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Q558Z2

- SUN1_DICDI

UniProt

Q558Z2 - SUN1_DICDI

Protein

Sun domain-containing protein 1

Gene

sun1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (24 May 2005)
      Previous versions | rss
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    Functioni

    May have an important role in defining the spacing of the nuclear envelope lumen. Essential for centrosome attachment to the nucleus, maintenance of correct ploidy, proper mitosis, association of the centromere cluster with the centrosome and the maintenance of genome stability. Requires direct chromatin binding for inner nuclear membrane targeting.2 Publications

    GO - Molecular functioni

    1. chromatin binding Source: dictyBase
    2. DNA binding Source: dictyBase
    3. protein homodimerization activity Source: dictyBase

    GO - Biological processi

    1. centromere complex assembly Source: dictyBase
    2. centrosome localization Source: dictyBase
    3. centrosome organization Source: dictyBase
    4. mitotic sister chromatid segregation Source: dictyBase
    5. nucleus organization Source: dictyBase

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Sun domain-containing protein 1
    Gene namesi
    Name:sun1
    ORF Names:DDB_G0272869
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0272869. sun1.

    Subcellular locationi

    Nucleus membrane 2 Publications; Single-pass membrane protein 2 Publications; Nucleoplasmic side 2 Publications

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. nuclear envelope Source: dictyBase
    3. nuclear inner membrane Source: dictyBase
    4. nuclear outer membrane Source: dictyBase
    5. nucleoplasm Source: dictyBase

    Keywords - Cellular componenti

    Membrane, Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Shows significant reduced growth.1 Publication

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 905905Sun domain-containing protein 1PRO_0000390618Add
    BLAST

    Proteomic databases

    PRIDEiQ558Z2.

    Interactioni

    Subunit structurei

    Homodimer and homooligomer.1 Publication

    Protein-protein interaction databases

    STRINGi44689.DDB_0219949.

    Structurei

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 290290NuclearSequence AnalysisAdd
    BLAST
    Topological domaini312 – 905594Perinuclear spaceSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei291 – 31121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini662 – 860199SUNPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili170 – 22152Sequence AnalysisAdd
    BLAST
    Coiled coili359 – 45698Sequence AnalysisAdd
    BLAST
    Coiled coili504 – 609106Sequence AnalysisAdd
    BLAST
    Coiled coili864 – 90138Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi117 – 1204Poly-Asp
    Compositional biasi177 – 21337Poly-GlnAdd
    BLAST
    Compositional biasi215 – 2217Poly-Asn
    Compositional biasi224 – 2274Poly-Asn
    Compositional biasi281 – 2844Poly-Asn
    Compositional biasi567 – 5726Poly-Ser
    Compositional biasi814 – 8196Poly-Thr

    Sequence similaritiesi

    Contains 1 SUN domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG285464.
    InParanoidiQ558Z2.
    OMAiVYSADKI.

    Family and domain databases

    InterProiIPR012919. Sad1_UNC_C.
    [Graphical view]
    PfamiPF07738. Sad1_UNC. 1 hit.
    [Graphical view]
    PROSITEiPS51469. SUN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q558Z2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSGDYKPNYQ SSPSRKRLPL QSKDQASIYK YQTPSTLNLY NNTVNNNSSN    50
    NSNNHLLHNS NPNSSYLYDS SKQYSNQINI RNNSNSNSNT NNITSKKASS 100
    SYSINNKVDH NSHNNNDDDD IEDDVDINYS TNNASSNILH NRFSNSNKDD 150
    SYIDYSTDEN PKILKQPQPL YNHLNNQIQQ QQQQQQQQQQ QQQQQQQQQQ 200
    QQQQQQQQQQ QQQRNNNNNS NSSNNNNTST TIKRNNQQID NNSNKNIISK 250
    FIGDPWKNFY YGSNKSLWPF ERNNNSNNSS NNNNKVNFKQ AIWIFIFSVL 300
    FIGCLLGLFS TNFYGIHIYF PSFSTTKTNS PFNSTNNNIQ FSNLITKEQL 350
    YPIIDEYFKK NEILKSYNKL FEKIENDIKY LSEREQYKDI INEIKEELKL 400
    VKLSNMDEDR VNQLISKMIN HYNNNENNKQ ELKELLSKSI EELTKLKSDS 450
    KEQLIQISTE SMNQLGQLKS ESINQLGQVK SESIDKFQST LKSLSKEEQS 500
    KIEREFNHQF NQLNKDADQL LSQHSLKIEK LREEINENQQ SSLLKLTQEY 550
    KQLEERLKEF SSKLQQSISS SSMDQFESWK LVFIKDIEER INKESSKLTN 600
    QYIQLTQQFT KIQSFIKDNP SIDSLTNTIE SLEGIKLLIE DILEVYSADK 650
    IAKVDYALGL AGASIEYNAL HYRVSETYPP IKGSGSGSGS GGANGNSLGL 700
    YYYNLATNWI FPQPKPNPPE TILDPMVNTG SCWGFYTGNG TIVIRLAKKI 750
    AITEVTMEHI SSNISHHIDS APKEFQVFGL INSSDIGQSL GVFTYDTTIN 800
    RHLQTFKVNK IQSTTTTTTN QDQNDDDNIQ EFSHVALRIL SNHGYRYTCI 850
    YRFRVHGYQI PHPEQEQIQI IQEEQSFKQE EINQQQIEQI EQIEQIEKQQ 900
    QSDEL 905
    Length:905
    Mass (Da):104,743
    Last modified:May 24, 2005 - v1
    Checksum:i208FA7368F3280D2
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000008 Genomic DNA. Translation: EAL71072.1.
    RefSeqiXP_644924.1. XM_639832.1.

    Genome annotation databases

    EnsemblProtistsiDDB0219949; DDB0219949; DDB_G0272869.
    GeneIDi8618603.
    KEGGiddi:DDB_G0272869.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000008 Genomic DNA. Translation: EAL71072.1 .
    RefSeqi XP_644924.1. XM_639832.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0219949.

    Proteomic databases

    PRIDEi Q558Z2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0219949 ; DDB0219949 ; DDB_G0272869 .
    GeneIDi 8618603.
    KEGGi ddi:DDB_G0272869.

    Organism-specific databases

    dictyBasei DDB_G0272869. sun1.

    Phylogenomic databases

    eggNOGi NOG285464.
    InParanoidi Q558Z2.
    OMAi VYSADKI.

    Family and domain databases

    InterProi IPR012919. Sad1_UNC_C.
    [Graphical view ]
    Pfami PF07738. Sad1_UNC. 1 hit.
    [Graphical view ]
    PROSITEi PS51469. SUN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    3. "Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability."
      Xiong H., Rivero F., Euteneuer U., Mondal S., Mana-Capelli S., Larochelle D., Vogel A., Gassen B., Noegel A.A.
      Traffic 9:708-724(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, SUBUNIT.
    4. "Dictyostelium Sun1 is a dynamic membrane protein of both nuclear membranes and required for centrosomal association with clustered centromeres."
      Schulz I., Baumann O., Samereier M., Zoglmeier C., Graef R.
      Eur. J. Cell Biol. 88:621-638(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, FUNCTION, DISRUPTION PHENOTYPE.

    Entry informationi

    Entry nameiSUN1_DICDI
    AccessioniPrimary (citable) accession number: Q558Z2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 19, 2010
    Last sequence update: May 24, 2005
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3