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Protein

Probable allantoinase 2

Gene

allB2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-allantoin + H2O = allantoate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Pathwayi: (S)-allantoin degradation

This protein is involved in step 1 of the subpathway that synthesizes allantoate from (S)-allantoin.
Proteins known to be involved in this subpathway in this organism are:
  1. Probable allantoinase 2 (allB2), Probable allantoinase 1 (allB1)
This subpathway is part of the pathway (S)-allantoin degradation, which is itself part of Nitrogen metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes allantoate from (S)-allantoin, the pathway (S)-allantoin degradation and in Nitrogen metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi97Zinc 1By similarity1
Metal bindingi99Zinc 1By similarity1
Metal bindingi185Zinc 1; via carbamate groupBy similarity1
Metal bindingi185Zinc 2; via carbamate groupBy similarity1
Metal bindingi228Zinc 2By similarity1
Metal bindingi287Zinc 2By similarity1
Metal bindingi360Zinc 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processPurine metabolism
LigandMetal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable allantoinase 2 (EC:3.5.2.5)
Gene namesi
Name:allB2
ORF Names:DDB_G0270162
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270162. allB2.

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003307511 – 510Probable allantoinase 2Add BLAST510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei185N6-carboxylysineBy similarity1

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.By similarity

Proteomic databases

PaxDbiQ55C91.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB0231351.

Structurei

3D structure databases

ProteinModelPortaliQ55C91.
SMRiQ55C91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2584. Eukaryota.
COG0044. LUCA.
InParanoidiQ55C91.
KOiK01466.
OMAiAGVHNED.
PhylomeDBiQ55C91.

Family and domain databases

Gene3Di2.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR017593. Allantoinase.
IPR006680. Amidohydro-rel.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
IPR032466. Metal_Hydrolase.
PfamiView protein in Pfam
PF01979. Amidohydro_1. 1 hit.
SUPFAMiSSF51338. SSF51338. 1 hit.
SSF51556. SSF51556. 1 hit.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
PROSITEiView protein in PROSITE
PS00482. DIHYDROOROTASE_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55C91-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEIWKVIFSI WFLLFQNFVL SAKNDDNKLK VIRGRNVIYN GNVIPLSILI
60 70 80 90 100
RNGKTIGIKD YSFNPKKLNE NYEILYDDRE CNNNEDFIIM GGLVDSHVHV
110 120 130 140 150
NEPGRTEWEG FESATSAAAA GGVTTIVDMP LNSSPVTTSF KNLLDKIESM
160 170 180 190 200
KGKLRVDVGL LGGIVPGNSK EIKKMVLQGG VLGFKSFLLP SGIDEFPPVN
210 220 230 240 250
ENDIQEAMNE MKLLKCQYNN SDVIMMFHAE VEEPIKEATV RLKNENADPK
260 270 280 290 300
LYKTYLDSRP KISENQAISK LIDITRQNQI VSTHIVHLSS SESIEQIREA
310 320 330 340 350
MDQGVPISAE TTYNYLHLTS ESVPYGNTLF KSAPPVREHE NKELLWNAII
360 370 380 390 400
NGTIKLIVSD HSPCTINLKQ LKEDNQSIGD FLKAWGGISS LELGLPIIWT
410 420 430 440 450
ECKNRGIPIT QLSEWLSNGP SKLVGLNDRK GSIEIGRDAD FVIFNPNESF
460 470 480 490 500
IVNEKKLFLK NKFSAYNGEK LFGVVYETIL RGNSIFKKGD NKIKKIIGQR
510
LIKSNLINKK
Length:510
Mass (Da):57,323
Last modified:May 24, 2005 - v1
Checksum:iAEA0E212B455B617
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72431.1.
RefSeqiXP_646590.1. XM_641498.1.

Genome annotation databases

EnsemblProtistsiEAL72431; EAL72431; DDB_G0270162.
GeneIDi8617561.
KEGGiddi:DDB_G0270162.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiALN2_DICDI
AccessioniPrimary (citable) accession number: Q55C91
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: July 5, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families