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Protein

Lysozyme D

Gene

alyD-1

more
Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Has antibacterial activity.By similarity

Catalytic activityi

Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

GO - Molecular functioni

  1. lysozyme activity Source: UniProtKB

GO - Biological processi

  1. cytolysis Source: UniProtKB-KW
  2. defense response to Gram-positive bacterium Source: UniProtKB
  3. peptidoglycan catabolic process Source: dictyBase
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

Names & Taxonomyi

Protein namesi
Recommended name:
Lysozyme D (EC:3.2.1.17)
Alternative name(s):
1,4-beta-N-acetylmuramidase D
Gene namesi
Name:alyD-1
ORF Names:DDB_G0273197
AND
Name:alyD-2
ORF Names:DDB_G0273731
OrganismiDictyostelium discoideum (Slime mold)
Taxonomic identifieri44689 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

Organism-specific databases

dictyBaseiDDB_G0273197. alyD-1.
DDB_G0273731. alyD-2.

Subcellular locationi

Cytoplasmic vesicle lumen By similarity

GO - Cellular componenti

  1. cytoplasmic membrane-bounded vesicle lumen Source: UniProtKB-SubCell
  2. cytoplasmic vesicle Source: UniProtKB
  3. vesicle lumen Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasmic vesicle

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919By similarityAdd
BLAST
Chaini20 – 260241Lysozyme DBy similarityPRO_0000315920Add
BLAST

Post-translational modificationi

Contains disulfide bonds.By similarity

Keywords - PTMi

Disulfide bond

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi79 – 14971Ser-richSequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the dictyostelium lysozyme family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

InParanoidiQ556Y7.
OMAiCDESTAC.
PhylomeDBiQ556Y7.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q556Y7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRLLVTLILL IFVLTVSGQY SCSNPCYGNM CCSIPSNNEY YLTTFCDEST
60 70 80 90 100
ACGTPCSAQT YFTADSQRFG CGVTLTICST SGGSTTTGGT GSAGTSTSSG
110 120 130 140 150
SGSGSGSGSG SGSGSGSGTS GSSSSGSSSG SGSGSSSGSG GSSGSGSGST
160 170 180 190 200
METGGFYGVC VKAITIDAGP NISVEEEAGM AIIDASSQIC QDLFGSSSCG
210 220 230 240 250
WSDKRSITAV QSSVEDGFPV NKPFNVTFED YNKIISNSLI LDQQCSNKNN
260
CKYNKLELMK
Length:260
Mass (Da):26,057
Last modified:May 2, 2006 - v1
Checksum:i8A118309949B6010
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70556.1.
AAFI02000009 Genomic DNA. Translation: EAL70816.1.
RefSeqiXP_644482.1. XM_639390.1.
XP_644768.1. XM_639676.1.

Genome annotation databases

EnsemblProtistsiDDB0231280; DDB0231280; DDB_G0273197.
DDB0266413; DDB0266413; DDB_G0273731.
GeneIDi8618870.
8619106.
KEGGiddi:DDB_G0273197.
ddi:DDB_G0273731.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAFI02000011 Genomic DNA. Translation: EAL70556.1.
AAFI02000009 Genomic DNA. Translation: EAL70816.1.
RefSeqiXP_644482.1. XM_639390.1.
XP_644768.1. XM_639676.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsiDDB0231280; DDB0231280; DDB_G0273197.
DDB0266413; DDB0266413; DDB_G0273731.
GeneIDi8618870.
8619106.
KEGGiddi:DDB_G0273197.
ddi:DDB_G0273731.

Organism-specific databases

dictyBaseiDDB_G0273197. alyD-1.
DDB_G0273731. alyD-2.

Phylogenomic databases

InParanoidiQ556Y7.
OMAiCDESTAC.
PhylomeDBiQ556Y7.

Family and domain databases

ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.
  2. "The genome of the social amoeba Dictyostelium discoideum."
    Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
    , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
    Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: AX4.

Entry informationi

Entry nameiLYSD_DICDI
AccessioniPrimary (citable) accession number: Q556Y7
Secondary accession number(s): Q86JT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: May 2, 2006
Last modified: January 7, 2015
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Dictyostelium discoideum
    Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
  2. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.