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Q55982

- PDXA_SYNY3

UniProt

Q55982 - PDXA_SYNY3

Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

    Catalytic activityi

    4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

    Cofactori

    Binds 1 divalent metal cation per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei136 – 1361SubstrateUniRule annotation
    Metal bindingi171 – 1711Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi216 – 2161Divalent metal cation; shared with dimeric partnerUniRule annotation
    Metal bindingi281 – 2811Divalent metal cation; shared with dimeric partnerUniRule annotation
    Binding sitei289 – 2891SubstrateUniRule annotation
    Binding sitei298 – 2981SubstrateUniRule annotation
    Binding sitei307 – 3071SubstrateUniRule annotation

    GO - Molecular functioni

    1. 4-hydroxythreonine-4-phosphate dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-HAMAP
    3. NAD binding Source: InterPro

    GO - Biological processi

    1. pyridoxal phosphate biosynthetic process Source: UniProtKB-HAMAP
    2. pyridoxine biosynthetic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pyridoxine biosynthesis

    Keywords - Ligandi

    Metal-binding, NAD, NADP

    Enzyme and pathway databases

    UniPathwayiUPA00244; UER00312.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
    Alternative name(s):
    4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
    Gene namesi
    Name:pdxAUniRule annotation
    Ordered Locus Names:sll0660
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 3493494-hydroxythreonine-4-phosphate dehydrogenasePRO_0000188832Add
    BLAST

    Proteomic databases

    PaxDbiQ55982.

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi1148.sll0660.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55982.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdxA family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1995.
    HOGENOMiHOG000221591.
    KOiK00097.
    OMAiMATSIEL.
    OrthoDBiEOG6GN6ZC.
    PhylomeDBiQ55982.

    Family and domain databases

    Gene3Di3.40.718.10. 1 hit.
    HAMAPiMF_00536. PdxA.
    InterProiIPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view]
    PfamiPF04166. PdxA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00557. pdxA. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q55982-1 [UniParc]FASTAAdd to Basket

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    MDCMSLPRLI LTLGDPAGIG PEVVLKALAE PGLASICQLT AIGSRSVLDQ    50
    TRRQLLAQNP GLNLADPETI NLLEVDLSYL GKITVGQGDA VSGAISFAYL 100
    NEAITRTLAG EFDAIVTAPI AKSAWQAAGH NYPGQTEVLA HRAGVESFAM 150
    AFVGRSPFTG WTLRTLLATT HIPLKEVPQA LTPQLMTAKL ELLLTCLAQD 200
    FGISNPSVAI AGLNPHSGEE GKLGSEEQDW LIPWLEQARK KYPQAQLIGP 250
    IPPDTMWVGP GKAWLTDGQT TVSDAYLALY HDQGLIPVKL LAFDQAINTT 300
    IGLPFVRTSP DHGTAFDIAG QGIARADSLI AAIKLAAELV EQRCRPRAQ 349
    Length:349
    Mass (Da):37,225
    Last modified:November 1, 1996 - v1
    Checksum:i32C7510714F2C7EA
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10762.1.
    PIRiS77070.
    RefSeqiNP_442691.1. NC_000911.1.
    YP_005652752.1. NC_017277.1.
    YP_007452567.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA10762; BAA10762; BAA10762.
    GeneIDi954222.
    KEGGisyn:sll0660.
    syy:SYNGTS_2799.
    syz:MYO_128250.
    PATRICi23843128. VBISynSp132158_3102.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10762.1 .
    PIRi S77070.
    RefSeqi NP_442691.1. NC_000911.1.
    YP_005652752.1. NC_017277.1.
    YP_007452567.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali Q55982.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.sll0660.

    Proteomic databases

    PaxDbi Q55982.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA10762 ; BAA10762 ; BAA10762 .
    GeneIDi 954222.
    KEGGi syn:sll0660.
    syy:SYNGTS_2799.
    syz:MYO_128250.
    PATRICi 23843128. VBISynSp132158_3102.

    Phylogenomic databases

    eggNOGi COG1995.
    HOGENOMi HOG000221591.
    KOi K00097.
    OMAi MATSIEL.
    OrthoDBi EOG6GN6ZC.
    PhylomeDBi Q55982.

    Enzyme and pathway databases

    UniPathwayi UPA00244 ; UER00312 .

    Family and domain databases

    Gene3Di 3.40.718.10. 1 hit.
    HAMAPi MF_00536. PdxA.
    InterProi IPR024084. IsoPropMal-DH-like_dom.
    IPR005255. PdxA.
    [Graphical view ]
    Pfami PF04166. PdxA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00557. pdxA. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
      Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
      DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27184 / PCC 6803 / N-1.
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiPDXA_SYNY3
    AccessioniPrimary (citable) accession number: Q55982
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    The active site is located at the dimer interface.UniRule annotation

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3