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Q55C91

- ALN2_DICDI

UniProt

Q55C91 - ALN2_DICDI

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Protein

Probable allantoinase 2

Gene
allB2, DDB_G0270162
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-allantoin + H2O = allantoate.

Cofactori

Binds 2 zinc ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi97 – 971Zinc 1 By similarity
Metal bindingi99 – 991Zinc 1 By similarity
Metal bindingi185 – 1851Zinc 1; via carbamate group By similarity
Metal bindingi185 – 1851Zinc 2; via carbamate group By similarity
Metal bindingi228 – 2281Zinc 2 By similarity
Metal bindingi287 – 2871Zinc 2 By similarity
Metal bindingi360 – 3601Zinc 1 By similarity

GO - Molecular functioni

  1. allantoinase activity Source: dictyBase
  2. cobalt ion binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. allantoin catabolic process Source: dictyBase
  2. purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable allantoinase 2 (EC:3.5.2.5)
Gene namesi
Name:allB2
ORF Names:DDB_G0270162
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270162. allB2.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Probable allantoinase 2PRO_0000330751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei185 – 1851N6-carboxylysine By similarity

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions By similarity.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi44689.DDB_0231351.

Structurei

3D structure databases

ProteinModelPortaliQ55C91.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0044.
KOiK01466.
OMAiHLEADEM.
PhylomeDBiQ55C91.

Family and domain databases

InterProiIPR017593. Allantoinase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 1 hit.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
PROSITEiPS00482. DIHYDROOROTASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55C91-1 [UniParc]FASTAAdd to Basket

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MEIWKVIFSI WFLLFQNFVL SAKNDDNKLK VIRGRNVIYN GNVIPLSILI    50
RNGKTIGIKD YSFNPKKLNE NYEILYDDRE CNNNEDFIIM GGLVDSHVHV 100
NEPGRTEWEG FESATSAAAA GGVTTIVDMP LNSSPVTTSF KNLLDKIESM 150
KGKLRVDVGL LGGIVPGNSK EIKKMVLQGG VLGFKSFLLP SGIDEFPPVN 200
ENDIQEAMNE MKLLKCQYNN SDVIMMFHAE VEEPIKEATV RLKNENADPK 250
LYKTYLDSRP KISENQAISK LIDITRQNQI VSTHIVHLSS SESIEQIREA 300
MDQGVPISAE TTYNYLHLTS ESVPYGNTLF KSAPPVREHE NKELLWNAII 350
NGTIKLIVSD HSPCTINLKQ LKEDNQSIGD FLKAWGGISS LELGLPIIWT 400
ECKNRGIPIT QLSEWLSNGP SKLVGLNDRK GSIEIGRDAD FVIFNPNESF 450
IVNEKKLFLK NKFSAYNGEK LFGVVYETIL RGNSIFKKGD NKIKKIIGQR 500
LIKSNLINKK 510
Length:510
Mass (Da):57,323
Last modified:May 24, 2005 - v1
Checksum:iAEA0E212B455B617
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72431.1.
RefSeqiXP_646590.1. XM_641498.1.

Genome annotation databases

EnsemblProtistsiDDB0231351; DDB0231351; DDB_G0270162.
GeneIDi8617561.
KEGGiddi:DDB_G0270162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72431.1 .
RefSeqi XP_646590.1. XM_641498.1.

3D structure databases

ProteinModelPortali Q55C91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231351.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231351 ; DDB0231351 ; DDB_G0270162 .
GeneIDi 8617561.
KEGGi ddi:DDB_G0270162.

Organism-specific databases

dictyBasei DDB_G0270162. allB2.

Phylogenomic databases

eggNOGi COG0044.
KOi K01466.
OMAi HLEADEM.
PhylomeDBi Q55C91.

Enzyme and pathway databases

UniPathwayi UPA00395 ; UER00653 .

Family and domain databases

InterProi IPR017593. Allantoinase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view ]
SUPFAMi SSF51338. SSF51338. 1 hit.
TIGRFAMsi TIGR03178. allantoinase. 1 hit.
PROSITEi PS00482. DIHYDROOROTASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiALN2_DICDI
AccessioniPrimary (citable) accession number: Q55C91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3