8617359.
KEGGiddi:DDB_G0270688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72694.2 .
RefSeqi XP_646403.2. XM_641311.2.

3D structure databases

ProteinModelPortali Q55CS8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0201902.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0238870 ; DDB0238870 ; DDB_G0270688 .
GeneIDi 8617359.
KEGGi ddi:DDB_G0270688.

Organism-specific databases

dictyBasei DDB_G0270688. mpl2.

Phylogenomic databases

eggNOGi COG4886.
InParanoidi Q55CS8.
OMAi NTEYENT.
PhylomeDBi Q55CS8.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR001611. Leu-rich_rpt.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
PF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view ]
SMARTi SM00195. DSPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS51450. LRR. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiMPL2_DICDI
AccessioniPrimary (citable) accession number: Q55CS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 2, 2006
Last modified: October 29, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3