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Q55BI3

- OTU1_DICDI

UniProt

Q55BI3 - OTU1_DICDI

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Protein
Ubiquitin thioesterase OTU1
Gene
yod1, DDB_G0271346
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation By similarity.

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei131 – 1311 By similarity
Active sitei134 – 1341Nucleophile By similarity
Active sitei316 – 3161 By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri292 – 31625C2H2-type
Add
BLAST

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ubiquitin-specific protease activity Source: dictyBase

GO - Biological processi

  1. protein deubiquitination Source: dictyBase
  2. sorocarp development Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiC85.007.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin thioesterase OTU1 (EC:3.4.19.12)
Gene namesi
Name:yod1
ORF Names:DDB_G0271346
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0271346. yod1.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 325325Ubiquitin thioesterase OTU1
PRO_0000328367Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi44689.DDBDRAFT_0202882.

Structurei

3D structure databases

ProteinModelPortaliQ55BI3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini123 – 246124OTU
Add
BLAST

Sequence similaritiesi

Contains 1 OTU domain.

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiCOG5539.
KOiK13719.
OMAiKSSRQFT.
PhylomeDBiQ55BI3.

Family and domain databases

InterProiIPR003323. OTU.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PfamiPF02338. OTU. 1 hit.
[Graphical view]
SUPFAMiSSF54236. SSF54236. 1 hit.
PROSITEiPS50802. OTU. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55BI3-1 [UniParc]FASTAAdd to Basket

« Hide

MSLISIRIRS KTGVENIKLE SQLKLKELQN IIEEKTKIST DTQKILYGFP    50
PKALDLSNQD AVISGFLANG DTITIENVSS ISSNPGVDSV TNDKVTSSTN 100
SFDRNIKSQP FISQEEEEDG GYATRRVTDD DNSCLFSAVA YVLEDKNRLK 150
GYSLRALIAQ NVKSDPFEYN EAVLGKSNEG YCNWIQNPKN WGGAIELSIL 200
SNHYKVEIAA FDISTQLMYC YGEDRKYTER VYLIYDGIHY DALSICLTKN 250
GPEDFDITRF SVDDKDSLAK MKVLIEKEFK AGKFTDTAKF SLICLNCNKT 300
LKGEKEAAIH ASTTGHGNFT EYKKR 325
Length:325
Mass (Da):36,456
Last modified:May 24, 2005 - v1
Checksum:iDFB2AB7B181E4BDD
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000006 Genomic DNA. Translation: EAL71803.1.
RefSeqiXP_645629.1. XM_640537.1.

Genome annotation databases

EnsemblProtistsiDDB0266410; DDB0266410; DDB_G0271346.
GeneIDi8617821.
KEGGiddi:DDB_G0271346.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000006 Genomic DNA. Translation: EAL71803.1 .
RefSeqi XP_645629.1. XM_640537.1.

3D structure databases

ProteinModelPortali Q55BI3.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDBDRAFT_0202882.

Protein family/group databases

MEROPSi C85.007.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0266410 ; DDB0266410 ; DDB_G0271346 .
GeneIDi 8617821.
KEGGi ddi:DDB_G0271346.

Organism-specific databases

dictyBasei DDB_G0271346. yod1.

Phylogenomic databases

eggNOGi COG5539.
KOi K13719.
OMAi KSSRQFT.
PhylomeDBi Q55BI3.

Miscellaneous databases

PROi Q55BI3.

Family and domain databases

InterProi IPR003323. OTU.
IPR029071. Ubiquitin-rel_dom.
[Graphical view ]
Pfami PF02338. OTU. 1 hit.
[Graphical view ]
SUPFAMi SSF54236. SSF54236. 1 hit.
PROSITEi PS50802. OTU. 1 hit.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiOTU1_DICDI
AccessioniPrimary (citable) accession number: Q55BI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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