Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q557D2

- G6PD_DICDI

UniProt

Q557D2 - G6PD_DICDI

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glucose-6-phosphate 1-dehydrogenase

Gene

g6pd-1

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).By similarity

Catalytic activityi

D-glucose 6-phosphate + NADP+ = 6-phospho-D-glucono-1,5-lactone + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511NADPBy similarity
Binding sitei151 – 1511NADP; via carbonyl oxygenBy similarity
Binding sitei151 – 1511SubstrateBy similarity
Binding sitei219 – 2191SubstrateBy similarity
Binding sitei238 – 2381SubstrateBy similarity
Active sitei243 – 2431Proton acceptorBy similarity
Binding sitei337 – 3371SubstrateBy similarity
Binding sitei342 – 3421SubstrateBy similarity
Binding sitei373 – 3731SubstrateBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi17 – 248NADPBy similarity

GO - Molecular functioni

  1. glucose-6-phosphate dehydrogenase activity Source: UniProtKB-EC
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pentose-phosphate shunt Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Carbohydrate metabolism, Glucose metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00115; UER00408.

Names & Taxonomyi

Protein namesi
Recommended name:
Glucose-6-phosphate 1-dehydrogenase (EC:1.1.1.49)
Short name:
G6PD
Gene namesi
Name:g6pd-1
Synonyms:zwf
ORF Names:DDB_G0273131
AND
Name:g6pd-2
Synonyms:zwf
ORF Names:DDB_G0273639
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0273131. g6pd-1.
DDB_G0273639. g6pd-2.

Subcellular locationi

GO - Cellular componenti

  1. phagocytic vesicle Source: dictyBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 497497Glucose-6-phosphate 1-dehydrogenasePRO_0000312855Add
BLAST

Proteomic databases

PRIDEiQ557D2.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB_0231285.

Structurei

3D structure databases

ProteinModelPortaliQ557D2.
SMRiQ557D2. Positions 11-487.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni181 – 1855Substrate bindingBy similarity

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0364.
InParanoidiQ557D2.
KOiK00036.
OMAiIETHPRE.
PhylomeDBiQ557D2.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00966. G6PD.
InterProiIPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR23429. PTHR23429. 1 hit.
PfamiPF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000110. G6PD. 1 hit.
PRINTSiPR00079. G6PDHDRGNASE.
TIGRFAMsiTIGR00871. zwf. 1 hit.
PROSITEiPS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q557D2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSTPDSRSV LTVIILGASG DLAKKKTYPA LFGLYLRDLL PSNTIIYGYA
60 70 80 90 100
RSHIEIGDFK ARISKGLKGD EEKKKQFLNL LHYHSGKYDE KASYDEFEKL
110 120 130 140 150
ILAEEKKQQG VDKFNRLFYM AIPPSIFIEV SIGIHGSLIS KNGWSRVIVE
160 170 180 190 200
KPFGRDLASS RELVSELGKL FKEKDLFRID HYLGKEMVQN LMVLRFANAV
210 220 230 240 250
FEPLWSKSHI SSITITFKED IGTEGRGGYF DQFGIIRDVM QNHLLQVLSL
260 270 280 290 300
VAMEPPVSLN ADDITNEKVK LLRCIQPIKM SEVVLGQYTS DPEGKIPAYL
310 320 330 340 350
DDEGVPKDST TPTYAAAVFH INNPRWRGMP FILKCGKALD ERKTEVRIQF
360 370 380 390 400
KRPDNFLFSD DDISRNELVM RIQPGEAVYL KLLSKKPGLE NKIEQTELDL
410 420 430 440 450
SYRHRFENLD LPDAYERLIL DSIKGDHNLF VRDDELDVAW QIFTPLLDQI
460 470 480 490
EKEKIKPEPY SFGSRGPKSA DELSKKFGFI RSLGYNWPGN SPQGSKK
Length:497
Mass (Da):56,697
Last modified:May 2, 2006 - v1
Checksum:i5ECF966E8C5AA31A
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000009 Genomic DNA. Translation: EAL70783.1.
AAFI02000011 Genomic DNA. Translation: EAL70510.1.
RefSeqiXP_644436.1. XM_639344.1.
XP_644814.1. XM_639722.1.

Genome annotation databases

EnsemblProtistsiDDB0231285; DDB0231285; DDB_G0273131.
DDB0238739; DDB0238739; DDB_G0273639.
GeneIDi8618916.
8619061.
KEGGiddi:DDB_G0273131.
ddi:DDB_G0273639.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000009 Genomic DNA. Translation: EAL70783.1 .
AAFI02000011 Genomic DNA. Translation: EAL70510.1 .
RefSeqi XP_644436.1. XM_639344.1.
XP_644814.1. XM_639722.1.

3D structure databases

ProteinModelPortali Q557D2.
SMRi Q557D2. Positions 11-487.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 44689.DDB_0231285.

Proteomic databases

PRIDEi Q557D2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231285 ; DDB0231285 ; DDB_G0273131 .
DDB0238739 ; DDB0238739 ; DDB_G0273639 .
GeneIDi 8618916.
8619061.
KEGGi ddi:DDB_G0273131.
ddi:DDB_G0273639.

Organism-specific databases

dictyBasei DDB_G0273131. g6pd-1.
DDB_G0273639. g6pd-2.

Phylogenomic databases

eggNOGi COG0364.
InParanoidi Q557D2.
KOi K00036.
OMAi IETHPRE.
PhylomeDBi Q557D2.

Enzyme and pathway databases

UniPathwayi UPA00115 ; UER00408 .

Miscellaneous databases

PROi Q557D2.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00966. G6PD.
InterProi IPR001282. G6P_DH.
IPR019796. G6P_DH_AS.
IPR022675. G6P_DH_C.
IPR022674. G6P_DH_NAD-bd.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR23429. PTHR23429. 1 hit.
Pfami PF02781. G6PD_C. 1 hit.
PF00479. G6PD_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000110. G6PD. 1 hit.
PRINTSi PR00079. G6PDHDRGNASE.
TIGRFAMsi TIGR00871. zwf. 1 hit.
PROSITEi PS00069. G6P_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiG6PD_DICDI
AccessioniPrimary (citable) accession number: Q557D2
Secondary accession number(s): Q869V9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: May 2, 2006
Last modified: October 29, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3