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Protein

Probable serine/threonine-protein kinase glkA

Gene

glkA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + [tau protein] = ADP + [tau protein] phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei119ATPPROSITE-ProRule annotation1
Active sitei208Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 105ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

  • activation of GTPase activity Source: dictyBase
  • glycogen metabolic process Source: dictyBase
  • negative regulation of protein serine/threonine kinase activity Source: dictyBase
  • protein phosphorylation Source: dictyBase
  • regulation of gene expression Source: GO_Central
  • regulation of myosin II filament assembly Source: dictyBase

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase glkA (EC:2.7.11.26)
Alternative name(s):
Glycogen synthase kinase-like kinase A
Gene namesi
Name:glkA
ORF Names:DDB_G0270218
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270218 glkA

Subcellular locationi

GO - Cellular componenti

  • cell leading edge Source: dictyBase
  • cytoplasm Source: GO_Central
  • nucleus Source: GO_Central

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003588851 – 473Probable serine/threonine-protein kinase glkAAdd BLAST473

Proteomic databases

PaxDbiQ55C57
PRIDEiQ55C57

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0216280

Structurei

3D structure databases

ProteinModelPortaliQ55C57
SMRiQ55C57
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini91 – 366Protein kinasePROSITE-ProRule annotationAdd BLAST276

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi16 – 40Poly-AsnAdd BLAST25
Compositional biasi45 – 60Poly-AsnAdd BLAST16
Compositional biasi64 – 69Poly-Ser6
Compositional biasi397 – 402Poly-Ser6
Compositional biasi412 – 415Poly-Ser4
Compositional biasi451 – 455Poly-Ser5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0658 Eukaryota
COG0515 LUCA
InParanoidiQ55C57
KOiK03083
OMAiFISREYD
PhylomeDBiQ55C57

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

Sequencei

Sequence statusi: Complete.

Q55C57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIPTDNNSS NNKGYNDNNN NNNNNNNNNN NNNNNNNNNN KEHPNINNNN
60 70 80 90 100
NNNNNNNNNN IKESSSSNSN HSSSQSSSTA TVNSNPKVYP YEIIKQVGQG
110 120 130 140 150
TFGKVYEAKN QDNKRVAIKK VEKSNHFISR EYDILKIVAH PNCLRILDMF
160 170 180 190 200
YTAEDNKKMQ NLVFDFIPYT LASLLKKRQL SINFIKVLFY QLCQAIKHIH
210 220 230 240 250
SKAICHRDIT PNNILLSSKG ELTLADFGSA KILESNHTSM SYICSRYYRA
260 270 280 290 300
PELLVGCSNY TTKIDIWSIG CILAEMLIGK PLFPGTNSND QLGRIIEVLG
310 320 330 340 350
SPTKDDMEAM KPSKPYHLQL PNINPKFFES LHNVEDKTVV DLLSKIFIFD
360 370 380 390 400
PVKRASIDEI IAHPFLRDVN INSLELFDEM KCFSVSGNGK SSLTTNSTSS
410 420 430 440 450
SSTTANMTSL ASSSSNNKTT CSETYLSRLP TSAITSSSNL KSIDNSNNGK
460 470
SSSSSNNIPS LNNSNNGVIT NTI
Length:473
Mass (Da):52,554
Last modified:May 24, 2005 - v1
Checksum:i72E4295165642D0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA Translation: EAL72459.1
RefSeqiXP_646624.1, XM_641532.1

Genome annotation databases

EnsemblProtistsiEAL72459; EAL72459; DDB_G0270218
GeneIDi8617596
KEGGiddi:DDB_G0270218

Similar proteinsi

Entry informationi

Entry nameiGLKA_DICDI
AccessioniPrimary (citable) accession number: Q55C57
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: May 24, 2005
Last modified: May 23, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

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