Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q55CS8 (MPL2_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
MAP kinase phosphatase with leucine-rich repeats protein 2

EC=3.1.3.16
EC=3.1.3.48
Gene names
Name:mpl2
ORF Names:DDB_G0270688
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length695 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Probable phosphatase with dual specificity toward Ser/Thr and Tyr-containing proteins By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 10 LRR (leucine-rich) repeats.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 695695MAP kinase phosphatase with leucine-rich repeats protein 2
PRO_0000332955

Regions

Repeat101 – 12222LRR 1
Repeat124 – 14522LRR 2
Repeat147 – 16721LRR 3
Repeat170 – 19122LRR 4
Repeat193 – 21422LRR 5
Repeat215 – 23521LRR 6
Repeat239 – 26022LRR 7
Repeat262 – 28322LRR 8
Repeat286 – 30722LRR 9
Repeat309 – 33022LRR 10
Domain556 – 694139Tyrosine-protein phosphatase
Compositional bias364 – 42259Asn-rich
Compositional bias368 – 3736Poly-Asn
Compositional bias459 – 52668Gln-rich
Compositional bias511 – 52212Poly-Gln

Sites

Active site6391Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q55CS8 [UniParc].

Last modified May 2, 2006. Version 2.
Checksum: 8E8B6432645BDC30

FASTA69579,425
        10         20         30         40         50         60 
MFLKKLLKGS SNSTRPRGAT FNGIYTGGDN LSGSSEQNYN NSLTTSTKQT NRQTLLLKSM 

        70         80         90        100        110        120 
EYINGSSTYY GNYMDYFDIP VQLFVGGEQS EIYPMLSYNQ SLKSLILDFN KITEIPDCIT 

       130        140        150        160        170        180 
LLPNLNHLSL AANQLTHVPE FLSQLKSLET FEIGINQFTC FPLNVCKIKS LTSLHLETNN 

       190        200        210        220        230        240 
IKSLPEEFLN LVNLKDLSLF DNQLKEIPDS LPNNIEKLNL GCNDISSSKS DSLIRISHSL 

       250        260        270        280        290        300 
TTLNLSENKI EELDESLSCL VNVKTLMLDC NMIKVIPGSV LGSWKSLVTL NLPHNLISDL 

       310        320        330        340        350        360 
PPEVILLSNL RIIDLRGNNF ENCKKLIPTE SSTPISFKIE DFIQNKERIN SLKFDNIEIL 

       370        380        390        400        410        420 
PTTNSIINSN NNNYEVITTT ATTKNIIENK EDNDEKLLNN STISIVLDSN NKSENNEINE 

       430        440        450        460        470        480 
NNQLLTTDDD YNTDKNDSFT ESEDIIKKIQ IELDSIEIQQ KQLLLKQIKL KEKMKKEKNK 

       490        500        510        520        530        540 
LFKFQQQEII HQEQLPQSKP ENEKLTNIPE QQQKQQQQQQ QQEVQQPIIT LTKSTSSKVE 

       550        560        570        580        590        600 
VEMIVPNQLI FWQSIVPDLI IDKLYLGCRE CAMNKSWLKD NNVTHILTVA NFKPLYPDLF 

       610        620        630        640        650        660 
KYLIINIEDV DEANIYQHFK EMNAFIDEGR EKGGVLIHCR AGVSRSASAT MAFIMMKNSL 

       670        680        690 
KFQEAFDITI KGRPRIYPNI GFINQLKKFE KDLFK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000005 Genomic DNA. Translation: EAL72694.2.
RefSeqXP_646403.2. XM_641311.2.

3D structure databases

ProteinModelPortalQ55CS8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0201902.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0238870; DDB0238870; DDB_G0270688.
GeneID8617359.
KEGGddi:DDB_G0270688.

Organism-specific databases

dictyBaseDDB_G0270688. mpl2.

Phylogenomic databases

eggNOGCOG4886.
OMANTEYENT.
PhylomeDBQ55CS8.

Family and domain databases

Gene3D3.90.190.10. 1 hit.
InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR001611. Leu-rich_rpt.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
PF00560. LRR_1. 1 hit.
PF13504. LRR_7. 1 hit.
PF13855. LRR_8. 2 hits.
[Graphical view]
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS51450. LRR. 9 hits.
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMPL2_DICDI
AccessionPrimary (citable) accession number: Q55CS8
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 2, 2006
Last modified: June 11, 2014
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase