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Q55BI2

- IDHA_DICDI

UniProt

Q55BI2 - IDHA_DICDI

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Protein
Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial
Gene
idhA, DDB_G0271344
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Performs an essential role in the oxidative function of the citric acid cycle By similarity.

Catalytic activityi

Isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH.

Cofactori

Binds 1 magnesium or manganese ion per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei95 – 951Substrate By similarity
Binding sitei97 – 971Substrate By similarity
Binding sitei101 – 1011Substrate By similarity
Binding sitei111 – 1111Substrate By similarity
Binding sitei132 – 1321Substrate By similarity
Sitei139 – 1391Critical for catalysis By similarity
Sitei186 – 1861Critical for catalysis By similarity
Metal bindingi243 – 2431Magnesium or manganese By similarity
Binding sitei289 – 2891NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi276 – 2827NADP By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. isocitrate dehydrogenase (NAD+) activity Source: UniProtKB
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. isocitrate metabolic process Source: UniProtKB
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrial (EC:1.1.1.41)
Gene namesi
Name:idhA
ORF Names:DDB_G0271344
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0271344. idhA.

Subcellular locationi

Mitochondrion By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 354Isocitrate dehydrogenase [NAD] regulatory subunit A, mitochondrialPRO_0000328018
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

PRIDEiQ55BI2.

Interactioni

Subunit structurei

Heterooligomer of catalytic and regulatory subunits By similarity.

Protein-protein interaction databases

STRINGi44689.DDB_0231288.

Structurei

3D structure databases

ProteinModelPortaliQ55BI2.
SMRiQ55BI2. Positions 21-348.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0473.
KOiK00030.
OMAiTEYTEAI.
PhylomeDBiQ55BI2.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00175. mito_nad_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q55BI2-1 [UniParc]FASTAAdd to Basket

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MFSRKSLSIF STLRNYSSST SKIQKVTLIP GDGIGPEISE SVKRVFSAVK    50
APIEWETVVV DANTGISKEV IESISKNKIG LKGPISTPIG TGHQSLNLGL 100
RKTFNLYANI RPCLSIPGHK TRYNNVNTVV VRENTEGEYS GIENQPVKGV 150
AQSIKIITKE ASTRIAHYAF QYALANGRKK VTCIHKANIM KQSDGLFVKS 200
CREVSTRYPS IKYEELTIDN NCMQLVLDPN QMDVMVLPNL YGDIVSDLCA 250
GLIGGLGLTP SGNIGENGSA IFEAVHGTAP DIAGKNKANP TALILSSIMM 300
LRHLGHFHEA SIIENAVLNT LTEGKVKTGD LGGNSSCSEY TDELVKKITE 350
SLNK 354
Length:354
Mass (Da):38,341
Last modified:May 24, 2005 - v1
Checksum:i07BC0DC939425EBE
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000006 Genomic DNA. Translation: EAL71802.1.
RefSeqiXP_645630.1. XM_640538.1.

Genome annotation databases

EnsemblProtistsiDDB0231288; DDB0231288; DDB_G0271344.
GeneIDi8617822.
KEGGiddi:DDB_G0271344.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000006 Genomic DNA. Translation: EAL71802.1 .
RefSeqi XP_645630.1. XM_640538.1.

3D structure databases

ProteinModelPortali Q55BI2.
SMRi Q55BI2. Positions 21-348.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231288.

Proteomic databases

PRIDEi Q55BI2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231288 ; DDB0231288 ; DDB_G0271344 .
GeneIDi 8617822.
KEGGi ddi:DDB_G0271344.

Organism-specific databases

dictyBasei DDB_G0271344. idhA.

Phylogenomic databases

eggNOGi COG0473.
KOi K00030.
OMAi TEYTEAI.
PhylomeDBi Q55BI2.

Miscellaneous databases

PROi Q55BI2.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004434. Isocitrate_DH_NAD.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00175. mito_nad_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiIDHA_DICDI
AccessioniPrimary (citable) accession number: Q55BI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: September 3, 2014
This is version 64 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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