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Protein

Frizzled and smoothened-like protein B

Gene

fslB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor

Names & Taxonomyi

Protein namesi
Recommended name:
Frizzled and smoothened-like protein B
Gene namesi
Name:fslB
ORF Names:DDB_G0270730
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270730. fslB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 264ExtracellularSequence analysisAdd BLAST238
Transmembranei265 – 285Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini286 – 294CytoplasmicSequence analysis9
Transmembranei295 – 315Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini316 – 344ExtracellularSequence analysisAdd BLAST29
Transmembranei345 – 365Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini366 – 375CytoplasmicSequence analysis10
Transmembranei376 – 398Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini399 – 416ExtracellularSequence analysisAdd BLAST18
Transmembranei417 – 437Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini438 – 460CytoplasmicSequence analysisAdd BLAST23
Transmembranei461 – 481Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini482 – 514ExtracellularSequence analysisAdd BLAST33
Transmembranei515 – 535Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini536 – 642CytoplasmicSequence analysisAdd BLAST107

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000037136427 – 642Frizzled and smoothened-like protein BAdd BLAST616

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 123By similarity
Disulfide bondi65 ↔ 116By similarity
Glycosylationi80N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi143 ↔ 194By similarity
Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi162N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi177N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi203N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi222N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi261N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi482N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ55CD6.

Expressioni

Inductioni

Down-regulated by phagocytic stimuli and growth on bacteria.1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 197FZAdd BLAST151

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili584 – 611Sequence analysisAdd BLAST28

Sequence similaritiesi

Keywords - Domaini

Coiled coil, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiQ55CD6.
OMAiLGYTFMG.
PhylomeDBiQ55CD6.

Family and domain databases

Gene3Di1.10.2000.10. 1 hit.
InterProiView protein in InterPro
IPR036790. Frizzled_dom_sf.
IPR017981. GPCR_2-like.
SUPFAMiSSF63501. SSF63501. 1 hit.
PROSITEiView protein in PROSITE
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q55CD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFNKNNNNNK IIIILKLFLI ILIVNNNNNI KTFGLNLPDG YGAGLVDPTA
60 70 80 90 100
TCSNYIGDSI DQPLCNEKLP NYKNIYTSKN ITIQYINQKI VEKTFISLTF
110 120 130 140 150
LQSKCFDLNF AEFGICDIYF PPCFQTPTTI TPIKSVSLPQ RLCKSACERM
160 170 180 190 200
VSNCSSLGAS LNCSDPLKFP RIATLYNLTD YGFTANGGFF PVPCSDPLAT
210 220 230 240 250
FENKSTTSEL IEICPSPLLL FNSSDPKYSA DRGYTYLTPT NCVLPCVAPI
260 270 280 290 300
YTEKKWHQMY NMSKILSTIS FVCSIYNVLT FGILNHRRSK YNYCITFFSA
310 320 330 340 350
SVIIITMMDI VTYGIGYEKL LCPEPGRFAV QSDVSCGATG ALFHIGITNG
360 370 380 390 400
VFWWTTMSIC LFAVVKRIKL FDFRYFIIFN TTASLISVII PLAGNAFMAG
410 420 430 440 450
TGSLACWIRK TWYVNSVFWI PCGIALTIGS VCIILVIYEI YKITKNVSTK
460 470 480 490 500
DNRMILLQIK PFLCVTLVGG SFYYLFIFNF DNESHSKEYK EKVVDYVMCL
510 520 530 540 550
LSDTGKECLM AGPNYVAYFV FYFFIRLFGI TFFCIYGTSQ NARDIWIHSK
560 570 580 590 600
ILNHPNIKPF LLKYNIINFN SMTHYGSGTN PTSNSKNSKN NQNNQNNNSR
610 620 630 640
KEFESKNIEL EVNESISKGQ TTRGADDEEE SNINSASNTS SD
Length:642
Mass (Da):72,406
Last modified:May 24, 2005 - v1
Checksum:i1D6F38ED27056949
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72715.1.
RefSeqiXP_646545.1. XM_641453.1.

Genome annotation databases

EnsemblProtistsiEAL72715; EAL72715; DDB_G0270730.
GeneIDi8617511.
KEGGiddi:DDB_G0270730.

Similar proteinsi

Entry informationi

Entry nameiFSLB_DICDI
AccessioniPrimary (citable) accession number: Q55CD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 5, 2009
Last sequence update: May 24, 2005
Last modified: October 25, 2017
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  3. SIMILARITY comments
    Index of protein domains and families