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Q55940

- ZIAR_SYNY3

UniProt

Q55940 - ZIAR_SYNY3

Protein

Transcriptional repressor SmtB homolog

Gene

ziaR

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Transcriptional repressor of the expression of the ziaA gene. Controls zinc homeostasis by triggering ZiaA-mediated efflux of excess zinc into the periplasm.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi20 – 201ZincPROSITE-ProRule annotation
    Metal bindingi26 – 261ZincPROSITE-ProRule annotation
    Metal bindingi71 – 711ZincPROSITE-ProRule annotation
    Metal bindingi73 – 731ZincPROSITE-ProRule annotation
    Metal bindingi114 – 1141ZincPROSITE-ProRule annotation
    Metal bindingi116 – 1161ZincPROSITE-ProRule annotation
    Metal bindingi127 – 1271ZincPROSITE-ProRule annotation
    Metal bindingi130 – 1301ZincPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi72 – 9120H-T-H motifPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcriptional repressor SmtB homolog
    Gene namesi
    Name:ziaR
    Synonyms:smtB
    Ordered Locus Names:sll0792
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. intracellular Source: InterPro

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi71 – 711C → S: Loss of ability to respond to zinc. Still capable of binding DNA; when associated with S-73. 1 Publication
    Mutagenesisi73 – 731C → S: Loss of ability to respond to zinc. Still capable of binding DNA; when associated with S-71. 1 Publication
    Mutagenesisi116 – 1161H → R: Loss of ability to respond to zinc. Still capable of binding DNA. 1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 132132Transcriptional repressor SmtB homologPRO_0000160627Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi1148.sll0792.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55940.
    SMRiQ55940. Positions 29-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini38 – 13295HTH arsR-typePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 HTH arsR-type DNA-binding domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0640.
    HOGENOMiHOG000144506.
    OMAiVIHNDIV.
    OrthoDBiEOG6Z3KS4.
    PhylomeDBiQ55940.

    Family and domain databases

    Gene3Di1.10.10.10. 1 hit.
    InterProiIPR018334. ArsR_HTH.
    IPR001845. HTH_ArsR_DNA-bd_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF01022. HTH_5. 1 hit.
    [Graphical view]
    PRINTSiPR00778. HTHARSR.
    SMARTiSM00418. HTH_ARSR. 1 hit.
    [Graphical view]
    PROSITEiPS00846. HTH_ARSR_1. 1 hit.
    PS50987. HTH_ARSR_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q55940-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKSSLSKSQ SCQNEEMPLC DQPLVHLEQV RQVQPEVMSL DQAQQMAEFF    50
    SALADPSRLR LMSALARQEL CVCDLAAAMK VSESAVSHQL RILRSQRLVK 100
    YRRVGRNVYY SLADNHVMNL YREVADHLQE SD 132
    Length:132
    Mass (Da):15,083
    Last modified:November 1, 1996 - v1
    Checksum:i08A7B19849B186C9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10706.1.
    PIRiS77014.
    RefSeqiNP_442635.1. NC_000911.1.
    YP_005652696.1. NC_017277.1.
    YP_007452511.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA10706; BAA10706; BAA10706.
    GeneIDi952462.
    KEGGisyn:sll0792.
    syy:SYNGTS_2743.
    syz:MYO_127690.
    PATRICi23843014. VBISynSp132158_3045.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10706.1 .
    PIRi S77014.
    RefSeqi NP_442635.1. NC_000911.1.
    YP_005652696.1. NC_017277.1.
    YP_007452511.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali Q55940.
    SMRi Q55940. Positions 29-130.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.sll0792.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA10706 ; BAA10706 ; BAA10706 .
    GeneIDi 952462.
    KEGGi syn:sll0792.
    syy:SYNGTS_2743.
    syz:MYO_127690.
    PATRICi 23843014. VBISynSp132158_3045.

    Phylogenomic databases

    eggNOGi COG0640.
    HOGENOMi HOG000144506.
    OMAi VIHNDIV.
    OrthoDBi EOG6Z3KS4.
    PhylomeDBi Q55940.

    Family and domain databases

    Gene3Di 1.10.10.10. 1 hit.
    InterProi IPR018334. ArsR_HTH.
    IPR001845. HTH_ArsR_DNA-bd_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF01022. HTH_5. 1 hit.
    [Graphical view ]
    PRINTSi PR00778. HTHARSR.
    SMARTi SM00418. HTH_ARSR. 1 hit.
    [Graphical view ]
    PROSITEi PS00846. HTH_ARSR_1. 1 hit.
    PS50987. HTH_ARSR_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
      Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
      DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27184 / PCC 6803 / N-1.
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.
    3. "An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc exporter."
      Thelwell C., Robinson N.J., Turner-Cavet J.S.
      Proc. Natl. Acad. Sci. U.S.A. 95:10728-10733(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, MUTAGENESIS OF CYS-71; CYS-73 AND HIS-116.
    4. "The SmtB/ArsR family of metalloregulatory transcriptional repressors: Structural insights into prokaryotic metal resistance."
      Busenlehner L.S., Pennella M.A., Giedroc D.P.
      FEMS Microbiol. Rev. 27:131-143(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiZIAR_SYNY3
    AccessioniPrimary (citable) accession number: Q55940
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 92 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3