Q55797 (GMHA_SYNY3) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphoheptose isomerase
EC=5.3.1.28

Alternative name(s):
Sedoheptulose 7-phosphate isomerase

Gene names

Name:	gmhA
Ordered Locus Names:	sll0083

Organism

Synechocystis sp. (strain PCC 6803 / Kazusa)

Taxonomic identifier

1111708 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	194 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate By similarity. HAMAP MF_00067
Catalytic activity	D-sedoheptulose 7-phosphate = D-glycero-D-manno-heptose 7-phosphate. HAMAP MF_00067
Cofactor	Binds 1 zinc ion per subunit By similarity. HAMAP MF_00067
Pathway	Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1. HAMAP MF_00067
Subcellular location	Cytoplasm By similarity HAMAP MF_00067.
Miscellaneous	The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate By similarity. HAMAP MF_00067
Sequence similarities	Belongs to the SIS family. GmhA subfamily. Contains 1 SIS domain.

Ontologies

Keywords
Biological process	Carbohydrate metabolism
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Isomerase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	lipopolysaccharide core region biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	D-sedoheptulose 7-phosphate isomerase activity Inferred from electronic annotation. Source: InterPro metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW sugar binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 194	194	Phosphoheptose isomerase HAMAP MF_00067		PRO_0000136547
Regions
	Domain	31 – 186	156	SIS
	Region	46 – 48	3	Substrate binding By similarity
	Region	88 – 89	2	Substrate binding By similarity
	Region	114 – 116	3	Substrate binding By similarity
Sites
	Metal binding	55	1	Zinc By similarity
	Metal binding	59	1	Zinc By similarity
	Metal binding	166	1	Zinc By similarity
	Metal binding	174	1	Zinc By similarity
	Binding site	59	1	Substrate By similarity
	Binding site	119	1	Substrate By similarity
	Binding site	166	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55797 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: CEA722DA56E11DBD	FASTA	194	21,137
	10 20 30 40 50 60 MSEWVEQRLQ SLAKAFDQSY CGAIEAVVDL ICQRFQAGNK LLICGNGGSA ADAQHLAAEF 70 80 90 100 110 120 VGRFHFNRQA LPAIALTANS SILTSVSNDY TYDIVFSRQV EALGQPGDIL WGLSTSGKST 130 140 150 160 170 180 NVLHALKCAK DKGLHTIGMA GNNGGLFQEF ADYPLFVADK NTPCIQEVHL MTYHHICEQV 190 ESRLFAQKSV GIKV

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

[2]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 27184 / PCC 6803 / N-1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BA000022 Genomic DNA. Translation: BAA10549.1.
PIR	S76605.
RefSeq	NP_442479.1. NC_000911.1.
3D structure databases
ProteinModelPortal	Q55797.
ModBase	Search...
Protein-protein interaction databases
STRING	Q55797.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	952344.
GenomeReviews	Gene locus sll0083 in contig BA000022_GR.
KEGG	syn:sll0083.
NMPDR	fig|1148.1.peg.2580.
PATRIC	23842664. VBISynSp132158_2871.
Phylogenomic databases
eggNOG	COG0279.
HOGENOM	HBG671955.
OMA	HITIIHI.
PhylomeDB	Q55797.
ProtClustDB	CLSK2301919.
Enzyme and pathway databases
BioCyc	SSP1148:SLL0083-MONOMER.
Family and domain databases
HAMAP	MF_00067. GmhA. [Tree]
InterPro	IPR004515. Phosphoheptose_Isoase_subgr. IPR020620. Phosphoheptose_isomerase. IPR001347. SIS. [Graphical view]
KO	K03271.
TIGRFAMs	TIGR00441. GmhA. 1 hit.
PROSITE	PS51464. SIS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMHA_SYNY3

Accession

Primary (citable) accession number: Q55797

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 78 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program