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Q55863

- KPYK1_SYNY3

UniProt

Q55863 - KPYK1_SYNY3

Protein

Pyruvate kinase 1

Gene

pyk1

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + pyruvate = ADP + phosphoenolpyruvate.

    Cofactori

    Magnesium.
    Potassium.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei46 – 461SubstrateBy similarity
    Metal bindingi48 – 481PotassiumBy similarity
    Metal bindingi50 – 501PotassiumBy similarity
    Metal bindingi80 – 801PotassiumBy similarity
    Sitei233 – 2331Transition state stabilizerBy similarity
    Metal bindingi235 – 2351MagnesiumBy similarity
    Binding sitei258 – 2581Substrate; via amide nitrogenBy similarity
    Metal bindingi259 – 2591MagnesiumBy similarity
    Binding sitei259 – 2591Substrate; via amide nitrogenBy similarity
    Binding sitei291 – 2911SubstrateBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. magnesium ion binding Source: InterPro
    3. potassium ion binding Source: InterPro
    4. pyruvate kinase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycolysis

    Keywords - Ligandi

    ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

    Enzyme and pathway databases

    UniPathwayiUPA00109; UER00188.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvate kinase 1 (EC:2.7.1.40)
    Short name:
    PK 1
    Gene namesi
    Name:pyk1
    Ordered Locus Names:sll0587
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 483483Pyruvate kinase 1PRO_0000112085Add
    BLAST

    Proteomic databases

    PaxDbiQ55863.

    Interactioni

    Subunit structurei

    Homotetramer.By similarity

    Protein-protein interaction databases

    IntActiQ55863. 1 interaction.
    STRINGi1148.sll0587.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55863.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the pyruvate kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0469.
    HOGENOMiHOG000021558.
    KOiK00873.
    OMAiCVTRNEQ.
    OrthoDBiEOG6GBMB0.
    PhylomeDBiQ55863.

    Family and domain databases

    Gene3Di2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProiIPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view]
    PANTHERiPTHR11817. PTHR11817. 1 hit.
    PfamiPF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view]
    PRINTSiPR01050. PYRUVTKNASE.
    SUPFAMiSSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.
    PROSITEiPS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q55863-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPALINPVKF MRPLSHRTKI VATIGPASSS VEVIRQMVDA GMNVARLNFS    50
    HGSYEDHATM VRLLRSVEQE MDTPITLLQD LQGPKIRIGQ LPGGEKQLRE 100
    GEKVSLVPVE IGDRHPGAVG IDYPHLATEA KVGERILLDD GLLEMKVVSI 150
    QDPEVICEVV TGGILKSRKG VNLPGLVLTL PSMTTKDKQD LEFGLSQGID 200
    WVSLSFVRKG EDIHTLKQFL AERGHPDLPV IAKIEKPQAI DNLEEIVAVS 250
    NGIMVARGDL GVEVNPEKVP RLQKEIIRRC NVRAIPVITA TQMLDSMIQN 300
    SRPTRAEASD VANAILDGTD AVMLSGESAV GQYPVKSVQM LRKIAEETEV 350
    GLHLVNNPPI ENTETHALSE ALVVIDGILD LKYIVTFTTS GFTSLLASNQ 400
    RPSVPVIAFT PSEKVYHSLN LVWGIIPFLI NEEFDTFEDL IQQAEVLLRD 450
    RKMVEKGDQL LIMAGIPTKI PRGTNFLKIH RIS 483
    Length:483
    Mass (Da):53,105
    Last modified:November 1, 1997 - v1
    Checksum:iF53C2D402CCB8445
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10621.1.
    PIRiS76677.
    RefSeqiNP_442551.1. NC_000911.1.
    YP_005652612.1. NC_017277.1.
    YP_007452427.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA10621; BAA10621; BAA10621.
    GeneIDi952279.
    KEGGisyn:sll0587.
    syy:SYNGTS_2659.
    syz:MYO_126840.
    PATRICi23842826. VBISynSp132158_2952.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10621.1 .
    PIRi S76677.
    RefSeqi NP_442551.1. NC_000911.1.
    YP_005652612.1. NC_017277.1.
    YP_007452427.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali Q55863.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q55863. 1 interaction.
    STRINGi 1148.sll0587.

    Proteomic databases

    PaxDbi Q55863.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA10621 ; BAA10621 ; BAA10621 .
    GeneIDi 952279.
    KEGGi syn:sll0587.
    syy:SYNGTS_2659.
    syz:MYO_126840.
    PATRICi 23842826. VBISynSp132158_2952.

    Phylogenomic databases

    eggNOGi COG0469.
    HOGENOMi HOG000021558.
    KOi K00873.
    OMAi CVTRNEQ.
    OrthoDBi EOG6GBMB0.
    PhylomeDBi Q55863.

    Enzyme and pathway databases

    UniPathwayi UPA00109 ; UER00188 .

    Family and domain databases

    Gene3Di 2.40.33.10. 1 hit.
    3.20.20.60. 2 hits.
    3.40.1380.20. 1 hit.
    InterProi IPR001697. Pyr_Knase.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    IPR011037. Pyrv_Knase-like_insert_dom.
    IPR015794. Pyrv_Knase_a/b.
    IPR018209. Pyrv_Knase_AS.
    IPR015793. Pyrv_Knase_brl.
    IPR015795. Pyrv_Knase_C.
    IPR015806. Pyrv_Knase_insert_dom.
    [Graphical view ]
    PANTHERi PTHR11817. PTHR11817. 1 hit.
    Pfami PF00224. PK. 1 hit.
    PF02887. PK_C. 1 hit.
    [Graphical view ]
    PRINTSi PR01050. PYRUVTKNASE.
    SUPFAMi SSF50800. SSF50800. 1 hit.
    SSF51621. SSF51621. 2 hits.
    SSF52935. SSF52935. 1 hit.
    TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
    PROSITEi PS00110. PYRUVATE_KINASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
      Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
      DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27184 / PCC 6803 / N-1.
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiKPYK1_SYNY3
    AccessioniPrimary (citable) accession number: Q55863
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3