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Q558Z2

- SUN1_DICDI

UniProt

Q558Z2 - SUN1_DICDI

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Protein

Sun domain-containing protein 1

Gene

sun1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

May have an important role in defining the spacing of the nuclear envelope lumen. Essential for centrosome attachment to the nucleus, maintenance of correct ploidy, proper mitosis, association of the centromere cluster with the centrosome and the maintenance of genome stability. Requires direct chromatin binding for inner nuclear membrane targeting.2 Publications

GO - Molecular functioni

  1. chromatin binding Source: dictyBase
  2. DNA binding Source: dictyBase
  3. protein homodimerization activity Source: dictyBase

GO - Biological processi

  1. centromere complex assembly Source: dictyBase
  2. centrosome localization Source: dictyBase
  3. centrosome organization Source: dictyBase
  4. mitotic sister chromatid segregation Source: dictyBase
  5. nucleus organization Source: dictyBase
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Sun domain-containing protein 1
Gene namesi
Name:sun1
ORF Names:DDB_G0272869
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0272869. sun1.

Subcellular locationi

Nucleus membrane 2 Publications; Single-pass membrane protein 2 Publications; Nucleoplasmic side 2 Publications

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nuclear envelope Source: dictyBase
  3. nuclear inner membrane Source: dictyBase
  4. nuclear outer membrane Source: dictyBase
  5. nucleoplasm Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Shows significant reduced growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 905905Sun domain-containing protein 1PRO_0000390618Add
BLAST

Proteomic databases

PRIDEiQ558Z2.

Interactioni

Subunit structurei

Homodimer and homooligomer.1 Publication

Protein-protein interaction databases

STRINGi44689.DDB_0219949.

Structurei

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 290290NuclearSequence AnalysisAdd
BLAST
Topological domaini312 – 905594Perinuclear spaceSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei291 – 31121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini662 – 860199SUNPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili170 – 22152Sequence AnalysisAdd
BLAST
Coiled coili359 – 45698Sequence AnalysisAdd
BLAST
Coiled coili504 – 609106Sequence AnalysisAdd
BLAST
Coiled coili864 – 90138Sequence AnalysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi117 – 1204Poly-Asp
Compositional biasi177 – 21337Poly-GlnAdd
BLAST
Compositional biasi215 – 2217Poly-Asn
Compositional biasi224 – 2274Poly-Asn
Compositional biasi281 – 2844Poly-Asn
Compositional biasi567 – 5726Poly-Ser
Compositional biasi814 – 8196Poly-Thr

Sequence similaritiesi

Contains 1 SUN domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285464.
InParanoidiQ558Z2.
OMAiVYSADKI.

Family and domain databases

InterProiIPR012919. Sad1_UNC_C.
[Graphical view]
PfamiPF07738. Sad1_UNC. 1 hit.
[Graphical view]
PROSITEiPS51469. SUN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q558Z2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSGDYKPNYQ SSPSRKRLPL QSKDQASIYK YQTPSTLNLY NNTVNNNSSN
60 70 80 90 100
NSNNHLLHNS NPNSSYLYDS SKQYSNQINI RNNSNSNSNT NNITSKKASS
110 120 130 140 150
SYSINNKVDH NSHNNNDDDD IEDDVDINYS TNNASSNILH NRFSNSNKDD
160 170 180 190 200
SYIDYSTDEN PKILKQPQPL YNHLNNQIQQ QQQQQQQQQQ QQQQQQQQQQ
210 220 230 240 250
QQQQQQQQQQ QQQRNNNNNS NSSNNNNTST TIKRNNQQID NNSNKNIISK
260 270 280 290 300
FIGDPWKNFY YGSNKSLWPF ERNNNSNNSS NNNNKVNFKQ AIWIFIFSVL
310 320 330 340 350
FIGCLLGLFS TNFYGIHIYF PSFSTTKTNS PFNSTNNNIQ FSNLITKEQL
360 370 380 390 400
YPIIDEYFKK NEILKSYNKL FEKIENDIKY LSEREQYKDI INEIKEELKL
410 420 430 440 450
VKLSNMDEDR VNQLISKMIN HYNNNENNKQ ELKELLSKSI EELTKLKSDS
460 470 480 490 500
KEQLIQISTE SMNQLGQLKS ESINQLGQVK SESIDKFQST LKSLSKEEQS
510 520 530 540 550
KIEREFNHQF NQLNKDADQL LSQHSLKIEK LREEINENQQ SSLLKLTQEY
560 570 580 590 600
KQLEERLKEF SSKLQQSISS SSMDQFESWK LVFIKDIEER INKESSKLTN
610 620 630 640 650
QYIQLTQQFT KIQSFIKDNP SIDSLTNTIE SLEGIKLLIE DILEVYSADK
660 670 680 690 700
IAKVDYALGL AGASIEYNAL HYRVSETYPP IKGSGSGSGS GGANGNSLGL
710 720 730 740 750
YYYNLATNWI FPQPKPNPPE TILDPMVNTG SCWGFYTGNG TIVIRLAKKI
760 770 780 790 800
AITEVTMEHI SSNISHHIDS APKEFQVFGL INSSDIGQSL GVFTYDTTIN
810 820 830 840 850
RHLQTFKVNK IQSTTTTTTN QDQNDDDNIQ EFSHVALRIL SNHGYRYTCI
860 870 880 890 900
YRFRVHGYQI PHPEQEQIQI IQEEQSFKQE EINQQQIEQI EQIEQIEKQQ

QSDEL
Length:905
Mass (Da):104,743
Last modified:May 24, 2005 - v1
Checksum:i208FA7368F3280D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000008 Genomic DNA. Translation: EAL71072.1.
RefSeqiXP_644924.1. XM_639832.1.

Genome annotation databases

EnsemblProtistsiDDB0219949; DDB0219949; DDB_G0272869.
GeneIDi8618603.
KEGGiddi:DDB_G0272869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000008 Genomic DNA. Translation: EAL71072.1 .
RefSeqi XP_644924.1. XM_639832.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0219949.

Proteomic databases

PRIDEi Q558Z2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0219949 ; DDB0219949 ; DDB_G0272869 .
GeneIDi 8618603.
KEGGi ddi:DDB_G0272869.

Organism-specific databases

dictyBasei DDB_G0272869. sun1.

Phylogenomic databases

eggNOGi NOG285464.
InParanoidi Q558Z2.
OMAi VYSADKI.

Family and domain databases

InterProi IPR012919. Sad1_UNC_C.
[Graphical view ]
Pfami PF07738. Sad1_UNC. 1 hit.
[Graphical view ]
PROSITEi PS51469. SUN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability."
    Xiong H., Rivero F., Euteneuer U., Mondal S., Mana-Capelli S., Larochelle D., Vogel A., Gassen B., Noegel A.A.
    Traffic 9:708-724(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, SUBUNIT.
  4. "Dictyostelium Sun1 is a dynamic membrane protein of both nuclear membranes and required for centrosomal association with clustered centromeres."
    Schulz I., Baumann O., Samereier M., Zoglmeier C., Graef R.
    Eur. J. Cell Biol. 88:621-638(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiSUN1_DICDI
AccessioniPrimary (citable) accession number: Q558Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: May 24, 2005
Last modified: October 1, 2014
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3