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Q556Y8 (DUSPR_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Probable rhodanese domain-containing dual specificity protein phosphatase

EC=3.1.3.16
EC=3.1.3.48
Gene names
ORF Names:DDB_G0273199
AND
ORF Names:DDB_G0273729
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length476 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has a dual specificity toward Ser/Thr and Tyr-containing proteins By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 rhodanese domain.

Contains 1 tyrosine-protein phosphatase domain.

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 476476Probable rhodanese domain-containing dual specificity protein phosphatase
PRO_0000332954

Regions

Domain32 – 190159Rhodanese
Domain209 – 349141Tyrosine-protein phosphatase
Compositional bias116 – 13520Thr-rich
Compositional bias192 – 1998Poly-Ser
Compositional bias200 – 2045Poly-Gly
Compositional bias361 – 3644Poly-Gln
Compositional bias367 – 3726Poly-Asn

Sites

Active site2941Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q556Y8 [UniParc].

Last modified May 2, 2006. Version 1.
Checksum: FFAF47417971D26F

FASTA47653,798
        10         20         30         40         50         60 
MVLINRVNIQ PEELPLLYHV NSMDVYNLLQ DIGSSKIIID LRTKEQYEKN HIRTSVNIPP 

        70         80         90        100        110        120 
PPSTTPLYEN GEIKEFNLSK YIGSNVTAKH WNLIFQKLIV YSDKPFLYNI DELEKTISTT 

       130        140        150        160        170        180 
TITTTATTTT TTTTTSNSIG SDQDIIKSLK VSDWDKVVLR HFLLKKKKTK VIIYQGGFDQ 

       190        200        210        220        230        240 
FQKDYSFMCN PSSSPSSSSG GGGGSQLYPS EIIKDFLYLG GAENAGNRQQ LINLKITHLV 

       250        260        270        280        290        300 
NMAGELDDVY PHLYKYYRAN LDDRPKANIY EHFEPVIQFI NDCKKQGGRV LIHCAMGISR 

       310        320        330        340        350        360 
STTVVLAYLM KEDHMTYSDA FTFCKQKRSC INPNFGFVKQ LKDYQQHLTL EWEKQEKLKK 

       370        380        390        400        410        420 
QQQQTLNINN NNTGIPLSKK LQLDVSDPLS NSSPSSPLIS STLPIPETPP AIILKNEVAS 

       430        440        450        460        470 
PCPIKTTTSS TTINNKGQQQ DKAQEEKDSI FSYADKQEKM THPTLHSPIE LPQSSL 

« Hide

References

[1]"Sequence and analysis of chromosome 2 of Dictyostelium discoideum."
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.
Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000011 Genomic DNA. Translation: EAL70555.1.
AAFI02000009 Genomic DNA. Translation: EAL70817.1.

3D structure databases

ProteinModelPortalQ556Y8.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0238327; DDB0238327; DDB_G0273199.
DDB0238328; DDB0238328; DDB_G0273729.
KEGGddi:DDB_G0273199.
ddi:DDB_G0273729.

Organism-specific databases

dictyBaseDDB_G0273199. mkpB-1.
DDB_G0273729. mkpB-2.

Phylogenomic databases

eggNOGCOG2453.
OMAAYLMKED.
ProtClustDBCLSZ2431153.

Family and domain databases

Gene3D3.40.250.10. 2 hits.
InterProIPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR001763. Rhodanese-like_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
SMARTSM00195. DSPc. 1 hit.
SM00450. RHOD. 1 hit.
[Graphical view]
SUPFAMSSF52821. SSF52821. 2 hits.
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDUSPR_DICDI
AccessionPrimary (citable) accession number: Q556Y8
Secondary accession number(s): Q86JT3
Entry history
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 2, 2006
Last modified: April 16, 2014
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase