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Q556Y7

- LYSD_DICDI

UniProt

Q556Y7 - LYSD_DICDI

Protein

Lysozyme D

Gene

alyD-1

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Organism
Dictyostelium discoideum (Slime mold)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 53 (01 Oct 2014)
      Sequence version 1 (02 May 2006)
      Previous versions | rss
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    Functioni

    Has antibacterial activity.By similarity

    Catalytic activityi

    Hydrolysis of (1->4)-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan and between N-acetyl-D-glucosamine residues in chitodextrins.

    GO - Molecular functioni

    1. lysozyme activity Source: UniProtKB

    GO - Biological processi

    1. cytolysis Source: UniProtKB-KW
    2. defense response to Gram-positive bacterium Source: UniProtKB
    3. peptidoglycan catabolic process Source: dictyBase

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial, Bacteriolytic enzyme, Glycosidase, Hydrolase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysozyme D (EC:3.2.1.17)
    Alternative name(s):
    1,4-beta-N-acetylmuramidase D
    Gene namesi
    Name:alyD-1
    ORF Names:DDB_G0273197
    AND
    Name:alyD-2
    ORF Names:DDB_G0273731
    OrganismiDictyostelium discoideum (Slime mold)
    Taxonomic identifieri44689 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaMycetozoaDictyosteliidaDictyostelium
    ProteomesiUP000002195: Chromosome 2, UP000002195: Unassembled WGS sequence

    Organism-specific databases

    dictyBaseiDDB_G0273197. alyD-1.
    DDB_G0273731. alyD-2.

    Subcellular locationi

    Cytoplasmic vesicle lumen By similarity

    GO - Cellular componenti

    1. cytoplasmic membrane-bounded vesicle lumen Source: UniProtKB-SubCell
    2. cytoplasmic vesicle Source: UniProtKB
    3. vesicle lumen Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasmic vesicle

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919By similarityAdd
    BLAST
    Chaini20 – 260241Lysozyme DBy similarityPRO_0000315920Add
    BLAST

    Post-translational modificationi

    Contains disulfide bonds.By similarity

    Keywords - PTMi

    Disulfide bond

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi79 – 14971Ser-richSequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the dictyostelium lysozyme family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    OMAiCDESTAC.
    PhylomeDBiQ556Y7.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q556Y7-1 [UniParc]FASTAAdd to Basket

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    MRLLVTLILL IFVLTVSGQY SCSNPCYGNM CCSIPSNNEY YLTTFCDEST    50
    ACGTPCSAQT YFTADSQRFG CGVTLTICST SGGSTTTGGT GSAGTSTSSG 100
    SGSGSGSGSG SGSGSGSGTS GSSSSGSSSG SGSGSSSGSG GSSGSGSGST 150
    METGGFYGVC VKAITIDAGP NISVEEEAGM AIIDASSQIC QDLFGSSSCG 200
    WSDKRSITAV QSSVEDGFPV NKPFNVTFED YNKIISNSLI LDQQCSNKNN 250
    CKYNKLELMK 260
    Length:260
    Mass (Da):26,057
    Last modified:May 2, 2006 - v1
    Checksum:i8A118309949B6010
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000011 Genomic DNA. Translation: EAL70556.1.
    AAFI02000009 Genomic DNA. Translation: EAL70816.1.
    RefSeqiXP_644482.1. XM_639390.1.
    XP_644768.1. XM_639676.1.

    Genome annotation databases

    EnsemblProtistsiDDB0231280; DDB0231280; DDB_G0273197.
    DDB0266413; DDB0266413; DDB_G0273731.
    GeneIDi8618870.
    8619106.
    KEGGiddi:DDB_G0273197.
    ddi:DDB_G0273731.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AAFI02000011 Genomic DNA. Translation: EAL70556.1 .
    AAFI02000009 Genomic DNA. Translation: EAL70816.1 .
    RefSeqi XP_644482.1. XM_639390.1.
    XP_644768.1. XM_639676.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblProtistsi DDB0231280 ; DDB0231280 ; DDB_G0273197 .
    DDB0266413 ; DDB0266413 ; DDB_G0273731 .
    GeneIDi 8618870.
    8619106.
    KEGGi ddi:DDB_G0273197.
    ddi:DDB_G0273731.

    Organism-specific databases

    dictyBasei DDB_G0273197. alyD-1.
    DDB_G0273731. alyD-2.

    Phylogenomic databases

    OMAi CDESTAC.
    PhylomeDBi Q556Y7.

    Family and domain databases

    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.
    2. "The genome of the social amoeba Dictyostelium discoideum."
      Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N.
      , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
      Nature 435:43-57(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: AX4.

    Entry informationi

    Entry nameiLYSD_DICDI
    AccessioniPrimary (citable) accession number: Q556Y7
    Secondary accession number(s): Q86JT4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: May 2, 2006
    Last modified: October 1, 2014
    This is version 53 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Caution

    The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Dictyostelium discoideum
      Dictyostelium discoideum: entries, gene names and cross-references to dictyBase
    2. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3