Q55C57 (GLKA_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable serine/threonine-protein kinase glkA
EC=2.7.11.26

Alternative name(s):
Glycogen synthase kinase-like kinase A

Gene names

Name:	glkA
ORF Names:	DDB_G0270218

Organism

Dictyostelium discoideum (Slime mold) [Reference proteome]

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	473 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + [tau protein] = ADP + [tau protein] phosphate.
Sequence similarities	Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Serine/threonine-protein kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	glycogen metabolic process Inferred from sequence or structural similarity. Source: dictyBase protein phosphorylation Inferred from sequence or structural similarity. Source: dictyBase
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein serine/threonine kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein tyrosine kinase activity Inferred from electronic annotation. Source: InterPro tau-protein kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 473	473	Probable serine/threonine-protein kinase glkA		PRO_0000358885
Regions
	Domain	91 – 366	276	Protein kinase
	Nucleotide binding	97 – 105	9	ATP By similarity
	Compositional bias	16 – 40	25	Poly-Asn
	Compositional bias	45 – 60	16	Poly-Asn
	Compositional bias	64 – 69	6	Poly-Ser
	Compositional bias	397 – 402	6	Poly-Ser
	Compositional bias	412 – 415	4	Poly-Ser
	Compositional bias	451 – 455	5	Poly-Ser
Sites
	Active site	208	1	Proton acceptor By similarity
	Binding site	119	1	ATP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55C57 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: 72E4295165642D0D	FASTA	473	52,554
	10 20 30 40 50 60 MTIPTDNNSS NNKGYNDNNN NNNNNNNNNN NNNNNNNNNN KEHPNINNNN NNNNNNNNNN 70 80 90 100 110 120 IKESSSSNSN HSSSQSSSTA TVNSNPKVYP YEIIKQVGQG TFGKVYEAKN QDNKRVAIKK 130 140 150 160 170 180 VEKSNHFISR EYDILKIVAH PNCLRILDMF YTAEDNKKMQ NLVFDFIPYT LASLLKKRQL 190 200 210 220 230 240 SINFIKVLFY QLCQAIKHIH SKAICHRDIT PNNILLSSKG ELTLADFGSA KILESNHTSM 250 260 270 280 290 300 SYICSRYYRA PELLVGCSNY TTKIDIWSIG CILAEMLIGK PLFPGTNSND QLGRIIEVLG 310 320 330 340 350 360 SPTKDDMEAM KPSKPYHLQL PNINPKFFES LHNVEDKTVV DLLSKIFIFD PVKRASIDEI 370 380 390 400 410 420 IAHPFLRDVN INSLELFDEM KCFSVSGNGK SSLTTNSTSS SSTTANMTSL ASSSSNNKTT 430 440 450 460 470 CSETYLSRLP TSAITSSSNL KSIDNSNNGK SSSSSNNIPS LNNSNNGVIT NTI

References

[1]

"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000005 Genomic DNA. Translation: EAL72459.1.
RefSeq	XP_646624.1. XM_641532.1.
3D structure databases
HSSP	HSSP built from PDB template 1Q3D based on UniProtKB P49841.
ProteinModelPortal	Q55C57.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0216280; DDB0216280; DDB_G0270218.
GeneID	8617596.
KEGG	ddi:DDB_G0270218.
Organism-specific databases
dictyBase	DDB_G0270218. glkA.
Phylogenomic databases
eggNOG	COG0515.
Family and domain databases
InterPro	IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR002290. Ser/Thr_dual-sp_kinase_dom. IPR008266. Tyr_kinase_AS. [Graphical view]
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
SMART	SM00220. S_TKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLKA_DICDI

Accession

Primary (citable) accession number: Q55C57

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 20, 2009
Last sequence update:	May 24, 2005
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)