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Q55894

- THIC_SYNY3

UniProt

Q55894 - THIC_SYNY3

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Protein

Phosphomethylpyrimidine synthase

Gene

thiC

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction.UniRule annotation

Catalytic activityi

5-amino-1-(5-phospho-D-ribosyl)imidazole + S-adenosyl-L-methionine = 4-amino-2-methyl-5-phosphomethylpyrimidine + 5'-deoxyadenosine + L-methionine + formate + CO.UniRule annotation

Cofactori

Binds 1 4Fe-4S cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801SubstrateUniRule annotation
Binding sitei109 – 1091SubstrateUniRule annotation
Binding sitei139 – 1391SubstrateUniRule annotation
Binding sitei175 – 1751SubstrateUniRule annotation
Binding sitei275 – 2751SubstrateUniRule annotation
Metal bindingi279 – 2791ZincUniRule annotation
Binding sitei302 – 3021SubstrateUniRule annotation
Metal bindingi343 – 3431ZincUniRule annotation
Metal bindingi423 – 4231Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation
Metal bindingi426 – 4261Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation
Metal bindingi431 – 4311Iron-sulfur (4Fe-4S-S-AdoMet)UniRule annotation

GO - Molecular functioni

  1. 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
  2. lyase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. thiamine biosynthetic process Source: UniProtKB-HAMAP
  2. thiamine diphosphate biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Thiamine biosynthesis

Keywords - Ligandi

4Fe-4S, Iron, Iron-sulfur, Metal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

UniPathwayiUPA00060.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphomethylpyrimidine synthaseUniRule annotation (EC:4.1.99.17UniRule annotation)
Alternative name(s):
Hydroxymethylpyrimidine phosphate synthaseUniRule annotation
Short name:
HMP-P synthaseUniRule annotation
Short name:
HMP-phosphate synthaseUniRule annotation
Short name:
HMPP synthaseUniRule annotation
Thiamine biosynthesis protein ThiCUniRule annotation
Gene namesi
Name:thiCUniRule annotation
Ordered Locus Names:slr0118
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 459459Phosphomethylpyrimidine synthasePRO_0000152842Add
BLAST

Proteomic databases

PaxDbiQ55894.

Interactioni

Protein-protein interaction databases

IntActiQ55894. 1 interaction.
STRINGi1148.slr0118.

Structurei

3D structure databases

ProteinModelPortaliQ55894.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni195 – 1973Substrate bindingUniRule annotation
Regioni236 – 2394Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the ThiC family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0422.
HOGENOMiHOG000224483.
InParanoidiQ55894.
KOiK03147.
OMAiWERQFEL.
OrthoDBiEOG6NWBM5.
PhylomeDBiQ55894.

Family and domain databases

HAMAPiMF_00089. ThiC.
InterProiIPR002817. ThiC.
[Graphical view]
PfamiPF01964. ThiC. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00190. thiC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55894-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRTAWVAKRQ GQTNVSQMHY ARKGVITEEM DYVAKRENLP VELIKDEVAR
60 70 80 90 100
GRMIIPANIN HTNLEPMAIG IASKCKVNAN IGASPNSSNI DEEVEKLLLS
110 120 130 140 150
VKYGADTVMD LSTGGGDLDV IRTAIINASP VPIGTVPIYQ ALESVHGSIE
160 170 180 190 200
NLTPDDFLHI IEKHAQQGVD YMTIHAGLLI EYLPLVKSRI TGIVSRGGGI
210 220 230 240 250
IAKWMLHHHK QNPLYTHFDE IIEIFKKYDV SFSLGDSLRP GCTHDASDDA
260 270 280 290 300
QLSELKTLGQ LTRRAWEHDV QVMVEGPGHV PIDQIEFNVK KQMEECSEAP
310 320 330 340 350
FYVLGPLVTD IAPGYDHITS AIGAAIAGWH GTAMLCYVTP KEHLGLPNAE
360 370 380 390 400
DVRNGLIAYK IAAHAADIAR HRPGARDRDD ELSKARYNFD WNRQFELSLD
410 420 430 440 450
PERAKEYHDE TLPADIYKTA EFCSMCGPKF CPMQTKVDAE MLEELEVFLA

KDKEMVSQR
Length:459
Mass (Da):51,137
Last modified:November 1, 1996 - v1
Checksum:i4819258FC5DBADA8
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA10656.1.
PIRiS76712.
RefSeqiNP_442586.1. NC_000911.1.
YP_005652647.1. NC_017277.1.
YP_007452462.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA10656; BAA10656; BAA10656.
GeneIDi952254.
KEGGisyn:slr0118.
syy:SYNGTS_2694.
syz:MYO_127200.
PATRICi23842900. VBISynSp132158_2988.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
BA000022 Genomic DNA. Translation: BAA10656.1 .
PIRi S76712.
RefSeqi NP_442586.1. NC_000911.1.
YP_005652647.1. NC_017277.1.
YP_007452462.1. NC_020286.1.

3D structure databases

ProteinModelPortali Q55894.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q55894. 1 interaction.
STRINGi 1148.slr0118.

Proteomic databases

PaxDbi Q55894.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA10656 ; BAA10656 ; BAA10656 .
GeneIDi 952254.
KEGGi syn:slr0118.
syy:SYNGTS_2694.
syz:MYO_127200.
PATRICi 23842900. VBISynSp132158_2988.

Phylogenomic databases

eggNOGi COG0422.
HOGENOMi HOG000224483.
InParanoidi Q55894.
KOi K03147.
OMAi WERQFEL.
OrthoDBi EOG6NWBM5.
PhylomeDBi Q55894.

Enzyme and pathway databases

UniPathwayi UPA00060 .

Family and domain databases

HAMAPi MF_00089. ThiC.
InterProi IPR002817. ThiC.
[Graphical view ]
Pfami PF01964. ThiC. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00190. thiC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
    Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
    DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27184 / PCC 6803 / N-1.
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiTHIC_SYNY3
AccessioniPrimary (citable) accession number: Q55894
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3