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Q55725

- MEND_SYNY3

UniProt

Q55725 - MEND_SYNY3

Protein

2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase

Gene

menD

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 97 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).UniRule annotation

    Catalytic activityi

    Isochorismate + 2-oxoglutarate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2.UniRule annotation

    Cofactori

    Magnesium or manganese.UniRule annotation
    Binds 1 thiamine pyrophosphate per subunit.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylic-acid synthase activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW
    3. thiamine pyrophosphate binding Source: InterPro

    GO - Biological processi

    1. menaquinone biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Transferase

    Keywords - Biological processi

    Menaquinone biosynthesis

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding, Thiamine pyrophosphate

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-13897.
    UniPathwayiUPA00079; UER00164.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthaseUniRule annotation (EC:2.2.1.9UniRule annotation)
    Short name:
    SEPHCHC synthaseUniRule annotation
    Alternative name(s):
    Menaquinone biosynthesis protein MenDUniRule annotation
    Gene namesi
    Name:menDUniRule annotation
    Ordered Locus Names:sll0603
    OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
    Taxonomic identifieri1111708 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
    ProteomesiUP000001425: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 5955952-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthasePRO_0000341878Add
    BLAST

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi1148.sll0603.

    Structurei

    3D structure databases

    ProteinModelPortaliQ55725.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TPP enzyme family. MenD subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1165.
    HOGENOMiHOG000218359.
    KOiK02551.
    OMAiFEMASNI.
    OrthoDBiEOG6NWBQW.
    PhylomeDBiQ55725.

    Family and domain databases

    Gene3Di3.40.50.970. 2 hits.
    HAMAPiMF_01659. MenD.
    InterProiIPR004433. MenaQ_synth_MenD.
    IPR029061. THDP-binding.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    IPR011766. TPP_enzyme-bd_C.
    [Graphical view]
    PfamiPF02775. TPP_enzyme_C. 1 hit.
    PF02776. TPP_enzyme_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004983. MenD. 1 hit.
    SUPFAMiSSF52518. SSF52518. 2 hits.
    TIGRFAMsiTIGR00173. menD. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q55725-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVDFTNPNTL AASVLVETLF RLGLQQAVIC PGSRSSPLTV ALARHGGIDC    50
    VVSLDERSAS FFALGHGKRT GQPVALVCTS GTAAANFLPA IIEAHYSQVP 100
    LLVLTGDRPP RLRHCRAGQT IDQTKLYGHY PQWQTELALP EPNMDYCHYL 150
    RQTALHSWQK CFWPGLGVVH LNCPFDEPLV PLEHARESLQ HLAEEFSKEH 200
    FYRGLTTFTT MNRGEAISLP VNFSIFSFPS PQLDFSPLGL ILVGVMPGGE 250
    TPSLLTDILA IARGLGYPVL CDALCSLRNY DDGQTALITN YDFLIRCPRW 300
    AEQLVPEQII QIGELPTSKA LRHWLGTIDC PRYILNFHGE NLDPLQGQTI 350
    YLSASVAQVA EYIHNQGFIP DAEQKNYAHS WLEKQRQSQT IIISALADAH 400
    TPLMVAQLAH CLPPQTNLFV ANSLPVRWLE FFWPANGDHH RIFVNRGANG 450
    IDGTLSTAMG IAHRSRGETV LLTGDLSLLH DSNGFLNQSQ MRGNLTIILL 500
    NNNGGGIFQT LPIAQCEDVF ETYFATPQGV DFGQLCRTYG VEHKIITNLW 550
    DLKEQWPSNN SSPIRVLEII GDRHQEAQWL KSLQAQFCCA DSLIQ 595
    Length:595
    Mass (Da):66,133
    Last modified:November 1, 1996 - v1
    Checksum:i62CF0EA48B20D87E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10366.1.
    PIRiS76520.
    RefSeqiNP_442296.1. NC_000911.1.
    YP_005652356.1. NC_017277.1.
    YP_007452172.1. NC_020286.1.

    Genome annotation databases

    EnsemblBacteriaiBAA10366; BAA10366; BAA10366.
    GeneIDi952514.
    KEGGisyn:sll0603.
    syy:SYNGTS_2403.
    syz:MYO_124280.
    PATRICi23842248. VBISynSp132158_2664.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BA000022 Genomic DNA. Translation: BAA10366.1 .
    PIRi S76520.
    RefSeqi NP_442296.1. NC_000911.1.
    YP_005652356.1. NC_017277.1.
    YP_007452172.1. NC_020286.1.

    3D structure databases

    ProteinModelPortali Q55725.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 1148.sll0603.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai BAA10366 ; BAA10366 ; BAA10366 .
    GeneIDi 952514.
    KEGGi syn:sll0603.
    syy:SYNGTS_2403.
    syz:MYO_124280.
    PATRICi 23842248. VBISynSp132158_2664.

    Phylogenomic databases

    eggNOGi COG1165.
    HOGENOMi HOG000218359.
    KOi K02551.
    OMAi FEMASNI.
    OrthoDBi EOG6NWBQW.
    PhylomeDBi Q55725.

    Enzyme and pathway databases

    UniPathwayi UPA00079 ; UER00164 .
    BioCyci MetaCyc:MONOMER-13897.

    Family and domain databases

    Gene3Di 3.40.50.970. 2 hits.
    HAMAPi MF_01659. MenD.
    InterProi IPR004433. MenaQ_synth_MenD.
    IPR029061. THDP-binding.
    IPR012001. Thiamin_PyroP_enz_TPP-bd_dom.
    IPR011766. TPP_enzyme-bd_C.
    [Graphical view ]
    Pfami PF02775. TPP_enzyme_C. 1 hit.
    PF02776. TPP_enzyme_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004983. MenD. 1 hit.
    SUPFAMi SSF52518. SSF52518. 2 hits.
    TIGRFAMsi TIGR00173. menD. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
      Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
      , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PCC 6803 / Kazusa.

    Entry informationi

    Entry nameiMEND_SYNY3
    AccessioniPrimary (citable) accession number: Q55725
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 2008
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 97 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Synechocystis PCC 6803
      Synechocystis (strain PCC 6803): entries and gene names

    External Data

    Dasty 3