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Q556W1 (OXDD_DICDI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-aspartate oxidase
Short name=DASOX
EC=1.4.3.1
Alternative name(s):
DDO
Gene names
Name:ddo-1
ORF Names:DDB_G0273783
AND
Name:ddo-2
ORF Names:DDB_G0273291
OrganismDictyostelium discoideum (Slime mold)
Taxonomic identifier44689 [NCBI]
Taxonomic lineageEukaryota › Amoebozoa › Mycetozoa › Dictyosteliida › Dictyostelium

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2.

Cofactor

FAD or 6-hydroxyflavin adenine dinucleotide By similarity.

Subcellular location

Peroxisome membrane; Single-pass type II membrane protein Potential.

Sequence similarities

Belongs to the DAMOX/DASOX family.

Caution

The gene for this protein is duplicated in strains AX3 and AX4. These strains contain a duplication of a segment of 750 kb of chromosome 2 compared to the corresponding sequence in strain AX2.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346D-aspartate oxidase
PRO_0000328215

Regions

Topological domain1 – 1212Cytoplasmic Potential
Transmembrane13 – 3220Helical; Signal-anchor for type II membrane protein; Potential
Topological domain33 – 346314Peroxisomal Potential
Nucleotide binding16 – 3015FAD By similarity
Nucleotide binding46 – 472FAD By similarity
Nucleotide binding53 – 542FAD By similarity
Nucleotide binding58 – 603FAD By similarity
Nucleotide binding311 – 3155FAD By similarity
Motif344 – 3463Microbody targeting signal Potential
Compositional bias2 – 1110Poly-Asn

Sites

Binding site1701FAD; via amide nitrogen and carbonyl oxygen By similarity
Binding site1871FAD By similarity
Binding site2271Substrate By similarity
Binding site2841Substrate By similarity
Binding site3121Substrate; via carbonyl oxygen By similarity
Binding site3161FAD By similarity

Amino acid modifications

Glycosylation511N-linked (GlcNAc...) Potential
Glycosylation1851N-linked (GlcNAc...) Potential
Glycosylation2121N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q556W1 [UniParc].

Last modified May 24, 2005. Version 1.
Checksum: 11D20516EFC86E45

FASTA34639,166
        10         20         30         40         50         60 
MNQNKNNNNK NPKINLLIIG CGCIGLSTGI IALKSGNYKS VSIWAKDLPP NTTSNKAAAL 

        70         80         90        100        110        120 
WYPFLCNPLD LVGKWSAETM QYYKDHIIND PKSGTITKKV NEIFRRPHPE DPEWKPYIKS 

       130        140        150        160        170        180 
FRRARKDELP DGYVDGYAID DGFVMDTDMY MDYLVDQFKS LGGIIEQRHL VDIREAFVDH 

       190        200        210        220        230        240 
DVVVNCTGLG SRELFNDRTI YPGRGQIIVI KNSTDRSIMD EEDHIAYVIP RLTNTVLGGT 

       250        260        270        280        290        300 
NQEHDYNTNP TKKDTEEILK RVAMISPRFA KNRIEIQGVK VGLRPARHEI RLENEFFEGG 

       310        320        330        340 
SKLVVHNYGH GGSGFTVSWG CAIEAIKLVD QGLPKLLHFN KLISKL

« Hide

References

[1]"Sequence and analysis of chromosome 2 of Dictyostelium discoideum."
Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T., Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R., Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A., Noegel A.A.
Nature 418:79-85(2002) [PubMed: 12097910] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.
[2]"The genome of the social amoeba Dictyostelium discoideum."
Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R., Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B., Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T., Lehmann R., Hamlin N. expand/collapse author list , Davies R., Gaudet P., Fey P., Pilcher K., Chen G., Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N., Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E., Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N., Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D., Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T., Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D., Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A., Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M., Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A., Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y., Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C., Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R., Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.
Nature 435:43-57(2005) [PubMed: 15875012] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AX4.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AAFI02000011 Genomic DNA. Translation: EAL70582.1.
AAFI02000009 Genomic DNA. Translation: EAL70863.1.
RefSeqXP_644508.1. XM_639416.1.
XP_644742.1. XM_639650.1.

3D structure databases

HSSPHSSP built from PDB template 1AN9 based on UniProtKB P00371.
ProteinModelPortalQ556W1.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblProtistsDDB0238431; DDB0238431; DDB_G0273291.
DDB0238432; DDB0238432; DDB_G0273783.
GeneID8618842.
8619134.
GenomeReviewsGene locus ddo-2 in contig CM000151_GR.
KEGGddi:DDB_G0273291.
ddi:DDB_G0273783.

Organism-specific databases

dictyBaseDDB_G0273783. ddo-1.
DDB_G0273291. ddo-2.

Phylogenomic databases

eggNOGKOG3923.
GeneTreeEPrGT00050000005603.
HOGENOMHBG735740.
OMAWPYRIEP.
PhylomeDBQ556W1.
ProtClustDBCLSZ2431171.

Family and domain databases

InterProIPR023209. D-aa_oxidase.
IPR006181. D-amino_acid_oxidase_CS.
IPR006076. FAD-dep_OxRdtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 3 hits.
KOK00273.
PANTHERPTHR11530. PTHR11530. 1 hit.
PfamPF01266. DAO. 1 hit.
[Graphical view]
PIRSFPIRSF000189. D-aa_oxidase. 1 hit.
PROSITEPS00677. DAO. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameOXDD_DICDI
AccessionPrimary (citable) accession number: Q556W1
Secondary accession number(s): Q86JV2
Entry history
Integrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: May 24, 2005
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

Dictyostelium discoideum

Dictyostelium discoideum: entries, gene names and cross-references to dictyBase

SIMILARITY comments

Index of protein domains and families

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