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Q55982

- PDXA_SYNY3

UniProt

Q55982 - PDXA_SYNY3

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Protein
4-hydroxythreonine-4-phosphate dehydrogenase
Gene
pdxA, sll0660
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) By similarity.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.UniRule annotation

Cofactori

Binds 1 divalent metal cation per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei136 – 1361Substrate By similarity
Metal bindingi171 – 1711Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi216 – 2161Divalent metal cation; shared with dimeric partner By similarity
Metal bindingi281 – 2811Divalent metal cation; shared with dimeric partner By similarity
Binding sitei289 – 2891Substrate By similarity
Binding sitei298 – 2981Substrate By similarity
Binding sitei307 – 3071Substrate By similarity

GO - Molecular functioni

  1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
  2. NAD binding Source: InterPro
  3. metal ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
  2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pyridoxine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, NADP

Enzyme and pathway databases

UniPathwayiUPA00244; UER00312.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenase (EC:1.1.1.262)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenase
Gene namesi
Name:pdxA
Ordered Locus Names:sll0660
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3493494-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation
PRO_0000188832Add
BLAST

Proteomic databases

PaxDbiQ55982.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi1148.sll0660.

Structurei

3D structure databases

ProteinModelPortaliQ55982.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.

Phylogenomic databases

eggNOGiCOG1995.
HOGENOMiHOG000221591.
KOiK00097.
OMAiMATSIEL.
OrthoDBiEOG6GN6ZC.
PhylomeDBiQ55982.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
HAMAPiMF_00536. PdxA.
InterProiIPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view]
PfamiPF04166. PdxA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00557. pdxA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55982-1 [UniParc]FASTAAdd to Basket

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MDCMSLPRLI LTLGDPAGIG PEVVLKALAE PGLASICQLT AIGSRSVLDQ    50
TRRQLLAQNP GLNLADPETI NLLEVDLSYL GKITVGQGDA VSGAISFAYL 100
NEAITRTLAG EFDAIVTAPI AKSAWQAAGH NYPGQTEVLA HRAGVESFAM 150
AFVGRSPFTG WTLRTLLATT HIPLKEVPQA LTPQLMTAKL ELLLTCLAQD 200
FGISNPSVAI AGLNPHSGEE GKLGSEEQDW LIPWLEQARK KYPQAQLIGP 250
IPPDTMWVGP GKAWLTDGQT TVSDAYLALY HDQGLIPVKL LAFDQAINTT 300
IGLPFVRTSP DHGTAFDIAG QGIARADSLI AAIKLAAELV EQRCRPRAQ 349
Length:349
Mass (Da):37,225
Last modified:November 1, 1996 - v1
Checksum:i32C7510714F2C7EA
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA10762.1.
PIRiS77070.
RefSeqiNP_442691.1. NC_000911.1.
YP_005652752.1. NC_017277.1.
YP_007452567.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA10762; BAA10762; BAA10762.
GeneIDi954222.
KEGGisyn:sll0660.
syy:SYNGTS_2799.
syz:MYO_128250.
PATRICi23843128. VBISynSp132158_3102.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA10762.1 .
PIRi S77070.
RefSeqi NP_442691.1. NC_000911.1.
YP_005652752.1. NC_017277.1.
YP_007452567.1. NC_020286.1.

3D structure databases

ProteinModelPortali Q55982.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1148.sll0660.

Proteomic databases

PaxDbi Q55982.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA10762 ; BAA10762 ; BAA10762 .
GeneIDi 954222.
KEGGi syn:sll0660.
syy:SYNGTS_2799.
syz:MYO_128250.
PATRICi 23843128. VBISynSp132158_3102.

Phylogenomic databases

eggNOGi COG1995.
HOGENOMi HOG000221591.
KOi K00097.
OMAi MATSIEL.
OrthoDBi EOG6GN6ZC.
PhylomeDBi Q55982.

Enzyme and pathway databases

UniPathwayi UPA00244 ; UER00312 .

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
HAMAPi MF_00536. PdxA.
InterProi IPR024084. IsoPropMal-DH-like_dom.
IPR005255. PdxA.
[Graphical view ]
Pfami PF04166. PdxA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00557. pdxA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
    Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
    DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27184 / PCC 6803 / N-1.
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiPDXA_SYNY3
AccessioniPrimary (citable) accession number: Q55982
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The active site is located at the dimer interface By similarity.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

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