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Q55860

- COBQ_SYNY3

UniProt

Q55860 - COBQ_SYNY3

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Protein

Cobyric acid synthase

Gene

cobQ

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity).By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei331 – 3311NucleophileBy similarity
Active sitei431 – 4311By similarity

GO - Molecular functioni

  1. cobalamin-transporting ATPase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cobalamin biosynthetic process Source: UniProtKB-HAMAP
  2. glutamine metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Biological processi

Cobalamin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00148.

Names & Taxonomyi

Protein namesi
Recommended name:
Cobyric acid synthase
Gene namesi
Name:cobQ
Synonyms:cbiP
Ordered Locus Names:slr0618
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Cobyric acid synthasePRO_0000141336Add
BLAST

Interactioni

Protein-protein interaction databases

IntActiQ55860. 1 interaction.
STRINGi1148.slr0618.

Structurei

3D structure databases

ProteinModelPortaliQ55860.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini250 – 439190GATase cobBQ-typeAdd
BLAST

Sequence similaritiesi

Belongs to the CobB/CobQ family. CobQ subfamily.Curated
Contains 1 GATase cobBQ-type domain.Curated

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

eggNOGiCOG1492.
HOGENOMiHOG000224803.
InParanoidiQ55860.
KOiK02232.
OMAiYPRTSNH.
OrthoDBiEOG6M9F07.
PhylomeDBiQ55860.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPiMF_00028. CobQ.
InterProiIPR029062. Class_I_gatase-like.
IPR017929. CobB/CobQ_GATase.
IPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom.
IPR004459. CobQ_synth.
IPR011698. GATase_3.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01656. CbiA. 1 hit.
PF07685. GATase_3. 1 hit.
[Graphical view]
SUPFAMiSSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00313. cobQ. 1 hit.
PROSITEiPS51274. GATASE_COBBQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55860-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKAIMVVGTT SHAGKSFLTT GLCRLLRRRG DRVTPFKGQN MALNAFVTID
60 70 80 90 100
GGEMGHAQAV QAWAAGTVPR VAMNPILLKP QGDMTSQVIM LGQAVGTTRA
110 120 130 140 150
QEYYQNYFDR GWQAIANSLE TLAQDFDVVV CEGAGSPAEI NLKHRDLTNM
160 170 180 190 200
RVATHLQAAT ILIADIDRGG VFAHVVGTLQ LLEPEERKLI KGIVINKFRG
210 220 230 240 250
QRSLLDSGIT WLEEYTGIPV LGVIPYGQNL FSAEDSLDIL ERSGRPSKED
260 270 280 290 300
IRIVVLRLPR IANFTDFEPL EAESGVYVDY LPLEKQLGNP DAVIIPGSKT
310 320 330 340 350
TIADLQALQN SGMAQQIMDY AQAGGTVMGI CGGYQMLGQT IADPENIEGN
360 370 380 390 400
VSNCQGLGLL PLTTVINQEK ITRQCQTITH APPSGLTVTG YEIHQGLSRR
410 420 430 440 450
SEHSQDFLPM FDQEELGMVN AQQNLWGCYL HGLFDNGAWR RCWLNNLRQR
460 470 480 490
RGLDPLPTSI GNYQEQREGM LDSLADFVET HVNLEPILQS LPEENETP
Length:498
Mass (Da):54,813
Last modified:May 30, 2000 - v2
Checksum:iAA265C71E2829299
GO

Sequence cautioni

The sequence BAA10617.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10617.1. Different initiation.
PIRiS76673.
RefSeqiNP_442547.1. NC_000911.1.
YP_007452423.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA10617; BAA10617; BAA10617.
GeneIDi954919.
KEGGisyn:slr0618.
PATRICi23842818. VBISynSp132158_2948.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10617.1 . Different initiation.
PIRi S76673.
RefSeqi NP_442547.1. NC_000911.1.
YP_007452423.1. NC_020286.1.

3D structure databases

ProteinModelPortali Q55860.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q55860. 1 interaction.
STRINGi 1148.slr0618.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA10617 ; BAA10617 ; BAA10617 .
GeneIDi 954919.
KEGGi syn:slr0618.
PATRICi 23842818. VBISynSp132158_2948.

Phylogenomic databases

eggNOGi COG1492.
HOGENOMi HOG000224803.
InParanoidi Q55860.
KOi K02232.
OMAi YPRTSNH.
OrthoDBi EOG6M9F07.
PhylomeDBi Q55860.

Enzyme and pathway databases

UniPathwayi UPA00148 .

Family and domain databases

Gene3Di 3.40.50.300. 1 hit.
3.40.50.880. 1 hit.
HAMAPi MF_00028. CobQ.
InterProi IPR029062. Class_I_gatase-like.
IPR017929. CobB/CobQ_GATase.
IPR002586. CobQ/CobB/MinD/ParA_Nub-bd_dom.
IPR004459. CobQ_synth.
IPR011698. GATase_3.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01656. CbiA. 1 hit.
PF07685. GATase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF52317. SSF52317. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsi TIGR00313. cobQ. 1 hit.
PROSITEi PS51274. GATASE_COBBQ. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
    Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
    DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27184 / PCC 6803 / N-1.
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiCOBQ_SYNY3
AccessioniPrimary (citable) accession number: Q55860
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: November 26, 2014
This is version 93 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3