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Q558Z2

- SUN1_DICDI

UniProt

Q558Z2 - SUN1_DICDI

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Protein

Sun domain-containing protein 1

Gene
sun1, DDB_G0272869
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

May have an important role in defining the spacing of the nuclear envelope lumen. Essential for centrosome attachment to the nucleus, maintenance of correct ploidy, proper mitosis, association of the centromere cluster with the centrosome and the maintenance of genome stability. Requires direct chromatin binding for inner nuclear membrane targeting.2 Publications

GO - Molecular functioni

  1. chromatin binding Source: dictyBase
  2. DNA binding Source: dictyBase
  3. protein homodimerization activity Source: dictyBase

GO - Biological processi

  1. centromere complex assembly Source: dictyBase
  2. centrosome localization Source: dictyBase
  3. centrosome organization Source: dictyBase
  4. mitotic sister chromatid segregation Source: dictyBase
  5. nucleus organization Source: dictyBase
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Mitosis

Names & Taxonomyi

Protein namesi
Recommended name:
Sun domain-containing protein 1
Gene namesi
Name:sun1
ORF Names:DDB_G0272869
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0272869. sun1.

Subcellular locationi

Nucleus membrane; Single-pass membrane protein; Nucleoplasmic side 2 Publications

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 290290Nuclear Reviewed predictionAdd
BLAST
Transmembranei291 – 31121Helical; Reviewed predictionAdd
BLAST
Topological domaini312 – 905594Perinuclear space Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. nuclear envelope Source: dictyBase
  3. nuclear inner membrane Source: dictyBase
  4. nuclear outer membrane Source: dictyBase
  5. nucleoplasm Source: dictyBase
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Nucleus

Pathology & Biotechi

Disruption phenotypei

Shows significant reduced growth.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 905905Sun domain-containing protein 1PRO_0000390618Add
BLAST

Proteomic databases

PRIDEiQ558Z2.

Interactioni

Subunit structurei

Homodimer and homooligomer.1 Publication

Protein-protein interaction databases

STRINGi44689.DDB_0219949.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini662 – 860199SUNAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili170 – 22152 Reviewed predictionAdd
BLAST
Coiled coili359 – 45698 Reviewed predictionAdd
BLAST
Coiled coili504 – 609106 Reviewed predictionAdd
BLAST
Coiled coili864 – 90138 Reviewed predictionAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi117 – 1204Poly-Asp
Compositional biasi177 – 21337Poly-GlnAdd
BLAST
Compositional biasi215 – 2217Poly-Asn
Compositional biasi224 – 2274Poly-Asn
Compositional biasi281 – 2844Poly-Asn
Compositional biasi567 – 5726Poly-Ser
Compositional biasi814 – 8196Poly-Thr

Sequence similaritiesi

Contains 1 SUN domain.

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG285464.
InParanoidiQ558Z2.
OMAiVYSADKI.

Family and domain databases

InterProiIPR012919. Sad1_UNC_C.
[Graphical view]
PfamiPF07738. Sad1_UNC. 1 hit.
[Graphical view]
PROSITEiPS51469. SUN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q558Z2-1 [UniParc]FASTAAdd to Basket

« Hide

MSGDYKPNYQ SSPSRKRLPL QSKDQASIYK YQTPSTLNLY NNTVNNNSSN    50
NSNNHLLHNS NPNSSYLYDS SKQYSNQINI RNNSNSNSNT NNITSKKASS 100
SYSINNKVDH NSHNNNDDDD IEDDVDINYS TNNASSNILH NRFSNSNKDD 150
SYIDYSTDEN PKILKQPQPL YNHLNNQIQQ QQQQQQQQQQ QQQQQQQQQQ 200
QQQQQQQQQQ QQQRNNNNNS NSSNNNNTST TIKRNNQQID NNSNKNIISK 250
FIGDPWKNFY YGSNKSLWPF ERNNNSNNSS NNNNKVNFKQ AIWIFIFSVL 300
FIGCLLGLFS TNFYGIHIYF PSFSTTKTNS PFNSTNNNIQ FSNLITKEQL 350
YPIIDEYFKK NEILKSYNKL FEKIENDIKY LSEREQYKDI INEIKEELKL 400
VKLSNMDEDR VNQLISKMIN HYNNNENNKQ ELKELLSKSI EELTKLKSDS 450
KEQLIQISTE SMNQLGQLKS ESINQLGQVK SESIDKFQST LKSLSKEEQS 500
KIEREFNHQF NQLNKDADQL LSQHSLKIEK LREEINENQQ SSLLKLTQEY 550
KQLEERLKEF SSKLQQSISS SSMDQFESWK LVFIKDIEER INKESSKLTN 600
QYIQLTQQFT KIQSFIKDNP SIDSLTNTIE SLEGIKLLIE DILEVYSADK 650
IAKVDYALGL AGASIEYNAL HYRVSETYPP IKGSGSGSGS GGANGNSLGL 700
YYYNLATNWI FPQPKPNPPE TILDPMVNTG SCWGFYTGNG TIVIRLAKKI 750
AITEVTMEHI SSNISHHIDS APKEFQVFGL INSSDIGQSL GVFTYDTTIN 800
RHLQTFKVNK IQSTTTTTTN QDQNDDDNIQ EFSHVALRIL SNHGYRYTCI 850
YRFRVHGYQI PHPEQEQIQI IQEEQSFKQE EINQQQIEQI EQIEQIEKQQ 900
QSDEL 905
Length:905
Mass (Da):104,743
Last modified:May 24, 2005 - v1
Checksum:i208FA7368F3280D2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000008 Genomic DNA. Translation: EAL71072.1.
RefSeqiXP_644924.1. XM_639832.1.

Genome annotation databases

EnsemblProtistsiDDB0219949; DDB0219949; DDB_G0272869.
GeneIDi8618603.
KEGGiddi:DDB_G0272869.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000008 Genomic DNA. Translation: EAL71072.1 .
RefSeqi XP_644924.1. XM_639832.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0219949.

Proteomic databases

PRIDEi Q558Z2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0219949 ; DDB0219949 ; DDB_G0272869 .
GeneIDi 8618603.
KEGGi ddi:DDB_G0272869.

Organism-specific databases

dictyBasei DDB_G0272869. sun1.

Phylogenomic databases

eggNOGi NOG285464.
InParanoidi Q558Z2.
OMAi VYSADKI.

Family and domain databases

InterProi IPR012919. Sad1_UNC_C.
[Graphical view ]
Pfami PF07738. Sad1_UNC. 1 hit.
[Graphical view ]
PROSITEi PS51469. SUN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  3. "Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability."
    Xiong H., Rivero F., Euteneuer U., Mondal S., Mana-Capelli S., Larochelle D., Vogel A., Gassen B., Noegel A.A.
    Traffic 9:708-724(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, SUBUNIT.
  4. "Dictyostelium Sun1 is a dynamic membrane protein of both nuclear membranes and required for centrosomal association with clustered centromeres."
    Schulz I., Baumann O., Samereier M., Zoglmeier C., Graef R.
    Eur. J. Cell Biol. 88:621-638(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiSUN1_DICDI
AccessioniPrimary (citable) accession number: Q558Z2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: May 24, 2005
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3