Reviewed, UniProtKB/Swiss-Prot Q55758 (PYRR_SYNY3)

Names and origin

Protein names

Recommended name:
    Bifunctional protein pyrR
Including the following 2 domains:
    1- Recommended name:
            Pyrimidine operon regulatory protein
    2- Recommended name:
            Uracil phosphoribosyltransferase
                Short name=UPRTase
              EC=2.4.2.9

Gene names

Name:	pyrR
Ordered Locus Names:	sll0368

Organism

Synechocystis sp. (strain PCC 6803) [Complete proteome] [HAMAP]

Taxonomic identifier

1148 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Synechocystis

Protein attributes

Sequence length	178 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines By similarity. Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant By similarity.
Catalytic activity	UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01219
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	nucleoside metabolic process Inferred from electronic annotation. Source: InterPro regulation of transcription Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	uracil phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 178	178	Bifunctional protein pyrR HAMAP MF_01219		PRO_0000183071
Regions
	Region	42 – 43	2	Substrate-binding By similarity
	Region	103 – 111	9	Substrate binding By similarity
	Motif	99 – 111	13	PRPP-binding By similarity
Sites
	Binding site	83	1	Substrate; shared with dimeric partner By similarity
	Binding site	136	1	Substrate By similarity
	Binding site	160	1	Substrate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q55758-1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 51041092F845917C	FASTA	178	19,946
	10 20 30 40 50 60 MAAQIIEILS PEEIRRTLTR LASQVIEKNS DLSELVLLGI YTRGVPLAHQ LAQQIEMLEQ 70 80 90 100 110 120 VKVPVGAIDV TLYRDDLKRI KTRTPAKTKI PLSLTGKRVV LVDDVIYKGR TIRAALNAVT 130 140 150 160 170 EYGRPQVIRL LTLVDRGHRE LPIHPDFVGK ILPTAAEEQV KVYLQDPDGR DTVELIKG

References

[1]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome." Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S. DNA Res. 2:153-166(1995) [PubMed: 8590279] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

[2]

"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions." Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S. , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S. DNA Res. 3:109-136(1996) [PubMed: 8905231] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	BA000022 Genomic DNA. Translation: BAA10405.1.
PIR	S76559.
RefSeq	NP_442335.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	Q55758.
Genome annotation databases
GeneID	952480.
GenomeReviews	Gene locus sll0368 in contig BA000022_GR.
KEGG	syn:sll0368.
NMPDR	fig|1148.1.peg.2436.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG641958.
OMA	MYRDDLA.
Enzyme and pathway databases
BioCyc	SSP1148:SLL0368-MON.
Family and domain databases
HAMAP	MF_01219. [Tree]
InterPro	IPR000836. PRibTrfase. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
PROSITE	PS00103. PUR_PYR_PR_TRANSFER. False negative. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PYRR_SYNY3

Accession

Primary (citable) accession number: Q55758

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	November 1, 1996
Last modified:	December 15, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)