Q55AX0 (DLPC_DICDI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Dynamin-like protein C
EC=3.6.5.5

Gene names

Name:	dlpC
ORF Names:	DDB_G0271628

Organism

Dictyostelium discoideum (Slime mold)

Taxonomic identifier

44689 [NCBI]

Taxonomic lineage

Eukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length	904 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Involved in cytokinesis. May hydrolyze GTP. Ref.3
Catalytic activity	GTP + H2O = GDP + phosphate.
Subcellular location	Cytoplasm Potential.
Developmental stage	Expression begins during cell cycle progression, between 12 and 24 hours after germination. Reach a maximum around mid-log phase and disappear during the stationary phase. Ref.3
Disruption phenotype	Produced cells are larger and a large amount of them contained more than two nuclei. Ref.3
Sequence similarities	Belongs to the dynamin family.

Ontologies

Keywords
Biological process	Cell cycle Cell division
Cellular component	Cytoplasm
Domain	Coiled coil
Ligand	GTP-binding Nucleotide-binding
Molecular function	Hydrolase Motor protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cytokinesis Inferred from mutant phenotype Ref.3. Source: dictyBase
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTPase activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 904	904	Dynamin-like protein C		PRO_0000371339
Regions
	Nucleotide binding	129 – 136	8	GTP Potential
	Nucleotide binding	278 – 282	5	GTP Potential
	Nucleotide binding	343 – 346	4	GTP Potential
	Coiled coil	44 – 102	59	Potential
	Coiled coil	781 – 811	31	Potential
	Compositional bias	4 – 7	4	Poly-Gln
	Compositional bias	189 – 194	6	Poly-Ser
	Compositional bias	215 – 219	5	Poly-Gly
	Compositional bias	830 – 840	11	Poly-Ser
	Compositional bias	882 – 885	4	Poly-Asn

Sequences

	Sequence		Length	Mass (Da)
	Q55AX0 [UniParc]. Last modified May 5, 2009. Version 2. Checksum: F6C3DA0FA08C7288	FASTA	904	104,370
	10 20 30 40 50 60 MSHQQQQAHF DISSNSTLTT NTIATTTNAS VSSSPQLNKA QMAIAEAMAL KMHEEEKKKR 70 80 90 100 110 120 EEKKRKRDNE ELLSKQVRTK LENERKKLDD SESINASTNQ ELYSLFNDLQ MISHDHNISF 130 140 150 160 170 180 DTPELVVVGM QSDGKSSFIE SLLGFQFNIV ETNIGTRRPL IIQMINNPSK QQPSCRFKKE 190 200 210 220 230 240 DYSNSYGGSS SSTSTTSGNS NHNTDKQQNV SSSQGGGGGS NNLNEDKWEE YETPVNELTE 250 260 270 280 290 300 EIIRRTNERT GRAGDRVSSI PIFLRVEFAH CSNLNIYDTP GFRKGGDERL KYEISEMVKK 310 320 330 340 350 360 LIEPKNRIIV CLEQSNVEWA NTISRPLVKK IDPDFSRTIL VNTKFDNRVK ELRNRESAHK 370 380 390 400 410 420 YLEGEGIIAQ KKPFFISLPL KRNLETHRFK DAMKETFLDD YRKLLEIGFD ENRFGGQIGI 430 440 450 460 470 480 YKVRQYVENL LHEKYQQNLL PSMLQLESIC KKTEADIVRV KKELSDNNIV TLKEKVMRFV 490 500 510 520 530 540 SNFNGQIERL LEGSVVGDPD EFGQTLLQEK ENCSVQPWPG YNFDFDIQNS NYSLYGGAQY 550 560 570 580 590 600 ERLLNEFEFV IHSKEFPETS INEVASAIGV SKSHNSPIYE LAATNIFQTK SKKVLLPLID 610 620 630 640 650 660 IVLQRSSYIM KRLFDISVSI LGKDENESSH TVSLYEHFLK ELQSQYEKFI QTIESECKSR 670 680 690 700 710 720 LKDDFEMFTK IVDWNLLSGL TEIKPYNYLK VSPEETKQRV ISIMDCKKLE DEPLSRSRNI 730 740 750 760 770 780 DDDTYQKVCM IAGRLFSGIR FFFSKLIRNK LNAFFLDPMF QKLGSFVTDY FSKLNDQKYE 790 800 810 820 830 840 EMFQLGLKEL ENKLHKLEFQ LIDCKKNRDK FKDVYNRMKQ SLNQNQNQNS SSSSNSASSS 850 860 870 880 890 900 NNNVIIKHQQ SLNGKFSTPD KNSLTMSPFT SPFTQSNYHQ HNNNNYQINQ QPLDINNDHY FDQN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of Dictyostelium discoideum." Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A. Nature 418:79-85(2002) [PubMed: 12097910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[2]	"The genome of the social amoeba Dictyostelium discoideum." Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A. Nature 435:43-57(2005) [PubMed: 15875012] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: AX4.
[3]	"Evolutionary linkage between eukaryotic cytokinesis and chloroplast division by dynamin proteins." Miyagishima S.Y., Kuwayama H., Urushihara H., Nakanishi H. Proc. Natl. Acad. Sci. U.S.A. 105:15202-15207(2008) [PubMed: 18809930] [Abstract] Cited for: FUNCTION, DISRUPTION PHENOTYPE, DEVELOPMENTAL STAGE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AAFI02000006 Genomic DNA. Translation: EAL71678.2.
RefSeq	XP_645576.2. XM_640484.2.
3D structure databases
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblProtists	DDB0302372; DDB0302372; DDB_G0271628.
GeneID	8618029.
GenomeReviews	Gene locus dlpC in contig CM000151_GR.
KEGG	ddi:DDB_G0271628.
Organism-specific databases
dictyBase	DDB_G0271628. dlpC.
Phylogenomic databases
eggNOG	KOG0446.
GeneTree	EPrGT00060000009519.
ProtClustDB	CLSZ2731536.
Family and domain databases
InterPro	IPR022812. Dynamin. IPR001401. Dynamin_GTPase. [Graphical view]
Pfam	PF00350. Dynamin_N. 1 hit. [Graphical view]
PRINTS	PR00195. DYNAMIN.
SMART	SM00053. DYNc. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DLPC_DICDI

Accession

Primary (citable) accession number: Q55AX0
Secondary accession number(s): Q86JH7

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 5, 2009
Last sequence update:	May 5, 2009
Last modified:	December 14, 2011
This is version 39 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)