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Q55801

- RNH_SYNY3

UniProt

Q55801 - RNH_SYNY3

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Protein

Ribonuclease HI

Gene

rnhA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.By similarity

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.

Cofactori

Mg2+By similarityNote: Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131Magnesium 1By similarity
Metal bindingi13 – 131Magnesium 2By similarity
Metal bindingi52 – 521Magnesium 1By similarity
Metal bindingi74 – 741Magnesium 1By similarity
Metal bindingi139 – 1391Magnesium 2By similarity

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. nucleic acid binding Source: InterPro
  3. RNA-DNA hybrid ribonuclease activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. RNA catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Endonuclease, Hydrolase, Nuclease

Keywords - Ligandi

Magnesium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease HI (EC:3.1.26.4)
Short name:
RNase HI
Gene namesi
Name:rnhA
Ordered Locus Names:slr0080
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
ProteomesiUP000001425: Chromosome

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 160160Ribonuclease HIPRO_0000195408Add
BLAST

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

IntActiQ55801. 1 interaction.
STRINGi1148.slr0080.

Structurei

3D structure databases

ProteinModelPortaliQ55801.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 147144RNase HAdd
BLAST

Sequence similaritiesi

Belongs to the RNase H family.Curated
Contains 1 RNase H domain.Curated

Phylogenomic databases

eggNOGiCOG0328.
HOGENOMiHOG000040465.
InParanoidiQ55801.
KOiK03469.
OMAiAYIVNAV.
OrthoDBiEOG696BTR.
PhylomeDBiQ55801.

Family and domain databases

Gene3Di3.30.420.10. 1 hit.
HAMAPiMF_00042. RNase_H.
InterProiIPR022892. RNaseH.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
[Graphical view]
PfamiPF00075. RNase_H. 1 hit.
[Graphical view]
SUPFAMiSSF53098. SSF53098. 1 hit.
PROSITEiPS50879. RNASE_H. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55801-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASTPNSVTL YTDGACSMNP GPGGYGAVIL YGDGRREELS AGYKMTTNNR
60 70 80 90 100
MEIMGAIAAL SHLQEPSQVL LYTDSRYMVD AMSKGWAKKW KANGWQRNAK
110 120 130 140 150
EKAKNPDLWE TMLTLCEKHQ VTFQWVKAHA GNKENERCDR LAVAAYQNNP
160
NLVDEGFGKF
Length:160
Mass (Da):17,856
Last modified:November 1, 1996 - v1
Checksum:iF25924F536CBF766
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10553.1.
PIRiS76609.
RefSeqiNP_442483.1. NC_000911.1.
YP_005652544.1. NC_017277.1.
YP_007452359.1. NC_020286.1.

Genome annotation databases

EnsemblBacteriaiBAA10553; BAA10553; BAA10553.
GeneIDi952423.
KEGGisyn:slr0080.
PATRICi23842672. VBISynSp132158_2875.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10553.1 .
PIRi S76609.
RefSeqi NP_442483.1. NC_000911.1.
YP_005652544.1. NC_017277.1.
YP_007452359.1. NC_020286.1.

3D structure databases

ProteinModelPortali Q55801.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q55801. 1 interaction.
STRINGi 1148.slr0080.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai BAA10553 ; BAA10553 ; BAA10553 .
GeneIDi 952423.
KEGGi syn:slr0080.
PATRICi 23842672. VBISynSp132158_2875.

Phylogenomic databases

eggNOGi COG0328.
HOGENOMi HOG000040465.
InParanoidi Q55801.
KOi K03469.
OMAi AYIVNAV.
OrthoDBi EOG696BTR.
PhylomeDBi Q55801.

Family and domain databases

Gene3Di 3.30.420.10. 1 hit.
HAMAPi MF_00042. RNase_H.
InterProi IPR022892. RNaseH.
IPR012337. RNaseH-like_dom.
IPR002156. RNaseH_domain.
[Graphical view ]
Pfami PF00075. RNase_H. 1 hit.
[Graphical view ]
SUPFAMi SSF53098. SSF53098. 1 hit.
PROSITEi PS50879. RNASE_H. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
    Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
    DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27184 / PCC 6803 / N-1.
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.

Entry informationi

Entry nameiRNH_SYNY3
AccessioniPrimary (citable) accession number: Q55801
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

External Data

Dasty 3