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Protein

Cobyric acid synthase

Gene

cobQ

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH2 groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity).By similarity

Pathwayi: adenosylcobalamin biosynthesis

This protein is involved in the pathway adenosylcobalamin biosynthesis, which is part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the pathway adenosylcobalamin biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei331NucleophileBy similarity1
Active sitei431By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCobalamin biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00148

Names & Taxonomyi

Protein namesi
Recommended name:
Cobyric acid synthase
Gene namesi
Name:cobQ
Synonyms:cbiP
Ordered Locus Names:slr0618
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001413361 – 498Cobyric acid synthaseAdd BLAST498

Proteomic databases

PaxDbiQ55860
PRIDEiQ55860

Interactioni

Protein-protein interaction databases

IntActiQ55860, 1 interactor
STRINGi1148.SYNGTS_2655

Structurei

3D structure databases

ProteinModelPortaliQ55860
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini250 – 439GATase cobBQ-typeAdd BLAST190

Sequence similaritiesi

Belongs to the CobB/CobQ family. CobQ subfamily.Curated

Keywords - Domaini

Glutamine amidotransferase

Phylogenomic databases

HOGENOMiHOG000224803
InParanoidiQ55860
KOiK02232
OMAiQVIIHGR
PhylomeDBiQ55860

Family and domain databases

CDDicd01750 GATase1_CobQ, 1 hit
Gene3Di3.40.50.880, 1 hit
HAMAPiMF_00028 CobQ, 1 hit
InterProiView protein in InterPro
IPR029062 Class_I_gatase-like
IPR017929 CobB/CobQ_GATase
IPR002586 CobQ/CobB/MinD/ParA_Nub-bd_dom
IPR033949 CobQ_GATase1
IPR004459 CobQ_synth
IPR011698 GATase_3
IPR027417 P-loop_NTPase
PANTHERiPTHR21343:SF1 PTHR21343:SF1, 1 hit
PfamiView protein in Pfam
PF01656 CbiA, 1 hit
PF07685 GATase_3, 1 hit
SUPFAMiSSF52317 SSF52317, 1 hit
SSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00313 cobQ, 1 hit
PROSITEiView protein in PROSITE
PS51274 GATASE_COBBQ, 1 hit

Sequencei

Sequence statusi: Complete.

Q55860-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAIMVVGTT SHAGKSFLTT GLCRLLRRRG DRVTPFKGQN MALNAFVTID
60 70 80 90 100
GGEMGHAQAV QAWAAGTVPR VAMNPILLKP QGDMTSQVIM LGQAVGTTRA
110 120 130 140 150
QEYYQNYFDR GWQAIANSLE TLAQDFDVVV CEGAGSPAEI NLKHRDLTNM
160 170 180 190 200
RVATHLQAAT ILIADIDRGG VFAHVVGTLQ LLEPEERKLI KGIVINKFRG
210 220 230 240 250
QRSLLDSGIT WLEEYTGIPV LGVIPYGQNL FSAEDSLDIL ERSGRPSKED
260 270 280 290 300
IRIVVLRLPR IANFTDFEPL EAESGVYVDY LPLEKQLGNP DAVIIPGSKT
310 320 330 340 350
TIADLQALQN SGMAQQIMDY AQAGGTVMGI CGGYQMLGQT IADPENIEGN
360 370 380 390 400
VSNCQGLGLL PLTTVINQEK ITRQCQTITH APPSGLTVTG YEIHQGLSRR
410 420 430 440 450
SEHSQDFLPM FDQEELGMVN AQQNLWGCYL HGLFDNGAWR RCWLNNLRQR
460 470 480 490
RGLDPLPTSI GNYQEQREGM LDSLADFVET HVNLEPILQS LPEENETP
Length:498
Mass (Da):54,813
Last modified:May 30, 2000 - v2
Checksum:iAA265C71E2829299
GO

Sequence cautioni

The sequence BAA10617 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA10617.1 Different initiation.
PIRiS76673

Genome annotation databases

EnsemblBacteriaiBAA10617; BAA10617; BAA10617
KEGGisyn:slr0618

Similar proteinsi

Entry informationi

Entry nameiCOBQ_SYNY3
AccessioniPrimary (citable) accession number: Q55860
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: May 23, 2018
This is version 111 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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