Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q55940 (ZIAR_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 91. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Transcriptional repressor SmtB homolog
Gene names
Name:ziaR
Synonyms:smtB
Ordered Locus Names:sll0792
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length132 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Transcriptional repressor of the expression of the ziaA gene. Controls zinc homeostasis by triggering ZiaA-mediated efflux of excess zinc into the periplasm.

Subunit structure

Homodimer By similarity.

Sequence similarities

Contains 1 HTH arsR-type DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 132132Transcriptional repressor SmtB homolog
PRO_0000160627

Regions

Domain38 – 13295HTH arsR-type
DNA binding72 – 9120H-T-H motif Potential

Sites

Metal binding201Zinc Potential
Metal binding261Zinc Potential
Metal binding711Zinc Potential
Metal binding731Zinc Potential
Metal binding1141Zinc Potential
Metal binding1161Zinc Potential
Metal binding1271Zinc Potential
Metal binding1301Zinc Potential

Experimental info

Mutagenesis711C → S: Loss of ability to respond to zinc. Still capable of binding DNA; when associated with S-73. Ref.3
Mutagenesis731C → S: Loss of ability to respond to zinc. Still capable of binding DNA; when associated with S-71. Ref.3
Mutagenesis1161H → R: Loss of ability to respond to zinc. Still capable of binding DNA. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q55940 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 08A7B19849B186C9

FASTA13215,083
        10         20         30         40         50         60 
MSKSSLSKSQ SCQNEEMPLC DQPLVHLEQV RQVQPEVMSL DQAQQMAEFF SALADPSRLR 

        70         80         90        100        110        120 
LMSALARQEL CVCDLAAAMK VSESAVSHQL RILRSQRLVK YRRVGRNVYY SLADNHVMNL 

       130 
YREVADHLQE SD 

« Hide

References

« Hide 'large scale' references
[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27184 / PCC 6803 / N-1.
[2]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.
[3]"An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc exporter."
Thelwell C., Robinson N.J., Turner-Cavet J.S.
Proc. Natl. Acad. Sci. U.S.A. 95:10728-10733(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION, MUTAGENESIS OF CYS-71; CYS-73 AND HIS-116.
[4]"The SmtB/ArsR family of metalloregulatory transcriptional repressors: Structural insights into prokaryotic metal resistance."
Busenlehner L.S., Pennella M.A., Giedroc D.P.
FEMS Microbiol. Rev. 27:131-143(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: REVIEW.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA10706.1.
PIRS77014.
RefSeqNP_442635.1. NC_000911.1.
YP_005652696.1. NC_017277.1.
YP_007452511.1. NC_020286.1.

3D structure databases

ProteinModelPortalQ55940.
SMRQ55940. Positions 29-130.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING1148.sll0792.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA10706; BAA10706; BAA10706.
GeneID952462.
KEGGsyn:sll0792.
syy:SYNGTS_2743.
syz:MYO_127690.
PATRIC23843014. VBISynSp132158_3045.

Phylogenomic databases

eggNOGCOG0640.
HOGENOMHOG000144506.
OMAVIHNDIV.
OrthoDBEOG6Z3KS4.
PhylomeDBQ55940.

Family and domain databases

Gene3D1.10.10.10. 1 hit.
InterProIPR018334. ArsR_HTH.
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSPR00778. HTHARSR.
SMARTSM00418. HTH_ARSR. 1 hit.
[Graphical view]
PROSITEPS00846. HTH_ARSR_1. 1 hit.
PS50987. HTH_ARSR_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameZIAR_SYNY3
AccessionPrimary (citable) accession number: Q55940
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families