ID ZIAR_SYNY3 Reviewed; 132 AA. AC Q55940; DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot. DT 01-NOV-1996, sequence version 1. DT 27-MAR-2024, entry version 137. DE RecName: Full=Transcriptional repressor SmtB homolog; GN Name=ziaR; Synonyms=smtB; OrderedLocusNames=sll0792; OS Synechocystis sp. (strain PCC 6803 / Kazusa). OC Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Merismopediaceae; OC Synechocystis. OX NCBI_TaxID=1111708; RN [1] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=ATCC 27184 / PCC 6803 / N-1; RX PubMed=8590279; DOI=10.1093/dnares/2.4.153; RA Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., RA Sugiura M., Tabata S.; RT "Sequence analysis of the genome of the unicellular cyanobacterium RT Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region RT from map positions 64% to 92% of the genome."; RL DNA Res. 2:153-166(1995). RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=PCC 6803 / Kazusa; RX PubMed=8905231; DOI=10.1093/dnares/3.3.109; RA Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., RA Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., RA Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S., RA Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.; RT "Sequence analysis of the genome of the unicellular cyanobacterium RT Synechocystis sp. strain PCC6803. II. Sequence determination of the entire RT genome and assignment of potential protein-coding regions."; RL DNA Res. 3:109-136(1996). RN [3] RP CHARACTERIZATION, AND MUTAGENESIS OF CYS-71; CYS-73 AND HIS-116. RX PubMed=9724772; DOI=10.1073/pnas.95.18.10728; RA Thelwell C., Robinson N.J., Turner-Cavet J.S.; RT "An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc RT exporter."; RL Proc. Natl. Acad. Sci. U.S.A. 95:10728-10733(1998). RN [4] RP REVIEW. RX PubMed=12829264; DOI=10.1016/s0168-6445(03)00054-8; RA Busenlehner L.S., Pennella M.A., Giedroc D.P.; RT "The SmtB/ArsR family of metalloregulatory transcriptional repressors: RT Structural insights into prokaryotic metal resistance."; RL FEMS Microbiol. Rev. 27:131-143(2003). CC -!- FUNCTION: Transcriptional repressor of the expression of the ziaA gene. CC Controls zinc homeostasis by triggering ZiaA-mediated efflux of excess CC zinc into the periplasm. CC -!- SUBUNIT: Homodimer. {ECO:0000250}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; BA000022; BAA10706.1; -; Genomic_DNA. DR PIR; S77014; S77014. DR AlphaFoldDB; Q55940; -. DR SMR; Q55940; -. DR STRING; 1148.gene:10500210; -. DR PaxDb; 1148-1001825; -. DR EnsemblBacteria; BAA10706; BAA10706; BAA10706. DR KEGG; syn:sll0792; -. DR eggNOG; COG0640; Bacteria. DR InParanoid; Q55940; -. DR PhylomeDB; Q55940; -. DR Proteomes; UP000001425; Chromosome. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR CDD; cd00090; HTH_ARSR; 1. DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1. DR InterPro; IPR011991; ArsR-like_HTH. DR InterPro; IPR018334; ArsR_HTH. DR InterPro; IPR001845; HTH_ArsR_DNA-bd_dom. DR InterPro; IPR036388; WH-like_DNA-bd_sf. DR InterPro; IPR036390; WH_DNA-bd_sf. DR NCBIfam; NF033788; HTH_metalloreg; 1. DR PANTHER; PTHR43132; ARSENICAL RESISTANCE OPERON REPRESSOR ARSR-RELATED; 1. DR PANTHER; PTHR43132:SF6; TRANSCRIPTIONAL REPRESSOR SMTB HOMOLOG; 1. DR Pfam; PF01022; HTH_5; 1. DR PRINTS; PR00778; HTHARSR. DR SMART; SM00418; HTH_ARSR; 1. DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1. DR PROSITE; PS00846; HTH_ARSR_1; 1. DR PROSITE; PS50987; HTH_ARSR_2; 1. PE 1: Evidence at protein level; KW DNA-binding; Metal-binding; Reference proteome; Repressor; Transcription; KW Transcription regulation; Zinc. FT CHAIN 1..132 FT /note="Transcriptional repressor SmtB homolog" FT /id="PRO_0000160627" FT DOMAIN 38..132 FT /note="HTH arsR-type" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00340" FT DNA_BIND 72..91 FT /note="H-T-H motif" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00340" FT BINDING 20 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00340" FT BINDING 26 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00340" FT BINDING 71 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00340" FT BINDING 73 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00340" FT BINDING 114 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00340" FT BINDING 116 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00340" FT BINDING 127 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00340" FT BINDING 130 FT /ligand="Zn(2+)" FT /ligand_id="ChEBI:CHEBI:29105" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00340" FT MUTAGEN 71 FT /note="C->S: Loss of ability to respond to zinc. Still FT capable of binding DNA; when associated with S-73." FT /evidence="ECO:0000269|PubMed:9724772" FT MUTAGEN 73 FT /note="C->S: Loss of ability to respond to zinc. Still FT capable of binding DNA; when associated with S-71." FT /evidence="ECO:0000269|PubMed:9724772" FT MUTAGEN 116 FT /note="H->R: Loss of ability to respond to zinc. Still FT capable of binding DNA." FT /evidence="ECO:0000269|PubMed:9724772" SQ SEQUENCE 132 AA; 15083 MW; 08A7B19849B186C9 CRC64; MSKSSLSKSQ SCQNEEMPLC DQPLVHLEQV RQVQPEVMSL DQAQQMAEFF SALADPSRLR LMSALARQEL CVCDLAAAMK VSESAVSHQL RILRSQRLVK YRRVGRNVYY SLADNHVMNL YREVADHLQE SD //