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Protein

Probable rhodanese domain-containing dual specificity protein phosphatase

Gene

DDB_G0273199

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has a dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei294Phosphocysteine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • response to cisplatin Source: dictyBase
  • sorocarp development Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Probable rhodanese domain-containing dual specificity protein phosphatase (EC:3.1.3.16, EC:3.1.3.48)
Gene namesi
ORF Names:DDB_G0273199
AND
ORF Names:DDB_G0273729
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
Proteomesi
  • UP000002195 Componentsi: Chromosome 2, Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0273199. mkpB-1.
DDB_G0273729. mkpB-2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003329541 – 476Probable rhodanese domain-containing dual specificity protein phosphataseAdd BLAST476

Proteomic databases

PaxDbiQ556Y8.
PRIDEiQ556Y8.

Interactioni

Protein-protein interaction databases

STRINGi44689.DDB0238328.

Structurei

3D structure databases

ProteinModelPortaliQ556Y8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 190RhodaneseAdd BLAST159
Domaini209 – 349Tyrosine-protein phosphataseAdd BLAST141

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi116 – 135Thr-richAdd BLAST20
Compositional biasi192 – 199Poly-Ser8
Compositional biasi200 – 204Poly-Gly5
Compositional biasi361 – 364Poly-Gln4
Compositional biasi367 – 372Poly-Asn6

Sequence similaritiesi

Contains 1 rhodanese domain.Curated

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
InParanoidiQ556Y8.
KOiK04459.
OMAiAYLMKED.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.40.250.10. 2 hits.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 3 hits.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q556Y8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLINRVNIQ PEELPLLYHV NSMDVYNLLQ DIGSSKIIID LRTKEQYEKN
60 70 80 90 100
HIRTSVNIPP PPSTTPLYEN GEIKEFNLSK YIGSNVTAKH WNLIFQKLIV
110 120 130 140 150
YSDKPFLYNI DELEKTISTT TITTTATTTT TTTTTSNSIG SDQDIIKSLK
160 170 180 190 200
VSDWDKVVLR HFLLKKKKTK VIIYQGGFDQ FQKDYSFMCN PSSSPSSSSG
210 220 230 240 250
GGGGSQLYPS EIIKDFLYLG GAENAGNRQQ LINLKITHLV NMAGELDDVY
260 270 280 290 300
PHLYKYYRAN LDDRPKANIY EHFEPVIQFI NDCKKQGGRV LIHCAMGISR
310 320 330 340 350
STTVVLAYLM KEDHMTYSDA FTFCKQKRSC INPNFGFVKQ LKDYQQHLTL
360 370 380 390 400
EWEKQEKLKK QQQQTLNINN NNTGIPLSKK LQLDVSDPLS NSSPSSPLIS
410 420 430 440 450
STLPIPETPP AIILKNEVAS PCPIKTTTSS TTINNKGQQQ DKAQEEKDSI
460 470
FSYADKQEKM THPTLHSPIE LPQSSL
Length:476
Mass (Da):53,798
Last modified:May 2, 2006 - v1
Checksum:iFFAF47417971D26F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70555.1.
AAFI02000009 Genomic DNA. Translation: EAL70817.1.
RefSeqiXP_644481.1. XM_639389.1.
XP_644769.1. XM_639677.1.

Genome annotation databases

EnsemblProtistsiEAL70555; EAL70555; DDB_G0273729.
EAL70817; EAL70817; DDB_G0273199.
GeneIDi8618871.
8619105.
KEGGiddi:DDB_G0273199.
ddi:DDB_G0273729.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70555.1.
AAFI02000009 Genomic DNA. Translation: EAL70817.1.
RefSeqiXP_644481.1. XM_639389.1.
XP_644769.1. XM_639677.1.

3D structure databases

ProteinModelPortaliQ556Y8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi44689.DDB0238328.

Proteomic databases

PaxDbiQ556Y8.
PRIDEiQ556Y8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiEAL70555; EAL70555; DDB_G0273729.
EAL70817; EAL70817; DDB_G0273199.
GeneIDi8618871.
8619105.
KEGGiddi:DDB_G0273199.
ddi:DDB_G0273729.

Organism-specific databases

dictyBaseiDDB_G0273199. mkpB-1.
DDB_G0273729. mkpB-2.

Phylogenomic databases

eggNOGiKOG1716. Eukaryota.
COG2453. LUCA.
InParanoidiQ556Y8.
KOiK04459.
OMAiAYLMKED.

Miscellaneous databases

PROiQ556Y8.

Family and domain databases

CDDicd00127. DSPc. 1 hit.
Gene3Di3.40.250.10. 2 hits.
3.90.190.10. 1 hit.
InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR001763. Rhodanese-like_dom.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
IPR020422. TYR_PHOSPHATASE_DUAL_dom.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 3 hits.
PfamiPF00782. DSPc. 1 hit.
PF00581. Rhodanese. 1 hit.
[Graphical view]
SMARTiSM00195. DSPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
SSF52821. SSF52821. 2 hits.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUSPR_DICDI
AccessioniPrimary (citable) accession number: Q556Y8
Secondary accession number(s): Q86JT3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: May 2, 2006
Last modified: November 30, 2016
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.