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Protein

Probable arginine--tRNA ligase, cytoplasmic

Gene

argS1

Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis.By similarity

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei132L-arginineBy similarity1
Binding sitei332L-arginineBy similarity1
Binding sitei336L-arginineBy similarity1
Binding sitei360L-arginineBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Probable arginine--tRNA ligase, cytoplasmic (EC:6.1.1.19By similarity)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS1
Synonyms:argS
ORF Names:DDB_G0272867
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0272867 argS1

Subcellular locationi

  • Cytoplasm By similarity
  • cytosol By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003275211 – 589Probable arginine--tRNA ligase, cytoplasmicAdd BLAST589

Proteomic databases

PaxDbiQ558Z0

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0231324

Structurei

3D structure databases

ProteinModelPortaliQ558Z0
SMRiQ558Z0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni121 – 123L-arginine bindingBy similarity3
Regioni469 – 483Interaction with tRNABy similarityAdd BLAST15

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi121 – 132"HIGH" regionAdd BLAST12

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1195 Eukaryota
COG0018 LUCA
InParanoidiQ558Z0
KOiK01887
OMAiHGMSTRQ
PhylomeDBiQ558Z0

Family and domain databases

CDDicd00671 ArgRS_core, 1 hit
Gene3Di3.30.1360.70, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00123 Arg_tRNA_synth, 1 hit
InterProiView protein in InterPro
IPR001412 aa-tRNA-synth_I_CS
IPR001278 Arg-tRNA-ligase
IPR005148 Arg-tRNA-synth_N
IPR036695 Arg-tRNA-synth_N_sf
IPR035684 ArgRS_core
IPR008909 DALR_anticod-bd
IPR014729 Rossmann-like_a/b/a_fold
IPR009080 tRNAsynth_Ia_anticodon-bd
PANTHERiPTHR11956 PTHR11956, 1 hit
PfamiView protein in Pfam
PF03485 Arg_tRNA_synt_N, 1 hit
PF05746 DALR_1, 1 hit
PF00750 tRNA-synt_1d, 1 hit
PRINTSiPR01038 TRNASYNTHARG
SMARTiView protein in SMART
SM01016 Arg_tRNA_synt_N, 1 hit
SM00836 DALR_1, 1 hit
SUPFAMiSSF47323 SSF47323, 1 hit
SSF55190 SSF55190, 1 hit
TIGRFAMsiTIGR00456 argS, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q558Z0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFQEEIAKQL SVLTEIEANK ILECIESTKN KDMADFAVPI PKLNKFKKLV
60 70 80 90 100
GKPDQLAIDF ASKIQLNDCI QGASATGNYL NFKVNRLLQV QEILKEVINQ
110 120 130 140 150
KEKYGMTEQG KGKKVIVEFS SPNIAKPFHA GHLRSTIIGN FMVNLFNELA
160 170 180 190 200
YETVSMNYLG DWGKQYGLLA VGFEKYGSEE ELLADPIKHL YNVYVQINGE
210 220 230 240 250
AEKEEEAKKK YAEEIAAGVE PTAPLQTTPT IHDTARAYFK RMEDGDAEAL
260 270 280 290 300
AIWKRFRDLS IVKYKDIYNR LNVKFDIYAG ESLVTEGMTI EFKKLQDKNL
310 320 330 340 350
LEDSQGAKVI DLSKPNKLGK VLVQKTDGTT LYITRDIAAA VDRKNNIGFD
360 370 380 390 400
KMYYVVASQQ DFHFRQLFDI LGKMDYQWQK DLTHINYGMV KGMSTRKGTV
410 420 430 440 450
VFLEDILNKT QKKMLKIMKQ NEQKFAEIED PEKVADIVGL SAVVIQDFNA
460 470 480 490 500
KRNKDYDFNW DRMLKSDGDT GPYLQYAHAR LCSLERKSGF EFNPNANLSL
510 520 530 540 550
LSEPEAFNLA ITIGRYPEII QLTHNQLEPS TLVGYLFELA HAVSSAHQVL
560 570 580
WIKDREKDVA EARFVLYWAA KVILGSGLRI LGLVPLERM
Length:589
Mass (Da):67,044
Last modified:May 24, 2005 - v1
Checksum:i557A91F67E0F08DE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000008 Genomic DNA Translation: EAL71071.1
RefSeqiXP_644926.1, XM_639834.1

Genome annotation databases

EnsemblProtistsiEAL71071; EAL71071; DDB_G0272867
GeneIDi8618605
KEGGiddi:DDB_G0272867

Entry informationi

Entry nameiSYRC_DICDI
AccessioniPrimary (citable) accession number: Q558Z0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: March 28, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health