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Q556Y8

- DUSPR_DICDI

UniProt

Q556Y8 - DUSPR_DICDI

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Protein

Probable rhodanese domain-containing dual specificity protein phosphatase

Gene

DDB_G0273199

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Has a dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei294 – 2941Phosphocysteine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

  1. phosphoprotein phosphatase activity Source: dictyBase
  2. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
  3. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. protein dephosphorylation Source: RefGenome
  2. response to cisplatin Source: dictyBase
  3. sorocarp development Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable rhodanese domain-containing dual specificity protein phosphatase (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
ORF Names:DDB_G0273199
AND
ORF Names:DDB_G0273729
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0273199. mkpB-1.
DDB_G0273729. mkpB-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 476476Probable rhodanese domain-containing dual specificity protein phosphatasePRO_0000332954Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ556Y8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 190159RhodaneseAdd
BLAST
Domaini209 – 349141Tyrosine-protein phosphataseAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi116 – 13520Thr-richAdd
BLAST
Compositional biasi192 – 1998Poly-Ser
Compositional biasi200 – 2045Poly-Gly
Compositional biasi361 – 3644Poly-Gln
Compositional biasi367 – 3726Poly-Asn

Sequence similaritiesi

Contains 1 rhodanese domain.Curated

Phylogenomic databases

eggNOGiCOG2453.
InParanoidiQ556Y8.
KOiK04459.
OMAiAYLMKED.

Family and domain databases

Gene3Di3.40.250.10. 2 hits.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q556Y8 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVLINRVNIQ PEELPLLYHV NSMDVYNLLQ DIGSSKIIID LRTKEQYEKN
60 70 80 90 100
HIRTSVNIPP PPSTTPLYEN GEIKEFNLSK YIGSNVTAKH WNLIFQKLIV
110 120 130 140 150
YSDKPFLYNI DELEKTISTT TITTTATTTT TTTTTSNSIG SDQDIIKSLK
160 170 180 190 200
VSDWDKVVLR HFLLKKKKTK VIIYQGGFDQ FQKDYSFMCN PSSSPSSSSG
210 220 230 240 250
GGGGSQLYPS EIIKDFLYLG GAENAGNRQQ LINLKITHLV NMAGELDDVY
260 270 280 290 300
PHLYKYYRAN LDDRPKANIY EHFEPVIQFI NDCKKQGGRV LIHCAMGISR
310 320 330 340 350
STTVVLAYLM KEDHMTYSDA FTFCKQKRSC INPNFGFVKQ LKDYQQHLTL
360 370 380 390 400
EWEKQEKLKK QQQQTLNINN NNTGIPLSKK LQLDVSDPLS NSSPSSPLIS
410 420 430 440 450
STLPIPETPP AIILKNEVAS PCPIKTTTSS TTINNKGQQQ DKAQEEKDSI
460 470
FSYADKQEKM THPTLHSPIE LPQSSL
Length:476
Mass (Da):53,798
Last modified:May 2, 2006 - v1
Checksum:iFFAF47417971D26F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70555.1.
AAFI02000009 Genomic DNA. Translation: EAL70817.1.
RefSeqiXP_644481.1. XM_639389.1.
XP_644769.1. XM_639677.1.

Genome annotation databases

EnsemblProtistsiDDB0238327; DDB0238327; DDB_G0273199.
DDB0238328; DDB0238328; DDB_G0273729.
GeneIDi8618871.
8619105.
KEGGiddi:DDB_G0273199.
ddi:DDB_G0273729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70555.1 .
AAFI02000009 Genomic DNA. Translation: EAL70817.1 .
RefSeqi XP_644481.1. XM_639389.1.
XP_644769.1. XM_639677.1.

3D structure databases

ProteinModelPortali Q556Y8.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0238327 ; DDB0238327 ; DDB_G0273199 .
DDB0238328 ; DDB0238328 ; DDB_G0273729 .
GeneIDi 8618871.
8619105.
KEGGi ddi:DDB_G0273199.
ddi:DDB_G0273729.

Organism-specific databases

dictyBasei DDB_G0273199. mkpB-1.
DDB_G0273729. mkpB-2.

Phylogenomic databases

eggNOGi COG2453.
InParanoidi Q556Y8.
KOi K04459.
OMAi AYLMKED.

Family and domain databases

Gene3Di 3.40.250.10. 2 hits.
3.90.190.10. 1 hit.
InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view ]
PANTHERi PTHR10159. PTHR10159. 1 hit.
Pfami PF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view ]
SMARTi SM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 2 hits.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiDUSPR_DICDI
AccessioniPrimary (citable) accession number: Q556Y8
Secondary accession number(s): Q86JT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 2, 2006
Last modified: October 29, 2014
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3