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Q55C57

- GLKA_DICDI

UniProt

Q55C57 - GLKA_DICDI

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Protein

Probable serine/threonine-protein kinase glkA

Gene
glkA, DDB_G0270218
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + [tau protein] = ADP + [tau protein] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191ATP By similarity
Active sitei208 – 2081Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 1059ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
  3. protein tyrosine kinase activity Source: InterPro
  4. tau-protein kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycogen metabolic process Source: dictyBase
  2. protein phosphorylation Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase glkA (EC:2.7.11.26)
Alternative name(s):
Glycogen synthase kinase-like kinase A
Gene namesi
Name:glkA
ORF Names:DDB_G0270218
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 1, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270218. glkA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Probable serine/threonine-protein kinase glkAPRO_0000358885Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0216280.

Structurei

3D structure databases

ProteinModelPortaliQ55C57.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini91 – 366276Protein kinaseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi16 – 4025Poly-AsnAdd
BLAST
Compositional biasi45 – 6016Poly-AsnAdd
BLAST
Compositional biasi64 – 696Poly-Ser
Compositional biasi397 – 4026Poly-Ser
Compositional biasi412 – 4154Poly-Ser
Compositional biasi451 – 4555Poly-Ser

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
KOiK03083.
PhylomeDBiQ55C57.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55C57-1 [UniParc]FASTAAdd to Basket

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MTIPTDNNSS NNKGYNDNNN NNNNNNNNNN NNNNNNNNNN KEHPNINNNN    50
NNNNNNNNNN IKESSSSNSN HSSSQSSSTA TVNSNPKVYP YEIIKQVGQG 100
TFGKVYEAKN QDNKRVAIKK VEKSNHFISR EYDILKIVAH PNCLRILDMF 150
YTAEDNKKMQ NLVFDFIPYT LASLLKKRQL SINFIKVLFY QLCQAIKHIH 200
SKAICHRDIT PNNILLSSKG ELTLADFGSA KILESNHTSM SYICSRYYRA 250
PELLVGCSNY TTKIDIWSIG CILAEMLIGK PLFPGTNSND QLGRIIEVLG 300
SPTKDDMEAM KPSKPYHLQL PNINPKFFES LHNVEDKTVV DLLSKIFIFD 350
PVKRASIDEI IAHPFLRDVN INSLELFDEM KCFSVSGNGK SSLTTNSTSS 400
SSTTANMTSL ASSSSNNKTT CSETYLSRLP TSAITSSSNL KSIDNSNNGK 450
SSSSSNNIPS LNNSNNGVIT NTI 473
Length:473
Mass (Da):52,554
Last modified:May 24, 2005 - v1
Checksum:i72E4295165642D0D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72459.1.
RefSeqiXP_646624.1. XM_641532.1.

Genome annotation databases

EnsemblProtistsiDDB0216280; DDB0216280; DDB_G0270218.
GeneIDi8617596.
KEGGiddi:DDB_G0270218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72459.1 .
RefSeqi XP_646624.1. XM_641532.1.

3D structure databases

ProteinModelPortali Q55C57.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0216280.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0216280 ; DDB0216280 ; DDB_G0270218 .
GeneIDi 8617596.
KEGGi ddi:DDB_G0270218.

Organism-specific databases

dictyBasei DDB_G0270218. glkA.

Phylogenomic databases

eggNOGi COG0515.
KOi K03083.
PhylomeDBi Q55C57.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase_dom.
IPR008266. Tyr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiGLKA_DICDI
AccessioniPrimary (citable) accession number: Q55C57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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