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Q556Y7

- LYSD_DICDI

UniProt

Q556Y7 - LYSD_DICDI

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Protein

Lysozyme D

Gene
alyD-1, DDB_G0273197
alyD-2, DDB_G0273731
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Has antibacterial activity By similarity.By similarity

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB

GO - Biological processi

  1. cytolysis Source: UniProtKB-KW
  2. defense response to Gram-positive bacterium Source: UniProtKB
  3. peptidoglycan catabolic process Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Names & Taxonomyi

Organism-specific databases

Protein namesi
Recommended name:
Lysozyme D (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase D
Gene namesi
Name:alyD-1
ORF Names:DDB_G0273197
AND
Name:alyD-2
ORF Names:DDB_G0273731
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence
dictyBaseiDDB_G0273197. alyD-1.
DDB_G0273731. alyD-2.

Subcellular locationi

Cytoplasmic vesicle lumen By similarity By similarity

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle lumen Source: UniProtKB-SubCell
  2. cytoplasmic vesicle Source: UniProtKB
  3. vesicle lumen Source: UniProtKB

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919 By similarityBy similarityAdd
BLAST
Chaini20 – 260241Lysozyme DBy similarityPRO_0000315920Add
BLAST

Post-translational modificationi

Contains disulfide bonds By similarity.By similarity

Keywords - PTMi

Disulfide bond

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi79 – 14971Ser-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

OMAiCDESTAC.
PhylomeDBiQ556Y7.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q556Y7-1 [UniParc]FASTAAdd to Basket

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MRLLVTLILL IFVLTVSGQY SCSNPCYGNM CCSIPSNNEY YLTTFCDEST    50
ACGTPCSAQT YFTADSQRFG CGVTLTICST SGGSTTTGGT GSAGTSTSSG 100
SGSGSGSGSG SGSGSGSGTS GSSSSGSSSG SGSGSSSGSG GSSGSGSGST 150
METGGFYGVC VKAITIDAGP NISVEEEAGM AIIDASSQIC QDLFGSSSCG 200
WSDKRSITAV QSSVEDGFPV NKPFNVTFED YNKIISNSLI LDQQCSNKNN 250
CKYNKLELMK 260
Length:260
Mass (Da):26,057
Last modified:May 2, 2006 - v1
Checksum:i8A118309949B6010
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70556.1.
AAFI02000009 Genomic DNA. Translation: EAL70816.1.
RefSeqiXP_644482.1. XM_639390.1.
XP_644768.1. XM_639676.1.

Genome annotation databases

EnsemblProtistsiDDB0231280; DDB0231280; DDB_G0273197.
DDB0266413; DDB0266413; DDB_G0273731.
GeneIDi8618870.
8619106.
KEGGiddi:DDB_G0273197.
ddi:DDB_G0273731.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70556.1 .
AAFI02000009 Genomic DNA. Translation: EAL70816.1 .
RefSeqi XP_644482.1. XM_639390.1.
XP_644768.1. XM_639676.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblProtistsi DDB0231280 ; DDB0231280 ; DDB_G0273197 .
DDB0266413 ; DDB0266413 ; DDB_G0273731 .
GeneIDi 8618870.
8619106.
KEGGi ddi:DDB_G0273197.
ddi:DDB_G0273731.

Organism-specific databases

dictyBasei DDB_G0273197. alyD-1.
DDB_G0273731. alyD-2.

Phylogenomic databases

OMAi CDESTAC.
PhylomeDBi Q556Y7.

Family and domain databases

ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiLYSD_DICDI
AccessioniPrimary (citable) accession number: Q556Y7
Secondary accession number(s): Q86JT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 2, 2006
Last modified: May 14, 2014
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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