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Protein

Mitochondrial substrate carrier family protein ucpA

Gene

ucpA

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Mitochondrial solute carriers shuttle metabolites, nucleotides, and cofactors through the mitochondrial inner membrane. Transports oxaloacetate and sulfate (By similarity).By similarity

Miscellaneous

Present with 5350 molecules/cell in log phase SD medium.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTransport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial substrate carrier family protein ucpA
Alternative name(s):
Solute carrier family 25 member 35 homolog
Uncoupler protein A
Gene namesi
Name:ucpA
Synonyms:slc25a35
ORF Names:DDB_G0271310
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0271310. ucpA.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 15Mitochondrial intermembraneBy similarityAdd BLAST15
Transmembranei16 – 36Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini37 – 83Mitochondrial matrixBy similarityAdd BLAST47
Transmembranei84 – 103Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini104 – 117Mitochondrial intermembraneBy similarityAdd BLAST14
Transmembranei118 – 138Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini139 – 174Mitochondrial matrixBy similarityAdd BLAST36
Transmembranei175 – 195Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini196 – 211Mitochondrial intermembraneBy similarityAdd BLAST16
Transmembranei212 – 232Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini233 – 276Mitochondrial matrixBy similarityAdd BLAST44
Transmembranei277 – 295Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini296 – 306Mitochondrial intermembraneBy similarityAdd BLAST11

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003855361 – 306Mitochondrial substrate carrier family protein ucpAAdd BLAST306

Proteomic databases

PaxDbiQ55BF4.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0237606.

Structurei

3D structure databases

ProteinModelPortaliQ55BF4.
SMRiQ55BF4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati13 – 103Solcar 1Add BLAST91
Repeati112 – 204Solcar 2Add BLAST93
Repeati211 – 301Solcar 3Add BLAST91

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0755. Eukaryota.
ENOG410XS37. LUCA.
InParanoidiQ55BF4.
KOiK15117.
OMAiRYTGTYN.
PhylomeDBiQ55BF4.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiView protein in InterPro
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
PfamiView protein in Pfam
PF00153. Mito_carr. 3 hits.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiView protein in PROSITE
PS50920. SOLCAR. 3 hits.

Sequencei

Sequence statusi: Complete.

Q55BF4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSVNLNNNKN NKNKVAIGFI SGSLASICAT TVTNPIELVK TRLQLQGELQ
60 70 80 90 100
LSQRIYNGVW DAFKQIYKTE GIRGLQSGLI PAYFSQATMQ GIRLGSFDLI
110 120 130 140 150
SNALGAKPNQ DYFFLKNLLA GATAGAIGAA AGSPFDLVKV RMQAANMYKN
160 170 180 190 200
DPQFVGYSSS FAAFKQIIQK EGFKGLTRGM LTSAQRTAVG SAIQLSTYGS
210 220 230 240 250
CKNLVLNFVD DGIYAYIISS MVAGFIVTFG MNPFDVARTR LYFQGKGNSH
260 270 280 290 300
GEIYKGLMDC VYKTVKKEGF GAVYKGFWAH YLRLGPHTIL TLVFWEQFKK

LFSGEL
Length:306
Mass (Da):33,605
Last modified:May 24, 2005 - v1
Checksum:iDA149C5E06C13BD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000006 Genomic DNA. Translation: EAL71785.1.
RefSeqiXP_645658.1. XM_640566.1.

Genome annotation databases

EnsemblProtistsiEAL71785; EAL71785; DDB_G0271310.
GeneIDi8617850.
KEGGiddi:DDB_G0271310.

Similar proteinsi

Entry informationi

Entry nameiUCPA_DICDI
AccessioniPrimary (citable) accession number: Q55BF4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 13, 2009
Last sequence update: May 24, 2005
Last modified: July 5, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families