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Q55CC2 (SDHB_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

EC=1.3.5.1
Alternative name(s):
Iron-sulfur subunit of complex II
Short name=Ip
Gene names
Name:sdhB
ORF Names:DDB_G0270120
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length287 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q) By similarity.

Catalytic activity

Succinate + a quinone = fumarate + a quinol.

Cofactor

Binds 1 2Fe-2S cluster By similarity.

Binds 1 3Fe-4S cluster By similarity.

Binds 1 4Fe-4S cluster By similarity.

Pathway

Carbohydrate metabolism; tricarboxylic acid cycle; fumarate from succinate (eukaryal route): step 1/1.

Subunit structure

Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b composed of a large and a small subunit By similarity.

Subcellular location

Mitochondrion inner membrane; Peripheral membrane protein; Matrix side By similarity.

Sequence similarities

Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.

Contains 1 2Fe-2S ferredoxin-type domain.

Contains 1 4Fe-4S ferredoxin-type domain.

Ontologies

Keywords
   Biological processElectron transport
Transport
Tricarboxylic acid cycle
   Cellular componentMembrane
Mitochondrion
Mitochondrion inner membrane
   DomainTransit peptide
   Ligand2Fe-2S
3Fe-4S
4Fe-4S
Iron
Iron-sulfur
Metal-binding
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processaerobic respiration

Inferred from sequence or structural similarity. Source: dictyBase

mitochondrial electron transport, succinate to ubiquinone

Inferred from sequence or structural similarity. Source: dictyBase

tricarboxylic acid cycle

Inferred from sequence or structural similarity. Source: dictyBase

   Cellular_componentmitochondrial inner membrane

Inferred from sequence or structural similarity. Source: UniProtKB

mitochondrial respiratory chain complex II

Inferred from sequence or structural similarity. Source: UniProtKB

mitochondrion

Inferred from sequence or structural similarity. Source: dictyBase

   Molecular_function2 iron, 2 sulfur cluster binding

Inferred from sequence or structural similarity. Source: UniProtKB

3 iron, 4 sulfur cluster binding

Inferred from sequence or structural similarity. Source: UniProtKB

4 iron, 4 sulfur cluster binding

Inferred from sequence or structural similarity. Source: UniProtKB

electron carrier activity

Inferred from electronic annotation. Source: InterPro

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

succinate dehydrogenase (ubiquinone) activity

Inferred from electronic annotation. Source: UniProtKB-EC

ubiquinone binding

Inferred from sequence or structural similarity. Source: UniProtKB

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2323Mitochondrion Potential
Chain24 – 287264Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial
PRO_0000327719

Regions

Domain51 – 140902Fe-2S ferredoxin-type
Domain186 – 216314Fe-4S ferredoxin-type

Sites

Metal binding1011Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1061Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1091Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1211Iron-sulfur 1 (2Fe-2S) By similarity
Metal binding1961Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding1991Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding2021Iron-sulfur 2 (4Fe-4S) By similarity
Metal binding2061Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2571Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2631Iron-sulfur 3 (3Fe-4S) By similarity
Metal binding2671Iron-sulfur 2 (4Fe-4S) By similarity
Binding site2111Ubiquinone; shared with DHSD By similarity

Sequences

Sequence LengthMass (Da)Tools
Q55CC2 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 86BF6C9A4980D0C4

FASTA28732,185
        10         20         30         40         50         60 
MISNVLKRAS VLARSNGIQS AFYTTTAKTE ASSSPQMKIK TAEKKDHFVN FQVYRYNEET 

        70         80         90        100        110        120 
TAKPYIQTYN INLKDCGPMV LDALLLIKNN IDPTLSFRRS CREGICGSCA MNLNGSNTLA 

       130        140        150        160        170        180 
CTKKITDCLS GDTVKVYPLP HMHVVRDLIP DLSHFYTQHK SIKPWLEPAV DVPRYNGKEI 

       190        200        210        220        230        240 
LQSKENRHKL DGLYECILCA CCSTSCPSYW WSEGGDGGYL GPAVLLQAYR WIADSRDSIQ 

       250        260        270        280 
KDRLAILSED QMKVYKCHTI MNCTAVCPKG LNPGKSIANI KYLLAHN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000005 Genomic DNA. Translation: EAL72410.1.

3D structure databases

ProteinModelPortalQ55CC2.
SMRQ55CC2. Positions 51-285.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0231383.

Proteomic databases

PRIDEQ55CC2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231383; DDB0231383; DDB_G0270120.
KEGGddi:DDB_G0270120.

Organism-specific databases

dictyBaseDDB_G0270120. sdhB.

Phylogenomic databases

eggNOGCOG0479.
KOK00235.
OMAEGVWRCR.
PhylomeDBQ55CC2.
ProtClustDBCLSZ2431440.

Enzyme and pathway databases

UniPathwayUPA00223; UER01006.

Family and domain databases

Gene3D3.10.20.30. 1 hit.
InterProIPR001041. 2Fe-2S_ferredoxin-type.
IPR006058. 2Fe2S_fd_BS.
IPR017896. 4Fe4S_Fe-S-bd.
IPR017900. 4Fe4S_Fe_S_CS.
IPR012675. Beta-grasp_dom.
IPR009051. Helical_ferredxn.
IPR004489. Succ_DH/fum_Rdtase_Fe-S.
IPR025192. Succ_DH/fum_Rdtase_N.
[Graphical view]
PfamPF13085. Fer2_3. 1 hit.
PF13183. Fer4_8. 1 hit.
[Graphical view]
SUPFAMSSF46548. SSF46548. 1 hit.
SSF54292. SSF54292. 1 hit.
TIGRFAMsTIGR00384. dhsB. 1 hit.
PROSITEPS00197. 2FE2S_FER_1. 1 hit.
PS51085. 2FE2S_FER_2. 1 hit.
PS00198. 4FE4S_FER_1. 1 hit.
PS51379. 4FE4S_FER_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ55CC2.

Entry information

Entry nameSDHB_DICDI
AccessionPrimary (citable) accession number: Q55CC2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase