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Q55988

- PFKA2_SYNY3

UniProt

Q55988 - PFKA2_SYNY3

Protein

ATP-dependent 6-phosphofructokinase 2

Gene

pfkA2

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 94 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.UniRule annotation

    Catalytic activityi

    ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei13 – 131ATP; via amide nitrogenUniRule annotation
    Metal bindingi121 – 1211Magnesium; catalyticUniRule annotation
    Sitei122 – 1221Important for substrate specificity; cannot use PPi as phosphoryl donorUniRule annotation
    Active sitei146 – 1461Proton acceptorUniRule annotation
    Binding sitei181 – 1811Substrate; shared with dimeric partnerUniRule annotation
    Binding sitei246 – 2461SubstrateUniRule annotation
    Binding sitei291 – 2911Substrate; shared with dimeric partnerUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi91 – 922ATPUniRule annotation
    Nucleotide bindingi120 – 1234ATPUniRule annotation

    GO - Molecular functioni

    1. 6-phosphofructokinase activity Source: UniProtKB-EC
    2. ATP binding Source: UniProtKB-KW
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. fructose 6-phosphate metabolic process Source: InterPro
    2. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00182.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ATP-dependent 6-phosphofructokinase 2UniRule annotation (EC:2.7.1.11UniRule annotation)
    Short name:
    ATP-PFK 2UniRule annotation
    Short name:
    Phosphofructokinase 2UniRule annotation
    Alternative name(s):
    Phosphohexokinase 2UniRule annotation
    Gene namesi
    Name:pfkA2UniRule annotation
    Synonyms:pfkA
    Ordered Locus Names:sll0745
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. 6-phosphofructokinase complex Source: InterPro

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 384384ATP-dependent 6-phosphofructokinase 2PRO_0000111999Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer or homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi1148.sll0745.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55988.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni144 – 1463Substrate bindingUniRule annotation
    Regioni188 – 1903Substrate bindingUniRule annotation
    Regioni297 – 3004Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0205.
    HOGENOMiHOG000248869.
    KOiK00850.
    OMAiCPGLNAI.
    OrthoDBiEOG644ZRM.
    PhylomeDBiQ55988.

    Family and domain databases

    HAMAPiMF_01976. Phosphofructokinase_III.
    InterProiIPR012003. ATP_PFK_prok.
    IPR022953. Phosphofructokinase.
    IPR015912. Phosphofructokinase_CS.
    IPR000023. Phosphofructokinase_dom.
    [Graphical view]
    PfamiPF00365. PFK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000532. ATP_PFK_prok. 1 hit.
    PRINTSiPR00476. PHFRCTKINASE.
    SUPFAMiSSF53784. SSF53784. 1 hit.
    PROSITEiPS00433. PHOSPHOFRUCTOKINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q55988-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGTKRIGILT SGGDCPGLNA VIRAVVKASA LKGWEVYGIP YGTDGFVEVA    50
    HGKYQAEDLL LTKHGYALPG MLKGLDVLQF LSGSVLGSLS KGHPEQPAIA 100
    EAILKGYAIL DLEALIVIGG DGSLDIIYDL AQKGNWHIIA IPKTIDNDVP 150
    FTDLAVGFST AVDIVTQALY DLTFTAASHE RIIIVQVMGR DAGHLTLHAG 200
    IAGGADIILI PEITPCLTSE IIRNCCYQLM NLRKSGRHFA LIVISEGVHD 250
    QNNKKNKHIA DYLAEEISET SQHLCDIKDP AFCDLISLDI RATTLGHLQR 300
    SGTPLSFDRL LATVFGIRAV ELIEQEIYDQ VVIWRSGKVE HADLKPIISI 350
    IKECHQENRC PFPVDRDGFM VKTAKSLGIY LGED 384
    Length:384
    Mass (Da):41,759
    Last modified:November 1, 1996 - v1
    Checksum:i03034C863DBD9133
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10770.1.
    PIRiS77078.
    RefSeqiNP_442699.1. NC_000911.1.
    YP_005652760.1. NC_017277.1.
    YP_007452575.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA10770; BAA10770; BAA10770.
    GeneIDi952855.
    KEGGisyn:sll0745.
    syy:SYNGTS_2807.
    syz:MYO_128330.
    PATRICi23843144. VBISynSp132158_3110.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10770.1 .
    PIRi S77078.
    RefSeqi NP_442699.1. NC_000911.1.
    YP_005652760.1. NC_017277.1.
    YP_007452575.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali Q55988.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.sll0745.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA10770 ; BAA10770 ; BAA10770 .
    GeneIDi 952855.
    KEGGi syn:sll0745.
    syy:SYNGTS_2807.
    syz:MYO_128330.
    PATRICi 23843144. VBISynSp132158_3110.

    Phylogenomic databases

    eggNOGi COG0205.
    HOGENOMi HOG000248869.
    KOi K00850.
    OMAi CPGLNAI.
    OrthoDBi EOG644ZRM.
    PhylomeDBi Q55988.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00182 .

    Family and domain databases

    HAMAPi MF_01976. Phosphofructokinase_III.
    InterProi IPR012003. ATP_PFK_prok.
    IPR022953. Phosphofructokinase.
    IPR015912. Phosphofructokinase_CS.
    IPR000023. Phosphofructokinase_dom.
    [Graphical view ]
    Pfami PF00365. PFK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000532. ATP_PFK_prok. 1 hit.
    PRINTSi PR00476. PHFRCTKINASE.
    SUPFAMi SSF53784. SSF53784. 1 hit.
    PROSITEi PS00433. PHOSPHOFRUCTOKINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
      Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
      DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27184 / PCC 6803 / N-1.
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiPFKA2_SYNY3
    AccessioniPrimary (citable) accession number: Q55988
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 16, 2003
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 94 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3