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Protein

DNA polymerase I

Gene

polA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

In addition to polymerase activity, this DNA polymerase exhibits 3'-5' and 5'-3' exonuclease activity.By similarity

Catalytic activityi

Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, DNA-directed DNA polymerase, Exonuclease, Hydrolase, Nuclease, Nucleotidyltransferase, Transferase
Biological processDNA damage, DNA repair, DNA replication

Names & Taxonomyi

Protein namesi
Recommended name:
DNA polymerase I (EC:2.7.7.7)
Short name:
POL I
Gene namesi
Name:polA
Ordered Locus Names:slr0707
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001012551 – 986DNA polymerase IAdd BLAST986

Proteomic databases

PaxDbiQ55971
PRIDEiQ55971

Interactioni

Subunit structurei

Single-chain monomer with multiple functions.By similarity

Protein-protein interaction databases

IntActiQ55971, 3 interactors
STRINGi1148.SYNGTS_2785

Structurei

3D structure databases

ProteinModelPortaliQ55971
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 3035'-3' exonucleaseAdd BLAST303
Domaini304 – 5923'-5' exonucleaseAdd BLAST289

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni593 – 986PolymeraseAdd BLAST394

Sequence similaritiesi

Belongs to the DNA polymerase type-A family.Curated

Phylogenomic databases

HOGENOMiHOG000020999
InParanoidiQ55971
KOiK02335
OMAiETGRVHT
PhylomeDBiQ55971

Family and domain databases

CDDicd09898 H3TH_53EXO, 1 hit
Gene3Di3.30.420.10, 1 hit
InterProiView protein in InterPro
IPR002562 3'-5'_exonuclease_dom
IPR020046 5-3_exonucl_a-hlix_arch_N
IPR036279 5-3_exonuclease_C_sf
IPR002421 5-3_exonuclease_N
IPR001098 DNA-dir_DNA_pol_A_palm_dom
IPR020045 DNA_polI_H3TH
IPR018320 DNA_polymerase_1
IPR002298 DNA_polymerase_A
IPR008918 HhH2
IPR029060 PIN-like_dom_sf
IPR012337 RNaseH-like_sf
IPR036397 RNaseH_sf
PANTHERiPTHR10133 PTHR10133, 1 hit
PfamiView protein in Pfam
PF01367 5_3_exonuc, 1 hit
PF02739 5_3_exonuc_N, 1 hit
PF00476 DNA_pol_A, 1 hit
PF01612 DNA_pol_A_exo1, 1 hit
PRINTSiPR00868 DNAPOLI
SMARTiView protein in SMART
SM00474 35EXOc, 1 hit
SM00475 53EXOc, 1 hit
SM00279 HhH2, 1 hit
SM00482 POLAc, 1 hit
SUPFAMiSSF47807 SSF47807, 1 hit
SSF53098 SSF53098, 1 hit
SSF88723 SSF88723, 1 hit
TIGRFAMsiTIGR00593 pola, 1 hit

Sequencei

Sequence statusi: Complete.

Q55971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFMSAKSPLL LLVDGHSLAF RAYYAFGLSK KGPLRTTAGI PTSVCFGFLN
60 70 80 90 100
SLMQVMESQK PAAIAIAFDR REPTFRHEAD GAYKSNRQET PEDFAEDLSY
110 120 130 140 150
LQQLLEALNL QTITYAGYEA DDILGTLACQ GSDAGYQVKI LSGDRDLFQL
160 170 180 190 200
VSPEKNISVL YLTRNPFSSN TGYDELDWQG VVDKMGVTPA QIVDFKALCG
210 220 230 240 250
DKSDCIPGIN GIGEKTAIKL LAEYETLEKV YENLAQIKGA LKTRLDNGKD
260 270 280 290 300
DAMHSQMLAR IVVDVPLPVT WEDLQLTGFS TDRLVPLLEK LELRTFIDKI
310 320 330 340 350
QAFHRNFSDN QSPVPMGNEA DNGEPKKTVK AKKSKEKVNP DDSQQLSLFD
360 370 380 390 400
GVPVVNQEDG LITIQLPKQI QPQIITTIAQ LEALVEELKK HTDADFPVAW
410 420 430 440 450
DTETDSLDPL VANLVGIGCA WGQEPNQVAY IPLKHHQGEQ LSLGIIKDLL
460 470 480 490 500
GEILGNAIYP KVLQNAKFDR RVLAHHGIEL GGVVLDTMLA SYVLQPEETH
510 520 530 540 550
NLTDLCRRYN LGLVALSYKD LGLKKDQTIA DLPLETAGQY CGLDCYATYL
560 570 580 590 600
LASKLQKELD QYPELKEILK EIEQPLEKIL AAMEDRGIRI DCDYLQTLSQ
610 620 630 640 650
QLAENLLTIE TAAYEAAGES FNLSSPKQLG TILFDKLGLD RKKSRKTKTG
660 670 680 690 700
YSTDHATLEK LQGDHPIIDA ILEHRTLAKL KSTYVDALPE LVNGQTQRIH
710 720 730 740 750
TDFNQAVTST GRLSSSNPNL QNIPIRSDFS RQIRRAFLPQ KDWLLVSADY
760 770 780 790 800
SQIELRILAH LSQEPVLLQA YGDRQDVHGV TAKLLFGKED ITPAERNLGK
810 820 830 840 850
TINFGVIYGM GAQRFARETG ISAVEGREFI DRYHRTYAQV FDYLETMKLE
860 870 880 890 900
AIAKGYVTTI VGRRRYFNFV TEALRQLRGK TVTELDLVDV KMNYNDAQLL
910 920 930 940 950
RSAANAPIQG SSADIIKIAM VKLAKLLESY QTRMLLQVHD ELIFEMPPEE
960 970 980
WEELAPLIQN TMEQALTLSV PLVVEMHRGS NWMEAK
Length:986
Mass (Da):110,287
Last modified:November 1, 1996 - v1
Checksum:iC87852AD07487FB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA10748.1
PIRiS77056

Genome annotation databases

EnsemblBacteriaiBAA10748; BAA10748; BAA10748
KEGGisyn:slr0707

Similar proteinsi

Entry informationi

Entry nameiDPO1_SYNY3
AccessioniPrimary (citable) accession number: Q55971
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: March 28, 2018
This is version 131 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health