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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

g6pd-1

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511NADPBy similarity
Binding sitei151 – 1511NADP; via carbonyl oxygenBy similarity
Binding sitei151 – 1511SubstrateBy similarity
Binding sitei219 – 2191SubstrateBy similarity
Binding sitei238 – 2381SubstrateBy similarity
Active sitei243 – 2431Proton acceptorBy similarity
Binding sitei337 – 3371SubstrateBy similarity
Binding sitei342 – 3421SubstrateBy similarity
Binding sitei373 – 3731SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 248NADPBy similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. glucose metabolic process Source: UniProtKB-KW
  2. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:g6pd-1
Synonyms:zwf
ORF Names:DDB_G0273131
AND
Name:g6pd-2
Synonyms:zwf
ORF Names:DDB_G0273639
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0273131. g6pd-1.
DDB_G0273639. g6pd-2.

Subcellular locationi

GO - Cellular componenti

  1. phagocytic vesicle Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Glucose-6-phosphate 1-dehydrogenasePRO_0000312855Add
BLAST

Proteomic databases

PRIDEiQ557D2.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231285.

Structurei

3D structure databases

ProteinModelPortaliQ557D2.
SMRiQ557D2. Positions 11-487.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni181 – 1855Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
InParanoidiQ557D2.
KOiK00036.
OMAiYNEPASF.
PhylomeDBiQ557D2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q557D2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTPDSRSV LTVIILGASG DLAKKKTYPA LFGLYLRDLL PSNTIIYGYA
60 70 80 90 100
RSHIEIGDFK ARISKGLKGD EEKKKQFLNL LHYHSGKYDE KASYDEFEKL
110 120 130 140 150
ILAEEKKQQG VDKFNRLFYM AIPPSIFIEV SIGIHGSLIS KNGWSRVIVE
160 170 180 190 200
KPFGRDLASS RELVSELGKL FKEKDLFRID HYLGKEMVQN LMVLRFANAV
210 220 230 240 250
FEPLWSKSHI SSITITFKED IGTEGRGGYF DQFGIIRDVM QNHLLQVLSL
260 270 280 290 300
VAMEPPVSLN ADDITNEKVK LLRCIQPIKM SEVVLGQYTS DPEGKIPAYL
310 320 330 340 350
DDEGVPKDST TPTYAAAVFH INNPRWRGMP FILKCGKALD ERKTEVRIQF
360 370 380 390 400
KRPDNFLFSD DDISRNELVM RIQPGEAVYL KLLSKKPGLE NKIEQTELDL
410 420 430 440 450
SYRHRFENLD LPDAYERLIL DSIKGDHNLF VRDDELDVAW QIFTPLLDQI
460 470 480 490
EKEKIKPEPY SFGSRGPKSA DELSKKFGFI RSLGYNWPGN SPQGSKK
Length:497
Mass (Da):56,697
Last modified:May 1, 2006 - v1
Checksum:i5ECF966E8C5AA31A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000009 Genomic DNA. Translation: EAL70783.1.
AAFI02000011 Genomic DNA. Translation: EAL70510.1.
RefSeqiXP_644436.1. XM_639344.1.
XP_644814.1. XM_639722.1.

Genome annotation databases

EnsemblProtistsiDDB0231285; DDB0231285; DDB_G0273131.
DDB0238739; DDB0238739; DDB_G0273639.
GeneIDi8618916.
8619061.
KEGGiddi:DDB_G0273131.
ddi:DDB_G0273639.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000009 Genomic DNA. Translation: EAL70783.1.
AAFI02000011 Genomic DNA. Translation: EAL70510.1.
RefSeqiXP_644436.1. XM_639344.1.
XP_644814.1. XM_639722.1.

3D structure databases

ProteinModelPortaliQ557D2.
SMRiQ557D2. Positions 11-487.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB_0231285.

Proteomic databases

PRIDEiQ557D2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231285; DDB0231285; DDB_G0273131.
DDB0238739; DDB0238739; DDB_G0273639.
GeneIDi8618916.
8619061.
KEGGiddi:DDB_G0273131.
ddi:DDB_G0273639.

Organism-specific databases

dictyBaseiDDB_G0273131. g6pd-1.
DDB_G0273639. g6pd-2.

Phylogenomic databases

eggNOGiCOG0364.
InParanoidiQ557D2.
KOiK00036.
OMAiYNEPASF.
PhylomeDBiQ557D2.

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Miscellaneous databases

PROiQ557D2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiG6PD_DICDI
AccessioniPrimary (citable) accession number: Q557D2
Secondary accession number(s): Q869V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 3, 2007
Last sequence update: May 1, 2006
Last modified: March 3, 2015
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.