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Protein

MAP kinase phosphatase with leucine-rich repeats protein 2

Gene

mpl2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei639Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
MAP kinase phosphatase with leucine-rich repeats protein 2 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
Name:mpl2
ORF Names:DDB_G0270688
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270688. mpl2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003329551 – 695MAP kinase phosphatase with leucine-rich repeats protein 2Add BLAST695

Proteomic databases

PaxDbiQ55CS8.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0238870.

Structurei

3D structure databases

ProteinModelPortaliQ55CS8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati101 – 122LRR 1Add BLAST22
Repeati124 – 145LRR 2Add BLAST22
Repeati147 – 167LRR 3Add BLAST21
Repeati170 – 191LRR 4Add BLAST22
Repeati193 – 214LRR 5Add BLAST22
Repeati215 – 235LRR 6Add BLAST21
Repeati239 – 260LRR 7Add BLAST22
Repeati262 – 283LRR 8Add BLAST22
Repeati286 – 307LRR 9Add BLAST22
Repeati309 – 330LRR 10Add BLAST22
Domaini556 – 694Tyrosine-protein phosphataseAdd BLAST139

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi364 – 422Asn-richAdd BLAST59
Compositional biasi368 – 373Poly-Asn6
Compositional biasi459 – 526Gln-richAdd BLAST68
Compositional biasi511 – 522Poly-GlnAdd BLAST12

Sequence similaritiesi

Contains 10 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG1716. Eukaryota.
COG2453. LUCA.
COG4886. LUCA.
InParanoidiQ55CS8.
PhylomeDBiQ55CS8.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.80.10.10. 2 hits.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 2 hits.
PfamiPF00782. DSPc. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
SM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55CS8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLKKLLKGS SNSTRPRGAT FNGIYTGGDN LSGSSEQNYN NSLTTSTKQT
60 70 80 90 100
NRQTLLLKSM EYINGSSTYY GNYMDYFDIP VQLFVGGEQS EIYPMLSYNQ
110 120 130 140 150
SLKSLILDFN KITEIPDCIT LLPNLNHLSL AANQLTHVPE FLSQLKSLET
160 170 180 190 200
FEIGINQFTC FPLNVCKIKS LTSLHLETNN IKSLPEEFLN LVNLKDLSLF
210 220 230 240 250
DNQLKEIPDS LPNNIEKLNL GCNDISSSKS DSLIRISHSL TTLNLSENKI
260 270 280 290 300
EELDESLSCL VNVKTLMLDC NMIKVIPGSV LGSWKSLVTL NLPHNLISDL
310 320 330 340 350
PPEVILLSNL RIIDLRGNNF ENCKKLIPTE SSTPISFKIE DFIQNKERIN
360 370 380 390 400
SLKFDNIEIL PTTNSIINSN NNNYEVITTT ATTKNIIENK EDNDEKLLNN
410 420 430 440 450
STISIVLDSN NKSENNEINE NNQLLTTDDD YNTDKNDSFT ESEDIIKKIQ
460 470 480 490 500
IELDSIEIQQ KQLLLKQIKL KEKMKKEKNK LFKFQQQEII HQEQLPQSKP
510 520 530 540 550
ENEKLTNIPE QQQKQQQQQQ QQEVQQPIIT LTKSTSSKVE VEMIVPNQLI
560 570 580 590 600
FWQSIVPDLI IDKLYLGCRE CAMNKSWLKD NNVTHILTVA NFKPLYPDLF
610 620 630 640 650
KYLIINIEDV DEANIYQHFK EMNAFIDEGR EKGGVLIHCR AGVSRSASAT
660 670 680 690
MAFIMMKNSL KFQEAFDITI KGRPRIYPNI GFINQLKKFE KDLFK
Length:695
Mass (Da):79,425
Last modified:May 2, 2006 - v2
Checksum:i8E8B6432645BDC30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72694.2.
RefSeqiXP_646403.2. XM_641311.2.

Genome annotation databases

EnsemblProtistsiEAL72694; EAL72694; DDB_G0270688.
GeneIDi8617359.
KEGGiddi:DDB_G0270688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72694.2.
RefSeqiXP_646403.2. XM_641311.2.

3D structure databases

ProteinModelPortaliQ55CS8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0238870.

Proteomic databases

PaxDbiQ55CS8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL72694; EAL72694; DDB_G0270688.
GeneIDi8617359.
KEGGiddi:DDB_G0270688.

Organism-specific databases

dictyBaseiDDB_G0270688. mpl2.

Phylogenomic databases

eggNOGiKOG0619. Eukaryota.
KOG1716. Eukaryota.
COG2453. LUCA.
COG4886. LUCA.
InParanoidiQ55CS8.
PhylomeDBiQ55CS8.

Miscellaneous databases

PROiQ55CS8.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.80.10.10. 2 hits.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 2 hits.
PfamiPF00782. DSPc. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
SM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
SSF52799. SSF52799. 1 hit.
PROSITEiPS51450. LRR. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMPL2_DICDI
AccessioniPrimary (citable) accession number: Q55CS8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 2, 2006
Last modified: November 30, 2016
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.