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Q557D2

- G6PD_DICDI

UniProt

Q557D2 - G6PD_DICDI

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

g6pd-1

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Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (02 May 2006)
      Previous versions | rss
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    Functioni

    Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis By similarity.By similarity

    Catalytic activityi

    D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei51 – 511NADPBy similarity
    Binding sitei151 – 1511NADP; via carbonyl oxygenBy similarity
    Binding sitei151 – 1511SubstrateBy similarity
    Binding sitei219 – 2191SubstrateBy similarity
    Binding sitei238 – 2381SubstrateBy similarity
    Active sitei243 – 2431Proton acceptorBy similarity
    Binding sitei337 – 3371SubstrateBy similarity
    Binding sitei342 – 3421SubstrateBy similarity
    Binding sitei373 – 3731SubstrateBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi17 – 248NADPBy similarity

    GO - Molecular functioni

    1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pentose-phosphate shunt Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Carbohydrate metabolism, Glucose metabolism

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00115; UER00408.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
    Short name:
    G6PD
    Gene namesi
    Name:g6pd-1
    Synonyms:zwf
    ORF Names:DDB_G0273131
    AND
    Name:g6pd-2
    Synonyms:zwf
    ORF Names:DDB_G0273639
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0273131. g6pd-1.
    DDB_G0273639. g6pd-2.

    Subcellular locationi

    GO - Cellular componenti

    1. phagocytic vesicle Source: dictyBase

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 497497Glucose-6-phosphate 1-dehydrogenasePRO_0000312855Add
    BLAST

    Proteomic databases

    PRIDEiQ557D2.

    Interactioni

    Protein-protein interaction databases

    STRINGi44689.DDB_0231285.

    Structurei

    3D structure databases

    ProteinModelPortaliQ557D2.
    SMRiQ557D2. Positions 11-487.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni181 – 1855Substrate bindingBy similarity

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0364.
    KOiK00036.
    OMAiIETHPRE.
    PhylomeDBiQ557D2.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00966. G6PD.
    InterProiIPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR23429. PTHR23429. 1 hit.
    PfamiPF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000110. G6PD. 1 hit.
    PRINTSiPR00079. G6PDHDRGNASE.
    TIGRFAMsiTIGR00871. zwf. 1 hit.
    PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q557D2-1 [UniParc]FASTAAdd to Basket

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    MTSTPDSRSV LTVIILGASG DLAKKKTYPA LFGLYLRDLL PSNTIIYGYA    50
    RSHIEIGDFK ARISKGLKGD EEKKKQFLNL LHYHSGKYDE KASYDEFEKL 100
    ILAEEKKQQG VDKFNRLFYM AIPPSIFIEV SIGIHGSLIS KNGWSRVIVE 150
    KPFGRDLASS RELVSELGKL FKEKDLFRID HYLGKEMVQN LMVLRFANAV 200
    FEPLWSKSHI SSITITFKED IGTEGRGGYF DQFGIIRDVM QNHLLQVLSL 250
    VAMEPPVSLN ADDITNEKVK LLRCIQPIKM SEVVLGQYTS DPEGKIPAYL 300
    DDEGVPKDST TPTYAAAVFH INNPRWRGMP FILKCGKALD ERKTEVRIQF 350
    KRPDNFLFSD DDISRNELVM RIQPGEAVYL KLLSKKPGLE NKIEQTELDL 400
    SYRHRFENLD LPDAYERLIL DSIKGDHNLF VRDDELDVAW QIFTPLLDQI 450
    EKEKIKPEPY SFGSRGPKSA DELSKKFGFI RSLGYNWPGN SPQGSKK 497
    Length:497
    Mass (Da):56,697
    Last modified:May 2, 2006 - v1
    Checksum:i5ECF966E8C5AA31A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000009 Genomic DNA. Translation: EAL70783.1.
    AAFI02000011 Genomic DNA. Translation: EAL70510.1.
    RefSeqiXP_644436.1. XM_639344.1.
    XP_644814.1. XM_639722.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231285; DDB0231285; DDB_G0273131.
    DDB0238739; DDB0238739; DDB_G0273639.
    GeneIDi8618916.
    8619061.
    KEGGiddi:DDB_G0273131.
    ddi:DDB_G0273639.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000009 Genomic DNA. Translation: EAL70783.1 .
    AAFI02000011 Genomic DNA. Translation: EAL70510.1 .
    RefSeqi XP_644436.1. XM_639344.1.
    XP_644814.1. XM_639722.1.

    3D structure databases

    ProteinModelPortali Q557D2.
    SMRi Q557D2. Positions 11-487.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 44689.DDB_0231285.

    Proteomic databases

    PRIDEi Q557D2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231285 ; DDB0231285 ; DDB_G0273131 .
    DDB0238739 ; DDB0238739 ; DDB_G0273639 .
    GeneIDi 8618916.
    8619061.
    KEGGi ddi:DDB_G0273131.
    ddi:DDB_G0273639.

    Organism-specific databases

    dictyBasei DDB_G0273131. g6pd-1.
    DDB_G0273639. g6pd-2.

    Phylogenomic databases

    eggNOGi COG0364.
    KOi K00036.
    OMAi IETHPRE.
    PhylomeDBi Q557D2.

    Enzyme and pathway databases

    UniPathwayi UPA00115 ; UER00408 .

    Miscellaneous databases

    PROi Q557D2.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00966. G6PD.
    InterProi IPR001282. G6P_DH.
    IPR019796. G6P_DH_AS.
    IPR022675. G6P_DH_C.
    IPR022674. G6P_DH_NAD-bd.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR23429. PTHR23429. 1 hit.
    Pfami PF02781. G6PD_C. 1 hit.
    PF00479. G6PD_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000110. G6PD. 1 hit.
    PRINTSi PR00079. G6PDHDRGNASE.
    TIGRFAMsi TIGR00871. zwf. 1 hit.
    PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiG6PD_DICDI
    AccessioniPrimary (citable) accession number: Q557D2
    Secondary accession number(s): Q869V9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 4, 2007
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Caution

    The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3