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Protein

Probable dual specificity protein phosphatase DDB_G0271350

Gene

DDB_G0271350

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Has a dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei87Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable dual specificity protein phosphatase DDB_G0271350 (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
ORF Names:DDB_G0271350
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0271350.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003329521 – 275Probable dual specificity protein phosphatase DDB_G0271350Add BLAST275

Proteomic databases

PaxDbiQ55BI8.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0202886.

Structurei

3D structure databases

ProteinModelPortaliQ55BI8.
SMRiQ55BI8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 142Tyrosine-protein phosphataseAdd BLAST140

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
InParanoidiQ55BI8.
OMAiLASTHQT.
PhylomeDBiQ55BI8.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.90.190.10. 1 hit.
InterProiView protein in InterPro
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR016130. Tyr_Pase_AS.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiView protein in Pfam
PF00782. DSPc. 1 hit.
SMARTiView protein in SMART
SM00195. DSPc. 1 hit.
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiView protein in PROSITE
PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55BI8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGISMILDNF LYLGAAKDTK DEKEMEKLKI THIFSCAGTV HSPEKYIIAN
60 70 80 90 100
EKFEDDETVD ISEQIEKAYW FIERVRMKKG ARVFIHCMAG KSRSASIVLS
110 120 130 140 150
YLLKRDIHSL SDCLFYLHSK RLEIRPNDGF MNQLCDLELK LTNKQTLSKE
160 170 180 190 200
IKEWRSLQSK ALKTKIDVQT CHFIQPSLDS TKKANEQYLL HIQSISFTFF
210 220 230 240 250
EIHLNQDKII QLYQQQCQLL HSNNIDIKYF TSILQEELSN STKKAFDFLL
260 270
IHYYLDWQDI INNLLNYTNL KLNLN
Length:275
Mass (Da):32,332
Last modified:May 24, 2005 - v1
Checksum:i819932FBED22A7F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000006 Genomic DNA. Translation: EAL71805.1.
RefSeqiXP_645624.1. XM_640532.1.

Genome annotation databases

EnsemblProtistsiEAL71805; EAL71805; DDB_G0271350.
GeneIDi8617816.
KEGGiddi:DDB_G0271350.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiDUSP3_DICDI
AccessioniPrimary (citable) accession number: Q55BI8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 24, 2005
Last modified: February 15, 2017
This is version 62 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families