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Q556Y7 (LYSD_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 51. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysozyme D

EC=3.2.1.17
Alternative name(s):
1,4-beta-N-acetylmuramidase D
Gene names
Name:alyD-1
ORF Names:DDB_G0273197
AND
Name:alyD-2
ORF Names:DDB_G0273731
OrganismDictyostelium discoideum (Slime mold) [Reference proteome]
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium

Protein attributes

Sequence length260 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Has antibacterial activity By similarity. UniProtKB Q554H2

Catalytic activity

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

Subcellular location

Cytoplasmic vesicle lumen By similarity UniProtKB Q554H2.

Post-translational modification

Contains disulfide bonds By similarity. UniProtKB Q554H2

Sequence similarities

Belongs to the dictyostelium lysozyme family.

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919 By similarity UniProtKB Q554H2
Chain20 – 260241Lysozyme D UniProtKB Q554H2
PRO_0000315920

Regions

Compositional bias79 – 14971Ser-rich

Sequences

Sequence LengthMass (Da)Tools
Q556Y7 [UniParc].

Last modified May 2, 2006. Version 1.
Checksum: 8A118309949B6010

FASTA26026,057
        10         20         30         40         50         60 
MRLLVTLILL IFVLTVSGQY SCSNPCYGNM CCSIPSNNEY YLTTFCDEST ACGTPCSAQT 

        70         80         90        100        110        120 
YFTADSQRFG CGVTLTICST SGGSTTTGGT GSAGTSTSSG SGSGSGSGSG SGSGSGSGTS 

       130        140        150        160        170        180 
GSSSSGSSSG SGSGSSSGSG GSSGSGSGST METGGFYGVC VKAITIDAGP NISVEEEAGM 

       190        200        210        220        230        240 
AIIDASSQIC QDLFGSSSCG WSDKRSITAV QSSVEDGFPV NKPFNVTFED YNKIISNSLI 

       250        260 
LDQQCSNKNN CKYNKLELMK 

« Hide

References

[1]"Sequence and analysis of chromosome 2 of Dictyostelium discoideum."
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.
Nature 418:79-85(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AAFI02000011 Genomic DNA. Translation: EAL70556.1.
AAFI02000009 Genomic DNA. Translation: EAL70816.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0231280; DDB0231280; DDB_G0273197.
DDB0266413; DDB0266413; DDB_G0273731.
KEGGddi:DDB_G0273197.
ddi:DDB_G0273731.

Organism-specific databases

dictyBaseDDB_G0273197. alyD-1.
DDB_G0273731. alyD-2.

Phylogenomic databases

OMACDESTAC.
PhylomeDBQ556Y7.
ProtClustDBCLSZ2430419.

Family and domain databases

ProtoNetSearch...

Entry information

Entry nameLYSD_DICDI
AccessionPrimary (citable) accession number: Q556Y7
Secondary accession number(s): Q86JT4
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 2, 2006
Last modified: April 16, 2014
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase