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Protein

Probable cysteine desulfurase

Gene

csd

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine.By similarity

Catalytic activityi

L-cysteine + acceptor = L-alanine + S-sulfanyl-acceptor.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei372 – 3721Cysteine persulfide intermediate1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-2258-MONOMER.
BRENDAi2.8.1.7. 382.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable cysteine desulfurase (EC:2.8.1.7)
Gene namesi
Name:csd
Synonyms:sufS
Ordered Locus Names:slr0077
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 420420Probable cysteine desulfurasePRO_0000150318Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei231 – 2311N6-(pyridoxal phosphate)lysine

Interactioni

Protein-protein interaction databases

IntActiQ55793. 2 interactions.

Structurei

Secondary structure

1
420
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi9 – 135Combined sources
Helixi14 – 163Combined sources
Helixi18 – 203Combined sources
Turni34 – 363Combined sources
Helixi42 – 5413Combined sources
Helixi65 – 8420Combined sources
Helixi90 – 923Combined sources
Beta strandi93 – 986Combined sources
Helixi99 – 10911Combined sources
Helixi111 – 1144Combined sources
Beta strandi120 – 1245Combined sources
Helixi129 – 1313Combined sources
Helixi133 – 14210Combined sources
Beta strandi145 – 1495Combined sources
Beta strandi155 – 1573Combined sources
Helixi159 – 1657Combined sources
Beta strandi170 – 1789Combined sources
Turni180 – 1823Combined sources
Helixi188 – 19710Combined sources
Beta strandi201 – 2055Combined sources
Turni207 – 2126Combined sources
Helixi217 – 2204Combined sources
Beta strandi223 – 2286Combined sources
Helixi229 – 2313Combined sources
Beta strandi239 – 2435Combined sources
Helixi245 – 2506Combined sources
Beta strandi260 – 2645Combined sources
Beta strandi269 – 2713Combined sources
Helixi276 – 2783Combined sources
Helixi285 – 30117Combined sources
Helixi303 – 32220Combined sources
Beta strandi327 – 3315Combined sources
Helixi334 – 3363Combined sources
Beta strandi341 – 3477Combined sources
Helixi352 – 3609Combined sources
Turni361 – 3633Combined sources
Helixi374 – 3796Combined sources
Beta strandi386 – 3894Combined sources
Helixi396 – 41217Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1T3IX-ray1.80A/B1-420[»]
ProteinModelPortaliQ55793.
SMRiQ55793. Positions 7-414.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ55793.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

HOGENOMiHOG000017511.
InParanoidiQ55793.
KOiK11717.
OMAiMIDFVGL.
OrthoDBiEOG68DD0M.
PhylomeDBiQ55793.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR010970. Cys_dSase_SufS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01979. sufS. 1 hit.

Sequencei

Sequence statusi: Complete.

Q55793-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVALQIPSLA ATVRQDFPIL NQEINGHPLV YLDNAATSQK PRAVLEKLMH
60 70 80 90 100
YYENDNANVH RGAHQLSVRA TDAYEAVRNK VAKFINARSP REIVYTRNAT
110 120 130 140 150
EAINLVAYSW GMNNLKAGDE IITTVMEHHS NLVPWQMVAA KTGAVLKFVQ
160 170 180 190 200
LDEQESFDLE HFKTLLSEKT KLVTVVHISN TLGCVNPAEE IAQLAHQAGA
210 220 230 240 250
KVLVDACQSA PHYPLDVQLI DCDWLVASGH KMCAPTGIGF LYGKEEILEA
260 270 280 290 300
MPPFFGGGEM IAEVFFDHFT TGELPHKFEA GTPAIAEAIA LGAAVDYLTD
310 320 330 340 350
LGMENIHNYE VELTHYLWQG LGQIPQLRLY GPNPKHGDRA ALASFNVAGL
360 370 380 390 400
HASDVATMVD QDGIAIRSGH HCTQPLHRLF DASGSARASL YFYNTKEEID
410 420
LFLQSLQATI RFFSDDDFTV
Length:420
Mass (Da):46,412
Last modified:November 1, 1996 - v1
Checksum:iB45043D9881AFA23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10545.1.
PIRiS76601.

Genome annotation databases

EnsemblBacteriaiBAA10545; BAA10545; BAA10545.
KEGGisyn:slr0077.
PATRICi23842656. VBISynSp132158_2867.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10545.1.
PIRiS76601.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1T3IX-ray1.80A/B1-420[»]
ProteinModelPortaliQ55793.
SMRiQ55793. Positions 7-414.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ55793. 2 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA10545; BAA10545; BAA10545.
KEGGisyn:slr0077.
PATRICi23842656. VBISynSp132158_2867.

Phylogenomic databases

HOGENOMiHOG000017511.
InParanoidiQ55793.
KOiK11717.
OMAiMIDFVGL.
OrthoDBiEOG68DD0M.
PhylomeDBiQ55793.

Enzyme and pathway databases

BioCyciRETL1328306-WGS:GSTH-2258-MONOMER.
BRENDAi2.8.1.7. 382.

Miscellaneous databases

EvolutionaryTraceiQ55793.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR000192. Aminotrans_V_dom.
IPR010970. Cys_dSase_SufS.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00266. Aminotran_5. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
TIGRFAMsiTIGR01979. sufS. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
    Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
    DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27184 / PCC 6803 / N-1.
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  3. "Kinetic and structural characterization of Slr0077/SufS, the essential cysteine desulfurase from Synechocystis sp. PCC 6803."
    Tirupati B., Vey J.L., Drennan C.L., Bollinger J.M. Jr.
    Biochemistry 43:12210-12219(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS), PYRIDOXAL PHOSPHATE AT LYS-231, ACTIVE SITE CYS-372.

Entry informationi

Entry nameiCSD_SYNY3
AccessioniPrimary (citable) accession number: Q55793
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.