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Q55CC2

- SDHB_DICDI

UniProt

Q55CC2 - SDHB_DICDI

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Protein

Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

Gene

sdhB

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi

Functioni

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).By similarity

Catalytic activityi

Succinate + a quinone = fumarate + a quinol.

Cofactori

Binds 1 2Fe-2S cluster.By similarity
Binds 1 3Fe-4S cluster.By similarity
Binds 1 4Fe-4S cluster.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi101 – 1011Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi106 – 1061Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi109 – 1091Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi121 – 1211Iron-sulfur 1 (2Fe-2S)By similarity
Metal bindingi196 – 1961Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi199 – 1991Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi202 – 2021Iron-sulfur 2 (4Fe-4S)By similarity
Metal bindingi206 – 2061Iron-sulfur 3 (3Fe-4S)By similarity
Binding sitei211 – 2111Ubiquinone; shared with DHSDBy similarity
Metal bindingi257 – 2571Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi263 – 2631Iron-sulfur 3 (3Fe-4S)By similarity
Metal bindingi267 – 2671Iron-sulfur 2 (4Fe-4S)By similarity

GO - Molecular functioni

  1. 2 iron, 2 sulfur cluster binding Source: UniProtKB
  2. 3 iron, 4 sulfur cluster binding Source: UniProtKB
  3. 4 iron, 4 sulfur cluster binding Source: UniProtKB
  4. electron carrier activity Source: InterPro
  5. metal ion binding Source: UniProtKB-KW
  6. succinate dehydrogenase (ubiquinone) activity Source: UniProtKB-EC
  7. ubiquinone binding Source: UniProtKB

GO - Biological processi

  1. aerobic respiration Source: dictyBase
  2. mitochondrial electron transport, succinate to ubiquinone Source: dictyBase
  3. tricarboxylic acid cycle Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Transport, Tricarboxylic acid cycle

Keywords - Ligandi

2Fe-2S, 3Fe-4S, 4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_215657. Respiratory electron transport.
UniPathwayiUPA00223; UER01006.

Names & Taxonomyi

Protein namesi
Recommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (EC:1.3.5.1)
Alternative name(s):
Iron-sulfur subunit of complex II
Short name:
Ip
Gene namesi
Name:sdhB
ORF Names:DDB_G0270120
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270120. sdhB.

Subcellular locationi

Mitochondrion inner membrane By similarity; Peripheral membrane protein By similarity; Matrix side By similarity

GO - Cellular componenti

  1. mitochondrial inner membrane Source: UniProtKB
  2. mitochondrial respiratory chain complex II Source: UniProtKB
  3. mitochondrion Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 2323MitochondrionSequence AnalysisAdd
BLAST
Chaini24 – 287264Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrialPRO_0000327719Add
BLAST

Proteomic databases

PRIDEiQ55CC2.

Interactioni

Subunit structurei

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b composed of a large and a small subunit.By similarity

Protein-protein interaction databases

STRINGi44689.DDB_0231383.

Structurei

3D structure databases

ProteinModelPortaliQ55CC2.
SMRiQ55CC2. Positions 51-285.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 140902Fe-2S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST
Domaini186 – 216314Fe-4S ferredoxin-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 2Fe-2S ferredoxin-type domain.PROSITE-ProRule annotation
Contains 1 4Fe-4S ferredoxin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0479.
InParanoidiQ55CC2.
KOiK00235.
OMAiSEPHWES.
PhylomeDBiQ55CC2.

Family and domain databases

Gene3Di3.10.20.30. 1 hit.
InterProiIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamiPF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view]
SUPFAMiSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsiTIGR00384. dhsB. 1 hit.
PROSITEiPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q55CC2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MISNVLKRAS VLARSNGIQS AFYTTTAKTE ASSSPQMKIK TAEKKDHFVN
60 70 80 90 100
FQVYRYNEET TAKPYIQTYN INLKDCGPMV LDALLLIKNN IDPTLSFRRS
110 120 130 140 150
CREGICGSCA MNLNGSNTLA CTKKITDCLS GDTVKVYPLP HMHVVRDLIP
160 170 180 190 200
DLSHFYTQHK SIKPWLEPAV DVPRYNGKEI LQSKENRHKL DGLYECILCA
210 220 230 240 250
CCSTSCPSYW WSEGGDGGYL GPAVLLQAYR WIADSRDSIQ KDRLAILSED
260 270 280
QMKVYKCHTI MNCTAVCPKG LNPGKSIANI KYLLAHN
Length:287
Mass (Da):32,185
Last modified:May 24, 2005 - v1
Checksum:i86BF6C9A4980D0C4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72410.1.
RefSeqiXP_646559.1. XM_641467.1.

Genome annotation databases

EnsemblProtistsiDDB0231383; DDB0231383; DDB_G0270120.
GeneIDi8617527.
KEGGiddi:DDB_G0270120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72410.1 .
RefSeqi XP_646559.1. XM_641467.1.

3D structure databases

ProteinModelPortali Q55CC2.
SMRi Q55CC2. Positions 51-285.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231383.

Proteomic databases

PRIDEi Q55CC2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231383 ; DDB0231383 ; DDB_G0270120 .
GeneIDi 8617527.
KEGGi ddi:DDB_G0270120.

Organism-specific databases

dictyBasei DDB_G0270120. sdhB.

Phylogenomic databases

eggNOGi COG0479.
InParanoidi Q55CC2.
KOi K00235.
OMAi SEPHWES.
PhylomeDBi Q55CC2.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER01006 .
Reactomei REACT_215657. Respiratory electron transport.

Miscellaneous databases

PROi Q55CC2.

Family and domain databases

Gene3Di 3.10.20.30. 1 hit.
InterProi IPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view ]
Pfami PF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view ]
SUPFAMi SSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsi TIGR00384. dhsB. 1 hit.
PROSITEi PS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiSDHB_DICDI
AccessioniPrimary (citable) accession number: Q55CC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: October 29, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3