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Q556Y8

- DUSPR_DICDI

UniProt

Q556Y8 - DUSPR_DICDI

Protein

Probable rhodanese domain-containing dual specificity protein phosphatase

Gene

DDB_G0273199

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Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 1 (02 May 2006)
      Previous versions | rss
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    Functioni

    Has a dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei294 – 2941Phosphocysteine intermediatePROSITE-ProRule annotation

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: dictyBase
    2. protein tyrosine/serine/threonine phosphatase activity Source: RefGenome
    3. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. protein dephosphorylation Source: RefGenome
    2. response to cisplatin Source: dictyBase
    3. sorocarp development Source: dictyBase

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable rhodanese domain-containing dual specificity protein phosphatase (EC:3.1.3.16, EC:3.1.3.48)
    Gene namesi
    ORF Names:DDB_G0273199
    AND
    ORF Names:DDB_G0273729
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0273199. mkpB-1.
    DDB_G0273729. mkpB-2.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 476476Probable rhodanese domain-containing dual specificity protein phosphatasePRO_0000332954Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ556Y8.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 190159RhodaneseAdd
    BLAST
    Domaini209 – 349141Tyrosine-protein phosphataseAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi116 – 13520Thr-richAdd
    BLAST
    Compositional biasi192 – 1998Poly-Ser
    Compositional biasi200 – 2045Poly-Gly
    Compositional biasi361 – 3644Poly-Gln
    Compositional biasi367 – 3726Poly-Asn

    Sequence similaritiesi

    Contains 1 rhodanese domain.Curated

    Phylogenomic databases

    eggNOGiCOG2453.
    KOiK04459.
    OMAiAYLMKED.

    Family and domain databases

    Gene3Di3.40.250.10. 2 hits.
    3.90.190.10. 1 hit.
    InterProiIPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view]
    SMARTiSM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 2 hits.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q556Y8-1 [UniParc]FASTAAdd to Basket

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    MVLINRVNIQ PEELPLLYHV NSMDVYNLLQ DIGSSKIIID LRTKEQYEKN    50
    HIRTSVNIPP PPSTTPLYEN GEIKEFNLSK YIGSNVTAKH WNLIFQKLIV 100
    YSDKPFLYNI DELEKTISTT TITTTATTTT TTTTTSNSIG SDQDIIKSLK 150
    VSDWDKVVLR HFLLKKKKTK VIIYQGGFDQ FQKDYSFMCN PSSSPSSSSG 200
    GGGGSQLYPS EIIKDFLYLG GAENAGNRQQ LINLKITHLV NMAGELDDVY 250
    PHLYKYYRAN LDDRPKANIY EHFEPVIQFI NDCKKQGGRV LIHCAMGISR 300
    STTVVLAYLM KEDHMTYSDA FTFCKQKRSC INPNFGFVKQ LKDYQQHLTL 350
    EWEKQEKLKK QQQQTLNINN NNTGIPLSKK LQLDVSDPLS NSSPSSPLIS 400
    STLPIPETPP AIILKNEVAS PCPIKTTTSS TTINNKGQQQ DKAQEEKDSI 450
    FSYADKQEKM THPTLHSPIE LPQSSL 476
    Length:476
    Mass (Da):53,798
    Last modified:May 2, 2006 - v1
    Checksum:iFFAF47417971D26F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000011 Genomic DNA. Translation: EAL70555.1.
    AAFI02000009 Genomic DNA. Translation: EAL70817.1.
    RefSeqiXP_644481.1. XM_639389.1.
    XP_644769.1. XM_639677.1.

    Genome annotation databases

    EnsemblProtistsiDDB0238327; DDB0238327; DDB_G0273199.
    DDB0238328; DDB0238328; DDB_G0273729.
    GeneIDi8618871.
    8619105.
    KEGGiddi:DDB_G0273199.
    ddi:DDB_G0273729.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000011 Genomic DNA. Translation: EAL70555.1 .
    AAFI02000009 Genomic DNA. Translation: EAL70817.1 .
    RefSeqi XP_644481.1. XM_639389.1.
    XP_644769.1. XM_639677.1.

    3D structure databases

    ProteinModelPortali Q556Y8.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0238327 ; DDB0238327 ; DDB_G0273199 .
    DDB0238328 ; DDB0238328 ; DDB_G0273729 .
    GeneIDi 8618871.
    8619105.
    KEGGi ddi:DDB_G0273199.
    ddi:DDB_G0273729.

    Organism-specific databases

    dictyBasei DDB_G0273199. mkpB-1.
    DDB_G0273729. mkpB-2.

    Phylogenomic databases

    eggNOGi COG2453.
    KOi K04459.
    OMAi AYLMKED.

    Family and domain databases

    Gene3Di 3.40.250.10. 2 hits.
    3.90.190.10. 1 hit.
    InterProi IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR001763. Rhodanese-like_dom.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    PF00581. Rhodanese. 1 hit.
    [Graphical view ]
    SMARTi SM00195. DSPc. 1 hit.
    SM00450. RHOD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    SSF52821. SSF52821. 2 hits.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiDUSPR_DICDI
    AccessioniPrimary (citable) accession number: Q556Y8
    Secondary accession number(s): Q86JT3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 29, 2008
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 59 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Caution

    The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3