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Protein

Protein translocase subunit SecA

Gene

secA

Organism
Synechocystis sp. (strain PCC 6803 / Kazusa)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation
Probably participates in protein translocation into and across both the cytoplasmic and thylakoid membranes in cyanobacterial cells.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi105 – 112ATPUniRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Translocation, Transport
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecAUniRule annotation
Gene namesi
Name:secAUniRule annotation
Ordered Locus Names:sll0616
OrganismiSynechocystis sp. (strain PCC 6803 / Kazusa)
Taxonomic identifieri1111708 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesMerismopediaceaeSynechocystis
Proteomesi
  • UP000001425 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cellular thylakoid membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane, Thylakoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001096181 – 932Protein translocase subunit SecAAdd BLAST932

Proteomic databases

PaxDbiQ55709
PRIDEiQ55709

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

IntActiQ55709, 9 interactors
STRINGi1148.SYNGTS_2384

Structurei

3D structure databases

ProteinModelPortaliQ55709
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000218168
InParanoidiQ55709
KOiK03070
OMAiFEYDEVM
PhylomeDBiQ55709

Family and domain databases

HAMAPiMF_01382 SecA, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR000185 SecA
IPR020937 SecA_CS
IPR011115 SecA_DEAD
IPR014018 SecA_motor_DEAD
IPR011130 SecA_preprotein_X-link_dom
IPR011116 SecA_Wing/Scaffold
IPR036266 SecA_Wing/Scaffold_sf
IPR036670 SecA_X-link_sf
PANTHERiPTHR30612 PTHR30612, 1 hit
PfamiView protein in Pfam
PF07517 SecA_DEAD, 1 hit
PF01043 SecA_PP_bind, 1 hit
PF07516 SecA_SW, 1 hit
PRINTSiPR00906 SECA
SMARTiView protein in SMART
SM00957 SecA_DEAD, 1 hit
SM00958 SecA_PP_bind, 1 hit
SUPFAMiSSF52540 SSF52540, 4 hits
SSF81767 SSF81767, 1 hit
SSF81886 SSF81886, 1 hit
TIGRFAMsiTIGR00963 secA, 1 hit
PROSITEiView protein in PROSITE
PS01312 SECA, 1 hit
PS51196 SECA_MOTOR_DEAD, 1 hit

Sequencei

Sequence statusi: Complete.

Q55709-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKALFGDPN TRKLKKFQPY VAEVNLYEED IEKLSDDELK YKTVEFREAL
60 70 80 90 100
DKARSDAETE EILDEILPEA FAVVREAGKR VLGMRHFDVQ LLGGIILHKG
110 120 130 140 150
QIAEMKTGEG KTLVATLPSY LNGLTGKGVH VVTVNDYLAR RDAEWMGQIH
160 170 180 190 200
RFLGLTVGLV QSGMNPEERK KNYACDITYT TNSELGFDYL RDNMSTAMIE
210 220 230 240 250
VVQRPFNFCI IDEVDSILID EARTPLIISG QVERPTEKYL QASDIAAQLE
260 270 280 290 300
PEIHYEVDEK QRNVLMTDEG FEKAEQLLQT TDLFDKNDPW AHYIFNAIKA
310 320 330 340 350
KELFLKDVNY IVRNGEVVIV DEFTGRIMVG RRWSDGLHQA IEAKERVEIQ
360 370 380 390 400
KESQTLATIT YQNFFLLYPK LSGMTGTAKT EETELEKVYN LQVTITPTNR
410 420 430 440 450
PSSRQDWPDV VYKNEEAKWK AVALECEELH QQGRPILVGT TSVEKSEVIS
460 470 480 490 500
RLLQSSGIHH NLLNARPENV ERESEIVAQA GRKGAVTIAT NMAGRGTDII
510 520 530 540 550
LGGNSDYMAR LKVREYLMPK IVRPEDDELG AGVTGWVSGR EKPQGFGNQN
560 570 580 590 600
GKKKVKTWQV SPDIYPTTIS QETEDLLKKA VKFAVDQYGL QSLTELEAED
610 620 630 640 650
KLAIASEKGP TDDPVILKLR EVYNQIRREY EVLTSAEHKE VVELGGLHVI
660 670 680 690 700
GTERHESRRV DNQLRGRAGR QGDPGSTRFF LSLEDNLLRI FGGDRVAGLM
710 720 730 740 750
NMFRVEEDMP IESKMLTGSL EGAQKKVETY YYDIRKQVFE YDEVMNNQRK
760 770 780 790 800
AIYAERRRVL EGLDLKEQVL VYAEKTMDEI VDAYVNPELP PEEWDVENML
810 820 830 840 850
DKAKQFVYLL EDLTVEDLGD MTVWEMKTFF HEEVRKAYDL KETQVDKVRP
860 870 880 890 900
GLMREAERYF ILQQIDNLWR EHLQSMEALR ESIGLRGYGQ KDPLIEYKQE
910 920 930
GYEMFLEMMI DIRRNVVYSL FQFQPQQQPQ AV
Length:932
Mass (Da):107,009
Last modified:November 1, 1997 - v1
Checksum:iB57502CDE3D69781
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BA000022 Genomic DNA Translation: BAA10347.1
U38892 Genomic DNA Translation: AAA96399.1
PIRiS76501

Genome annotation databases

EnsemblBacteriaiBAA10347; BAA10347; BAA10347
KEGGisyn:sll0616

Similar proteinsi

Entry informationi

Entry nameiSECA_SYNY3
AccessioniPrimary (citable) accession number: Q55709
Secondary accession number(s): Q55065
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 25, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health