ID   LYSD_DICDI              Reviewed;         260 AA.
AC   Q556Y7; Q86JT4;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   02-MAY-2006, sequence version 1.
DT   08-NOV-2023, entry version 79.
DE   RecName: Full=Lysozyme D;
DE            EC=3.2.1.17;
DE   AltName: Full=1,4-beta-N-acetylmuramidase D;
DE   Flags: Precursor;
GN   Name=alyD-1; ORFNames=DDB_G0273197;
GN   and
GN   Name=alyD-2; ORFNames=DDB_G0273731;
OS   Dictyostelium discoideum (Social amoeba).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [2] {ECO:0000312|EMBL:EAL70556.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
CC   -!- FUNCTION: Has antibacterial activity. {ECO:0000250|UniProtKB:Q554H2}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic
CC         acid and N-acetyl-D-glucosamine residues in a peptidoglycan and
CC         between N-acetyl-D-glucosamine residues in chitodextrins.;
CC         EC=3.2.1.17;
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle lumen
CC       {ECO:0000250|UniProtKB:Q554H2}.
CC   -!- PTM: Contains disulfide bonds. {ECO:0000250|UniProtKB:Q554H2}.
CC   -!- SIMILARITY: Belongs to the dictyostelium lysozyme family.
CC       {ECO:0000305}.
CC   -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC       AX4. These strains contain a duplication of a segment of 750 kb of
CC       chromosome 2 compared to the corresponding sequence in strain AX2.
CC       {ECO:0000305}.
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DR   EMBL; AAFI02000011; EAL70556.1; -; Genomic_DNA.
DR   EMBL; AAFI02000009; EAL70816.1; -; Genomic_DNA.
DR   RefSeq; XP_644482.1; XM_639390.1.
DR   RefSeq; XP_644768.1; XM_639676.1.
DR   AlphaFoldDB; Q556Y7; -.
DR   PaxDb; 44689-DDB0231280; -.
DR   EnsemblProtists; EAL70556; EAL70556; DDB_G0273731.
DR   EnsemblProtists; EAL70816; EAL70816; DDB_G0273197.
DR   GeneID; 8618870; -.
DR   GeneID; 8619106; -.
DR   KEGG; ddi:DDB_G0273197; -.
DR   KEGG; ddi:DDB_G0273731; -.
DR   dictyBase; DDB_G0273197; alyD-1.
DR   dictyBase; DDB_G0273731; alyD-2.
DR   eggNOG; ENOG502RD7J; Eukaryota.
DR   HOGENOM; CLU_1071285_0_0_1; -.
DR   InParanoid; Q556Y7; -.
DR   OMA; FCDESTA; -.
DR   PhylomeDB; Q556Y7; -.
DR   PRO; PR:Q556Y7; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0031410; C:cytoplasmic vesicle; ISS:UniProtKB.
DR   GO; GO:0060205; C:cytoplasmic vesicle lumen; IEA:UniProtKB-SubCell.
DR   GO; GO:0031983; C:vesicle lumen; ISS:UniProtKB.
DR   GO; GO:0003796; F:lysozyme activity; ISS:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; ISS:UniProtKB.
DR   GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR   GO; GO:0009253; P:peptidoglycan catabolic process; IC:dictyBase.
DR   PANTHER; PTHR37612; FIBROIN HEAVY CHAIN FIB-H LIKE PROTEIN; 1.
DR   PANTHER; PTHR37612:SF17; LYSOZYME D; 1.
PE   3: Inferred from homology;
KW   Antibiotic; Antimicrobial; Bacteriolytic enzyme; Cytoplasmic vesicle;
KW   Disulfide bond; Glycosidase; Hydrolase; Reference proteome; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250|UniProtKB:Q554H2"
FT   CHAIN           20..260
FT                   /note="Lysozyme D"
FT                   /evidence="ECO:0000250|UniProtKB:Q554H2"
FT                   /id="PRO_0000315920"
FT   REGION          83..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   260 AA;  26057 MW;  8A118309949B6010 CRC64;
     MRLLVTLILL IFVLTVSGQY SCSNPCYGNM CCSIPSNNEY YLTTFCDEST ACGTPCSAQT
     YFTADSQRFG CGVTLTICST SGGSTTTGGT GSAGTSTSSG SGSGSGSGSG SGSGSGSGTS
     GSSSSGSSSG SGSGSSSGSG GSSGSGSGST METGGFYGVC VKAITIDAGP NISVEEEAGM
     AIIDASSQIC QDLFGSSSCG WSDKRSITAV QSSVEDGFPV NKPFNVTFED YNKIISNSLI
     LDQQCSNKNN CKYNKLELMK
//