Q55BC0 (ABCA8_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ABC transporter A family member 8

Alternative name(s):
ABC transporter ABCA.8

Gene names

Name:	abcA8
ORF Names:	DDB_G0271138

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	837 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the ABC transporter superfamily. ABCA family. Contains 1 ABC transporter domain.
Sequence caution	The sequence AAL85301.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Transport
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW ATPase activity, coupled to transmembrane movement of substances Inferred from sequence or structural similarity Ref.1. Source: dictyBase
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 837	837	ABC transporter A family member 8		PRO_0000363840
Regions
	Transmembrane	29 – 49	21	Helical; Potential
	Transmembrane	244 – 264	21	Helical; Potential
	Transmembrane	303 – 323	21	Helical; Potential
	Transmembrane	326 – 346	21	Helical; Potential
	Transmembrane	356 – 376	21	Helical; Potential
	Transmembrane	393 – 413	21	Helical; Potential
	Transmembrane	455 – 475	21	Helical; Potential
	Domain	516 – 750	235	ABC transporter
	Nucleotide binding	553 – 560	8	ATP Potential
	Compositional bias	339 – 342	4	Poly-Ser

Sequences

	Sequence		Length	Mass (Da)
	Q55BC0 [UniParc]. Last modified May 24, 2005. Version 1. Checksum: F99D6D0FEBA8523D	FASTA	837	93,818
	10 20 30 40 50 60 MSIGETIHRE FIHLKLLLKK NFLVSIRSYF STIIELLSPI VFVLIFYIIY SYGSAVDYSN 70 80 90 100 110 120 VSYEQNLPNC IVSVENRCIN LMFSPMNSTC TVEIMKILAK NNNMEIYNYP TDTGPLPNLE 130 140 150 160 170 180 NTIGFHGGII AMDSLNSTEQ FILAHPNVTL AVVDFENFPL NFTINGVKPN DSLIGFNDFY 190 200 210 220 230 240 DLSFNVLLNL STSGGFIEPV DYSIPVTTSI QKAIYDFYAI NNQKQIPTIN FDSTQFIEYS 250 260 270 280 290 300 SVNVVSLFGG LFYYCAIMIS FIFLLYKVAF EKEKNLKQGM VMMGLSRSMY WLSWVITSFT 310 320 330 340 350 360 IDLIICLLLI AIGAICKLPF FLGTNFLVLL LNFFLFAISS SSMAFFMLTF IGKTKVAIGI 370 380 390 400 410 420 GMAFFIVGSG LQLTFNSLGS LIFQIIYQTD SNGAAFVRVI LFILPMFHFS KVLTDINDKV 430 440 450 460 470 480 QSYPTSQFKI SDLNDNLDGS QYGMDYLVPT TGQSLAYMFI LVIVYLSLSA IIEYALSGGF 490 500 510 520 530 540 SFKTVKHINV PHFDDQDVAN ATNRSLDPSN KSPFIIRGLS KTFNKFLRPS KSVHALKYLS 550 560 570 580 590 600 LDIQEGTVLG LLGSNGAGKS TTIGILTGIH SPTSGDAIIY GHSVVKDIHS VRKITSVVPQ 610 620 630 640 650 660 DDILWLELTA MEHLHLFAEL KGIPVRERDF QIAKVLEQVK LTKVANDQCS TFSGGMKRRL 670 680 690 700 710 720 SVAIGCIGDP KIIFMDEPTT GLDPRSKRRI YTLVKEIKKD KVIILTSHDM HEIEILAQNL 730 740 750 760 770 780 VILNDGIMVC NGNALQLKTK YGEGYSVQVI AKSLEVIPEI INFVTSSLPY CRFLKQSALQ 790 800 810 820 830 LNFGFPINTD PKIIVNFFKR LESITKDENN NLMRDWSISH SNMDDVFIKV SNKPKLQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary analyses of ABC transporters of Dictyostelium discoideum." Anjard C., Loomis W.F. Eukaryot. Cell 1:643-652(2002) [PubMed: 12456012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], NOMENCLATURE. Strain: AX4.
[2]	"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[3]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF465310 Genomic DNA. Translation: AAL85301.1. Sequence problems. AAFI02000006 Genomic DNA. Translation: EAL71699.1.
RefSeq	XP_645692.1. XM_640600.1.
3D structure databases
HSSP	HSSP built from PDB template 1US8 based on UniProtKB P58301.
ProteinModelPortal	Q55BC0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0216250; DDB0216250; DDB_G0271138.
GeneID	8617885.
GenomeReviews	Gene locus abcA8 in contig CM000151_GR.
KEGG	ddi:DDB_G0271138.
Organism-specific databases
dictyBase	DDB_G0271138. abcA8.
Phylogenomic databases
eggNOG	KOG0059.
GeneTree	EPrGT00050000002981.
HOGENOM	HBG082641.
InParanoid	Q55BC0.
OMA	QASFCAF.
ProtClustDB	CLSZ2429467.
Family and domain databases
InterPro	IPR003439. ABC_transporter-like. IPR003593. ATPase_AAA+_core. [Graphical view]
Pfam	PF00005. ABC_tran. 1 hit. [Graphical view]
SMART	SM00382. AAA. 1 hit. [Graphical view]
PROSITE	PS00211. ABC_TRANSPORTER_1. False negative. PS50893. ABC_TRANSPORTER_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ABCA8_DICDI

Accession

Primary (citable) accession number: Q55BC0
Secondary accession number(s): Q8T6I9

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	May 24, 2005
Last modified:	September 21, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)