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Q55860 (COBQ_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cobyric acid synthase
Gene names
Name:cobQ
Synonyms:cbiP
Ordered Locus Names:slr0618
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation By similarity. HAMAP-Rule MF_00028

Pathway

Cofactor biosynthesis; adenosylcobalamin biosynthesis. HAMAP-Rule MF_00028

Sequence similarities

Belongs to the CobB/CobQ family. CobQ subfamily.

Contains 1 GATase cobBQ-type domain.

Sequence caution

The sequence BAA10617.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Cobyric acid synthase HAMAP-Rule MF_00028
PRO_0000141336

Regions

Domain250 – 439190GATase cobBQ-type

Sites

Active site3311Nucleophile By similarity
Active site4311 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q55860 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: AA265C71E2829299

FASTA49854,813
        10         20         30         40         50         60 
MKAIMVVGTT SHAGKSFLTT GLCRLLRRRG DRVTPFKGQN MALNAFVTID GGEMGHAQAV 

        70         80         90        100        110        120 
QAWAAGTVPR VAMNPILLKP QGDMTSQVIM LGQAVGTTRA QEYYQNYFDR GWQAIANSLE 

       130        140        150        160        170        180 
TLAQDFDVVV CEGAGSPAEI NLKHRDLTNM RVATHLQAAT ILIADIDRGG VFAHVVGTLQ 

       190        200        210        220        230        240 
LLEPEERKLI KGIVINKFRG QRSLLDSGIT WLEEYTGIPV LGVIPYGQNL FSAEDSLDIL 

       250        260        270        280        290        300 
ERSGRPSKED IRIVVLRLPR IANFTDFEPL EAESGVYVDY LPLEKQLGNP DAVIIPGSKT 

       310        320        330        340        350        360 
TIADLQALQN SGMAQQIMDY AQAGGTVMGI CGGYQMLGQT IADPENIEGN VSNCQGLGLL 

       370        380        390        400        410        420 
PLTTVINQEK ITRQCQTITH APPSGLTVTG YEIHQGLSRR SEHSQDFLPM FDQEELGMVN 

       430        440        450        460        470        480 
AQQNLWGCYL HGLFDNGAWR RCWLNNLRQR RGLDPLPTSI GNYQEQREGM LDSLADFVET 

       490 
HVNLEPILQS LPEENETP 

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27184 / PCC 6803 / N-1.
[2]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BA000022 Genomic DNA. Translation: BAA10617.1. Different initiation.
PIRS76673.
RefSeqNP_442547.1. NC_000911.1.
YP_007452423.1. NC_020286.1.

3D structure databases

ProteinModelPortalQ55860.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ55860. 1 interaction.
STRING1148.slr0618.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA10617; BAA10617; BAA10617.
GeneID14618104.
954919.
KEGGsyn:slr0618.
syz:MYO_126800.
PATRIC23842818. VBISynSp132158_2948.

Phylogenomic databases

eggNOGCOG1492.
HOGENOMHOG000224803.
KOK02232.
OMAAHTDLNP.
OrthoDBEOG6M9F07.
PhylomeDBQ55860.
ProtClustDBPRK00784.

Enzyme and pathway databases

UniPathwayUPA00148.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00028. CobQ.
InterProIPR017929. CobB/CobQ_GATase.
IPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom.
IPR004459. CobQ_synth.
IPR011698. GATase_3.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01656. CbiA. 1 hit.
PF07685. GATase_3. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
TIGRFAMsTIGR00313. cobQ. 1 hit.
PROSITEPS51274. GATASE_COBBQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCOBQ_SYNY3
AccessionPrimary (citable) accession number: Q55860
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: April 16, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways