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Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

g6pd-1

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi: pentose phosphate pathway

This protein is involved in step 1 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (g6pd-1)
  2. Probable 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (gnd)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51NADPBy similarity1
Binding sitei151NADP; via carbonyl oxygenBy similarity1
Binding sitei151SubstrateBy similarity1
Binding sitei219SubstrateBy similarity1
Binding sitei238SubstrateBy similarity1
Active sitei243Proton acceptorBy similarity1
Binding sitei337SubstrateBy similarity1
Binding sitei342SubstrateBy similarity1
Binding sitei373SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi17 – 24NADPBy similarity8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processCarbohydrate metabolism, Glucose metabolism
LigandNADP

Enzyme and pathway databases

ReactomeiR-DDI-5628897 TP53 Regulates Metabolic Genes
R-DDI-71336 Pentose phosphate pathway (hexose monophosphate shunt)
UniPathwayiUPA00115; UER00408

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:g6pd-1
Synonyms:zwf
ORF Names:DDB_G0273131
AND
Name:g6pd-2
Synonyms:zwf
ORF Names:DDB_G0273639
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyostelidsDictyostelialesDictyosteliaceaeDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0273131 g6pd-1
DDB_G0273639 g6pd-2

Subcellular locationi

GO - Cellular componenti

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003128551 – 497Glucose-6-phosphate 1-dehydrogenaseAdd BLAST497

Proteomic databases

PaxDbiQ557D2
PRIDEiQ557D2

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0238739

Structurei

3D structure databases

ProteinModelPortaliQ557D2
SMRiQ557D2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni181 – 185Substrate bindingBy similarity5

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0563 Eukaryota
COG0364 LUCA
InParanoidiQ557D2
KOiK00036
OMAiFQLLAMV
PhylomeDBiQ557D2

Family and domain databases

HAMAPiMF_00966 G6PD, 1 hit
InterProiView protein in InterPro
IPR001282 G6P_DH
IPR019796 G6P_DH_AS
IPR022675 G6P_DH_C
IPR022674 G6P_DH_NAD-bd
IPR036291 NAD(P)-bd_dom_sf
PANTHERiPTHR23429 PTHR23429, 1 hit
PfamiView protein in Pfam
PF02781 G6PD_C, 1 hit
PF00479 G6PD_N, 1 hit
PIRSFiPIRSF000110 G6PD, 1 hit
PRINTSiPR00079 G6PDHDRGNASE
SUPFAMiSSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR00871 zwf, 1 hit
PROSITEiView protein in PROSITE
PS00069 G6P_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q557D2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSTPDSRSV LTVIILGASG DLAKKKTYPA LFGLYLRDLL PSNTIIYGYA
60 70 80 90 100
RSHIEIGDFK ARISKGLKGD EEKKKQFLNL LHYHSGKYDE KASYDEFEKL
110 120 130 140 150
ILAEEKKQQG VDKFNRLFYM AIPPSIFIEV SIGIHGSLIS KNGWSRVIVE
160 170 180 190 200
KPFGRDLASS RELVSELGKL FKEKDLFRID HYLGKEMVQN LMVLRFANAV
210 220 230 240 250
FEPLWSKSHI SSITITFKED IGTEGRGGYF DQFGIIRDVM QNHLLQVLSL
260 270 280 290 300
VAMEPPVSLN ADDITNEKVK LLRCIQPIKM SEVVLGQYTS DPEGKIPAYL
310 320 330 340 350
DDEGVPKDST TPTYAAAVFH INNPRWRGMP FILKCGKALD ERKTEVRIQF
360 370 380 390 400
KRPDNFLFSD DDISRNELVM RIQPGEAVYL KLLSKKPGLE NKIEQTELDL
410 420 430 440 450
SYRHRFENLD LPDAYERLIL DSIKGDHNLF VRDDELDVAW QIFTPLLDQI
460 470 480 490
EKEKIKPEPY SFGSRGPKSA DELSKKFGFI RSLGYNWPGN SPQGSKK
Length:497
Mass (Da):56,697
Last modified:May 2, 2006 - v1
Checksum:i5ECF966E8C5AA31A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000009 Genomic DNA Translation: EAL70783.1
AAFI02000011 Genomic DNA Translation: EAL70510.1
RefSeqiXP_644436.1, XM_639344.1
XP_644814.1, XM_639722.1

Genome annotation databases

EnsemblProtistsiEAL70510; EAL70510; DDB_G0273639
EAL70783; EAL70783; DDB_G0273131
GeneIDi8618916
8619061
KEGGiddi:DDB_G0273131
ddi:DDB_G0273639

Similar proteinsi

Entry informationi

Entry nameiG6PD_DICDI
AccessioniPrimary (citable) accession number: Q557D2
Secondary accession number(s): Q869V9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 2, 2006
Last modified: April 25, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health