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Q558Z2 (SUN1_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 52. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Sun domain-containing protein 1
Gene names
Name:sun1
ORF Names:DDB_G0272869
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length905 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May have an important role in defining the spacing of the nuclear envelope lumen. Essential for centrosome attachment to the nucleus, maintenance of correct ploidy, proper mitosis, association of the centromere cluster with the centrosome and the maintenance of genome stability. Requires direct chromatin binding for inner nuclear membrane targeting. Ref.3 Ref.4

Subunit structure

Homodimer and homooligomer. Ref.3

Subcellular location

Nucleus membrane; Single-pass membrane protein; Nucleoplasmic side Ref.3 Ref.4.

Disruption phenotype

Shows significant reduced growth. Ref.4

Sequence similarities

Contains 1 SUN domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 905905Sun domain-containing protein 1
PRO_0000390618

Regions

Topological domain1 – 290290Nuclear Potential
Transmembrane291 – 31121Helical; Potential
Topological domain312 – 905594Perinuclear space Potential
Domain662 – 860199SUN
Coiled coil170 – 22152 Potential
Coiled coil359 – 45698 Potential
Coiled coil504 – 609106 Potential
Coiled coil864 – 90138 Potential
Compositional bias117 – 1204Poly-Asp
Compositional bias177 – 21337Poly-Gln
Compositional bias215 – 2217Poly-Asn
Compositional bias224 – 2274Poly-Asn
Compositional bias281 – 2844Poly-Asn
Compositional bias567 – 5726Poly-Ser
Compositional bias814 – 8196Poly-Thr

Sequences

Sequence LengthMass (Da)Tools
Q558Z2 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 208FA7368F3280D2

FASTA905104,743
        10         20         30         40         50         60 
MSGDYKPNYQ SSPSRKRLPL QSKDQASIYK YQTPSTLNLY NNTVNNNSSN NSNNHLLHNS 

        70         80         90        100        110        120 
NPNSSYLYDS SKQYSNQINI RNNSNSNSNT NNITSKKASS SYSINNKVDH NSHNNNDDDD 

       130        140        150        160        170        180 
IEDDVDINYS TNNASSNILH NRFSNSNKDD SYIDYSTDEN PKILKQPQPL YNHLNNQIQQ 

       190        200        210        220        230        240 
QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ QQQRNNNNNS NSSNNNNTST TIKRNNQQID 

       250        260        270        280        290        300 
NNSNKNIISK FIGDPWKNFY YGSNKSLWPF ERNNNSNNSS NNNNKVNFKQ AIWIFIFSVL 

       310        320        330        340        350        360 
FIGCLLGLFS TNFYGIHIYF PSFSTTKTNS PFNSTNNNIQ FSNLITKEQL YPIIDEYFKK 

       370        380        390        400        410        420 
NEILKSYNKL FEKIENDIKY LSEREQYKDI INEIKEELKL VKLSNMDEDR VNQLISKMIN 

       430        440        450        460        470        480 
HYNNNENNKQ ELKELLSKSI EELTKLKSDS KEQLIQISTE SMNQLGQLKS ESINQLGQVK 

       490        500        510        520        530        540 
SESIDKFQST LKSLSKEEQS KIEREFNHQF NQLNKDADQL LSQHSLKIEK LREEINENQQ 

       550        560        570        580        590        600 
SSLLKLTQEY KQLEERLKEF SSKLQQSISS SSMDQFESWK LVFIKDIEER INKESSKLTN 

       610        620        630        640        650        660 
QYIQLTQQFT KIQSFIKDNP SIDSLTNTIE SLEGIKLLIE DILEVYSADK IAKVDYALGL 

       670        680        690        700        710        720 
AGASIEYNAL HYRVSETYPP IKGSGSGSGS GGANGNSLGL YYYNLATNWI FPQPKPNPPE 

       730        740        750        760        770        780 
TILDPMVNTG SCWGFYTGNG TIVIRLAKKI AITEVTMEHI SSNISHHIDS APKEFQVFGL 

       790        800        810        820        830        840 
INSSDIGQSL GVFTYDTTIN RHLQTFKVNK IQSTTTTTTN QDQNDDDNIQ EFSHVALRIL 

       850        860        870        880        890        900 
SNHGYRYTCI YRFRVHGYQI PHPEQEQIQI IQEEQSFKQE EINQQQIEQI EQIEQIEKQQ 


QSDEL 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 2 of Dictyostelium discoideum."
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.
Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[3]"Dictyostelium Sun-1 connects the centrosome to chromatin and ensures genome stability."
Xiong H., Rivero F., Euteneuer U., Mondal S., Mana-Capelli S., Larochelle D., Vogel A., Gassen B., Noegel A.A.
Traffic 9:708-724(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TOPOLOGY, SUBUNIT.
[4]"Dictyostelium Sun1 is a dynamic membrane protein of both nuclear membranes and required for centrosomal association with clustered centromeres."
Schulz I., Baumann O., Samereier M., Zoglmeier C., Graef R.
Eur. J. Cell Biol. 88:621-638(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, FUNCTION, DISRUPTION PHENOTYPE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000008 Genomic DNA. Translation: EAL71072.1.
RefSeqXP_644924.1. XM_639832.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING44689.DDB_0219949.

Proteomic databases

PRIDEQ558Z2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0219949; DDB0219949; DDB_G0272869.
GeneID8618603.
KEGGddi:DDB_G0272869.

Organism-specific databases

dictyBaseDDB_G0272869. sun1.

Phylogenomic databases

eggNOGNOG285464.
InParanoidQ558Z2.
OMAVYSADKI.

Family and domain databases

InterProIPR012919. Sad1_UNC_C.
[Graphical view]
PfamPF07738. Sad1_UNC. 1 hit.
[Graphical view]
PROSITEPS51469. SUN. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSUN1_DICDI
AccessionPrimary (citable) accession number: Q558Z2
Entry history
Integrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: May 24, 2005
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase