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Protein

Probable serine/threonine-protein kinase glkA

Gene

glkA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + [tau protein] = ADP + [tau protein] phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei119 – 1191ATPPROSITE-ProRule annotation
Active sitei208 – 2081Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi97 – 1059ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. protein serine/threonine kinase activity Source: UniProtKB-KW
  3. tau-protein kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycogen metabolic process Source: dictyBase
  2. protein phosphorylation Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable serine/threonine-protein kinase glkA (EC:2.7.11.26)
Alternative name(s):
Glycogen synthase kinase-like kinase A
Gene namesi
Name:glkA
ORF Names:DDB_G0270218
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 1, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0270218. glkA.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 473473Probable serine/threonine-protein kinase glkAPRO_0000358885Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0216280.

Structurei

3D structure databases

ProteinModelPortaliQ55C57.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini91 – 366276Protein kinasePROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi16 – 4025Poly-AsnAdd
BLAST
Compositional biasi45 – 6016Poly-AsnAdd
BLAST
Compositional biasi64 – 696Poly-Ser
Compositional biasi397 – 4026Poly-Ser
Compositional biasi412 – 4154Poly-Ser
Compositional biasi451 – 4555Poly-Ser

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ55C57.
KOiK03083.
PhylomeDBiQ55C57.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55C57-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTIPTDNNSS NNKGYNDNNN NNNNNNNNNN NNNNNNNNNN KEHPNINNNN
60 70 80 90 100
NNNNNNNNNN IKESSSSNSN HSSSQSSSTA TVNSNPKVYP YEIIKQVGQG
110 120 130 140 150
TFGKVYEAKN QDNKRVAIKK VEKSNHFISR EYDILKIVAH PNCLRILDMF
160 170 180 190 200
YTAEDNKKMQ NLVFDFIPYT LASLLKKRQL SINFIKVLFY QLCQAIKHIH
210 220 230 240 250
SKAICHRDIT PNNILLSSKG ELTLADFGSA KILESNHTSM SYICSRYYRA
260 270 280 290 300
PELLVGCSNY TTKIDIWSIG CILAEMLIGK PLFPGTNSND QLGRIIEVLG
310 320 330 340 350
SPTKDDMEAM KPSKPYHLQL PNINPKFFES LHNVEDKTVV DLLSKIFIFD
360 370 380 390 400
PVKRASIDEI IAHPFLRDVN INSLELFDEM KCFSVSGNGK SSLTTNSTSS
410 420 430 440 450
SSTTANMTSL ASSSSNNKTT CSETYLSRLP TSAITSSSNL KSIDNSNNGK
460 470
SSSSSNNIPS LNNSNNGVIT NTI
Length:473
Mass (Da):52,554
Last modified:May 24, 2005 - v1
Checksum:i72E4295165642D0D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72459.1.
RefSeqiXP_646624.1. XM_641532.1.

Genome annotation databases

EnsemblProtistsiDDB0216280; DDB0216280; DDB_G0270218.
GeneIDi8617596.
KEGGiddi:DDB_G0270218.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000005 Genomic DNA. Translation: EAL72459.1.
RefSeqiXP_646624.1. XM_641532.1.

3D structure databases

ProteinModelPortaliQ55C57.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB_0216280.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0216280; DDB0216280; DDB_G0270218.
GeneIDi8617596.
KEGGiddi:DDB_G0270218.

Organism-specific databases

dictyBaseiDDB_G0270218. glkA.

Phylogenomic databases

eggNOGiCOG0515.
InParanoidiQ55C57.
KOiK03083.
PhylomeDBiQ55C57.

Miscellaneous databases

PROiQ55C57.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008266. Tyr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiGLKA_DICDI
AccessioniPrimary (citable) accession number: Q55C57
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: May 24, 2005
Last modified: April 29, 2015
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.