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Q55863

- KPYK1_SYNY3

UniProt

Q55863 - KPYK1_SYNY3

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Protein

Pyruvate kinase 1

Gene

pyk1

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Protein has several cofactor binding sites:

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei46 – 461SubstrateBy similarity
Metal bindingi48 – 481PotassiumBy similarity
Metal bindingi50 – 501PotassiumBy similarity
Metal bindingi80 – 801PotassiumBy similarity
Sitei233 – 2331Transition state stabilizerBy similarity
Metal bindingi235 – 2351MagnesiumBy similarity
Binding sitei258 – 2581Substrate; via amide nitrogenBy similarity
Metal bindingi259 – 2591MagnesiumBy similarity
Binding sitei259 – 2591Substrate; via amide nitrogenBy similarity
Binding sitei291 – 2911SubstrateBy similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase 1 (EC:2.7.1.40)
Short name:
PK 1
Gene namesi
Name:pyk1
Ordered Locus Names:sll0587
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 483483Pyruvate kinase 1PRO_0000112085Add
BLAST

Proteomic databases

PaxDbiQ55863.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

IntActiQ55863. 1 interaction.
STRINGi1148.sll0587.

Structurei

3D structure databases

ProteinModelPortaliQ55863.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.Curated

Phylogenomic databases

eggNOGiCOG0469.
HOGENOMiHOG000021558.
InParanoidiQ55863.
KOiK00873.
OMAiCVTRNEQ.
OrthoDBiEOG6GBMB0.
PhylomeDBiQ55863.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55863-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MPALINPVKF MRPLSHRTKI VATIGPASSS VEVIRQMVDA GMNVARLNFS
60 70 80 90 100
HGSYEDHATM VRLLRSVEQE MDTPITLLQD LQGPKIRIGQ LPGGEKQLRE
110 120 130 140 150
GEKVSLVPVE IGDRHPGAVG IDYPHLATEA KVGERILLDD GLLEMKVVSI
160 170 180 190 200
QDPEVICEVV TGGILKSRKG VNLPGLVLTL PSMTTKDKQD LEFGLSQGID
210 220 230 240 250
WVSLSFVRKG EDIHTLKQFL AERGHPDLPV IAKIEKPQAI DNLEEIVAVS
260 270 280 290 300
NGIMVARGDL GVEVNPEKVP RLQKEIIRRC NVRAIPVITA TQMLDSMIQN
310 320 330 340 350
SRPTRAEASD VANAILDGTD AVMLSGESAV GQYPVKSVQM LRKIAEETEV
360 370 380 390 400
GLHLVNNPPI ENTETHALSE ALVVIDGILD LKYIVTFTTS GFTSLLASNQ
410 420 430 440 450
RPSVPVIAFT PSEKVYHSLN LVWGIIPFLI NEEFDTFEDL IQQAEVLLRD
460 470 480
RKMVEKGDQL LIMAGIPTKI PRGTNFLKIH RIS
Length:483
Mass (Da):53,105
Last modified:November 1, 1997 - v1
Checksum:iF53C2D402CCB8445
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10621.1.
PIRiS76677.
RefSeqiNP_442551.1. NC_000911.1.
YP_005652612.1. NC_017277.1.
YP_007452427.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA10621; BAA10621; BAA10621.
GeneIDi952279.
KEGGisyn:sll0587.
PATRICi23842826. VBISynSp132158_2952.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10621.1 .
PIRi S76677.
RefSeqi NP_442551.1. NC_000911.1.
YP_005652612.1. NC_017277.1.
YP_007452427.1. NC_020286.1.

3D structure databases

ProteinModelPortali Q55863.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q55863. 1 interaction.
STRINGi 1148.sll0587.

Proteomic databases

PaxDbi Q55863.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA10621 ; BAA10621 ; BAA10621 .
GeneIDi 952279.
KEGGi syn:sll0587.
PATRICi 23842826. VBISynSp132158_2952.

Phylogenomic databases

eggNOGi COG0469.
HOGENOMi HOG000021558.
InParanoidi Q55863.
KOi K00873.
OMAi CVTRNEQ.
OrthoDBi EOG6GBMB0.
PhylomeDBi Q55863.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR018209. Pyrv_Knase_AS.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
    Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
    DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27184 / PCC 6803 / N-1.
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiKPYK1_SYNY3
AccessioniPrimary (citable) accession number: Q55863
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3