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Q55C91

- ALN2_DICDI

UniProt

Q55C91 - ALN2_DICDI

Protein

Probable allantoinase 2

Gene

allB2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 64 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    (S)-allantoin + H2O = allantoate.

    Cofactori

    Binds 2 zinc ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi97 – 971Zinc 1By similarity
    Metal bindingi99 – 991Zinc 1By similarity
    Metal bindingi185 – 1851Zinc 1; via carbamate groupBy similarity
    Metal bindingi185 – 1851Zinc 2; via carbamate groupBy similarity
    Metal bindingi228 – 2281Zinc 2By similarity
    Metal bindingi287 – 2871Zinc 2By similarity
    Metal bindingi360 – 3601Zinc 1By similarity

    GO - Molecular functioni

    1. allantoinase activity Source: dictyBase
    2. cobalt ion binding Source: InterPro
    3. zinc ion binding Source: InterPro

    GO - Biological processi

    1. allantoin catabolic process Source: dictyBase
    2. purine nucleobase metabolic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Biological processi

    Purine metabolism

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    UniPathwayiUPA00395; UER00653.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable allantoinase 2 (EC:3.5.2.5)
    Gene namesi
    Name:allB2
    ORF Names:DDB_G0270162
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0270162. allB2.

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: dictyBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 510510Probable allantoinase 2PRO_0000330751Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei185 – 1851N6-carboxylysineBy similarity

    Post-translational modificationi

    Carbamylation allows a single lysine to coordinate two zinc ions.By similarity

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    STRINGi44689.DDB_0231351.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55C91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the DHOase family. Allantoinase subfamily.Curated

    Phylogenomic databases

    eggNOGiCOG0044.
    KOiK01466.
    OMAiHLEADEM.
    PhylomeDBiQ55C91.

    Family and domain databases

    InterProiIPR017593. Allantoinase.
    IPR002195. Dihydroorotase_CS.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view]
    SUPFAMiSSF51338. SSF51338. 1 hit.
    TIGRFAMsiTIGR03178. allantoinase. 1 hit.
    PROSITEiPS00482. DIHYDROOROTASE_1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q55C91-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEIWKVIFSI WFLLFQNFVL SAKNDDNKLK VIRGRNVIYN GNVIPLSILI    50
    RNGKTIGIKD YSFNPKKLNE NYEILYDDRE CNNNEDFIIM GGLVDSHVHV 100
    NEPGRTEWEG FESATSAAAA GGVTTIVDMP LNSSPVTTSF KNLLDKIESM 150
    KGKLRVDVGL LGGIVPGNSK EIKKMVLQGG VLGFKSFLLP SGIDEFPPVN 200
    ENDIQEAMNE MKLLKCQYNN SDVIMMFHAE VEEPIKEATV RLKNENADPK 250
    LYKTYLDSRP KISENQAISK LIDITRQNQI VSTHIVHLSS SESIEQIREA 300
    MDQGVPISAE TTYNYLHLTS ESVPYGNTLF KSAPPVREHE NKELLWNAII 350
    NGTIKLIVSD HSPCTINLKQ LKEDNQSIGD FLKAWGGISS LELGLPIIWT 400
    ECKNRGIPIT QLSEWLSNGP SKLVGLNDRK GSIEIGRDAD FVIFNPNESF 450
    IVNEKKLFLK NKFSAYNGEK LFGVVYETIL RGNSIFKKGD NKIKKIIGQR 500
    LIKSNLINKK 510
    Length:510
    Mass (Da):57,323
    Last modified:May 24, 2005 - v1
    Checksum:iAEA0E212B455B617
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAL72431.1.
    RefSeqiXP_646590.1. XM_641498.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231351; DDB0231351; DDB_G0270162.
    GeneIDi8617561.
    KEGGiddi:DDB_G0270162.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000005 Genomic DNA. Translation: EAL72431.1 .
    RefSeqi XP_646590.1. XM_641498.1.

    3D structure databases

    ProteinModelPortali Q55C91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231351.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231351 ; DDB0231351 ; DDB_G0270162 .
    GeneIDi 8617561.
    KEGGi ddi:DDB_G0270162.

    Organism-specific databases

    dictyBasei DDB_G0270162. allB2.

    Phylogenomic databases

    eggNOGi COG0044.
    KOi K01466.
    OMAi HLEADEM.
    PhylomeDBi Q55C91.

    Enzyme and pathway databases

    UniPathwayi UPA00395 ; UER00653 .

    Family and domain databases

    InterProi IPR017593. Allantoinase.
    IPR002195. Dihydroorotase_CS.
    IPR011059. Metal-dep_hydrolase_composite.
    [Graphical view ]
    SUPFAMi SSF51338. SSF51338. 1 hit.
    TIGRFAMsi TIGR03178. allantoinase. 1 hit.
    PROSITEi PS00482. DIHYDROOROTASE_1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiALN2_DICDI
    AccessioniPrimary (citable) accession number: Q55C91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 64 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3