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Q55BW2 (HDA12_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Histone deacetylase B

Short name=DdHdaB
Alternative name(s):
Type-1 histone deacetylase 2
EC=3.5.1.98
Gene names
Name:hdaB
ORF Names:DDB_G0270338
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length422 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes By similarity. May play a role in the regulation of the timing of gene expression during the development and in the definition aspects of the phenotype that mediate social behavior in genetically heterogeneous groups. Ref.2

Catalytic activity

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.

Enzyme regulation

Its activity is inhibited by trichostatin A (TSA), a well known histone deacetylase inhibitor. Cytosolic activity is refractory to inhibition by TSA, while the nuclear activity is inhibited completely. Ref.2

Subcellular location

Nucleus. Cytoplasm Ref.2.

Developmental stage

Expressed throughout growth and development. Ref.2

Disruption phenotype

Develop normally but when mixed with wild type cells they sporulate less efficiently than the wild type. Do not show major alterations in gross histone acetylation levels. Ref.2

Sequence similarities

Belongs to the histone deacetylase family. HD type 1 subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 422422Histone deacetylase B
PRO_0000331370

Regions

Compositional bias303 – 3064Poly-Gly

Sites

Active site1441Proton acceptor By similarity
Metal binding1791Divalent metal cation By similarity
Metal binding1811Divalent metal cation By similarity
Metal binding2681Divalent metal cation By similarity
Binding site1021Substrate By similarity
Binding site1521Substrate; via carbonyl oxygen By similarity
Binding site3071Substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q55BW2 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 732B1FFDAF4F21DC

FASTA42248,641
        10         20         30         40         50         60 
MEYNTILNNT SKTRVCYFFD QDVGNYFYGP YHPMKPHRLC LTNNLVLNYG LHKKMHLYKA 

        70         80         90        100        110        120 
RPADAEDMLK FHSEDYVDFL ERVTPENINE WKDVKRFHIG EDCPVFPGLY DYCSIYSGGS 

       130        140        150        160        170        180 
IEGALKLNHR MYDIAINWSG GLHHARKDEA SGFCYVNDIV LAILELLKFH ARVLYIDIDV 

       190        200        210        220        230        240 
HHGDGVQEAF YLTDRVMTVS FHKFGGDFFP GTGDIDEIGA KTGKLYSVNV PLADGIDDKN 

       250        260        270        280        290        300 
YLNIFKPVIQ GVMDYYRPSV IVLQCGADSL RFDRLGCFNL TIKGHAECVR FVKSFNIPTL 

       310        320        330        340        350        360 
VLGGGGYTVR NVARCWTYET SVCVDTEVNN ELPYNDYIQF YSPDFQLIPD YTGLPFKYEN 

       370        380        390        400        410        420 
ANTKSYLESL RIKILENLRI LQWAPSVQIQ DVPPDIMPID FDRDEDSKEN MDKRKKKHND 


FS 

« Hide

References

« Hide 'large scale' references
[1]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"Histone deacetylases regulate multicellular development in the social amoeba Dictyostelium discoideum."
Sawarkar R., Visweswariah S.S., Nellen W., Nanjundiah V.
J. Mol. Biol. 391:833-848(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, ENZYME REGULATION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000005 Genomic DNA. Translation: EAL72519.1.

3D structure databases

ProteinModelPortalQ55BW2.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDBDRAFT_0190980.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0237652; DDB0237652; DDB_G0270338.
KEGGddi:DDB_G0270338.

Organism-specific databases

dictyBaseDDB_G0270338. hdaB.

Phylogenomic databases

eggNOGCOG0123.
OMAHRLSVIH.
PhylomeDBQ55BW2.

Family and domain databases

Gene3D3.40.800.20. 1 hit.
InterProIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERPTHR10625. PTHR10625. 1 hit.
PfamPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSPR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNetSearch...

Other

PROQ55BW2.

Entry information

Entry nameHDA12_DICDI
AccessionPrimary (citable) accession number: Q55BW2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: April 16, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase