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Q55940

- ZIAR_SYNY3

UniProt

Q55940 - ZIAR_SYNY3

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Protein
Transcriptional repressor SmtB homolog
Gene
ziaR, smtB, sll0792
Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Transcriptional repressor of the expression of the ziaA gene. Controls zinc homeostasis by triggering ZiaA-mediated efflux of excess zinc into the periplasm.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi20 – 201Zinc Reviewed prediction
Metal bindingi26 – 261Zinc Reviewed prediction
Metal bindingi71 – 711Zinc Reviewed prediction
Metal bindingi73 – 731Zinc Reviewed prediction
Metal bindingi114 – 1141Zinc Reviewed prediction
Metal bindingi116 – 1161Zinc Reviewed prediction
Metal bindingi127 – 1271Zinc Reviewed prediction
Metal bindingi130 – 1301Zinc Reviewed prediction

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi72 – 9120H-T-H motif Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. DNA binding Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcriptional repressor SmtB homolog
Gene namesi
Name:ziaR
Synonyms:smtB
Ordered Locus Names:sll0792
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. intracellular Source: InterPro
Complete GO annotation...

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi71 – 711C → S: Loss of ability to respond to zinc. Still capable of binding DNA; when associated with S-73. 1 Publication
Mutagenesisi73 – 731C → S: Loss of ability to respond to zinc. Still capable of binding DNA; when associated with S-71. 1 Publication
Mutagenesisi116 – 1161H → R: Loss of ability to respond to zinc. Still capable of binding DNA. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 132132Transcriptional repressor SmtB homolog
PRO_0000160627Add
BLAST

Interactioni

Subunit structurei

Homodimer By similarity.

Protein-protein interaction databases

STRINGi1148.sll0792.

Structurei

3D structure databases

ProteinModelPortaliQ55940.
SMRiQ55940. Positions 29-130.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini38 – 13295HTH arsR-type
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0640.
HOGENOMiHOG000144506.
OMAiVIHNDIV.
OrthoDBiEOG6Z3KS4.
PhylomeDBiQ55940.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR018334. ArsR_HTH.
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF01022. HTH_5. 1 hit.
[Graphical view]
PRINTSiPR00778. HTHARSR.
SMARTiSM00418. HTH_ARSR. 1 hit.
[Graphical view]
PROSITEiPS00846. HTH_ARSR_1. 1 hit.
PS50987. HTH_ARSR_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55940-1 [UniParc]FASTAAdd to Basket

« Hide

MSKSSLSKSQ SCQNEEMPLC DQPLVHLEQV RQVQPEVMSL DQAQQMAEFF    50
SALADPSRLR LMSALARQEL CVCDLAAAMK VSESAVSHQL RILRSQRLVK 100
YRRVGRNVYY SLADNHVMNL YREVADHLQE SD 132
Length:132
Mass (Da):15,083
Last modified:November 1, 1996 - v1
Checksum:i08A7B19849B186C9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA10706.1.
PIRiS77014.
RefSeqiNP_442635.1. NC_000911.1.
YP_005652696.1. NC_017277.1.
YP_007452511.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA10706; BAA10706; BAA10706.
GeneIDi952462.
KEGGisyn:sll0792.
syy:SYNGTS_2743.
syz:MYO_127690.
PATRICi23843014. VBISynSp132158_3045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA10706.1 .
PIRi S77014.
RefSeqi NP_442635.1. NC_000911.1.
YP_005652696.1. NC_017277.1.
YP_007452511.1. NC_020286.1.

3D structure databases

ProteinModelPortali Q55940.
SMRi Q55940. Positions 29-130.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 1148.sll0792.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA10706 ; BAA10706 ; BAA10706 .
GeneIDi 952462.
KEGGi syn:sll0792.
syy:SYNGTS_2743.
syz:MYO_127690.
PATRICi 23843014. VBISynSp132158_3045.

Phylogenomic databases

eggNOGi COG0640.
HOGENOMi HOG000144506.
OMAi VIHNDIV.
OrthoDBi EOG6Z3KS4.
PhylomeDBi Q55940.

Family and domain databases

Gene3Di 1.10.10.10. 1 hit.
InterProi IPR018334. ArsR_HTH.
IPR001845. HTH_ArsR_DNA-bd_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF01022. HTH_5. 1 hit.
[Graphical view ]
PRINTSi PR00778. HTHARSR.
SMARTi SM00418. HTH_ARSR. 1 hit.
[Graphical view ]
PROSITEi PS00846. HTH_ARSR_1. 1 hit.
PS50987. HTH_ARSR_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
    Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
    DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27184 / PCC 6803 / N-1.
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  3. "An SmtB-like repressor from Synechocystis PCC 6803 regulates a zinc exporter."
    Thelwell C., Robinson N.J., Turner-Cavet J.S.
    Proc. Natl. Acad. Sci. U.S.A. 95:10728-10733(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION, MUTAGENESIS OF CYS-71; CYS-73 AND HIS-116.
  4. "The SmtB/ArsR family of metalloregulatory transcriptional repressors: Structural insights into prokaryotic metal resistance."
    Busenlehner L.S., Pennella M.A., Giedroc D.P.
    FEMS Microbiol. Rev. 27:131-143(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.

Entry informationi

Entry nameiZIAR_SYNY3
AccessioniPrimary (citable) accession number: Q55940
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3

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