ID   CYSR_SYNY3              Reviewed;         205 AA.
AC   Q55854;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   27-MAR-2024, entry version 133.
DE   RecName: Full=Regulatory protein CysR homolog;
GN   Name=cysR; OrderedLocusNames=sll0594;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Synechococcales; Merismopediaceae;
OC   Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 27184 / PCC 6803 / N-1;
RX   PubMed=8590279; DOI=10.1093/dnares/2.4.153;
RA   Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N.,
RA   Sugiura M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region
RT   from map positions 64% to 92% of the genome.";
RL   DNA Res. 2:153-166(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Probably regulates the expression of genes from the sulfate
CC       permease complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
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DR   EMBL; BA000022; BAA10610.1; -; Genomic_DNA.
DR   PIR; S76666; S76666.
DR   AlphaFoldDB; Q55854; -.
DR   SMR; Q55854; -.
DR   STRING; 1148.gene:10500114; -.
DR   PaxDb; 1148-1001772; -.
DR   EnsemblBacteria; BAA10610; BAA10610; BAA10610.
DR   KEGG; syn:sll0594; -.
DR   eggNOG; COG0664; Bacteria.
DR   InParanoid; Q55854; -.
DR   PhylomeDB; Q55854; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0008272; P:sulfate transport; IEA:UniProtKB-KW.
DR   CDD; cd00092; HTH_CRP; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR018490; cNMP-bd_dom_sf.
DR   InterPro; IPR012318; HTH_CRP.
DR   InterPro; IPR018335; Tscrpt_reg_HTH_Crp-type_CS.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   Pfam; PF13545; HTH_Crp_2; 1.
DR   SMART; SM00419; HTH_CRP; 1.
DR   SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS00042; HTH_CRP_1; 1.
DR   PROSITE; PS51063; HTH_CRP_2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; DNA-binding; Reference proteome; Sulfate transport;
KW   Transcription; Transcription regulation; Transport.
FT   CHAIN           1..205
FT                   /note="Regulatory protein CysR homolog"
FT                   /id="PRO_0000100154"
FT   DOMAIN          131..204
FT                   /note="HTH crp-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
FT   DNA_BIND        164..183
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00387"
SQ   SEQUENCE   205 AA;  22656 MW;  3B09A55E0BD37EAB CRC64;
     MFVNSSPIAD GLSALVGLDS QPLQFYERGD VVPPKDQGCW QIYRGILQVS QWTLGGDEVL
     MGWAQPGSFV GLDFSAHQRE TYQIRALTDV YLRGYSLEMI TNNANLCRLV LDQTLQQVRQ
     REALLAIAGY KRVDERLQGL LNLLGQELGQ PGTGGMRLSV RLTHQMLANA IGTTRVTVTR
     LLGEFQTQGK VSLDGDRHLV IALGN
//