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Q55C91

- ALN2_DICDI

UniProt

Q55C91 - ALN2_DICDI

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Protein

Probable allantoinase 2

Gene

allB2

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

(S)-allantoin + H2O = allantoate.

Cofactori

Zn2+By similarityNote: Binds 2 Zn(2+) ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi97 – 971Zinc 1By similarity
Metal bindingi99 – 991Zinc 1By similarity
Metal bindingi185 – 1851Zinc 1; via carbamate groupBy similarity
Metal bindingi185 – 1851Zinc 2; via carbamate groupBy similarity
Metal bindingi228 – 2281Zinc 2By similarity
Metal bindingi287 – 2871Zinc 2By similarity
Metal bindingi360 – 3601Zinc 1By similarity

GO - Molecular functioni

  1. allantoinase activity Source: dictyBase
  2. cobalt ion binding Source: InterPro
  3. zinc ion binding Source: InterPro

GO - Biological processi

  1. allantoin catabolic process Source: dictyBase
  2. purine nucleobase metabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Purine metabolism

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00395; UER00653.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable allantoinase 2 (EC:3.5.2.5)
Gene namesi
Name:allB2
ORF Names:DDB_G0270162
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270162. allB2.

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 510510Probable allantoinase 2PRO_0000330751Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei185 – 1851N6-carboxylysineBy similarity

Post-translational modificationi

Carbamylation allows a single lysine to coordinate two zinc ions.By similarity

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

STRINGi44689.DDB_0231351.

Structurei

3D structure databases

ProteinModelPortaliQ55C91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the DHOase family. Allantoinase subfamily.Curated

Phylogenomic databases

eggNOGiCOG0044.
InParanoidiQ55C91.
KOiK01466.
OMAiHLEADEM.
PhylomeDBiQ55C91.

Family and domain databases

InterProiIPR017593. Allantoinase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
SUPFAMiSSF51338. SSF51338. 1 hit.
TIGRFAMsiTIGR03178. allantoinase. 1 hit.
PROSITEiPS00482. DIHYDROOROTASE_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55C91-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEIWKVIFSI WFLLFQNFVL SAKNDDNKLK VIRGRNVIYN GNVIPLSILI
60 70 80 90 100
RNGKTIGIKD YSFNPKKLNE NYEILYDDRE CNNNEDFIIM GGLVDSHVHV
110 120 130 140 150
NEPGRTEWEG FESATSAAAA GGVTTIVDMP LNSSPVTTSF KNLLDKIESM
160 170 180 190 200
KGKLRVDVGL LGGIVPGNSK EIKKMVLQGG VLGFKSFLLP SGIDEFPPVN
210 220 230 240 250
ENDIQEAMNE MKLLKCQYNN SDVIMMFHAE VEEPIKEATV RLKNENADPK
260 270 280 290 300
LYKTYLDSRP KISENQAISK LIDITRQNQI VSTHIVHLSS SESIEQIREA
310 320 330 340 350
MDQGVPISAE TTYNYLHLTS ESVPYGNTLF KSAPPVREHE NKELLWNAII
360 370 380 390 400
NGTIKLIVSD HSPCTINLKQ LKEDNQSIGD FLKAWGGISS LELGLPIIWT
410 420 430 440 450
ECKNRGIPIT QLSEWLSNGP SKLVGLNDRK GSIEIGRDAD FVIFNPNESF
460 470 480 490 500
IVNEKKLFLK NKFSAYNGEK LFGVVYETIL RGNSIFKKGD NKIKKIIGQR
510
LIKSNLINKK
Length:510
Mass (Da):57,323
Last modified:May 24, 2005 - v1
Checksum:iAEA0E212B455B617
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72431.1.
RefSeqiXP_646590.1. XM_641498.1.

Genome annotation databases

EnsemblProtistsiDDB0231351; DDB0231351; DDB_G0270162.
GeneIDi8617561.
KEGGiddi:DDB_G0270162.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72431.1 .
RefSeqi XP_646590.1. XM_641498.1.

3D structure databases

ProteinModelPortali Q55C91.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231351.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231351 ; DDB0231351 ; DDB_G0270162 .
GeneIDi 8617561.
KEGGi ddi:DDB_G0270162.

Organism-specific databases

dictyBasei DDB_G0270162. allB2.

Phylogenomic databases

eggNOGi COG0044.
InParanoidi Q55C91.
KOi K01466.
OMAi HLEADEM.
PhylomeDBi Q55C91.

Enzyme and pathway databases

UniPathwayi UPA00395 ; UER00653 .

Family and domain databases

InterProi IPR017593. Allantoinase.
IPR002195. Dihydroorotase_CS.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view ]
SUPFAMi SSF51338. SSF51338. 1 hit.
TIGRFAMsi TIGR03178. allantoinase. 1 hit.
PROSITEi PS00482. DIHYDROOROTASE_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiALN2_DICDI
AccessioniPrimary (citable) accession number: Q55C91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: November 26, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3