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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation
Probably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi105 – 1128ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:sll0616
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cellular thylakoid membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane, Thylakoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 932932Protein translocase subunit SecAPRO_0000109618Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

IntActiQ55709. 9 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ55709.
SMRiQ55709. Positions 10-237.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218168.
InParanoidiQ55709.
KOiK03070.
OMAiIATERHE.
OrthoDBiEOG654P48.
PhylomeDBiQ55709.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 4 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q55709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKALFGDPN TRKLKKFQPY VAEVNLYEED IEKLSDDELK YKTVEFREAL
60 70 80 90 100
DKARSDAETE EILDEILPEA FAVVREAGKR VLGMRHFDVQ LLGGIILHKG
110 120 130 140 150
QIAEMKTGEG KTLVATLPSY LNGLTGKGVH VVTVNDYLAR RDAEWMGQIH
160 170 180 190 200
RFLGLTVGLV QSGMNPEERK KNYACDITYT TNSELGFDYL RDNMSTAMIE
210 220 230 240 250
VVQRPFNFCI IDEVDSILID EARTPLIISG QVERPTEKYL QASDIAAQLE
260 270 280 290 300
PEIHYEVDEK QRNVLMTDEG FEKAEQLLQT TDLFDKNDPW AHYIFNAIKA
310 320 330 340 350
KELFLKDVNY IVRNGEVVIV DEFTGRIMVG RRWSDGLHQA IEAKERVEIQ
360 370 380 390 400
KESQTLATIT YQNFFLLYPK LSGMTGTAKT EETELEKVYN LQVTITPTNR
410 420 430 440 450
PSSRQDWPDV VYKNEEAKWK AVALECEELH QQGRPILVGT TSVEKSEVIS
460 470 480 490 500
RLLQSSGIHH NLLNARPENV ERESEIVAQA GRKGAVTIAT NMAGRGTDII
510 520 530 540 550
LGGNSDYMAR LKVREYLMPK IVRPEDDELG AGVTGWVSGR EKPQGFGNQN
560 570 580 590 600
GKKKVKTWQV SPDIYPTTIS QETEDLLKKA VKFAVDQYGL QSLTELEAED
610 620 630 640 650
KLAIASEKGP TDDPVILKLR EVYNQIRREY EVLTSAEHKE VVELGGLHVI
660 670 680 690 700
GTERHESRRV DNQLRGRAGR QGDPGSTRFF LSLEDNLLRI FGGDRVAGLM
710 720 730 740 750
NMFRVEEDMP IESKMLTGSL EGAQKKVETY YYDIRKQVFE YDEVMNNQRK
760 770 780 790 800
AIYAERRRVL EGLDLKEQVL VYAEKTMDEI VDAYVNPELP PEEWDVENML
810 820 830 840 850
DKAKQFVYLL EDLTVEDLGD MTVWEMKTFF HEEVRKAYDL KETQVDKVRP
860 870 880 890 900
GLMREAERYF ILQQIDNLWR EHLQSMEALR ESIGLRGYGQ KDPLIEYKQE
910 920 930
GYEMFLEMMI DIRRNVVYSL FQFQPQQQPQ AV
Length:932
Mass (Da):107,009
Last modified:November 1, 1997 - v1
Checksum:iB57502CDE3D69781
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10347.1.
U38892 Genomic DNA. Translation: AAA96399.1.
PIRiS76501.

Genome annotation databases

EnsemblBacteriaiBAA10347; BAA10347; BAA10347.
KEGGisyn:sll0616.
PATRICi23842206. VBISynSp132158_2643.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA. Translation: BAA10347.1.
U38892 Genomic DNA. Translation: AAA96399.1.
PIRiS76501.

3D structure databases

ProteinModelPortaliQ55709.
SMRiQ55709. Positions 10-237.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ55709. 9 interactions.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiBAA10347; BAA10347; BAA10347.
KEGGisyn:sll0616.
PATRICi23842206. VBISynSp132158_2643.

Phylogenomic databases

HOGENOMiHOG000218168.
InParanoidiQ55709.
KOiK03070.
OMAiIATERHE.
OrthoDBiEOG654P48.
PhylomeDBiQ55709.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 4 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 4 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. I. Sequence features in the 1 Mb region from map positions 64% to 92% of the genome."
    Kaneko T., Tanaka A., Sato S., Kotani H., Sazuka T., Miyajima N., Sugiura M., Tabata S.
    DNA Res. 2:153-166(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 27184 / PCC 6803 / N-1.
  2. "Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions."
    Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y., Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T., Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.
    , Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    DNA Res. 3:109-136(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PCC 6803 / Kazusa.
  3. "Promoter element spacing controls basal expression and light inducibility of the cyanobacterial secA gene."
    Mazouni K., Bulteau S., Cassier-Chauvat C., Chauvat F.
    Mol. Microbiol. 30:1113-1122(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-777.

Entry informationi

Entry nameiSECA_SYNY3
AccessioniPrimary (citable) accession number: Q55709
Secondary accession number(s): Q55065
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: July 6, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Synechocystis PCC 6803
    Synechocystis (strain PCC 6803): entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.