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Q55848 (KPRS_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Ribose-phosphate pyrophosphokinase
Short name=RPPK
EC=2.7.6.1
Alternative name(s):
Phosphoribosyl pyrophosphate synthase
Short name=P-Rib-PP synthase
Short name=PRPP synthase
Gene names
Name:prs
Synonyms:prsA
Ordered Locus Names:sll0469
OrganismSynechocystis sp. (strain PCC 6803 / Kazusa) [Reference proteome] [HAMAP]
Taxonomic identifier1111708 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Oscillatoriophycideae › Chroococcales › Synechocystis ›

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_00583

Cofactor

Binds 1 magnesium ion per subunit By similarity.

Pathway

Metabolic intermediate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate biosynthesis; 5-phospho-alpha-D-ribose 1-diphosphate from D-ribose 5-phosphate (route I): step 1/1. HAMAP-Rule MF_00583

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the ribose-phosphate pyrophosphokinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 333333Ribose-phosphate pyrophosphokinase HAMAP-Rule MF_00583
PRO_0000141218

Regions

Region233 – 24614Binding of phosphoribosylpyrophosphate By similarity

Sites

Metal binding1491Magnesium Potential
Metal binding1511Magnesium Potential
Metal binding1601Magnesium Potential
Metal binding1641Magnesium Potential

Sequences

Sequence LengthMass (Da)Tools
Q55848 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: FA7FEE6A6573BA32

FASTA33336,396
        10         20         30         40         50         60 
MSAVSRIATL TRQSMLSALS DNNRLRLFSG SSNPSLSQEV ARYLGMDIGP MLRKRFADGE 

        70         80         90        100        110        120 
LYIQIQESIR GGDVYLIQPC CHPVNDNLME LLIMIDACRR ASARQITAVL PYYGYARADR 

       130        140        150        160        170        180 
KTAGRESISA KLVANLITGA GAQRVLAMDL HSAQIQGYFD IPCDHMYGSP VIIDYLKSKQ 

       190        200        210        220        230        240 
LTDLVVVSPD VGGVARARAF AKKLNDAPLA IIDKRRQSHN VAEVLNLIGD VDGKTAVLVD 

       250        260        270        280        290        300 
DMIDTAGTLS EGSRLLRAQG ARQVYACATH AVFSEPAINR LSGGLFEEVI VTNTIPVPDD 

       310        320        330 
HHFPQLTILS VANLIGEAIW RIHEESSVSS MFR

« Hide

References

[1]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 27184 / PCC 6803 / N-1.
[2]"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. expand/collapse author list , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PCC 6803 / Kazusa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BA000022 Genomic DNA. Translation: BAA10604.1.
PIRS76660.
RefSeqNP_442534.1. NC_000911.1.
YP_005652595.1. NC_017277.1.
YP_007452410.1. NC_020286.1.

3D structure databases

ProteinModelPortalQ55848.
SMRQ55848. Positions 25-333.
ModBaseSearch...

Protein-protein interaction databases

STRING1148.sll0469.

Proteomic databases

PaxDbQ55848.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaBAA10604; BAA10604; BAA10604.
GeneID12253987.
14618091.
954934.
KEGGsyn:sll0469.
syy:SYNGTS_2642.
PATRIC23842786. VBISynSp132158_2932.

Phylogenomic databases

eggNOGCOG0462.
HOGENOMHOG000210449.
KOK00948.
OMAYVQIQES.
ProtClustDBPRK02812.

Enzyme and pathway databases

UniPathwayUPA00087; UER00172.

Family and domain databases

HAMAPMF_00583_B. RibP_PPkinase_B.
InterProIPR000842. PRib_PP_synth_CS.
IPR000836. PRibTrfase_dom.
IPR005946. Rib-P_diPkinase.
[Graphical view]
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR01251. ribP_PPkin. 1 hit.
PROSITEPS00114. PRPP_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKPRS_SYNY3
AccessionPrimary (citable) accession number: Q55848
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 1, 2013
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Synechocystis PCC 6803

Synechocystis (strain PCC 6803): entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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