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Q55860

- COBQ_SYNY3

UniProt

Q55860 - COBQ_SYNY3

Protein

Cobyric acid synthase

Gene

cobQ

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation By similarity.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei331 – 3311NucleophileBy similarity
    Active sitei431 – 4311By similarity

    GO - Molecular functioni

    1. cobalamin-transporting ATPase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. cobalamin biosynthetic process Source: UniProtKB-HAMAP
    2. glutamine metabolic process Source: UniProtKB-HAMAP

    Keywords - Biological processi

    Cobalamin biosynthesis

    Enzyme and pathway databases

    UniPathwayiUPA00148.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cobyric acid synthase
    Gene namesi
    Name:cobQ
    Synonyms:cbiP
    Ordered Locus Names:slr0618
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498Cobyric acid synthasePRO_0000141336Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    IntActiQ55860. 1 interaction.
    STRINGi1148.slr0618.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55860.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini250 – 439190GATase cobBQ-typeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the CobB/CobQ family. CobQ subfamily.Curated
    Contains 1 GATase cobBQ-type domain.Curated

    Keywords - Domaini

    Glutamine amidotransferase

    Phylogenomic databases

    eggNOGiCOG1492.
    HOGENOMiHOG000224803.
    KOiK02232.
    OMAiYPRTSNH.
    OrthoDBiEOG6M9F07.
    PhylomeDBiQ55860.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPiMF_00028. CobQ.
    InterProiIPR029062. Class_I_gatase-like.
    IPR017929. CobB/CobQ_GATase.
    IPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom.
    IPR004459. CobQ_synth.
    IPR011698. GATase_3.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01656. CbiA. 1 hit.
    PF07685. GATase_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF52317. SSF52317. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00313. cobQ. 1 hit.
    PROSITEiPS51274. GATASE_COBBQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q55860-1 [UniParc]FASTAAdd to Basket

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    MKAIMVVGTT SHAGKSFLTT GLCRLLRRRG DRVTPFKGQN MALNAFVTID    50
    GGEMGHAQAV QAWAAGTVPR VAMNPILLKP QGDMTSQVIM LGQAVGTTRA 100
    QEYYQNYFDR GWQAIANSLE TLAQDFDVVV CEGAGSPAEI NLKHRDLTNM 150
    RVATHLQAAT ILIADIDRGG VFAHVVGTLQ LLEPEERKLI KGIVINKFRG 200
    QRSLLDSGIT WLEEYTGIPV LGVIPYGQNL FSAEDSLDIL ERSGRPSKED 250
    IRIVVLRLPR IANFTDFEPL EAESGVYVDY LPLEKQLGNP DAVIIPGSKT 300
    TIADLQALQN SGMAQQIMDY AQAGGTVMGI CGGYQMLGQT IADPENIEGN 350
    VSNCQGLGLL PLTTVINQEK ITRQCQTITH APPSGLTVTG YEIHQGLSRR 400
    SEHSQDFLPM FDQEELGMVN AQQNLWGCYL HGLFDNGAWR RCWLNNLRQR 450
    RGLDPLPTSI GNYQEQREGM LDSLADFVET HVNLEPILQS LPEENETP 498
    Length:498
    Mass (Da):54,813
    Last modified:May 30, 2000 - v2
    Checksum:iAA265C71E2829299
    GO

    Sequence cautioni

    The sequence BAA10617.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10617.1. Different initiation.
    PIRiS76673.
    RefSeqiNP_442547.1. NC_000911.1.
    YP_007452423.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA10617; BAA10617; BAA10617.
    GeneIDi954919.
    KEGGisyn:slr0618.
    syz:MYO_126800.
    PATRICi23842818. VBISynSp132158_2948.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10617.1 . Different initiation.
    PIRi S76673.
    RefSeqi NP_442547.1. NC_000911.1.
    YP_007452423.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali Q55860.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q55860. 1 interaction.
    STRINGi 1148.slr0618.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA10617 ; BAA10617 ; BAA10617 .
    GeneIDi 954919.
    KEGGi syn:slr0618.
    syz:MYO_126800.
    PATRICi 23842818. VBISynSp132158_2948.

    Phylogenomic databases

    eggNOGi COG1492.
    HOGENOMi HOG000224803.
    KOi K02232.
    OMAi YPRTSNH.
    OrthoDBi EOG6M9F07.
    PhylomeDBi Q55860.

    Enzyme and pathway databases

    UniPathwayi UPA00148 .

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    3.40.50.880. 1 hit.
    HAMAPi MF_00028. CobQ.
    InterProi IPR029062. Class_I_gatase-like.
    IPR017929. CobB/CobQ_GATase.
    IPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom.
    IPR004459. CobQ_synth.
    IPR011698. GATase_3.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01656. CbiA. 1 hit.
    PF07685. GATase_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52317. SSF52317. 1 hit.
    SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00313. cobQ. 1 hit.
    PROSITEi PS51274. GATASE_COBBQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
      Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
      DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 27184 / PCC 6803 / N-1.
    2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiCOBQ_SYNY3
    AccessioniPrimary (citable) accession number: Q55860
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3